BR112015023414A2 - animais transgênicos com características personalizáveis - Google Patents
animais transgênicos com características personalizáveisInfo
- Publication number
- BR112015023414A2 BR112015023414A2 BR112015023414A BR112015023414A BR112015023414A2 BR 112015023414 A2 BR112015023414 A2 BR 112015023414A2 BR 112015023414 A BR112015023414 A BR 112015023414A BR 112015023414 A BR112015023414 A BR 112015023414A BR 112015023414 A2 BR112015023414 A2 BR 112015023414A2
- Authority
- BR
- Brazil
- Prior art keywords
- htncre
- skin
- cassette
- black
- animals
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title abstract 6
- 230000009261 transgenic effect Effects 0.000 title abstract 2
- 102100026887 Beta-defensin 103 Human genes 0.000 abstract 2
- 101710187196 Beta-defensin 103 Proteins 0.000 abstract 2
- 102000018332 Keratin-14 Human genes 0.000 abstract 2
- 108010066321 Keratin-14 Proteins 0.000 abstract 2
- 239000000232 Lipid Bilayer Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 239000000049 pigment Substances 0.000 abstract 2
- 230000008488 polyadenylation Effects 0.000 abstract 2
- 108010054624 red fluorescent protein Proteins 0.000 abstract 2
- 108010051219 Cre recombinase Proteins 0.000 abstract 1
- 108010091086 Recombinases Proteins 0.000 abstract 1
- 102000018120 Recombinases Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Molecular Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
abstract disclosed are materials and methods for creating customizable traits in animals. in the demonstration of the principle of the subject invention, a keratin-14 specific promoter is used with red fluorescent protein in the loxp cassette, dominant black (?g23) beta defensin 103 in the pigment cassette, and an sv40 (with intron) polyadenylation sequence. when cre recombinase (or htncre) is applied to the animal's skin in a carrier base (e.g., lipid bilayers), fur is permanently genetically modified to tum black in the shape in which thehtncre was applied. tradução do resumo resumo "animais transgênicos com características personalizáveis" a presente invenção descreve-se materiais e métodos para a criação de características de personalização em animais. na demonstração do princípio da presente invenção, um promotor específico de queratina-14 é usado com proteína fluorescente vermelha na cassete loxp, preto dominante (?g23) beta-defensina 103 na cassete de pigmento, e uma sequência de poliadenilação de sv40 (com íntron). quando a recombinase cre (ou htncre) é aplicada à pele do animal na base de um transportador (por exemplo, bicamadas de lipídeos), a pele é, permanentemente, geneticamente modificada para a tum negra na forma em que foi aplicada a htncre.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/837,405 US20130212723A1 (en) | 2012-02-15 | 2013-03-15 | Transgenic animals with customizable traits |
| PCT/US2014/029918 WO2014145196A2 (en) | 2013-03-15 | 2014-03-15 | Transgenic animals with customizable traits |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015023414A2 true BR112015023414A2 (pt) | 2017-11-28 |
Family
ID=51538427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015023414A BR112015023414A2 (pt) | 2013-03-15 | 2014-03-15 | animais transgênicos com características personalizáveis |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2967017A4 (pt) |
| JP (1) | JP2016512697A (pt) |
| CN (1) | CN105357960B (pt) |
| AU (3) | AU2014233317B2 (pt) |
| BR (1) | BR112015023414A2 (pt) |
| CA (1) | CA2906936A1 (pt) |
| HK (1) | HK1214732A1 (pt) |
| MX (1) | MX2015013253A (pt) |
| WO (1) | WO2014145196A2 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105814214A (zh) | 2013-10-25 | 2016-07-27 | 家畜改良有限公司 | 遗传标记和其用途 |
| CN107022549B (zh) * | 2017-04-19 | 2021-06-01 | 华中农业大学 | 黄颡鱼β防御素基因及其β防御素抗菌肽及其应用 |
| CN107177630A (zh) * | 2017-05-09 | 2017-09-19 | 华南农业大学 | 一种无外源标记基因的抗pcv2转基因猪制备方法 |
| CN111206042B (zh) * | 2020-02-25 | 2021-08-31 | 中国科学院昆明植物研究所 | 一种表达酮式类胡萝卜素的融合基因、重组载体及其应用 |
| CN113564186B (zh) * | 2021-07-16 | 2023-07-25 | 山西大学 | 苹果黄蚜Tre基因及其核酸干扰剂制备方法与应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1324100A (en) * | 1998-10-27 | 2000-05-15 | Anticancer, Inc. | Method and model for hair pigmentation |
| WO2002086098A2 (en) * | 2001-03-05 | 2002-10-31 | University Of Virginia Patent Foundation | A lac operator-repressor system |
| CN102203259A (zh) * | 2008-09-05 | 2011-09-28 | 奥胡斯大学 | 转基因动物内的核受体传感器系统 |
| JP6282600B2 (ja) * | 2012-02-15 | 2018-02-21 | エージージェネティクス インコーポレイテッド | カスタマイズ可能な形質を有するトランスジェニック動物 |
-
2014
- 2014-03-15 BR BR112015023414A patent/BR112015023414A2/pt not_active Application Discontinuation
- 2014-03-15 CA CA2906936A patent/CA2906936A1/en not_active Abandoned
- 2014-03-15 AU AU2014233317A patent/AU2014233317B2/en not_active Ceased
- 2014-03-15 CN CN201480024934.7A patent/CN105357960B/zh not_active Expired - Fee Related
- 2014-03-15 WO PCT/US2014/029918 patent/WO2014145196A2/en active Application Filing
- 2014-03-15 MX MX2015013253A patent/MX2015013253A/es unknown
- 2014-03-15 JP JP2016503281A patent/JP2016512697A/ja active Pending
- 2014-03-15 EP EP14763711.0A patent/EP2967017A4/en not_active Withdrawn
-
2016
- 2016-03-08 HK HK16102648.4A patent/HK1214732A1/zh unknown
-
2017
- 2017-08-09 AU AU2017213487A patent/AU2017213487B2/en not_active Ceased
-
2019
- 2019-06-11 AU AU2019204084A patent/AU2019204084A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HK1214732A1 (zh) | 2016-08-05 |
| EP2967017A4 (en) | 2016-11-09 |
| CN105357960B (zh) | 2018-02-16 |
| WO2014145196A2 (en) | 2014-09-18 |
| WO2014145196A3 (en) | 2015-02-19 |
| AU2014233317B2 (en) | 2017-08-31 |
| MX2015013253A (es) | 2016-04-07 |
| CA2906936A1 (en) | 2014-09-18 |
| AU2014233317A1 (en) | 2015-10-29 |
| JP2016512697A (ja) | 2016-05-09 |
| CN105357960A (zh) | 2016-02-24 |
| AU2017213487A1 (en) | 2017-08-31 |
| EP2967017A2 (en) | 2016-01-20 |
| AU2019204084A1 (en) | 2019-07-04 |
| AU2017213487B2 (en) | 2019-07-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according art. 34 industrial property law | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |