JP2016511753A - 15−ohepaを含む組成物および同組成物を使用する方法 - Google Patents
15−ohepaを含む組成物および同組成物を使用する方法 Download PDFInfo
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- JP2016511753A JP2016511753A JP2015555661A JP2015555661A JP2016511753A JP 2016511753 A JP2016511753 A JP 2016511753A JP 2015555661 A JP2015555661 A JP 2015555661A JP 2015555661 A JP2015555661 A JP 2015555661A JP 2016511753 A JP2016511753 A JP 2016511753A
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Abstract
Description
本発明を種々の形態で具体化することが可能であるが、本開示が本発明の例示とみなされるべきであり、本発明を例示されている特定の実施形態に限定することを意図していないという理解の下に、いくつかの実施形態の下記の説明を行う。表題は便宜上提供するに過ぎず、本発明をなんら限定するものと解釈されるべきではない。いずれの表題の下に示される実施形態も、他の表題の下に示される実施形態と組み合わせることができる。
一実施形態では、本発明の組成物が有効成分として15−OHEPAを含む。15−OHEPAは、15−ヒドロキシエイコサペンタエン酸、エイコサペンタエン酸(EPA)の酵素15−リポキシゲナーゼへの暴露などの当技術分野で既知の方法を介して合成することができるエイコサペンタエン酸の代謝産物の略語である。本明細書で使用される場合、「15−OHEPA」という用語は、その遊離酸型の15−OHEPA(例えば、15−ヒドロキシエイコサペンタエン酸)および/またはその薬学的に許容されるエステル、抱合体もしくは塩、または前記のいずれかの混合物を指す。15−OHEPAの誘導体が代わりに使用され得るが、これは15−OHEPAのヒドロキシ基を欠くいずれの誘導体化合物も含まない。本文脈中の「薬学的に許容される」という用語は、当の物質が対象に対する許容されない毒性も組成物の他の成分との相互作用ももたらさないことを意味する。
一実施形態では、医薬組成物が、1種または複数のさらなる活性剤をさらに含む。一実施形態では、医薬組成物が、さらなる活性剤について一般的に認識されている治療上有効量未満の量のその剤を含む。一実施形態では、医薬組成物が、さらなる活性剤について一般的に認識されている治療上有効量に等しいまたはそれより多い量のその剤を含む。
本開示により使用するための組成物を1種または複数の投与量単位として製剤化することができる。本明細書の「用量単位」および「投与量単位」という用語は、治療効果をもたらすための単回投与に適した量の治療剤を含有する医薬組成物の一部を指す。このような投与量単位は、1日当たり1回〜複数回(すなわち、1〜約10回、1〜8回、1〜6回、1〜4回または1〜2回)、または治療反応を誘発するのに必要なだけの回数で投与され得る。
本明細書に開示される組成物および製剤は、脂肪性肝疾患の治療に使用され得る。一実施形態では、脂肪性肝疾患が非アルコール性脂肪性肝疾患である。別の実施形態では、脂肪性肝疾患が非アルコール性脂肪性肝炎である。一実施形態では、方法が、本明細書に開示される医薬組成物を対象に、1日1回、1日2回、1日3回または1日4回以上投与するステップを含む。
病原体フリーの15日妊娠C57BL/6マウスをCharles River Laboratories in Japan Inc.(神奈川、日本)から得た。生後のストレプトゾトシン(STZ)(Sigma、米国)の単回皮下注射、および4週齢(28±2日)後に自由に高脂肪食(HFD;CLEA)Japan、日本)を給餌することによって、NASHを雄マウスで確立した。処理の開始の前日にマウスを5週齢(35±2日)の8匹のマウスの5つの群にランダム化した。処理期間中、個体の体重を毎日、ならびに行動の臨床徴候および生存を測定した。
1群(ビヒクル):8匹のNASHマウスに5週齢から9週齢まで1日1回10mL/kgの体積でビヒクル[オリーブ油]を経口投与した。
・個体の肝臓重量
・肝臓重量対体重の比
図1.1は、実験群のいずれにおいても体重の有意な変化がなかったことを示している。
Claims (10)
- 脂肪性肝障害の治療に使用するための15−OHEPA。
- 前記脂肪性肝障害が非アルコール性脂肪性肝疾患および非アルコール性脂肪性肝炎から選択される、請求項1に記載の使用するための15−OHEPA。
- C1〜C5アルキルエステルを含む、請求項1または請求項2に記載の使用するための15−OHEPA。
- 医薬組成物の形態である、請求項1から3のいずれか一項に記載の使用するための15−OHEPA。
- 前記医薬組成物が薬学的に許容される賦形剤をさらに含む、請求項4に記載の使用するための15−OHEPA。
- 前記医薬組成物が経口医薬組成物である、請求項4または請求項5に記載の使用するための15−OHEPA。
- 存在する全脂肪酸の少なくとも約90重量%となる、請求項1から6のいずれか一項に記載の使用するための15−OHEPA。
- 任意の他のω−3脂肪酸が実質的な量で存在しない、請求項1から7のいずれか一項に記載の使用するための15−OHEPA。
- 他のω−3脂肪酸が全く存在しない、請求項1から8のいずれか一項に記載の使用するための15−OHEPA。
- 約50mg〜約3000mg存在する、請求項1から9のいずれか一項に記載の使用するための15−OHEPA。
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