JP2016512697A5 - - Google Patents
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- JP2016512697A5 JP2016512697A5 JP2016503281A JP2016503281A JP2016512697A5 JP 2016512697 A5 JP2016512697 A5 JP 2016512697A5 JP 2016503281 A JP2016503281 A JP 2016503281A JP 2016503281 A JP2016503281 A JP 2016503281A JP 2016512697 A5 JP2016512697 A5 JP 2016512697A5
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- JP
- Japan
- Prior art keywords
- promoter
- protein
- proteins involved
- animal
- human transgenic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 102000004169 proteins and genes Human genes 0.000 claims description 53
- 108090000623 proteins and genes Proteins 0.000 claims description 53
- 230000009261 transgenic effect Effects 0.000 claims description 35
- 241001465754 Metazoa Species 0.000 claims description 29
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 claims description 21
- 230000002401 inhibitory effect Effects 0.000 claims description 19
- 241000283690 Bos taurus Species 0.000 claims description 18
- 108020004707 nucleic acids Proteins 0.000 claims description 18
- 102000039446 nucleic acids Human genes 0.000 claims description 18
- 150000007523 nucleic acids Chemical class 0.000 claims description 18
- 108091026890 Coding region Proteins 0.000 claims description 14
- 230000014509 gene expression Effects 0.000 claims description 14
- 210000002752 melanocyte Anatomy 0.000 claims description 13
- 210000004027 cell Anatomy 0.000 claims description 10
- 230000008099 melanin synthesis Effects 0.000 claims description 10
- 238000013508 migration Methods 0.000 claims description 10
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- YVLPJIGOMTXXLP-UHFFFAOYSA-N 15-cis-phytoene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CC=CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C YVLPJIGOMTXXLP-UHFFFAOYSA-N 0.000 claims description 8
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- YVLPJIGOMTXXLP-BAHRDPFUSA-N 15Z-phytoene Natural products CC(=CCCC(=CCCC(=CCCC(=CC=C/C=C(C)/CCC=C(/C)CCC=C(/C)CCC=C(C)C)C)C)C)C YVLPJIGOMTXXLP-BAHRDPFUSA-N 0.000 claims description 4
- 102000006822 Agouti Signaling Protein Human genes 0.000 claims description 4
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- 241000701022 Cytomegalovirus Species 0.000 claims description 4
- 241000287828 Gallus gallus Species 0.000 claims description 4
- 101000620359 Homo sapiens Melanocyte protein PMEL Proteins 0.000 claims description 4
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- 108090000950 Melanocortin Receptors Proteins 0.000 claims description 4
- 102100022430 Melanocyte protein PMEL Human genes 0.000 claims description 4
- 239000000637 Melanocyte-Stimulating Hormone Substances 0.000 claims description 4
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- UPEZCKBFRMILAV-JNEQICEOSA-N Ecdysone Natural products O=C1[C@H]2[C@@](C)([C@@H]3C([C@@]4(O)[C@@](C)([C@H]([C@H]([C@@H](O)CCC(O)(C)C)C)CC4)CC3)=C1)C[C@H](O)[C@H](O)C2 UPEZCKBFRMILAV-JNEQICEOSA-N 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
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- 241000283073 Equus caballus Species 0.000 claims description 2
- 241000282326 Felis catus Species 0.000 claims description 2
- 102100039556 Galectin-4 Human genes 0.000 claims description 2
- 102100021519 Hemoglobin subunit beta Human genes 0.000 claims description 2
- 108091005904 Hemoglobin subunit beta Proteins 0.000 claims description 2
- 101000872516 Homo sapiens E3 ubiquitin-protein ligase HERC2 Proteins 0.000 claims description 2
- 101000608765 Homo sapiens Galectin-4 Proteins 0.000 claims description 2
- 241000270322 Lepidosauria Species 0.000 claims description 2
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- 241001508691 Martes zibellina Species 0.000 claims description 2
- 235000011779 Menyanthes trifoliata Nutrition 0.000 claims description 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 2
- 101100413186 Mus musculus Ripply2 gene Proteins 0.000 claims description 2
- 241001504654 Mustela nivalis Species 0.000 claims description 2
- 241000772415 Neovison vison Species 0.000 claims description 2
- 102000004459 Nitroreductase Human genes 0.000 claims description 2
- YJQPYGGHQPGBLI-UHFFFAOYSA-N Novobiocin Natural products O1C(C)(C)C(OC)C(OC(N)=O)C(O)C1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-UHFFFAOYSA-N 0.000 claims description 2
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- 241001494479 Pecora Species 0.000 claims description 2
- 102000010292 Peptide Elongation Factor 1 Human genes 0.000 claims description 2
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- 241000009328 Perro Species 0.000 claims description 2
- 241000283216 Phocidae Species 0.000 claims description 2
- 241000288906 Primates Species 0.000 claims description 2
- 101150002757 RSL1 gene Proteins 0.000 claims description 2
- 101710138480 Ras-related protein Rab7 Proteins 0.000 claims description 2
- 241000700159 Rattus Species 0.000 claims description 2
- 102000009661 Repressor Proteins Human genes 0.000 claims description 2
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- 229930182558 Sterol Natural products 0.000 claims description 2
- 241000282898 Sus scrofa Species 0.000 claims description 2
- 239000004098 Tetracycline Substances 0.000 claims description 2
- 108090000848 Ubiquitin Proteins 0.000 claims description 2
- 102000044159 Ubiquitin Human genes 0.000 claims description 2
- 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 claims description 2
- 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 claims description 2
- 241000282485 Vulpes vulpes Species 0.000 claims description 2
- WTIJXIZOODAMJT-WBACWINTSA-N [(3r,4s,5r,6s)-5-hydroxy-6-[4-hydroxy-3-[[5-[[4-hydroxy-7-[(2s,3r,4s,5r)-3-hydroxy-5-methoxy-6,6-dimethyl-4-(5-methyl-1h-pyrrole-2-carbonyl)oxyoxan-2-yl]oxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-4-methyl-1h-pyrrole-3-carbonyl]amino]-8-methyl-2-oxochromen- Chemical compound O([C@@H]1[C@H](C(O[C@H](OC=2C(=C3OC(=O)C(NC(=O)C=4C(=C(C(=O)NC=5C(OC6=C(C)C(O[C@@H]7[C@@H]([C@H](OC(=O)C=8NC(C)=CC=8)[C@@H](OC)C(C)(C)O7)O)=CC=C6C=5O)=O)NC=4)C)=C(O)C3=CC=2)C)[C@@H]1O)(C)C)OC)C(=O)C1=CC=C(C)N1 WTIJXIZOODAMJT-WBACWINTSA-N 0.000 claims description 2
- 230000004913 activation Effects 0.000 claims description 2
- UPEZCKBFRMILAV-UHFFFAOYSA-N alpha-Ecdysone Natural products C1C(O)C(O)CC2(C)C(CCC3(C(C(C(O)CCC(C)(C)O)C)CCC33O)C)C3=CC(=O)C21 UPEZCKBFRMILAV-UHFFFAOYSA-N 0.000 claims description 2
- 210000004102 animal cell Anatomy 0.000 claims description 2
- 230000001588 bifunctional effect Effects 0.000 claims description 2
- UPEZCKBFRMILAV-JMZLNJERSA-N ecdysone Chemical compound C1[C@@H](O)[C@@H](O)C[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@H]([C@H](O)CCC(C)(C)O)C)CC[C@]33O)C)C3=CC(=O)[C@@H]21 UPEZCKBFRMILAV-JMZLNJERSA-N 0.000 claims description 2
- 230000002500 effect on skin Effects 0.000 claims description 2
- 230000006698 induction Effects 0.000 claims description 2
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 claims description 2
- 210000002510 keratinocyte Anatomy 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims description 2
- 108060004506 lycopene beta-cyclase Proteins 0.000 claims description 2
- 108060004507 lycopene cyclase Proteins 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- QYYXITIZXRMPSZ-UHFFFAOYSA-N n'-tert-butyl-n'-(3,5-dimethylbenzoyl)-2-ethyl-3-methoxybenzohydrazide Chemical compound CCC1=C(OC)C=CC=C1C(=O)NN(C(C)(C)C)C(=O)C1=CC(C)=CC(C)=C1 QYYXITIZXRMPSZ-UHFFFAOYSA-N 0.000 claims description 2
- 108020001162 nitroreductase Proteins 0.000 claims description 2
- YJQPYGGHQPGBLI-KGSXXDOSSA-N novobiocin Chemical compound O1C(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@@H](O)[C@@H]1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-KGSXXDOSSA-N 0.000 claims description 2
- 229960002950 novobiocin Drugs 0.000 claims description 2
- 108020003175 receptors Proteins 0.000 claims description 2
- 102000005962 receptors Human genes 0.000 claims description 2
- 230000035939 shock Effects 0.000 claims description 2
- 150000003432 sterols Chemical class 0.000 claims description 2
- 235000003702 sterols Nutrition 0.000 claims description 2
- 229960002180 tetracycline Drugs 0.000 claims description 2
- 229930101283 tetracycline Natural products 0.000 claims description 2
- 235000019364 tetracycline Nutrition 0.000 claims description 2
- 150000003522 tetracyclines Chemical class 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 230000035897 transcription Effects 0.000 claims description 2
- 238000013518 transcription Methods 0.000 claims description 2
- 230000018109 developmental process Effects 0.000 claims 4
- 230000011712 cell development Effects 0.000 claims 1
- 230000012292 cell migration Effects 0.000 claims 1
- 108010050749 geranylgeranyltransferase type-I Proteins 0.000 claims 1
- 230000002452 interceptive effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
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- 108090000992 Transferases Proteins 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 125000002686 geranylgeranyl group Chemical group [H]C([*])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 241000894007 species Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/837,405 US20130212723A1 (en) | 2012-02-15 | 2013-03-15 | Transgenic animals with customizable traits |
| US13/837,405 | 2013-03-15 | ||
| PCT/US2014/029918 WO2014145196A2 (en) | 2013-03-15 | 2014-03-15 | Transgenic animals with customizable traits |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016512697A JP2016512697A (ja) | 2016-05-09 |
| JP2016512697A5 true JP2016512697A5 (enExample) | 2017-04-20 |
Family
ID=51538427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503281A Pending JP2016512697A (ja) | 2013-03-15 | 2014-03-15 | カスタマイズ可能な形質を有するトランスジェニック動物 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2967017A4 (enExample) |
| JP (1) | JP2016512697A (enExample) |
| CN (1) | CN105357960B (enExample) |
| AU (3) | AU2014233317B2 (enExample) |
| BR (1) | BR112015023414A2 (enExample) |
| CA (1) | CA2906936A1 (enExample) |
| HK (1) | HK1214732A1 (enExample) |
| MX (1) | MX2015013253A (enExample) |
| WO (1) | WO2014145196A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3060682B1 (en) | 2013-10-25 | 2023-08-30 | Livestock Improvement Corporation Limited | Genetic markers and uses therefor |
| CN107022549B (zh) * | 2017-04-19 | 2021-06-01 | 华中农业大学 | 黄颡鱼β防御素基因及其β防御素抗菌肽及其应用 |
| CN107177630A (zh) * | 2017-05-09 | 2017-09-19 | 华南农业大学 | 一种无外源标记基因的抗pcv2转基因猪制备方法 |
| CN111206042B (zh) * | 2020-02-25 | 2021-08-31 | 中国科学院昆明植物研究所 | 一种表达酮式类胡萝卜素的融合基因、重组载体及其应用 |
| CN113564186B (zh) * | 2021-07-16 | 2023-07-25 | 山西大学 | 苹果黄蚜Tre基因及其核酸干扰剂制备方法与应用 |
| CN117016497B (zh) * | 2023-08-23 | 2025-08-05 | 西部(重庆)科学城种质创制大科学中心 | 一种利用雌激素相关受体调控家蚕表皮黑色素形成的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1324100A (en) * | 1998-10-27 | 2000-05-15 | Anticancer, Inc. | Method and model for hair pigmentation |
| US20040171824A1 (en) * | 2001-03-05 | 2004-09-02 | Scrable Heidi Jean | A Lac operator-repressor system |
| US20110265192A1 (en) * | 2008-09-05 | 2011-10-27 | Syddansk Universitet | Nuclear receptor sensor system in transgenic animal |
| BR112014020089A2 (pt) * | 2012-02-15 | 2017-07-04 | Mice With Horns Llc | animais transgênicos com características que podem ser customizadas |
-
2014
- 2014-03-15 CN CN201480024934.7A patent/CN105357960B/zh not_active Expired - Fee Related
- 2014-03-15 WO PCT/US2014/029918 patent/WO2014145196A2/en not_active Ceased
- 2014-03-15 CA CA2906936A patent/CA2906936A1/en not_active Abandoned
- 2014-03-15 MX MX2015013253A patent/MX2015013253A/es unknown
- 2014-03-15 AU AU2014233317A patent/AU2014233317B2/en not_active Ceased
- 2014-03-15 HK HK16102648.4A patent/HK1214732A1/zh unknown
- 2014-03-15 BR BR112015023414A patent/BR112015023414A2/pt not_active Application Discontinuation
- 2014-03-15 EP EP14763711.0A patent/EP2967017A4/en not_active Withdrawn
- 2014-03-15 JP JP2016503281A patent/JP2016512697A/ja active Pending
-
2017
- 2017-08-09 AU AU2017213487A patent/AU2017213487B2/en not_active Ceased
-
2019
- 2019-06-11 AU AU2019204084A patent/AU2019204084A1/en not_active Abandoned
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