JP2016513950A5 - - Google Patents
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- Publication number
- JP2016513950A5 JP2016513950A5 JP2015533454A JP2015533454A JP2016513950A5 JP 2016513950 A5 JP2016513950 A5 JP 2016513950A5 JP 2015533454 A JP2015533454 A JP 2015533454A JP 2015533454 A JP2015533454 A JP 2015533454A JP 2016513950 A5 JP2016513950 A5 JP 2016513950A5
- Authority
- JP
- Japan
- Prior art keywords
- oligomer
- monomers
- affinity region
- region consisting
- microrna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000178 monomer Substances 0.000 claims 9
- 108700011259 MicroRNAs Proteins 0.000 claims 4
- 239000002679 microRNA Substances 0.000 claims 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261705668P | 2012-09-26 | 2012-09-26 | |
| DKPA201200587 | 2012-09-26 | ||
| US61/705,668 | 2012-09-26 | ||
| DKPA201200587 | 2012-09-26 | ||
| PCT/DK2013/050308 WO2014048441A1 (en) | 2012-09-26 | 2013-09-26 | Oligomers with improved off-target profile |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513950A JP2016513950A (ja) | 2016-05-19 |
| JP2016513950A5 true JP2016513950A5 (https=) | 2017-06-22 |
| JP6352269B2 JP6352269B2 (ja) | 2018-07-04 |
Family
ID=50387035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015533454A Active JP6352269B2 (ja) | 2012-09-26 | 2013-09-26 | オフターゲットプロファイルの改善されたオリゴマー |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9725721B2 (https=) |
| EP (1) | EP2900822B1 (https=) |
| JP (1) | JP6352269B2 (https=) |
| CN (1) | CN104955950B (https=) |
| AU (1) | AU2013324716B2 (https=) |
| CA (1) | CA2886116C (https=) |
| WO (1) | WO2014048441A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3211082B1 (en) | 2011-04-25 | 2021-02-17 | Sanofi | Microrna compounds and methods for modulating mir-21 activity |
| PE20142404A1 (es) | 2012-04-25 | 2015-02-02 | Regulus Therapeutics Inc | Compuestos de microarn y metodos de modulacion de la actividad de mir-21 |
| JP6430945B2 (ja) | 2012-10-02 | 2018-11-28 | センテナリ インスティテュート オブ キャンサー メディシン アンド セル バイオロジーＣｅｎｔｅｎａｒｙ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｃａｎｃｅｒ Ｍｅｄｉｃｉｎｅ Ａｎｄ Ｃｅｌｌ Ｂｉｏｌｏｇｙ | Ｒｎａ活性及び血管透過性の調節 |
| UA116639C2 (uk) | 2012-10-09 | 2018-04-25 | Рег'Юлес Терап'Ютікс Інк. | Способи лікування синдрому альпорта |
| SG11201508925WA (en) | 2013-05-01 | 2015-11-27 | Regulus Therapeutics Inc | Microrna compounds and methods for modulating mir-122 |
| US9994846B2 (en) | 2013-10-25 | 2018-06-12 | Regulus Therapeutics Inc. | MicroRNA compounds and methods for modulating miR-21 activity |
| RU2017100434A (ru) | 2014-06-13 | 2018-07-18 | Торэй Индастриз, Инк. | Набор или устройство для обнаружения рака молочной железы и способ обнаружения |
| US10604810B2 (en) | 2014-06-13 | 2020-03-31 | Toray Industries, Inc. | Colorectal cancer detection kit or device, and detection method |
| CN106460068B (zh) * | 2014-06-16 | 2024-08-23 | 东丽株式会社 | 胃癌的检测试剂盒或装置以及检测方法 |
| EP3862439B1 (en) | 2014-06-18 | 2025-10-01 | Toray Industries, Inc. | Liver cancer detection kit or device, and detection method |
| JP6385732B2 (ja) * | 2014-06-27 | 2018-09-05 | 国立大学法人北海道大学 | 免疫応答制御剤 |
| TW201613949A (en) | 2014-08-07 | 2016-04-16 | Regulus Therapeutics Inc | Targeting microRNAs for metabolic disorders |
| US11348663B2 (en) | 2014-09-16 | 2022-05-31 | Toray Industries, Inc. | Method and device for comparative analysis of miRNA expression level |
| WO2016115609A1 (en) * | 2015-01-20 | 2016-07-28 | Katholieke Universiteit Leuven | Colon cancer |
| RU2686313C2 (ru) | 2015-02-25 | 2019-04-25 | Байонир Корпорейшн | Фармацевтическая композиция для лечения рака, содержащая микроРНК в качестве активного ингредиента |
| CN104826133B (zh) * | 2015-05-01 | 2020-11-24 | 北京博奥医学检验所有限公司 | 一种与肺腺癌有关的miRNA及其药物组合物 |
| CN107058473B (zh) * | 2016-11-03 | 2020-10-27 | 中国人民解放军陆军军医大学 | 一种联合miR-676、miR-181b和miR-3591诊断急性高山病的试剂盒 |
| CN107058471B (zh) * | 2016-11-03 | 2020-09-01 | 中国人民解放军陆军军医大学 | 一种通过四种microRNA生物标志物联合预测急性高山病发病风险的试剂盒 |
| CN107058470B (zh) * | 2016-11-03 | 2020-09-01 | 中国人民解放军陆军军医大学 | 一种通过联合miR-136和miR-4791预测急性高山病发病风险的诊断试剂盒 |
| CN107058472B (zh) * | 2016-11-03 | 2020-10-27 | 中国人民解放军陆军军医大学 | 一种通过四种血浆microRNA联合诊断急性高山病的诊断试剂盒 |
| CN107058475B (zh) * | 2016-11-03 | 2020-10-27 | 中国人民解放军陆军军医大学 | 一种联合miR-676、miR-181b和miR-193b诊断急性高山病的试剂盒 |
| CN107058474B (zh) * | 2016-11-03 | 2020-09-01 | 中国人民解放军陆军军医大学 | 一种通过血浆microRNA-3591-3p诊断急性高山病的诊断试剂盒 |
| CN108251422A (zh) * | 2016-12-29 | 2018-07-06 | 昆山彭济凯丰生物科技有限公司 | 通过miR-6069进行抗癌的方法和药物及其应用 |
| CN108295086B (zh) * | 2017-01-13 | 2021-11-02 | 昆山彭济凯丰生物科技有限公司 | 通过miR-4418进行抗癌的方法和药物及其应用 |
| CN108295260A (zh) * | 2017-01-13 | 2018-07-20 | 彭长庚 | 通过miR-1915-3p进行抗癌的方法和药物及其应用 |
| CN108310381A (zh) * | 2017-01-16 | 2018-07-24 | 昆山彭济凯丰生物科技有限公司 | 通过miR-6511b-3p进行抗癌的方法和药物及其应用 |
| CN107502609A (zh) * | 2017-09-08 | 2017-12-22 | 中国科学院深圳先进技术研究院 | 一种靶向cJun信号通路的miRNA及其制备方法和应用 |
| KR102070969B1 (ko) * | 2018-04-10 | 2020-01-29 | 한국한의학연구원 | 통증 판별용 마커 |
| EP3790972A1 (en) | 2018-05-08 | 2021-03-17 | Regulus Therapeutics Inc. | Galnac conjugated modified oligonucleotide as mir-122 inhibitor having hcv antiviral activity with reduced hyperbilirubinemia side-effect |
| CN109468375B (zh) * | 2018-12-28 | 2021-05-14 | 固安博健生物技术有限公司 | 分子标志物在骨质疏松症中的应用 |
| EP3981473A4 (en) * | 2019-06-05 | 2023-06-28 | Cancerstem Tech Inc. | Therapeutic agent for cancer |
| CN111073973A (zh) * | 2019-12-10 | 2020-04-28 | 石河子大学 | 一种用于早期诊断2型糖尿病的microRNA序列及其应用 |
| CN114767703B (zh) * | 2022-06-20 | 2022-09-02 | 山东恺悌生物制品有限公司 | miR-4311模拟物在制备肺癌治疗药物中的应用 |
| AU2024353921A1 (en) * | 2023-09-27 | 2026-04-16 | Neuro3 Therapeutics (Suzhou) Ltd. | Novel sirna constructs, therapeutics, and modifications |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5898031A (en) * | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
| RU2377301C2 (ru) * | 2003-12-23 | 2009-12-27 | Сантарис Фарма А/С | ОЛИГОМЕРНОЕ СОЕДИНЕНИЕ, ПОНИЖАЮЩЕЕ ЭКСПРЕССИЮ ЧЕЛОВЕЧЕСКОГО ГЕНА Bcl-2, КОНЪЮГАТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ПРИМЕНЕНИЕ ОЛИГОМЕРНОГО СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ РАКА |
| AU2006291836B2 (en) * | 2005-09-15 | 2012-02-23 | Santaris Pharma A/S | RNA antagonist compounds for the inhibition of Apo-Bl00 expression |
| US20100021914A1 (en) * | 2006-11-23 | 2010-01-28 | Querdenker Aps | Oligonucleotides for modulating target rna activity |
| US20090137504A1 (en) * | 2006-12-21 | 2009-05-28 | Soren Morgenthaler Echwald | Microrna target site blocking oligos and uses thereof |
| US8691965B2 (en) * | 2007-06-14 | 2014-04-08 | Mirx Therapeutics Aps | Oligonucleotides for modulating target RNA activity |
| JP5872162B2 (ja) * | 2007-11-26 | 2016-03-01 | エンゾン ファーマシューティカルズ，インコーポレーテッド | アンドロゲン受容体を標的化するｌｎａアンタゴニスト |
| WO2009090182A1 (en) * | 2008-01-14 | 2009-07-23 | Santaris Pharma A/S | C4'-substituted - dna nucleotide gapmer oligonucleotides |
| ES2599979T3 (es) * | 2009-04-24 | 2017-02-06 | Roche Innovation Center Copenhagen A/S | Composiciones farmacéuticas para el tratamiento de pacientes de VHC que no responden al interferón |
| WO2011115818A1 (en) * | 2010-03-17 | 2011-09-22 | Isis Pharmaceuticals, Inc. | 5'-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom |
| US20130079505A1 (en) * | 2010-03-24 | 2013-03-28 | Mirrx Therapeutics A/S | Bivalent antisense oligonucleotides |
-
2013
- 2013-09-26 CN CN201380057694.6A patent/CN104955950B/zh active Active
- 2013-09-26 AU AU2013324716A patent/AU2013324716B2/en active Active
- 2013-09-26 CA CA2886116A patent/CA2886116C/en active Active
- 2013-09-26 US US14/431,212 patent/US9725721B2/en active Active
- 2013-09-26 JP JP2015533454A patent/JP6352269B2/ja active Active
- 2013-09-26 WO PCT/DK2013/050308 patent/WO2014048441A1/en not_active Ceased
- 2013-09-26 EP EP13842025.2A patent/EP2900822B1/en active Active
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