JP2016513107A5 - - Google Patents
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- JP2016513107A5 JP2016513107A5 JP2015558016A JP2015558016A JP2016513107A5 JP 2016513107 A5 JP2016513107 A5 JP 2016513107A5 JP 2015558016 A JP2015558016 A JP 2015558016A JP 2015558016 A JP2015558016 A JP 2015558016A JP 2016513107 A5 JP2016513107 A5 JP 2016513107A5
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- JP
- Japan
- Prior art keywords
- seq
- peptide
- mgrn
- composition
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- Prior art date
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- 239000000203 mixture Substances 0.000 claims 5
- 200000000019 wound Diseases 0.000 claims 4
- 150000001412 amines Chemical class 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 150000008574 D-amino acids Chemical class 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000008313 Contusions Diseases 0.000 claims 1
- 206010072082 Environmental exposure Diseases 0.000 claims 1
- 208000010201 Exanthema Diseases 0.000 claims 1
- 206010049796 Excoriation Diseases 0.000 claims 1
- 150000008575 L-amino acids Chemical class 0.000 claims 1
- 208000002473 Lacerations Diseases 0.000 claims 1
- 210000004400 Mucous Membrane Anatomy 0.000 claims 1
- 206010037844 Rash Diseases 0.000 claims 1
- 210000003491 Skin Anatomy 0.000 claims 1
- 206010040925 Skin striae Diseases 0.000 claims 1
- 206010068760 Ulcers Diseases 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000003094 microcapsule Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
Claims (12)
- 単離されたペプチドであって、配列がＳＥＱ ＩＤ ＮＯ：５（ＭＧＲＮ）又はＳＥＱ ＩＤ ＮＯ：２（ＫＭＧＲＮ）からなり、遊離酸の形態であって、カルボキシ末端でアミド化されているか又はアミン末端で脂質化されている、ペプチド。
- ペプチドが、 ＳＥＱ ＩＤ ＮＯ：５（ＭＧＲＮ）又はＳＥＱ ＩＤ ＮＯ：２（ＫＭＧＲＮ）であり、カルボキシ末端でアミド化されているか又はアミン末端で脂質化されている、請求項１のペプチド。
- Ｌ−アミノ酸エナンチオマーとＤ−アミノ酸エナンチオマーのどちらか一方又は両方を含む、請求項１のペプチド。
- 請求項１に記載の少なくとも一種のペプチドと、薬学的に許容される担体とを含む組成物。
- ペプチドは、０．１μｇ／ｍＬ〜５００μｇ／ｍＬ、又は０．１μｇ／ｍＬ〜２０ｍｇ／ｍＬの範囲の濃度で存在する、請求項４の組成物。
- 薬学的に許容される担体は、エアロゾル、エマルジョン、液体、ローション、溶液、ゲル、マイクロカプセル、クリーム、ペースト、軟膏、粉末又はフォームである、請求項４の組成物。
- ペプチドが、 ＳＥＱ ＩＤ ＮＯ：５（ＭＧＲＮ）又はＳＥＱ ＩＤ ＮＯ：２（ＫＭＧＲＮ）であり、カルボキシ末端でアミド化されているか又はアミン末端で脂質化されている、請求項４の組成物。
- 哺乳動物の皮膚又は粘膜組織の創傷を治療する方法であって、ＳＥＱ ＩＤ ＮＯ：４（ＥＫＭＧ）、ＳＥＱ ＩＤ ＮＯ：５（ＭＧＲＮ）及びＳＥＱ ＩＤ ＮＯ：２（ＫＭＧＲＮ）からなる群から選択される配列を有するペプチドを含む組成物を、創傷部位に投与することを含む方法。
- ペプチドが、ＳＥＱ ＩＤ ＮＯ：４（ＥＫＭＧ）又はＳＥＱ ＩＤ ＮＯ：５（ＭＧＲＮ）又はＳＥＱ ＩＤ ＮＯ：２（ＫＭＧＲＮ）である、請求項８の方法。
- ペプチドが、 Ｌ−アミノ酸エナンチオマーとＤ−アミノ酸エナンチオマーのどちらか一方又は両方を含むか、又は担体分子に共役化されているか、アミド化されるか若しくは脂質化されている、請求項８の方法。
- ペプチドが遊離酸の形態である、請求項８の方法。
- 創傷が、擦過傷、水疱、火傷、裂傷、潰瘍、打撲、発疹、瘡痕、ストレッチマーク又は老化又は環境曝露に起因する創傷である、請求項８の方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361764913P | 2013-02-14 | 2013-02-14 | |
| US61/764,913 | 2013-02-14 | ||
| PCT/US2014/012378 WO2014126681A1 (en) | 2013-02-14 | 2014-01-21 | Short bio-active peptides for promoting wound healing |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513107A JP2016513107A (ja) | 2016-05-12 |
| JP2016513107A5 true JP2016513107A5 (ja) | 2017-02-09 |
| JP6348126B2 JP6348126B2 (ja) | 2018-06-27 |
Family
ID=50069319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558016A Active JP6348126B2 (ja) | 2013-02-14 | 2014-01-21 | 創傷治癒を促進する生物活性短鎖ペプチド |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9487558B2 (ja) |
| EP (1) | EP2956155B1 (ja) |
| JP (1) | JP6348126B2 (ja) |
| KR (1) | KR101894829B1 (ja) |
| CN (1) | CN105120884B (ja) |
| AR (1) | AR094835A1 (ja) |
| AU (1) | AU2014216730B2 (ja) |
| BR (1) | BR112015019568A2 (ja) |
| CA (1) | CA2898717C (ja) |
| CY (1) | CY1119087T1 (ja) |
| DK (1) | DK2956155T3 (ja) |
| ES (1) | ES2633437T3 (ja) |
| HK (1) | HK1212243A1 (ja) |
| HU (1) | HUE033976T2 (ja) |
| MX (1) | MX363955B (ja) |
| MY (1) | MY173174A (ja) |
| NZ (1) | NZ711281A (ja) |
| PL (1) | PL2956155T3 (ja) |
| RU (1) | RU2606753C1 (ja) |
| SG (1) | SG11201505538QA (ja) |
| SI (1) | SI2956155T1 (ja) |
| TW (1) | TWI587867B (ja) |
| WO (1) | WO2014126681A1 (ja) |
| ZA (1) | ZA201505516B (ja) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017267370B2 (en) * | 2016-04-08 | 2021-07-08 | Cornell University | A method to enhance wound healing using silk-derived protein |
| EP3312608B1 (en) * | 2016-10-24 | 2019-10-02 | Akribes Biomedical GmbH | Methods for identifying a non-healing skin wound and for monitoring the healing of a skin wound |
| US10232009B1 (en) * | 2017-09-29 | 2019-03-19 | Pro Sunfun Biotech Research And Development Co., Ltd. | Peptide for promoting wound healing, its composition and method of using the same |
| CN108586575B (zh) * | 2018-04-11 | 2020-08-14 | 福建省中科生物股份有限公司 | 一种多肽及其皮肤修复功能的应用 |
| CZ308845B6 (cs) * | 2019-01-21 | 2021-07-07 | Globetech Innovation S.R.O | Farmaceutická směs topicky hojivých peptidových složek pro použití k topické léčbě kožních defektů a/nebo k topickému hojení ran |
| CN116407611A (zh) * | 2021-12-29 | 2023-07-11 | 四川好医生攀西药业有限责任公司 | 一种多肽在制备预防或治疗皮肤损伤疾病产品上的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6360939A (ja) * | 1986-08-29 | 1988-03-17 | Shin Etsu Chem Co Ltd | 抗菌物質 |
| US5861478A (en) | 1987-07-06 | 1999-01-19 | Helix Biomedix, Inc. | Lytic peptides |
| JP2962555B2 (ja) | 1987-07-06 | 1999-10-12 | ヘリックス バイオメディックス，インコーポレイテッド | 溶菌ペプチドによる真核性病原体と新生物の抑制及び繊維芽細胞とリンパ球の刺激 |
| RU2441877C2 (ru) | 2006-06-13 | 2012-02-10 | Хеликс Байомедикс Инк. | Тетрапептид, композиция (варианты) и способ стимуляции продукции коллагена фибробластом |
| US7696174B2 (en) * | 2007-01-05 | 2010-04-13 | Helix Biomedix, Inc. | Short bio-active peptides for cellular and immunological modulation |
| RU2447896C1 (ru) * | 2010-11-15 | 2012-04-20 | Общество с ограниченной ответственностью "Аллофарм" | Антимикробное вещество |
| CA2846629C (en) * | 2011-08-25 | 2023-08-01 | University Of Central Florida Research Foundation, Inc. | Methods and compositions comprising a c-terminal bax peptide |
-
2014
- 2014-01-21 RU RU2015138925A patent/RU2606753C1/ru not_active IP Right Cessation
- 2014-01-21 NZ NZ711281A patent/NZ711281A/en not_active IP Right Cessation
- 2014-01-21 HU HUE14703220A patent/HUE033976T2/en unknown
- 2014-01-21 SG SG11201505538QA patent/SG11201505538QA/en unknown
- 2014-01-21 DK DK14703220.5T patent/DK2956155T3/en active
- 2014-01-21 JP JP2015558016A patent/JP6348126B2/ja active Active
- 2014-01-21 EP EP14703220.5A patent/EP2956155B1/en active Active
- 2014-01-21 WO PCT/US2014/012378 patent/WO2014126681A1/en active Application Filing
- 2014-01-21 MY MYPI2015702327A patent/MY173174A/en unknown
- 2014-01-21 ES ES14703220.5T patent/ES2633437T3/es active Active
- 2014-01-21 MX MX2015009404A patent/MX363955B/es active IP Right Grant
- 2014-01-21 SI SI201430277T patent/SI2956155T1/sl unknown
- 2014-01-21 CN CN201480009001.0A patent/CN105120884B/zh active Active
- 2014-01-21 US US14/762,407 patent/US9487558B2/en active Active
- 2014-01-21 PL PL14703220T patent/PL2956155T3/pl unknown
- 2014-01-21 CA CA2898717A patent/CA2898717C/en active Active
- 2014-01-21 BR BR112015019568A patent/BR112015019568A2/pt not_active Application Discontinuation
- 2014-01-21 AU AU2014216730A patent/AU2014216730B2/en not_active Ceased
- 2014-01-21 KR KR1020157024070A patent/KR101894829B1/ko active IP Right Grant
- 2014-01-29 TW TW103103686A patent/TWI587867B/zh not_active IP Right Cessation
- 2014-02-14 AR ARP140100481A patent/AR094835A1/es unknown
-
2015
- 2015-07-31 ZA ZA2015/05516A patent/ZA201505516B/en unknown
-
2016
- 2016-01-13 HK HK16100340.9A patent/HK1212243A1/xx unknown
- 2016-09-20 US US15/270,186 patent/US20170000848A1/en not_active Abandoned
-
2017
- 2017-07-14 CY CY20171100747T patent/CY1119087T1/el unknown
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