JP2016512205A5 - - Google Patents
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- JP2016512205A5 JP2016512205A5 JP2015561930A JP2015561930A JP2016512205A5 JP 2016512205 A5 JP2016512205 A5 JP 2016512205A5 JP 2015561930 A JP2015561930 A JP 2015561930A JP 2015561930 A JP2015561930 A JP 2015561930A JP 2016512205 A5 JP2016512205 A5 JP 2016512205A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- analog
- analogue
- pharmaceutical composition
- fasting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 57
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 210000004153 islets of langerhan Anatomy 0.000 claims 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 8
- 102000004877 Insulin Human genes 0.000 claims 8
- 108090001061 Insulin Proteins 0.000 claims 8
- 239000008280 blood Substances 0.000 claims 8
- 210000004369 blood Anatomy 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 239000008103 glucose Substances 0.000 claims 8
- 229940125396 insulin Drugs 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 8
- 230000001737 promoting effect Effects 0.000 claims 7
- 230000007812 deficiency Effects 0.000 claims 6
- 230000008929 regeneration Effects 0.000 claims 6
- 238000011069 regeneration method Methods 0.000 claims 6
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 6
- 230000004064 dysfunction Effects 0.000 claims 5
- 208000030159 metabolic disease Diseases 0.000 claims 5
- 201000009104 prediabetes syndrome Diseases 0.000 claims 5
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims 4
- 206010022489 Insulin Resistance Diseases 0.000 claims 4
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 4
- 206010012601 diabetes mellitus Diseases 0.000 claims 4
- 208000016097 disease of metabolism Diseases 0.000 claims 4
- 230000003451 hyperinsulinaemic effect Effects 0.000 claims 4
- 201000008980 hyperinsulinism Diseases 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 230000004048 modification Effects 0.000 claims 4
- 238000012986 modification Methods 0.000 claims 4
- 230000004936 stimulating effect Effects 0.000 claims 4
- 208000002705 Glucose Intolerance Diseases 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 210000004185 liver Anatomy 0.000 claims 3
- 210000005036 nerve Anatomy 0.000 claims 3
- 230000004112 neuroprotection Effects 0.000 claims 3
- VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 2
- 108010075254 C-Peptide Proteins 0.000 claims 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 230000005856 abnormality Effects 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 2
- 230000010261 cell growth Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000000291 postprandial effect Effects 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 150000008574 D-amino acids Chemical class 0.000 claims 1
- 230000021736 acetylation Effects 0.000 claims 1
- 238000006640 acetylation reaction Methods 0.000 claims 1
- 230000009435 amidation Effects 0.000 claims 1
- 238000007112 amidation reaction Methods 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000032050 esterification Effects 0.000 claims 1
- 238000005886 esterification reaction Methods 0.000 claims 1
- 229930195729 fatty acid Chemical class 0.000 claims 1
- 239000000194 fatty acid Chemical class 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2013/072771 WO2014139182A1 (en) | 2013-03-15 | 2013-03-15 | Compositions and methods of using islet neogenesis peptides and analogs thereof |
| CNPCT/CN2013/072771 | 2013-03-15 | ||
| PCT/CN2014/073483 WO2014139472A1 (en) | 2013-03-15 | 2014-03-14 | Compositions and methods of using islet neogenesis peptides and analogs thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019225049A Division JP7075918B2 (ja) | 2013-03-15 | 2019-12-13 | 膵島新生ペプチド及びその類似体を使用する組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512205A JP2016512205A (ja) | 2016-04-25 |
| JP2016512205A5 true JP2016512205A5 (enExample) | 2017-04-20 |
| JP6674258B2 JP6674258B2 (ja) | 2020-04-01 |
Family
ID=51535856
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015561930A Active JP6674258B2 (ja) | 2013-03-15 | 2014-03-14 | 膵島新生ペプチド及びその類似体を使用する組成物及び方法 |
| JP2019225049A Active JP7075918B2 (ja) | 2013-03-15 | 2019-12-13 | 膵島新生ペプチド及びその類似体を使用する組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019225049A Active JP7075918B2 (ja) | 2013-03-15 | 2019-12-13 | 膵島新生ペプチド及びその類似体を使用する組成物及び方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US20160039877A1 (enExample) |
| EP (2) | EP2970385B1 (enExample) |
| JP (2) | JP6674258B2 (enExample) |
| KR (1) | KR102244349B1 (enExample) |
| AU (3) | AU2014231444B2 (enExample) |
| BR (1) | BR112015022469A2 (enExample) |
| CA (1) | CA2906240C (enExample) |
| ES (1) | ES2703110T3 (enExample) |
| IL (1) | IL241383B (enExample) |
| MX (2) | MX378245B (enExample) |
| NZ (1) | NZ711958A (enExample) |
| RU (1) | RU2685958C2 (enExample) |
| SG (1) | SG11201507404RA (enExample) |
| WO (2) | WO2014139182A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4560952B2 (ja) * | 1999-12-03 | 2010-10-13 | 株式会社セガ | ゲーム装置及びゲームシステム |
| CN105492459A (zh) * | 2013-02-15 | 2016-04-13 | 高端学术皇家研究会/麦吉尔大学 | 用于治疗糖尿病的修饰的ingap肽 |
| AU2016392719A1 (en) | 2016-02-10 | 2018-08-02 | Pfizer Inc. | Therapeutic nanoparticles having EGFR ligands and methods of making and using same |
| CN108616978B (zh) * | 2016-12-14 | 2022-04-15 | 中兴通讯股份有限公司 | 一种网络功能实体进行无状态处理的方法及装置 |
| KR102006890B1 (ko) * | 2016-12-27 | 2019-08-05 | 한양대학교 산학협력단 | 췌장 소도 세포 표적 펩타이드 및 이의 용도 |
| US10772929B2 (en) * | 2017-05-11 | 2020-09-15 | Shenzhen Hightide Biopharmaceutical, Ltd. | Use of peptide compounds in treating acute pancreatitis |
| US20190142901A1 (en) * | 2017-11-16 | 2019-05-16 | Claresa Levetan | Compositions and methods for treating or preventing type 1 diabetes using a biologic response modifier in combination with one or more islet or beta cell regeneration or replacement therapies |
| CN114621324B (zh) * | 2018-09-18 | 2023-09-12 | 广州领晟医疗科技有限公司 | 促进肝细胞增殖和/或抑制肝细胞凋亡的多肽及其用途 |
| KR101995768B1 (ko) | 2019-03-13 | 2019-07-03 | (주)엔솔바이오사이언스 | 신규 펩타이드 및 그 용도 |
| EP4143305A4 (en) * | 2020-05-01 | 2024-09-11 | The Broad Institute, Inc. | GENETICALLY MODIFIED CENTRAL NERVOUS SYSTEM COMPOSITIONS |
| CN118922432A (zh) * | 2022-01-25 | 2024-11-08 | 深圳君圣泰生物技术有限公司 | 用于治疗细胞因子风暴的组合物和方法 |
| CN120659618A (zh) * | 2023-02-16 | 2025-09-16 | 深圳君圣泰生物技术有限公司 | 用于治疗肝病的组合物和方法 |
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| JP2012507723A (ja) | 2008-11-03 | 2012-03-29 | シェーリング コーポレイション | 炎症性腸疾患生物マーカーおよび関連治療方法 |
| US8012928B2 (en) | 2008-12-19 | 2011-09-06 | The Research Foundation Of State University Of New York | Truncated PAP2 and methods of making and using same |
| WO2010091122A1 (en) | 2009-02-03 | 2010-08-12 | Amunix, Inc. | Extended recombinant polypeptides and compositions comprising same |
| EP2260857A1 (en) | 2009-06-11 | 2010-12-15 | Alfact Innovation | Novel applications of HIP/PAP or derivatives thereof |
| ES2356217B1 (es) | 2009-08-04 | 2012-02-13 | Universidad De Salamanca | Método para la detección de daño renal. |
| CA2777162A1 (en) | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Polypeptides that bind il-23r |
| CN102686727A (zh) | 2009-10-09 | 2012-09-19 | 阿纳福公司 | 基于c-型凝集素结构域的组合文库 |
| WO2011084808A2 (en) | 2009-12-21 | 2011-07-14 | Amunix Operating Inc. | Bifunctional polypeptide compositions and methods for treatment of metabolic and cardiovascular diseases |
| ES2374370B1 (es) | 2010-08-04 | 2013-01-08 | Universidad De Salamanca | Método para la detección de daño renal. |
| CN102827253B (zh) * | 2011-06-17 | 2017-07-21 | 上海市第一人民医院 | 一种抑制炎症反应的小分子多肽及其应用 |
| CN105492459A (zh) * | 2013-02-15 | 2016-04-13 | 高端学术皇家研究会/麦吉尔大学 | 用于治疗糖尿病的修饰的ingap肽 |
-
2013
- 2013-03-15 WO PCT/CN2013/072771 patent/WO2014139182A1/en not_active Ceased
- 2013-03-15 US US14/775,568 patent/US20160039877A1/en not_active Abandoned
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2014
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- 2014-03-14 NZ NZ711958A patent/NZ711958A/en unknown
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- 2014-03-14 JP JP2015561930A patent/JP6674258B2/ja active Active
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- 2014-03-14 MX MX2015012038A patent/MX378245B/es unknown
- 2014-03-14 KR KR1020157029362A patent/KR102244349B1/ko active Active
- 2014-03-14 WO PCT/CN2014/073483 patent/WO2014139472A1/en not_active Ceased
- 2014-03-14 RU RU2015143655A patent/RU2685958C2/ru active
- 2014-03-14 SG SG11201507404RA patent/SG11201507404RA/en unknown
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2017
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