JP2016512205A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016512205A5 JP2016512205A5 JP2015561930A JP2015561930A JP2016512205A5 JP 2016512205 A5 JP2016512205 A5 JP 2016512205A5 JP 2015561930 A JP2015561930 A JP 2015561930A JP 2015561930 A JP2015561930 A JP 2015561930A JP 2016512205 A5 JP2016512205 A5 JP 2016512205A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- analog
- analogue
- pharmaceutical composition
- fasting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 57
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 210000004153 islets of langerhan Anatomy 0.000 claims 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 8
- 102000004877 Insulin Human genes 0.000 claims 8
- 108090001061 Insulin Proteins 0.000 claims 8
- 239000008280 blood Substances 0.000 claims 8
- 210000004369 blood Anatomy 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 239000008103 glucose Substances 0.000 claims 8
- 229940125396 insulin Drugs 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 8
- 230000001737 promoting effect Effects 0.000 claims 7
- 230000007812 deficiency Effects 0.000 claims 6
- 230000008929 regeneration Effects 0.000 claims 6
- 238000011069 regeneration method Methods 0.000 claims 6
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 6
- 230000004064 dysfunction Effects 0.000 claims 5
- 208000030159 metabolic disease Diseases 0.000 claims 5
- 201000009104 prediabetes syndrome Diseases 0.000 claims 5
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims 4
- 206010022489 Insulin Resistance Diseases 0.000 claims 4
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 4
- 206010012601 diabetes mellitus Diseases 0.000 claims 4
- 208000016097 disease of metabolism Diseases 0.000 claims 4
- 230000003451 hyperinsulinaemic effect Effects 0.000 claims 4
- 201000008980 hyperinsulinism Diseases 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 230000004048 modification Effects 0.000 claims 4
- 238000012986 modification Methods 0.000 claims 4
- 230000004936 stimulating effect Effects 0.000 claims 4
- 208000002705 Glucose Intolerance Diseases 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 210000004185 liver Anatomy 0.000 claims 3
- 210000005036 nerve Anatomy 0.000 claims 3
- 230000004112 neuroprotection Effects 0.000 claims 3
- VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 2
- 108010075254 C-Peptide Proteins 0.000 claims 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 230000005856 abnormality Effects 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 2
- 230000010261 cell growth Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000000291 postprandial effect Effects 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 150000008574 D-amino acids Chemical class 0.000 claims 1
- 230000021736 acetylation Effects 0.000 claims 1
- 238000006640 acetylation reaction Methods 0.000 claims 1
- 230000009435 amidation Effects 0.000 claims 1
- 238000007112 amidation reaction Methods 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000032050 esterification Effects 0.000 claims 1
- 238000005886 esterification reaction Methods 0.000 claims 1
- 229930195729 fatty acid Chemical class 0.000 claims 1
- 239000000194 fatty acid Chemical class 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2013/072771 WO2014139182A1 (en) | 2013-03-15 | 2013-03-15 | Compositions and methods of using islet neogenesis peptides and analogs thereof |
| CNPCT/CN2013/072771 | 2013-03-15 | ||
| PCT/CN2014/073483 WO2014139472A1 (en) | 2013-03-15 | 2014-03-14 | Compositions and methods of using islet neogenesis peptides and analogs thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019225049A Division JP7075918B2 (ja) | 2013-03-15 | 2019-12-13 | 膵島新生ペプチド及びその類似体を使用する組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512205A JP2016512205A (ja) | 2016-04-25 |
| JP2016512205A5 true JP2016512205A5 (OSRAM) | 2017-04-20 |
| JP6674258B2 JP6674258B2 (ja) | 2020-04-01 |
Family
ID=51535856
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015561930A Active JP6674258B2 (ja) | 2013-03-15 | 2014-03-14 | 膵島新生ペプチド及びその類似体を使用する組成物及び方法 |
| JP2019225049A Active JP7075918B2 (ja) | 2013-03-15 | 2019-12-13 | 膵島新生ペプチド及びその類似体を使用する組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019225049A Active JP7075918B2 (ja) | 2013-03-15 | 2019-12-13 | 膵島新生ペプチド及びその類似体を使用する組成物及び方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US20160039877A1 (OSRAM) |
| EP (2) | EP3473642B1 (OSRAM) |
| JP (2) | JP6674258B2 (OSRAM) |
| KR (1) | KR102244349B1 (OSRAM) |
| AU (3) | AU2014231444B2 (OSRAM) |
| BR (1) | BR112015022469A2 (OSRAM) |
| CA (1) | CA2906240C (OSRAM) |
| ES (1) | ES2703110T3 (OSRAM) |
| IL (1) | IL241383B (OSRAM) |
| MX (2) | MX378245B (OSRAM) |
| NZ (1) | NZ711958A (OSRAM) |
| RU (1) | RU2685958C2 (OSRAM) |
| SG (1) | SG11201507404RA (OSRAM) |
| WO (2) | WO2014139182A1 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4560952B2 (ja) * | 1999-12-03 | 2010-10-13 | 株式会社セガ | ゲーム装置及びゲームシステム |
| JP2016508509A (ja) * | 2013-02-15 | 2016-03-22 | ザ・ロイヤル・インスティテューション・フォア・ジ・アドヴァンスメント・オブ・ラーニング／マックギル・ユニバーシティＴｈｅ Ｒｏｙａｌ Ｉｎｓｔｉｔｕｔｉｏｎ Ｆｏｒ Ｔｈｅ Ａｄｖａｎｃｅｍｅｎｔ Ｏｆ Ｌｅａｒｎｉｎｇ／Ｍｃｇｉｌｌ Ｕｎｉｖｅｒｓｉｔｙ | 糖尿病を治療するための改変されたｉｎｇａｐペプチド |
| WO2017138983A1 (en) * | 2016-02-10 | 2017-08-17 | Pfizer Inc. | Therapeutic nanoparticles having egfr ligands and methods of making and using same |
| CN108616978B (zh) * | 2016-12-14 | 2022-04-15 | 中兴通讯股份有限公司 | 一种网络功能实体进行无状态处理的方法及装置 |
| KR102006890B1 (ko) * | 2016-12-27 | 2019-08-05 | 한양대학교 산학협력단 | 췌장 소도 세포 표적 펩타이드 및 이의 용도 |
| US10772929B2 (en) * | 2017-05-11 | 2020-09-15 | Shenzhen Hightide Biopharmaceutical, Ltd. | Use of peptide compounds in treating acute pancreatitis |
| US20190142901A1 (en) * | 2017-11-16 | 2019-05-16 | Claresa Levetan | Compositions and methods for treating or preventing type 1 diabetes using a biologic response modifier in combination with one or more islet or beta cell regeneration or replacement therapies |
| CN114644683B (zh) * | 2018-09-18 | 2023-09-12 | 广州领晟医疗科技有限公司 | 促进肝细胞增殖和/或抑制肝细胞凋亡的多肽及其用途 |
| KR101995768B1 (ko) | 2019-03-13 | 2019-07-03 | (주)엔솔바이오사이언스 | 신규 펩타이드 및 그 용도 |
| EP4143305A4 (en) * | 2020-05-01 | 2024-09-11 | The Broad Institute, Inc. | GENETICALLY MODIFIED CENTRAL NERVOUS SYSTEM COMPOSITIONS |
| WO2023143446A1 (en) * | 2022-01-25 | 2023-08-03 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions and methods for treating cytokine storm |
| EP4665376A1 (en) * | 2023-02-16 | 2025-12-24 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions and methods for treating liver diseases |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2661187B1 (fr) | 1990-04-20 | 1994-08-05 | Inst Nat Sante Rech Med | Proteine associee a la pancreatite aiguue. moyens pour le diagnostic de la pancreatite aiguue. |
| FR2700011B1 (fr) | 1992-12-24 | 1995-02-24 | Inst Nat Sante Rech Med | Détection de la mucoviscidose ou d'une mutation du gêne CFTR au moyen d'un dosage de la PAP. |
| JP3532566B2 (ja) | 1993-06-24 | 2004-05-31 | エル． グラハム，フランク | 遺伝子治療のためのアデノウイルスベクター |
| CN1263864C (zh) | 1993-10-25 | 2006-07-12 | 坎吉公司 | 重组腺病毒载体及其使用方法 |
| US7252989B1 (en) | 1994-04-04 | 2007-08-07 | Board Of Regents, The University Of Texas System | Adenovirus supervector system |
| US5834590A (en) | 1995-02-22 | 1998-11-10 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Ingap protein involved in pancreatic islet neogenesis |
| US5688489A (en) | 1995-09-15 | 1997-11-18 | Resolution Pharmaceuticals, Inc. | Non-receptor mediated imaging agents |
| US5804421A (en) | 1996-10-30 | 1998-09-08 | Eastern Virginia Medical School Of The Medical College Fo Hampton Roads | High level of expression of ingap in bacterial and euraryotic cells |
| US5935813A (en) | 1997-03-20 | 1999-08-10 | Incyte Pharmaceuticals, Inc. | Human pancreatitis-associated protein |
| US20020052308A1 (en) | 1999-03-12 | 2002-05-02 | Rosen Craig A. | Nucleic acids, proteins and antibodies |
| AU3395900A (en) | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | Human lung cancer associated gene sequences and polypeptides |
| US20040018623A1 (en) | 1999-10-29 | 2004-01-29 | Lawrence Rosenberg | Medium for preparing dedifferentiated cells |
| US20020009730A1 (en) | 1999-11-17 | 2002-01-24 | Alex Chenchik | Human stress array |
| CA2343602A1 (en) | 2000-04-18 | 2001-10-18 | Genset | Est's and encoded human proteins |
| US6812339B1 (en) | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| US20070037165A1 (en) | 2000-09-08 | 2007-02-15 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| US6824822B2 (en) | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
| DE10056802B4 (de) | 2000-11-14 | 2005-06-16 | Epigenomics Ag | Verfahren zur Detektion von Methylierungszuständen zur toxikologischen Diagnostik |
| CA2430953A1 (en) | 2000-12-13 | 2002-06-20 | Borean Pharma A/S | Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains |
| US20040018970A1 (en) | 2000-12-19 | 2004-01-29 | Shimkets Richard A. | Novel nucleic acids and polypeptides and methods of use thereof |
| AU2002246808A1 (en) | 2000-12-19 | 2002-08-06 | Curagen Corporation | Human nucleic acids and polypeptides and methods of use thereof |
| US6986994B2 (en) | 2001-01-09 | 2006-01-17 | Gmp Endotherapeutics, Inc. | INGAP displacement assays |
| US20040158036A1 (en) | 2001-03-01 | 2004-08-12 | Lawrence Rosenberg | Neuritogenic compound and uses thereof |
| WO2003016475A2 (en) | 2001-08-14 | 2003-02-27 | The General Hospital Corporation | Nucleic acid and amino acid sequences involved in pain |
| CN1628126A (zh) | 2001-08-30 | 2005-06-15 | 比奥雷克西斯药物公司 | 经修饰的运铁蛋白融合蛋白 |
| US20040132644A1 (en) | 2001-10-16 | 2004-07-08 | The Procter & Gamble Company | Composition and method for treating diabetes |
| AU2002351505B2 (en) | 2001-10-19 | 2008-04-03 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of inflammatory bowel disorders |
| US20060194265A1 (en) | 2001-10-23 | 2006-08-31 | Morris David W | Novel therapeutic targets in cancer |
| AU2002364587A1 (en) | 2001-12-21 | 2003-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7662768B2 (en) | 2002-01-11 | 2010-02-16 | Mcgill University | Transdifferentiation of pancreatic acinar cells |
| US7166439B2 (en) | 2002-03-01 | 2007-01-23 | Gmp Endotherapeutics, Inc. | Assay for anti-INGAP antibodies |
| US20070015271A1 (en) | 2002-04-04 | 2007-01-18 | Rosen Craig A | Human secreted proteins |
| US20040018522A1 (en) | 2002-05-09 | 2004-01-29 | Brigham And Women's Hospital, Inc. | Identification of dysregulated genes in patients with multiple sclerosis |
| AU2003241388A1 (en) | 2002-05-09 | 2003-11-11 | Medtronic Minimed, Inc. | Immunoprotective methods for beta cell neogenesis |
| AU2003280991A1 (en) | 2002-07-10 | 2004-02-02 | Japan As Represented By The President Of The University Of Tokyo | Method for diagnosis of intestinal-type gastric tumors |
| JP2004065120A (ja) | 2002-08-07 | 2004-03-04 | Sumitomo Pharmaceut Co Ltd | 炎症性腸疾患の疾患マーカー及びその利用 |
| EP1539221B1 (en) | 2002-08-30 | 2009-12-23 | Biorexis Pharmaceutical Corporation | Transferrin fusion protein libraries |
| US20060009516A1 (en) | 2002-10-24 | 2006-01-12 | Mcgill University | Use of ingap for reversing diabetes |
| WO2004055519A2 (en) | 2002-12-17 | 2004-07-01 | Sinogenomax Co. Ltd. | Specific markers for pancreatic cancer |
| US7510708B2 (en) | 2003-04-14 | 2009-03-31 | Washington University | Disruption of the REG pathway |
| EP1488798A1 (en) | 2003-06-18 | 2004-12-22 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | HIP/PAP polypeptide composition for use in liver regeneration and for the prevention of liver failure |
| WO2005113812A2 (en) | 2004-04-23 | 2005-12-01 | Invitrogen Corporation | Collections of matched biological reagents and methods for identifying matched reagents |
| US20050277593A1 (en) | 2004-05-24 | 2005-12-15 | Washington University | Therapeutic uses of Reg protein |
| EP1751174A4 (en) | 2004-06-04 | 2008-07-23 | Wyeth Corp | PROTEIN INHIBITORS REGIII, THERAPEUTIC AGENTS AGAINST ASTHMA |
| KR100639677B1 (ko) | 2004-11-08 | 2006-10-30 | 삼성전자주식회사 | 위상 및 지연 동기 루프와 이를 구비한 반도체 메모리 장치 |
| KR100664586B1 (ko) | 2004-12-22 | 2007-01-04 | 김현기 | 인간 원암 유전자, 이에 의해 코드되는 단백질, 이를포함하는 발현벡터 및 이 벡터로 형질 전환된 세포 |
| US20090142338A1 (en) * | 2005-03-04 | 2009-06-04 | Curedm, Inc. | Methods and Compositions for Treating Type 1 and Type 2 Diabetes Mellitus and Related Conditions |
| US20060275794A1 (en) | 2005-03-07 | 2006-12-07 | Invitrogen Corporation | Collections of matched biological reagents and methods for identifying matched reagents |
| EP1883417A2 (en) | 2005-05-25 | 2008-02-06 | Curedm Inc. | Peptides, derivatives and analogs thereof, and methods of using same |
| WO2007024700A2 (en) | 2005-08-19 | 2007-03-01 | Amylin Pharmaceuticals, Inc. | Exendin for treating diabetes and reducing body weight |
| US7807459B2 (en) | 2005-09-27 | 2010-10-05 | Reneuron, Inc. | EphA4-positive human adult pancreatic endocrine progenitor cells |
| US20080039393A1 (en) | 2005-11-09 | 2008-02-14 | Desmond Mascarenhas | Metal-binding therapeutic peptides |
| US7618816B2 (en) | 2005-11-09 | 2009-11-17 | Ontherix, Inc. | Metal-binding therapeutic peptides |
| WO2007071437A2 (en) | 2005-12-22 | 2007-06-28 | Ares Trading S.A. | Compositions and methods for treating inflammatory disorders |
| US20090269313A1 (en) | 2006-07-19 | 2009-10-29 | Diakine Therapeutics, Inc. | Encapsulation system |
| KR20060089873A (ko) | 2006-07-25 | 2006-08-09 | 김현기 | 인간 원암 유전자, 이에 의해 코드되는 단백질, 이를포함하는 발현벡터 및 이 벡터로 형질 전환된 세포 |
| AU2007284651B2 (en) | 2006-08-09 | 2014-03-20 | Institute For Systems Biology | Organ-specific proteins and methods of their use |
| WO2008085601A2 (en) | 2006-11-02 | 2008-07-17 | Genizon Biosciences Inc. | Genemap of the human genes associated with asthma disease |
| WO2008064306A2 (en) * | 2006-11-22 | 2008-05-29 | Curedm, Inc. | Methods and compositions relating to islet cell neogenesis |
| WO2008079406A2 (en) | 2006-12-19 | 2008-07-03 | Genentech, Inc. | Gene expression markers for inflammatory bowel disease |
| FR2910311B1 (fr) | 2006-12-20 | 2009-02-13 | Oreal | Composition comprenant un compose silicone et un organosilane particulier |
| US7923014B2 (en) | 2007-02-12 | 2011-04-12 | The Board Of Regents Of The University Of Texas System | Expression and purification of HIP/PAP and uses therefor |
| CA2682258A1 (en) * | 2007-03-26 | 2008-10-02 | Salutria Pharmaceuticals Llc | Methods and compositions of derivatives of probucol for the treatment of diabetes |
| US20080280985A1 (en) | 2007-03-27 | 2008-11-13 | Scott Robert A D | Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes |
| ES2534434T3 (es) * | 2007-08-30 | 2015-04-22 | Curedm Group Holdings, Llc | Composiciones y métodos de uso de péptidos proislotes y análogos de los mismos |
| US20110082080A1 (en) * | 2007-10-12 | 2011-04-07 | Curedm Group Holdings, Llc | Compositions and methods of using the human proislet peptide receptor |
| NO2514436T3 (OSRAM) | 2007-11-07 | 2018-05-19 | ||
| US20100004213A1 (en) | 2007-11-29 | 2010-01-07 | Abbas Alexander R | Gene expression markers for inflammatory bowel disease |
| JP2011509071A (ja) | 2007-11-29 | 2011-03-24 | ジェネンテック， インコーポレイテッド | 炎症性腸疾患のための遺伝子発現マーカー |
| EP2080812A1 (en) | 2008-01-18 | 2009-07-22 | Transmedi SA | Compositions and methods of detecting post-stop peptides |
| US20110052625A1 (en) | 2008-01-31 | 2011-03-03 | Diakine Therapeutics, Inc. | Compositions and methods for treating diabetes using lisofylline analogs and islet neogenesis associated peptide |
| EP2257814B1 (en) | 2008-03-21 | 2012-08-29 | Podiceps B.v. | Diagnostic of pre-symptomatic metabolic syndrome |
| WO2010033240A2 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Carbohydrate-based drug delivery polymers and conjugates thereof |
| JP2010085375A (ja) | 2008-10-02 | 2010-04-15 | Nationa Hospital Organization | 細胞増殖を伴う糖尿病合併症の検査のための方法、組成物およびキット |
| US20110212104A1 (en) | 2008-11-03 | 2011-09-01 | Schering Corporation | Inflammatory bowel disease biomarkers and related methods of treatment |
| US8012928B2 (en) | 2008-12-19 | 2011-09-06 | The Research Foundation Of State University Of New York | Truncated PAP2 and methods of making and using same |
| EP3178835B1 (en) | 2009-02-03 | 2019-04-10 | Amunix Pharmaceuticals, Inc. | Extended recombinant polypeptides and compositions comprising same |
| EP2260857A1 (en) | 2009-06-11 | 2010-12-15 | Alfact Innovation | Novel applications of HIP/PAP or derivatives thereof |
| ES2356217B1 (es) | 2009-08-04 | 2012-02-13 | Universidad De Salamanca | Método para la detección de daño renal. |
| CA2776954A1 (en) | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Combinatorial libraries based on c-type lectin domain |
| WO2011043835A1 (en) | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Polypeptides that bind il-23r |
| US20110312881A1 (en) | 2009-12-21 | 2011-12-22 | Amunix, Inc. | Bifunctional polypeptide compositions and methods for treatment of metabolic and cardiovascular diseases |
| ES2374370B1 (es) | 2010-08-04 | 2013-01-08 | Universidad De Salamanca | Método para la detección de daño renal. |
| CN102827253B (zh) * | 2011-06-17 | 2017-07-21 | 上海市第一人民医院 | 一种抑制炎症反应的小分子多肽及其应用 |
| JP2016508509A (ja) * | 2013-02-15 | 2016-03-22 | ザ・ロイヤル・インスティテューション・フォア・ジ・アドヴァンスメント・オブ・ラーニング／マックギル・ユニバーシティＴｈｅ Ｒｏｙａｌ Ｉｎｓｔｉｔｕｔｉｏｎ Ｆｏｒ Ｔｈｅ Ａｄｖａｎｃｅｍｅｎｔ Ｏｆ Ｌｅａｒｎｉｎｇ／Ｍｃｇｉｌｌ Ｕｎｉｖｅｒｓｉｔｙ | 糖尿病を治療するための改変されたｉｎｇａｐペプチド |
-
2013
- 2013-03-15 WO PCT/CN2013/072771 patent/WO2014139182A1/en not_active Ceased
- 2013-03-15 US US14/775,568 patent/US20160039877A1/en not_active Abandoned
-
2014
- 2014-03-14 NZ NZ711958A patent/NZ711958A/en unknown
- 2014-03-14 AU AU2014231444A patent/AU2014231444B2/en active Active
- 2014-03-14 CA CA2906240A patent/CA2906240C/en active Active
- 2014-03-14 ES ES14762306T patent/ES2703110T3/es active Active
- 2014-03-14 EP EP18196856.1A patent/EP3473642B1/en active Active
- 2014-03-14 MX MX2015012038A patent/MX378245B/es unknown
- 2014-03-14 RU RU2015143655A patent/RU2685958C2/ru active
- 2014-03-14 KR KR1020157029362A patent/KR102244349B1/ko active Active
- 2014-03-14 US US14/417,110 patent/US9388215B2/en active Active
- 2014-03-14 EP EP14762306.0A patent/EP2970385B1/en active Active
- 2014-03-14 SG SG11201507404RA patent/SG11201507404RA/en unknown
- 2014-03-14 JP JP2015561930A patent/JP6674258B2/ja active Active
- 2014-03-14 BR BR112015022469A patent/BR112015022469A2/pt not_active IP Right Cessation
- 2014-03-14 WO PCT/CN2014/073483 patent/WO2014139472A1/en not_active Ceased
-
2015
- 2015-09-09 MX MX2019009886A patent/MX2019009886A/es unknown
- 2015-09-09 IL IL241383A patent/IL241383B/en active IP Right Grant
-
2016
- 2016-06-08 US US15/177,206 patent/US9738695B2/en active Active
-
2017
- 2017-07-19 US US15/654,516 patent/US20180009861A1/en not_active Abandoned
-
2018
- 2018-05-29 US US15/992,039 patent/US10899815B2/en not_active Expired - Fee Related
- 2018-10-08 AU AU2018241212A patent/AU2018241212B2/en not_active Ceased
-
2019
- 2019-10-21 US US16/658,218 patent/US20200347106A1/en not_active Abandoned
- 2019-12-13 JP JP2019225049A patent/JP7075918B2/ja active Active
-
2020
- 2020-11-30 AU AU2020280993A patent/AU2020280993B2/en not_active Ceased
-
2022
- 2022-05-18 US US17/747,788 patent/US20220348618A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016512205A5 (OSRAM) | ||
| JP2020062028A5 (OSRAM) | ||
| Liu et al. | A preliminary evaluation of efficacy and safety of Wharton’s jelly mesenchymal stem cell transplantation in patients with type 2 diabetes mellitus | |
| RU2015143655A (ru) | Композиции и способы использования пептидов неогенеза островков и их аналогов | |
| Pessina et al. | Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy | |
| JP2015057427A5 (OSRAM) | ||
| Naranjo et al. | Regenerative medicine approaches for age-related muscle loss and sarcopenia: a mini-review | |
| JP2011241213A5 (OSRAM) | ||
| Hu et al. | Effect of combined therapy of human Wharton’s jelly-derived mesenchymal stem cells from umbilical cord with sitagliptin in type 2 diabetic rats | |
| JP2020502140A5 (OSRAM) | ||
| Alway et al. | The role of mitochondria in mediation of skeletal muscle repair | |
| EP3539537A1 (en) | Pharmaceutical use of an extended-release composition containing pirfenidone for the treatment and reversal of human steatohepatitis (nafld/nash) | |
| CN106279400A (zh) | P8降糖肽的设计及其用途 | |
| Thuy et al. | Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction | |
| Angeli et al. | Incretin-based therapies: can we achieve glycemic control and cardioprotection? | |
| Hao et al. | Glucagon-like peptide 1 receptor agonist ameliorates the insulin resistance function of islet β cells via the activation of PDX-1/JAK signaling transduction in C57/BL6 mice with high-fat diet-induced diabetes | |
| MX2014002155A (es) | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa. | |
| JP2018503644A5 (OSRAM) | ||
| JP2019520837A (ja) | Β細胞ミメティック細胞 | |
| BR112020024643A2 (pt) | método de tratamento de pré-diabetes ou diabetes mellitus tipo 1 ou tipo 2, método de melhoria do controle glicêmico em um sujeito tendo pré-diabetes ou diabetes tipo 1 ou tipo 2, imeglimina para uso em um método para tratamento de pré-diabetes ou diabetes mellitus tipo 1 ou tipo 2 de um sujeito, imeglimina para uso em um método para melhoria do controle glicêmico em um sujeito tendo pré-diabetes ou diabetes tipo 1 ou tipo 2, uso de imeglimina para a fabricação de um medicamento para o tratamento de um sujeito tendo pré-diabetes ou diabetes mellitus tipo 1 ou tipo 2 e uso de imeglimina para a fabricação de um medicamento para melhoria do controle glicêmico em um sujeito tendo pré-diabetes ou diabetes tipo 1 ou tipo 2 | |
| Kruczkowska et al. | Senescent adipocytes and type 2 diabetes–current knowledge and perspective concepts | |
| Li et al. | Signal transduction mechanism of exosomes in diabetic complications | |
| JP2016515123A5 (OSRAM) | ||
| BR112021017315A2 (pt) | Usos terapêuticos de dulaglutida | |
| CN106519016A (zh) | 降糖调脂肽——Progly肽的设计及其用途 |