JP2016513950A5 - - Google Patents
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- Publication number
- JP2016513950A5 JP2016513950A5 JP2015533454A JP2015533454A JP2016513950A5 JP 2016513950 A5 JP2016513950 A5 JP 2016513950A5 JP 2015533454 A JP2015533454 A JP 2015533454A JP 2015533454 A JP2015533454 A JP 2015533454A JP 2016513950 A5 JP2016513950 A5 JP 2016513950A5
- Authority
- JP
- Japan
- Prior art keywords
- oligomer
- monomers
- affinity region
- region consisting
- microrna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000178 monomer Substances 0.000 claims 9
- 108700011259 MicroRNAs Proteins 0.000 claims 4
- 239000002679 microRNA Substances 0.000 claims 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261705668P | 2012-09-26 | 2012-09-26 | |
| DKPA201200587 | 2012-09-26 | ||
| US61/705,668 | 2012-09-26 | ||
| DKPA201200587 | 2012-09-26 | ||
| PCT/DK2013/050308 WO2014048441A1 (en) | 2012-09-26 | 2013-09-26 | Oligomers with improved off-target profile |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513950A JP2016513950A (ja) | 2016-05-19 |
| JP2016513950A5 true JP2016513950A5 (https=) | 2017-06-22 |
| JP6352269B2 JP6352269B2 (ja) | 2018-07-04 |
Family
ID=50387035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015533454A Active JP6352269B2 (ja) | 2012-09-26 | 2013-09-26 | オフターゲットプロファイルの改善されたオリゴマー |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9725721B2 (https=) |
| EP (1) | EP2900822B1 (https=) |
| JP (1) | JP6352269B2 (https=) |
| CN (1) | CN104955950B (https=) |
| AU (1) | AU2013324716B2 (https=) |
| CA (1) | CA2886116C (https=) |
| WO (1) | WO2014048441A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE031595T2 (en) | 2011-04-25 | 2017-07-28 | Regulus Therapeutics Inc | Micro RNA Compounds s Methods for Modulating Mir-21 Activity |
| EA030211B1 (ru) | 2012-04-25 | 2018-07-31 | Регьюлэс Терапьютикс Инк. | Соединения на основе микрорнк и способы модулирования активности mir-21 |
| CA2886745A1 (en) | 2012-10-02 | 2014-04-10 | Centenary Institute Of Cancer Medicine And Cell Biology | Modulation of rna activity and vascular permeability |
| UA116639C2 (uk) | 2012-10-09 | 2018-04-25 | Рег'Юлес Терап'Ютікс Інк. | Способи лікування синдрому альпорта |
| SG10201803157XA (en) | 2013-05-01 | 2018-05-30 | Regulus Therapeutics Inc | Microrna compounds and methods for modulating mir-122 |
| US9994846B2 (en) | 2013-10-25 | 2018-06-12 | Regulus Therapeutics Inc. | MicroRNA compounds and methods for modulating miR-21 activity |
| KR102511711B1 (ko) * | 2014-06-13 | 2023-03-20 | 국립연구개발법인 고쿠리츠간켄큐센터 | 유방암 검출 키트 또는 디바이스 및 검출 방법 |
| CN118813801A (zh) * | 2014-06-13 | 2024-10-22 | 东丽株式会社 | 大肠癌的检测试剂盒或装置以及检测方法 |
| EP4718079A2 (en) * | 2014-06-16 | 2026-04-01 | Toray Industries, Inc. | Stomach cancer biomarker and detection method |
| BR112016029634A2 (pt) * | 2014-06-18 | 2017-10-24 | Nat Cancer Ct | kit, dispositivo e método para a detecção de câncer de fígado |
| JP6385732B2 (ja) * | 2014-06-27 | 2018-09-05 | 国立大学法人北海道大学 | 免疫応答制御剤 |
| KR20170033439A (ko) | 2014-08-07 | 2017-03-24 | 레굴루스 테라퓨틱스 인크 | 대사 장애에 대한 마이크로rna의 표적화 |
| CN107075578B (zh) * | 2014-09-16 | 2021-06-01 | 东丽株式会社 | miRNA表达量的比较分析方法和装置 |
| WO2016115609A1 (en) * | 2015-01-20 | 2016-07-28 | Katholieke Universiteit Leuven | Colon cancer |
| KR101862080B1 (ko) | 2015-02-25 | 2018-07-04 | (주)바이오니아 | 마이크로 rna 를 유효 성분으로 포함하는 암 치료용 약학 조성물 |
| CN104826133B (zh) * | 2015-05-01 | 2020-11-24 | 北京博奥医学检验所有限公司 | 一种与肺腺癌有关的miRNA及其药物组合物 |
| CN107058474B (zh) * | 2016-11-03 | 2020-09-01 | 中国人民解放军陆军军医大学 | 一种通过血浆microRNA-3591-3p诊断急性高山病的诊断试剂盒 |
| CN107058475B (zh) * | 2016-11-03 | 2020-10-27 | 中国人民解放军陆军军医大学 | 一种联合miR-676、miR-181b和miR-193b诊断急性高山病的试剂盒 |
| CN107058472B (zh) * | 2016-11-03 | 2020-10-27 | 中国人民解放军陆军军医大学 | 一种通过四种血浆microRNA联合诊断急性高山病的诊断试剂盒 |
| CN107058473B (zh) * | 2016-11-03 | 2020-10-27 | 中国人民解放军陆军军医大学 | 一种联合miR-676、miR-181b和miR-3591诊断急性高山病的试剂盒 |
| CN107058470B (zh) * | 2016-11-03 | 2020-09-01 | 中国人民解放军陆军军医大学 | 一种通过联合miR-136和miR-4791预测急性高山病发病风险的诊断试剂盒 |
| CN107058471B (zh) * | 2016-11-03 | 2020-09-01 | 中国人民解放军陆军军医大学 | 一种通过四种microRNA生物标志物联合预测急性高山病发病风险的试剂盒 |
| CN108251422A (zh) * | 2016-12-29 | 2018-07-06 | 昆山彭济凯丰生物科技有限公司 | 通过miR-6069进行抗癌的方法和药物及其应用 |
| CN108295086B (zh) * | 2017-01-13 | 2021-11-02 | 昆山彭济凯丰生物科技有限公司 | 通过miR-4418进行抗癌的方法和药物及其应用 |
| CN108295260A (zh) * | 2017-01-13 | 2018-07-20 | 彭长庚 | 通过miR-1915-3p进行抗癌的方法和药物及其应用 |
| CN108310381A (zh) * | 2017-01-16 | 2018-07-24 | 昆山彭济凯丰生物科技有限公司 | 通过miR-6511b-3p进行抗癌的方法和药物及其应用 |
| CN107502609A (zh) * | 2017-09-08 | 2017-12-22 | 中国科学院深圳先进技术研究院 | 一种靶向cJun信号通路的miRNA及其制备方法和应用 |
| KR102070969B1 (ko) * | 2018-04-10 | 2020-01-29 | 한국한의학연구원 | 통증 판별용 마커 |
| US12005120B2 (en) | 2018-05-08 | 2024-06-11 | Regulus Therapeutics Inc. | Galnac conjugated modified oligonucleotides as miR-122 inhibitor having HCV antiviral activity with reduced hyperbilirubinemia side-effect |
| CN109468375B (zh) * | 2018-12-28 | 2021-05-14 | 固安博健生物技术有限公司 | 分子标志物在骨质疏松症中的应用 |
| US20220241315A1 (en) * | 2019-06-05 | 2022-08-04 | Cancerstem Tech Inc. | Therapeutic agent for cancer |
| CN111073973A (zh) * | 2019-12-10 | 2020-04-28 | 石河子大学 | 一种用于早期诊断2型糖尿病的microRNA序列及其应用 |
| CN114767703B (zh) * | 2022-06-20 | 2022-09-02 | 山东恺悌生物制品有限公司 | miR-4311模拟物在制备肺癌治疗药物中的应用 |
| AU2024353921A1 (en) * | 2023-09-27 | 2026-04-16 | Neuro3 Therapeutics (Suzhou) Ltd. | Novel sirna constructs, therapeutics, and modifications |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5898031A (en) * | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
| WO2005061710A1 (en) * | 2003-12-23 | 2005-07-07 | Santaris Pharma A/S | Oligomeric compounds for the modulation of bcl-2 |
| KR20080068019A (ko) * | 2005-09-15 | 2008-07-22 | 산타리스 팔마 에이/에스 | 아포지단백질-ｂ100 발현 억제용 ｒｎａ 길항제 화합물 |
| AU2007323469B2 (en) | 2006-11-23 | 2014-07-24 | Guangdong Maijinjia Biotechnology Co., Ltd | Oligonucleotides for modulating target RNA activity |
| WO2008074328A2 (en) | 2006-12-21 | 2008-06-26 | Exiqon A/S | Microrna target site blocking oligos and uses thereof |
| EP2714904B1 (en) | 2007-06-14 | 2017-04-12 | Mirx Therapeutics ApS | Oligonucleotides for modulation of target rna activity |
| WO2009068033A2 (en) * | 2007-11-26 | 2009-06-04 | Santaris Pharma A/S | Lna antagonists targeting the androgen receptor |
| WO2009090182A1 (en) | 2008-01-14 | 2009-07-23 | Santaris Pharma A/S | C4'-substituted - dna nucleotide gapmer oligonucleotides |
| ES2599979T3 (es) * | 2009-04-24 | 2017-02-06 | Roche Innovation Center Copenhagen A/S | Composiciones farmacéuticas para el tratamiento de pacientes de VHC que no responden al interferón |
| US9193752B2 (en) | 2010-03-17 | 2015-11-24 | Isis Pharmaceuticals, Inc. | 5′-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom |
| WO2011117353A1 (en) * | 2010-03-24 | 2011-09-29 | Mirrx Therapeutics A/S | Bivalent antisense oligonucleotides |
-
2013
- 2013-09-26 AU AU2013324716A patent/AU2013324716B2/en active Active
- 2013-09-26 US US14/431,212 patent/US9725721B2/en active Active
- 2013-09-26 CN CN201380057694.6A patent/CN104955950B/zh active Active
- 2013-09-26 CA CA2886116A patent/CA2886116C/en active Active
- 2013-09-26 JP JP2015533454A patent/JP6352269B2/ja active Active
- 2013-09-26 WO PCT/DK2013/050308 patent/WO2014048441A1/en not_active Ceased
- 2013-09-26 EP EP13842025.2A patent/EP2900822B1/en active Active
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