JP2016509029A5

JP2016509029A5 -

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Publication number: JP2016509029A5
Authority: JP; Japan
Prior art keywords: chlorophenyl; morpholinyl; oxo; bis; acid
Prior art date: 2014-02-18
Legal status : Granted

Application number

JP2015558205A

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English (en)

Japanese (ja)

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JP2016509029A (ja

JP6417338B2 (ja

Filing date

2014-02-18

Publication date

2017-03-02

2014-02-18 Application filed filed Critical

2014-02-18 Priority claimed from PCT/US2014/016971 external-priority patent/WO2014130470A1/en

2016-03-24 Publication of JP2016509029A publication Critical patent/JP2016509029A/ja

2017-03-02 Publication of JP2016509029A5 publication Critical patent/JP2016509029A5/ja

2018-11-07 Application granted granted Critical

2018-11-07 Publication of JP6417338B2 publication Critical patent/JP6417338B2/ja

Status Active legal-status Critical Current

2034-02-18 Anticipated expiration legal-status Critical

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QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 234
235000011054 acetic acid Nutrition 0.000 claims 78
229960000583 acetic acid Drugs 0.000 claims 78
IPWFJLQDVFKJDU-UHFFFAOYSA-N pentanamide Chemical compound CCCCC(N)=O IPWFJLQDVFKJDU-UHFFFAOYSA-N 0.000 claims 59
150000001875 compounds Chemical class 0.000 claims 48
-1 —CF 3 Chemical group 0.000 claims 34
125000000217 alkyl group Chemical group 0.000 claims 27
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 22
125000001072 heteroaryl group Chemical group 0.000 claims 21
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 20
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 18
125000005843 halogen group Chemical group 0.000 claims 16
229910052739 hydrogen Inorganic materials 0.000 claims 16
239000001257 hydrogen Substances 0.000 claims 16
125000003118 aryl group Chemical group 0.000 claims 15
125000000592 heterocycloalkyl group Chemical group 0.000 claims 15
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims 13
125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 12
229940000635 beta-alanine Drugs 0.000 claims 12
125000004093 cyano group Chemical group *C#N 0.000 claims 11
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 10
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
239000002253 acid Substances 0.000 claims 10
150000003839 salts Chemical class 0.000 claims 10
125000001424 substituent group Chemical group 0.000 claims 10
239000004471 Glycine Substances 0.000 claims 9
ZMSIFDIKIXVLDF-UHFFFAOYSA-N 2-methyl-1,3,4-oxadiazole Chemical compound CC1=NN=CO1 ZMSIFDIKIXVLDF-UHFFFAOYSA-N 0.000 claims 8
DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 8
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 8
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 6
150000002431 hydrogen Chemical class 0.000 claims 6
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 5
125000005842 heteroatom Chemical group 0.000 claims 5
SBIUCEQISUZNJO-CAOCKLPOSA-N (2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-(2-morpholin-4-yl-2-oxoethyl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1N(CC2CC2)C(=O)[C@H](CC(=O)N2CCOCC2)O[C@H]1C1=CC=CC(Cl)=C1 SBIUCEQISUZNJO-CAOCKLPOSA-N 0.000 claims 4
125000000753 cycloalkyl group Chemical group 0.000 claims 4
MYDQAEQZZKVJSL-UHFFFAOYSA-N pentyl carbamate Chemical compound CCCCCOC(N)=O MYDQAEQZZKVJSL-UHFFFAOYSA-N 0.000 claims 4
239000008194 pharmaceutical composition Substances 0.000 claims 4
206010028980 Neoplasm Diseases 0.000 claims 3
201000011510 cancer Diseases 0.000 claims 3
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
MURGPOPKNPYXAX-HVWQDESWSA-N (2R)-2-[(2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound ClC1=CC=C(C=C1)[C@H]1O[C@@H](C(N([C@H]1C1=CC=C(C=C1)Cl)[C@@H](C(=O)O)C1CC1)=O)CC1=CC=C(C=C1)C#N MURGPOPKNPYXAX-HVWQDESWSA-N 0.000 claims 2
MURGPOPKNPYXAX-LGTXBLIGSA-N (2S)-2-[(2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound ClC1=CC=C(C=C1)[C@H]1O[C@@H](C(N([C@H]1C1=CC=C(C=C1)Cl)[C@H](C(=O)O)C1CC1)=O)CC1=CC=C(C=C1)C#N MURGPOPKNPYXAX-LGTXBLIGSA-N 0.000 claims 2
YFIAXOHWIQXCTA-KAGYGMCKSA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-2-methyl-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2N(C(CO[C@]2(C)C=2C=CC(Cl)=CC=2)=O)[C@H](CCC)C(O)=O)=CC=C(Cl)C=C1 YFIAXOHWIQXCTA-KAGYGMCKSA-N 0.000 claims 2
YEWIXZBJFKGKIX-YFNKSVMNSA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-3-phenylpropanoic acid Chemical compound C([C@H](C(=O)O)N1C(CO[C@@H]([C@@H]1C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)=O)C1=CC=CC=C1 YEWIXZBJFKGKIX-YFNKSVMNSA-N 0.000 claims 2
KGYXFUQDTGFHHL-HLAWJBBLSA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]hexanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 KGYXFUQDTGFHHL-HLAWJBBLSA-N 0.000 claims 2
VVXLJODXWXBXLX-XUVXKRRUSA-N (2r)-2-[(2r,3s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound C1([C@H](C(=O)O)N2C(CO[C@@H]([C@@H]2C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)=O)CC1 VVXLJODXWXBXLX-XUVXKRRUSA-N 0.000 claims 2
HQRAQGJHPUFZPL-BAGYTPMASA-N (2r)-2-[(2r,3s)-2-(4-chlorophenyl)-3-(1h-indol-2-yl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2NC3=CC=CC=C3C=2)=CC=C(Cl)C=C1 HQRAQGJHPUFZPL-BAGYTPMASA-N 0.000 claims 2
RHMLZVFYKALLBD-MTQWCTHYSA-N (2r)-2-[(2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]-2-hydroxyacetic acid Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)[C@@H](O)C(O)=O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 RHMLZVFYKALLBD-MTQWCTHYSA-N 0.000 claims 2
YFIAXOHWIQXCTA-UZKOGDIHSA-N (2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-2-methyl-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2N(C(CO[C@@]2(C)C=2C=CC(Cl)=CC=2)=O)[C@H](CCC)C(O)=O)=CC=C(Cl)C=C1 YFIAXOHWIQXCTA-UZKOGDIHSA-N 0.000 claims 2
YEWIXZBJFKGKIX-JRFVFWCSSA-N (2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-3-phenylpropanoic acid Chemical compound C([C@H](C(=O)O)N1C(CO[C@H]([C@H]1C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)=O)C1=CC=CC=C1 YEWIXZBJFKGKIX-JRFVFWCSSA-N 0.000 claims 2
NHDJKSJILSOCFS-RLLQIKCJSA-N (2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 NHDJKSJILSOCFS-RLLQIKCJSA-N 0.000 claims 2
VVXLJODXWXBXLX-AQNXPRMDSA-N (2r)-2-[(2s,3r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound C1([C@H](C(=O)O)N2C(CO[C@H]([C@H]2C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)=O)CC1 VVXLJODXWXBXLX-AQNXPRMDSA-N 0.000 claims 2
DELFMJQSZBLXHR-RLLQIKCJSA-N (2r)-2-[(2s,3r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 DELFMJQSZBLXHR-RLLQIKCJSA-N 0.000 claims 2
YVJUKVSHQAHNBQ-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-5-oxo-6-[[4-(trifluoromethylsulfonyl)phenyl]methyl]morpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(=O)(=O)C(F)(F)F)C=C1 YVJUKVSHQAHNBQ-ZJSPYRCASA-N 0.000 claims 2
CEEOVMWEVYLGRQ-MBDNFAEBSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-5-oxo-6-prop-2-enylmorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C([C@H](CC=C)O2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 CEEOVMWEVYLGRQ-MBDNFAEBSA-N 0.000 claims 2
WDHFWCFVVPABNM-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(3-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC(F)=C1 WDHFWCFVVPABNM-ZJSPYRCASA-N 0.000 claims 2
MURGPOPKNPYXAX-YAOOYPAMSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound C1([C@H](C(=O)O)N2C([C@H](CC=3C=CC(=CC=3)C#N)O[C@H]([C@H]2C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)=O)CC1 MURGPOPKNPYXAX-YAOOYPAMSA-N 0.000 claims 2
AKVZPAVYTSBNGJ-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 AKVZPAVYTSBNGJ-RAVGUYNFSA-N 0.000 claims 2
BPTXICQAEGSTHS-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 BPTXICQAEGSTHS-ZJSPYRCASA-N 0.000 claims 2
XGYPQDITWWTTAX-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-iodophenyl)methyl]-5-oxomorpholin-4-yl]-n-hydroxypentanamide Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NO)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 XGYPQDITWWTTAX-ZJSPYRCASA-N 0.000 claims 2
SOTSYTXAFGARSV-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(C)(=O)=O)C=C1 SOTSYTXAFGARSV-RAVGUYNFSA-N 0.000 claims 2
RHMLZVFYKALLBD-ZRNYENFQSA-N (2r)-2-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]-2-hydroxyacetic acid Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)[C@@H](O)C(O)=O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 RHMLZVFYKALLBD-ZRNYENFQSA-N 0.000 claims 2
IRPCEHWYFCBCLC-VJLURNNQSA-N (2r)-3-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NC[C@@H](NC(=O)OC(C)(C)C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 IRPCEHWYFCBCLC-VJLURNNQSA-N 0.000 claims 2
UNGZHGDTNAHJNZ-GJZXTFMBSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-[(2s)-1-[4-(cyclopropylmethyl)piperazin-1-yl]-1-oxopentan-2-yl]-2-[(4-iodophenyl)methyl]morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)N1CCN(CC2CC2)CC1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 UNGZHGDTNAHJNZ-GJZXTFMBSA-N 0.000 claims 2
YEWIXZBJFKGKIX-OEMFJLHTSA-N (2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-3-phenylpropanoic acid Chemical compound C([C@@H](C(=O)O)N1C(CO[C@@H]([C@@H]1C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)=O)C1=CC=CC=C1 YEWIXZBJFKGKIX-OEMFJLHTSA-N 0.000 claims 2
KGYXFUQDTGFHHL-SESVDKBCSA-N (2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]hexanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 KGYXFUQDTGFHHL-SESVDKBCSA-N 0.000 claims 2
VVXLJODXWXBXLX-SLFFLAALSA-N (2s)-2-[(2r,3s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound C1([C@@H](C(=O)O)N2C(CO[C@@H]([C@@H]2C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)=O)CC1 VVXLJODXWXBXLX-SLFFLAALSA-N 0.000 claims 2
DELFMJQSZBLXHR-YSIASYRMSA-N (2s)-2-[(2r,3s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 DELFMJQSZBLXHR-YSIASYRMSA-N 0.000 claims 2
BPTXICQAEGSTHS-ROXDYWFKSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 BPTXICQAEGSTHS-ROXDYWFKSA-N 0.000 claims 2
XGYPQDITWWTTAX-ROXDYWFKSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-iodophenyl)methyl]-5-oxomorpholin-4-yl]-n-hydroxypentanamide Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)NO)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 XGYPQDITWWTTAX-ROXDYWFKSA-N 0.000 claims 2
RHMLZVFYKALLBD-VNTMZGSJSA-N (2s)-2-[(2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]-2-hydroxyacetic acid Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)[C@H](O)C(O)=O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 RHMLZVFYKALLBD-VNTMZGSJSA-N 0.000 claims 2
YFIAXOHWIQXCTA-DWLFOUALSA-N (2s)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-2-methyl-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2N(C(CO[C@@]2(C)C=2C=CC(Cl)=CC=2)=O)[C@@H](CCC)C(O)=O)=CC=C(Cl)C=C1 YFIAXOHWIQXCTA-DWLFOUALSA-N 0.000 claims 2
YEWIXZBJFKGKIX-QTJGBDASSA-N (2s)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-3-phenylpropanoic acid Chemical compound C([C@@H](C(=O)O)N1C(CO[C@H]([C@H]1C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)=O)C1=CC=CC=C1 YEWIXZBJFKGKIX-QTJGBDASSA-N 0.000 claims 2
KGYXFUQDTGFHHL-TYPHKJRUSA-N (2s)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]hexanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CCCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 KGYXFUQDTGFHHL-TYPHKJRUSA-N 0.000 claims 2
VVXLJODXWXBXLX-AABGKKOBSA-N (2s)-2-[(2s,3r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound C1([C@@H](C(=O)O)N2C(CO[C@H]([C@H]2C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)=O)CC1 VVXLJODXWXBXLX-AABGKKOBSA-N 0.000 claims 2
HQRAQGJHPUFZPL-NNWRFLSQSA-N (2s)-2-[(2s,3r)-2-(4-chlorophenyl)-3-(1h-indol-2-yl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2NC3=CC=CC=C3C=2)=CC=C(Cl)C=C1 HQRAQGJHPUFZPL-NNWRFLSQSA-N 0.000 claims 2
MURGPOPKNPYXAX-XUJYPJAKSA-N (2s)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound C1([C@@H](C(=O)O)N2C([C@H](CC=3C=CC(=CC=3)C#N)O[C@H]([C@H]2C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)=O)CC1 MURGPOPKNPYXAX-XUJYPJAKSA-N 0.000 claims 2
OZZCSOBIPVVGCN-RAVGUYNFSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2r)-1-hydroxypentan-2-yl]morpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CO)CCC)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 OZZCSOBIPVVGCN-RAVGUYNFSA-N 0.000 claims 2
OZZCSOBIPVVGCN-NFGXINMFSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2s)-1-hydroxypentan-2-yl]morpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CO)CCC)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 OZZCSOBIPVVGCN-NFGXINMFSA-N 0.000 claims 2
VPGKHHKAWPXNLG-VJGNERBWSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-pyridin-4-ylmorpholin-3-one Chemical compound C1=CC(F)=CC=C1C[C@H]1C(=O)N(C=2C=CN=CC=2)[C@H](C=2C=CC(Cl)=CC=2)[C@H](C=2C=CC(Cl)=CC=2)O1 VPGKHHKAWPXNLG-VJGNERBWSA-N 0.000 claims 2
VCCRUVHDRWIPAK-NRSPTQNISA-N (3r,5r,6s)-5,6-bis(4-chlorophenyl)-3-propyl-3,5,6,8-tetrahydro-2h-imidazo[2,1-c][1,4]oxazine Chemical compound C1([C@@H]2[C@@H](OCC3=NC[C@H](N23)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 VCCRUVHDRWIPAK-NRSPTQNISA-N 0.000 claims 2
VCCRUVHDRWIPAK-HLAWJBBLSA-N (3r,5s,6r)-5,6-bis(4-chlorophenyl)-3-propyl-3,5,6,8-tetrahydro-2h-imidazo[2,1-c][1,4]oxazine Chemical compound C1([C@H]2[C@H](OCC3=NC[C@H](N23)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 VCCRUVHDRWIPAK-HLAWJBBLSA-N 0.000 claims 2
VCCRUVHDRWIPAK-TYPHKJRUSA-N (3s,5r,6s)-5,6-bis(4-chlorophenyl)-3-propyl-3,5,6,8-tetrahydro-2h-imidazo[2,1-c][1,4]oxazine Chemical compound C1([C@@H]2[C@@H](OCC3=NC[C@@H](N23)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 VCCRUVHDRWIPAK-TYPHKJRUSA-N 0.000 claims 2
VCCRUVHDRWIPAK-SESVDKBCSA-N (3s,5s,6r)-5,6-bis(4-chlorophenyl)-3-propyl-3,5,6,8-tetrahydro-2h-imidazo[2,1-c][1,4]oxazine Chemical compound C1([C@H]2[C@H](OCC3=NC[C@@H](N23)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 VCCRUVHDRWIPAK-SESVDKBCSA-N 0.000 claims 2
USNQYGDSTBFBSK-UXHICEINSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1N(CC2CC2)C(=O)CO[C@H]1C1=CC=CC(Cl)=C1 USNQYGDSTBFBSK-UXHICEINSA-N 0.000 claims 2
NFFXQTHZDQEVMP-ATTQYFOMSA-N (5s,6r)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one Chemical compound O([C@@H]([C@@H](N(C1=O)C)C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C1CC1=CC=CC=C1 NFFXQTHZDQEVMP-ATTQYFOMSA-N 0.000 claims 2
USNQYGDSTBFBSK-VQTJNVASSA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1N(CC2CC2)C(=O)CO[C@@H]1C1=CC=CC(Cl)=C1 USNQYGDSTBFBSK-VQTJNVASSA-N 0.000 claims 2
NWWKOBFNPRJOND-IQLXHWPESA-N 1-[[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]methyl]cyclopentane-1-carboxylic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NCC1(CCCC1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 NWWKOBFNPRJOND-IQLXHWPESA-N 0.000 claims 2
NWWKOBFNPRJOND-MLMSKLGMSA-N 1-[[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]methyl]cyclopentane-1-carboxylic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)NCC1(CCCC1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 NWWKOBFNPRJOND-MLMSKLGMSA-N 0.000 claims 2
GOJFTLJDUNFYCJ-ZSXPUABSSA-N 2-[(2r,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2s)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl]acetic acid Chemical compound C1([C@H]2[C@H](N(C([C@@H](CC(O)=O)O2)=O)[C@H](CO)CC)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 GOJFTLJDUNFYCJ-ZSXPUABSSA-N 0.000 claims 2
PLSLYOZGYCPTIL-HLAWJBBLSA-N 2-[(2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 PLSLYOZGYCPTIL-HLAWJBBLSA-N 0.000 claims 2
PLSLYOZGYCPTIL-TYPHKJRUSA-N 2-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)CC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 PLSLYOZGYCPTIL-TYPHKJRUSA-N 0.000 claims 2
GOJFTLJDUNFYCJ-MMKMLUHNSA-N 2-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2s)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl]acetic acid Chemical compound C1([C@H]2[C@H](N(C([C@H](CC(O)=O)O2)=O)[C@H](CO)CC)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 GOJFTLJDUNFYCJ-MMKMLUHNSA-N 0.000 claims 2
125000000979 2-amino-2-oxoethyl group Chemical group [H]C([*])([H])C(=O)N([H])[H] 0.000 claims 2
FOKODXFSOLFBDK-OQIMXIDESA-N 4-[[(2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-[(2S)-1-[4-(cyclopropylmethyl)piperazin-1-yl]-1-oxopentan-2-yl]-3-oxomorpholin-2-yl]methyl]benzonitrile Chemical compound ClC1=CC=C(C=C1)[C@H]1[C@H](O[C@@H](C(N1[C@@H](CCC)C(=O)N1CCN(CC1)CC1CC1)=O)CC1=CC=C(C#N)C=C1)C1=CC=C(C=C1)Cl FOKODXFSOLFBDK-OQIMXIDESA-N 0.000 claims 2
FOKODXFSOLFBDK-AXXKPAGNSA-N 4-[[(2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-[(2r)-1-[4-(cyclopropylmethyl)piperazin-1-yl]-1-oxopentan-2-yl]-3-oxomorpholin-2-yl]methyl]benzonitrile Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)N1CCN(CC2CC2)CC1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 FOKODXFSOLFBDK-AXXKPAGNSA-N 0.000 claims 2
HADIOTCRIITNPW-FDFHNCONSA-N 4-[[(2s,5r,6s)-5-(4-chlorophenyl)-4-methyl-6-(2-methylpropyl)-3-oxomorpholin-2-yl]methyl]-2-fluorobenzonitrile Chemical compound C([C@@H]1O[C@H]([C@H](N(C)C1=O)C=1C=CC(Cl)=CC=1)CC(C)C)C1=CC=C(C#N)C(F)=C1 HADIOTCRIITNPW-FDFHNCONSA-N 0.000 claims 2
125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 2
208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 2
208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
229910052794 bromium Inorganic materials 0.000 claims 2
125000001246 bromo group Chemical group Br* 0.000 claims 2
229910052731 fluorine Inorganic materials 0.000 claims 2
239000011737 fluorine Substances 0.000 claims 2
125000001153 fluoro group Chemical group F* 0.000 claims 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
VCHJPDFVEKENPJ-OUMDNPPYSA-N (2R)-2-[(2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(2-morpholin-4-yl-2-oxoethyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound ClC=1C=C(C=CC1)[C@H]1[C@H](N(C([C@@H](O1)CC(=O)N1CCOCC1)=O)[C@@H](C(=O)O)CCC)C1=CC=C(C=C1)Cl VCHJPDFVEKENPJ-OUMDNPPYSA-N 0.000 claims 1
CFFTUKRUWPPPBY-NMQUZHGHSA-N (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-[(2R)-2,3-dihydroxypropyl]-4-[(2S)-pentan-2-yl]morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@@H]1[C@@H](N(C([C@H](O1)C[C@H](CO)O)=O)[C@@H](C)CCC)C1=CC=C(C=C1)Cl CFFTUKRUWPPPBY-NMQUZHGHSA-N 0.000 claims 1
YZXNLAQFGPTWEK-DMTNHVFBSA-N (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-(1-methylimidazol-4-yl)morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@H]1[C@H](O[C@@H](C(N1C=1N=CN(C1)C)=O)CC1=CC=C(C=C1)F)C1=CC=C(C=C1)Cl YZXNLAQFGPTWEK-DMTNHVFBSA-N 0.000 claims 1
GAQCTUBQELXKFM-DSNGMDLFSA-N (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-(1H-pyrazol-4-yl)morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@H]1[C@H](O[C@@H](C(N1C=1C=NNC1)=O)CC1=CC=C(C=C1)F)C1=CC=C(C=C1)Cl GAQCTUBQELXKFM-DSNGMDLFSA-N 0.000 claims 1
XBDLXEHVSZYECN-XFBWMNOSSA-N (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2S)-1-(4-methylpiperazin-1-yl)-1-oxopentan-2-yl]morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@H]1[C@H](O[C@@H](C(N1[C@@H](CCC)C(=O)N1CCN(CC1)C)=O)CC1=CC=C(C=C1)F)C1=CC=C(C=C1)Cl XBDLXEHVSZYECN-XFBWMNOSSA-N 0.000 claims 1
OZZCSOBIPVVGCN-YYGZZXRFSA-N (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2S)-1-hydroxypentan-2-yl]morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@H]1[C@H](O[C@@H](C(N1[C@@H](CCC)CO)=O)CC1=CC=C(C=C1)F)C1=CC=C(C=C1)Cl OZZCSOBIPVVGCN-YYGZZXRFSA-N 0.000 claims 1
XMOWLFHORUUXHL-RRGQHJHPSA-N (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2S)-1-morpholin-4-yl-1-oxopentan-2-yl]morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@H]1[C@H](O[C@@H](C(N1[C@@H](CCC)C(=O)N1CCOCC1)=O)CC1=CC=C(C=C1)F)C1=CC=C(C=C1)Cl XMOWLFHORUUXHL-RRGQHJHPSA-N 0.000 claims 1
GHBPXNGRPGLEEC-XFBWMNOSSA-N (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2S)-1-morpholin-4-ylpentan-2-yl]morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@H]1[C@H](O[C@@H](C(N1[C@@H](CCC)CN1CCOCC1)=O)CC1=CC=C(C=C1)F)C1=CC=C(C=C1)Cl GHBPXNGRPGLEEC-XFBWMNOSSA-N 0.000 claims 1
DMOPFPDBKUOWQW-DMTNHVFBSA-N (2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]morpholin-3-one Chemical compound ClC=1C=C(C=CC1)[C@H]1O[C@@H](C(N([C@H]1C1=CC=C(C=C1)Cl)CC1CC1)=O)CC(=O)N1CCN(CC1)C DMOPFPDBKUOWQW-DMTNHVFBSA-N 0.000 claims 1
LTDIAJLOLCVPIG-RAVGUYNFSA-N (2S,5R,6S)-4-[(2R)-1-aminopentan-2-yl]-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]morpholin-3-one Chemical compound CCC[C@H](CN)N1[C@@H]([C@@H](O[C@@H](Cc2ccc(F)cc2)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1 LTDIAJLOLCVPIG-RAVGUYNFSA-N 0.000 claims 1
XBDLXEHVSZYECN-ITGKQZKFSA-N (2S,5R,6S)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2R)-1-(4-methylpiperazin-1-yl)-1-oxopentan-2-yl]morpholin-3-one Chemical compound CCC[C@@H](N1[C@@H]([C@@H](O[C@@H](Cc2ccc(F)cc2)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(=O)N1CCN(C)CC1 XBDLXEHVSZYECN-ITGKQZKFSA-N 0.000 claims 1
XMOWLFHORUUXHL-ATIZSFMBSA-N (2S,5R,6S)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2R)-1-morpholin-4-yl-1-oxopentan-2-yl]morpholin-3-one Chemical compound CCC[C@@H](N1[C@@H]([C@@H](O[C@@H](Cc2ccc(F)cc2)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(=O)N1CCOCC1 XMOWLFHORUUXHL-ATIZSFMBSA-N 0.000 claims 1
GHBPXNGRPGLEEC-ITGKQZKFSA-N (2S,5R,6S)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2R)-1-morpholin-4-ylpentan-2-yl]morpholin-3-one Chemical compound CCC[C@H](CN1CCOCC1)N1[C@@H]([C@@H](O[C@@H](Cc2ccc(F)cc2)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1 GHBPXNGRPGLEEC-ITGKQZKFSA-N 0.000 claims 1
UNGZHGDTNAHJNZ-ITHRCTNCSA-N (2S,5R,6S)-5,6-bis(4-chlorophenyl)-4-[(2R)-1-[4-(cyclopropylmethyl)piperazin-1-yl]-1-oxopentan-2-yl]-2-[(4-iodophenyl)methyl]morpholin-3-one Chemical compound CCC[C@@H](N1[C@@H]([C@@H](O[C@@H](Cc2ccc(I)cc2)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(=O)N1CCN(CC2CC2)CC1 UNGZHGDTNAHJNZ-ITHRCTNCSA-N 0.000 claims 1
DMOPFPDBKUOWQW-DMDYGQEQSA-N (2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]morpholin-3-one Chemical compound ClC=1C=C(C=CC1)[C@@H]1O[C@H](C(N([C@@H]1C1=CC=C(C=C1)Cl)CC1CC1)=O)CC(=O)N1CCN(CC1)C DMOPFPDBKUOWQW-DMDYGQEQSA-N 0.000 claims 1
XLGVHHSVXOPPOL-YADHBBJMSA-N (2Z,5R,6S)-5,6-bis(4-chlorophenyl)-4-methyl-2-(pyridin-3-ylmethylidene)morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@@H]1[C@@H](OC(C(N1C)=O)=C/C=1C=NC=CC1)C1=CC=C(C=C1)Cl XLGVHHSVXOPPOL-YADHBBJMSA-N 0.000 claims 1
XLGVHHSVXOPPOL-FCHUYYIVSA-N (2Z,5S,6R)-5,6-bis(4-chlorophenyl)-4-methyl-2-(pyridin-3-ylmethylidene)morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@H]1[C@H](OC(C(N1C)=O)=C/C=1C=NC=CC1)C1=CC=C(C=C1)Cl XLGVHHSVXOPPOL-FCHUYYIVSA-N 0.000 claims 1
BWAAIHSLCUTHBS-RLXMVLCYSA-N (2r)-1-[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]pyrrolidine-2-carboxylic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)N1[C@H](CCC1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 BWAAIHSLCUTHBS-RLXMVLCYSA-N 0.000 claims 1
BWAAIHSLCUTHBS-NAGJOQLLSA-N (2r)-1-[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]pyrrolidine-2-carboxylic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)N1[C@H](CCC1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 BWAAIHSLCUTHBS-NAGJOQLLSA-N 0.000 claims 1
QVHJQCGUWFKTSE-RXMQYKEDSA-N (2r)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound OC(=O)[C@@H](C)NC(=O)OC(C)(C)C QVHJQCGUWFKTSE-RXMQYKEDSA-N 0.000 claims 1
MRDGLMFSEFPRMJ-YTFSRNRJSA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-2-(4-chlorophenyl)acetic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](C(=O)O)C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 MRDGLMFSEFPRMJ-YTFSRNRJSA-N 0.000 claims 1
CIHVZMMIYHRVQW-YTFSRNRJSA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-2-phenylacetic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](C(=O)O)C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 CIHVZMMIYHRVQW-YTFSRNRJSA-N 0.000 claims 1
CNFXEWFDZZINFW-HSALFYBXSA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-3-methylbutanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](C(C)C)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 CNFXEWFDZZINFW-HSALFYBXSA-N 0.000 claims 1
XJWXASPVMUYFHO-HLAWJBBLSA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-4-methylpentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CC(C)C)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 XJWXASPVMUYFHO-HLAWJBBLSA-N 0.000 claims 1
AEBYGXOLYVPIPA-BAGYTPMASA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-n,n-dimethylpentanamide Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(=O)N(C)C)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 AEBYGXOLYVPIPA-BAGYTPMASA-N 0.000 claims 1
BAMQKGWVIVISCO-HLAWJBBLSA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-n-methylpentanamide Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(=O)NC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 BAMQKGWVIVISCO-HLAWJBBLSA-N 0.000 claims 1
NMDQLMUYNFLIHG-AKIFATBCSA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-n-propylpentanamide Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(=O)NCCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 NMDQLMUYNFLIHG-AKIFATBCSA-N 0.000 claims 1
IHLREHZHMFDKGL-NZSAHSFTSA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]butanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 IHLREHZHMFDKGL-NZSAHSFTSA-N 0.000 claims 1
NHDJKSJILSOCFS-YZGWKJHDSA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 NHDJKSJILSOCFS-YZGWKJHDSA-N 0.000 claims 1
XUKXVBWPEVYIRP-CNOZUTPLSA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]propanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](C)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 XUKXVBWPEVYIRP-CNOZUTPLSA-N 0.000 claims 1
UQASTWWEIVFSHY-KAGYGMCKSA-N (2r)-2-[(2r,3s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-2-methyl-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2N(C(CO[C@]2(C)C=2C=C(Cl)C=CC=2)=O)[C@H](CCC)C(O)=O)=CC=C(Cl)C=C1 UQASTWWEIVFSHY-KAGYGMCKSA-N 0.000 claims 1
LOBJSWXKCWZHRU-SDFBABIMSA-N (2r)-2-[(2r,3s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound O([C@@H]([C@@H](N(C1=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)C1CC1=CC=C(F)C=C1 LOBJSWXKCWZHRU-SDFBABIMSA-N 0.000 claims 1
VPLIEYIAKCWJBX-HLAWJBBLSA-N (2r)-2-[(2r,3s)-2-(4-chloro-2-methylphenyl)-3-(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1C VPLIEYIAKCWJBX-HLAWJBBLSA-N 0.000 claims 1
ZAWNFLSCDKKZCP-YZGWKJHDSA-N (2r)-2-[(2r,3s)-2-(4-chlorophenyl)-3-(3,4-dichlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=C(Cl)C(Cl)=CC=2)=CC=C(Cl)C=C1 ZAWNFLSCDKKZCP-YZGWKJHDSA-N 0.000 claims 1
IIIKIXKRUIFYHN-AKIFATBCSA-N (2r)-2-[(2r,3s)-2-(4-chlorophenyl)-3-(4-cyclopropylphenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(=CC=2)C2CC2)=CC=C(Cl)C=C1 IIIKIXKRUIFYHN-AKIFATBCSA-N 0.000 claims 1
BUGVQKZOFPGGOD-YZGWKJHDSA-N (2r)-2-[(2r,3s)-3-(4-bromophenyl)-2-(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Br)=CC=2)=CC=C(Cl)C=C1 BUGVQKZOFPGGOD-YZGWKJHDSA-N 0.000 claims 1
KSNIEWKPHUKWIK-YZGWKJHDSA-N (2r)-2-[(2r,3s)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1Cl KSNIEWKPHUKWIK-YZGWKJHDSA-N 0.000 claims 1
MJJBTJKKAKENBZ-HLAWJBBLSA-N (2r)-2-[(2r,3s)-3-(4-chlorophenyl)-2-(4-cyanophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(C#N)C=C1 MJJBTJKKAKENBZ-HLAWJBBLSA-N 0.000 claims 1
NPPZSLNNEJILGK-JVYGEBFASA-N (2r)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(2-fluoro-4-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(C)(=O)=O)C=C1F NPPZSLNNEJILGK-JVYGEBFASA-N 0.000 claims 1
SXEUXSPFRBDCHM-NANFOGFDSA-N (2r)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-2-methyl-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2N(C([C@@H](CC=3C=CC(F)=CC=3)O[C@]2(C)C=2C=CC(Cl)=CC=2)=O)[C@H](CCC)C(O)=O)=CC=C(Cl)C=C1 SXEUXSPFRBDCHM-NANFOGFDSA-N 0.000 claims 1
ROAXJFVTHGLTIQ-VJLHXPKFSA-N (2r)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-(3-chlorophenyl)acetic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](C(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 ROAXJFVTHGLTIQ-VJLHXPKFSA-N 0.000 claims 1
QYBDMSRKFASBLX-VJLHXPKFSA-N (2r)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-(4-chlorophenyl)acetic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](C(=O)O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 QYBDMSRKFASBLX-VJLHXPKFSA-N 0.000 claims 1
TVTKMFRTMDPMSM-VJLHXPKFSA-N (2r)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-phenylacetic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](C(=O)O)C=1C=CC=CC=1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 TVTKMFRTMDPMSM-VJLHXPKFSA-N 0.000 claims 1
MWHYTIMDFDUUCL-JVYGEBFASA-N (2r)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]hexanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CCCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 MWHYTIMDFDUUCL-JVYGEBFASA-N 0.000 claims 1
FFYWGOJJTFJPLJ-FXSWLTOZSA-N (2r)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pent-4-enoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CC=C)C(=O)O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 FFYWGOJJTFJPLJ-FXSWLTOZSA-N 0.000 claims 1
BPTXICQAEGSTHS-FXSWLTOZSA-N (2r)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 BPTXICQAEGSTHS-FXSWLTOZSA-N 0.000 claims 1
SOTSYTXAFGARSV-JVYGEBFASA-N (2r)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(C)(=O)=O)C=C1 SOTSYTXAFGARSV-JVYGEBFASA-N 0.000 claims 1
VCHJPDFVEKENPJ-YQIMAOPZSA-N (2r)-2-[(2r,3s,6r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(2-morpholin-4-yl-2-oxoethyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)C(=O)N1CCOCC1 VCHJPDFVEKENPJ-YQIMAOPZSA-N 0.000 claims 1
VWWCPRURKNDDAR-ZGHMXWQUSA-N (2r)-2-[(2r,3s,6r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-[(4-fluorophenyl)methyl]pentanoic acid Chemical compound C([C@@](CCC)(N1C([C@@H](CC=2C=CC(F)=CC=2)O[C@@H]([C@@H]1C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)=O)C(O)=O)C1=CC=C(F)C=C1 VWWCPRURKNDDAR-ZGHMXWQUSA-N 0.000 claims 1
YYFBIAHAZGHHSV-XDZVQPMWSA-N (2r)-2-[(2r,3s,6r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound C1([C@H](C(=O)O)N2C([C@@H](CC=3C=CC(F)=CC=3)O[C@@H]([C@@H]2C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)=O)CC1 YYFBIAHAZGHHSV-XDZVQPMWSA-N 0.000 claims 1
LOBJSWXKCWZHRU-FXSWLTOZSA-N (2r)-2-[(2r,3s,6r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)C1=CC=C(F)C=C1 LOBJSWXKCWZHRU-FXSWLTOZSA-N 0.000 claims 1
UVXJEGSLASNFDS-JVYGEBFASA-N (2r)-2-[(2r,3s,6r)-2-(4-chloro-2-methylphenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C(=CC(Cl)=CC=1)C)C1=CC=C(F)C=C1 UVXJEGSLASNFDS-JVYGEBFASA-N 0.000 claims 1
JGSDUUHREWFLDE-FXSWLTOZSA-N (2r)-2-[(2r,3s,6r)-2-(4-chloro-3-fluorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(F)C(Cl)=CC=1)C1=CC=C(F)C=C1 JGSDUUHREWFLDE-FXSWLTOZSA-N 0.000 claims 1
TVGRZWHDCBETPU-FXSWLTOZSA-N (2r)-2-[(2r,3s,6r)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C(=CC(Cl)=CC=1)Cl)C1=CC=C(F)C=C1 TVGRZWHDCBETPU-FXSWLTOZSA-N 0.000 claims 1
BZLYRIZTBQBHRB-FXSWLTOZSA-N (2r)-2-[(2r,3s,6r)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C(Cl)=CC=1)C1=CC=C(F)C=C1 BZLYRIZTBQBHRB-FXSWLTOZSA-N 0.000 claims 1
RNOUYZSZHKHMEU-FXSWLTOZSA-N (2r)-2-[(2r,5s,6r)-5-(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-3-oxo-6-phenylmorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC=CC=1)C1=CC=C(F)C=C1 RNOUYZSZHKHMEU-FXSWLTOZSA-N 0.000 claims 1
MRDGLMFSEFPRMJ-ZLNRFVROSA-N (2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-2-(4-chlorophenyl)acetic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](C(=O)O)C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 MRDGLMFSEFPRMJ-ZLNRFVROSA-N 0.000 claims 1
CIHVZMMIYHRVQW-ZLNRFVROSA-N (2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-2-phenylacetic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](C(=O)O)C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 CIHVZMMIYHRVQW-ZLNRFVROSA-N 0.000 claims 1
CNFXEWFDZZINFW-AQNXPRMDSA-N (2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-3-methylbutanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](C(C)C)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 CNFXEWFDZZINFW-AQNXPRMDSA-N 0.000 claims 1
XJWXASPVMUYFHO-NRSPTQNISA-N (2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-4-methylpentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CC(C)C)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 XJWXASPVMUYFHO-NRSPTQNISA-N 0.000 claims 1
AEBYGXOLYVPIPA-FCEUIQTBSA-N (2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-n,n-dimethylpentanamide Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(=O)N(C)C)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 AEBYGXOLYVPIPA-FCEUIQTBSA-N 0.000 claims 1
BAMQKGWVIVISCO-NRSPTQNISA-N (2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-n-methylpentanamide Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(=O)NC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 BAMQKGWVIVISCO-NRSPTQNISA-N 0.000 claims 1
NMDQLMUYNFLIHG-MZYLBHOOSA-N (2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-n-propylpentanamide Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(=O)NCCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 NMDQLMUYNFLIHG-MZYLBHOOSA-N 0.000 claims 1
IHLREHZHMFDKGL-QRQLOZEOSA-N (2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]butanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 IHLREHZHMFDKGL-QRQLOZEOSA-N 0.000 claims 1
KGYXFUQDTGFHHL-NRSPTQNISA-N (2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]hexanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 KGYXFUQDTGFHHL-NRSPTQNISA-N 0.000 claims 1
XUKXVBWPEVYIRP-AFBMGJRZSA-N (2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]propanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](C)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 XUKXVBWPEVYIRP-AFBMGJRZSA-N 0.000 claims 1
UQASTWWEIVFSHY-UZKOGDIHSA-N (2r)-2-[(2s,3r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-2-methyl-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2N(C(CO[C@@]2(C)C=2C=C(Cl)C=CC=2)=O)[C@H](CCC)C(O)=O)=CC=C(Cl)C=C1 UQASTWWEIVFSHY-UZKOGDIHSA-N 0.000 claims 1
LOBJSWXKCWZHRU-TZZBBBQFSA-N (2r)-2-[(2s,3r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound O([C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)C1CC1=CC=C(F)C=C1 LOBJSWXKCWZHRU-TZZBBBQFSA-N 0.000 claims 1
VPLIEYIAKCWJBX-NRSPTQNISA-N (2r)-2-[(2s,3r)-2-(4-chloro-2-methylphenyl)-3-(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1C VPLIEYIAKCWJBX-NRSPTQNISA-N 0.000 claims 1
HQRAQGJHPUFZPL-FCEUIQTBSA-N (2r)-2-[(2s,3r)-2-(4-chlorophenyl)-3-(1h-indol-2-yl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2NC3=CC=CC=C3C=2)=CC=C(Cl)C=C1 HQRAQGJHPUFZPL-FCEUIQTBSA-N 0.000 claims 1
ZAWNFLSCDKKZCP-RLLQIKCJSA-N (2r)-2-[(2s,3r)-2-(4-chlorophenyl)-3-(3,4-dichlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=C(Cl)C(Cl)=CC=2)=CC=C(Cl)C=C1 ZAWNFLSCDKKZCP-RLLQIKCJSA-N 0.000 claims 1
IIIKIXKRUIFYHN-MZYLBHOOSA-N (2r)-2-[(2s,3r)-2-(4-chlorophenyl)-3-(4-cyclopropylphenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(=CC=2)C2CC2)=CC=C(Cl)C=C1 IIIKIXKRUIFYHN-MZYLBHOOSA-N 0.000 claims 1
BUGVQKZOFPGGOD-RLLQIKCJSA-N (2r)-2-[(2s,3r)-3-(4-bromophenyl)-2-(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Br)=CC=2)=CC=C(Cl)C=C1 BUGVQKZOFPGGOD-RLLQIKCJSA-N 0.000 claims 1
KSNIEWKPHUKWIK-RLLQIKCJSA-N (2r)-2-[(2s,3r)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1Cl KSNIEWKPHUKWIK-RLLQIKCJSA-N 0.000 claims 1
MJJBTJKKAKENBZ-NRSPTQNISA-N (2r)-2-[(2s,3r)-3-(4-chlorophenyl)-2-(4-cyanophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(C#N)C=C1 MJJBTJKKAKENBZ-NRSPTQNISA-N 0.000 claims 1
AZFLTOXKWCAQHN-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-5-oxo-6-(2-piperidin-1-ylethyl)morpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)CN1CCCCC1 AZFLTOXKWCAQHN-ZJSPYRCASA-N 0.000 claims 1
FSCVIBLJKPENPF-RCTAOEEJSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-5-oxo-6-(pyridin-4-ylmethyl)morpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=NC=C1 FSCVIBLJKPENPF-RCTAOEEJSA-N 0.000 claims 1
NOBZFGZQPIWTKF-IQLXHWPESA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-5-oxo-6-[(4-phenylphenyl)methyl]morpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1C1=CC=CC=C1 NOBZFGZQPIWTKF-IQLXHWPESA-N 0.000 claims 1
JDASRZQWSYKDDN-AIQXTLEGSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-5-oxo-6-[(4-pyrazol-1-ylphenyl)methyl]morpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N1C=CC=N1 JDASRZQWSYKDDN-AIQXTLEGSA-N 0.000 claims 1
MCUYMYIUXMDUGR-ATIZSFMBSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-5-oxo-6-[(4-pyrrol-1-ylphenyl)methyl]morpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N1C=CC=C1 MCUYMYIUXMDUGR-ATIZSFMBSA-N 0.000 claims 1
FIHSOWJVKMUORE-GCFVYEKYSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-5-oxo-6-[[4-(1,2,4-triazol-1-yl)phenyl]methyl]morpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N1C=NC=N1 FIHSOWJVKMUORE-GCFVYEKYSA-N 0.000 claims 1
SWFMHJVNYHSKFW-RCTAOEEJSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-(2-morpholin-4-ylethyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)CN1CCOCC1 SWFMHJVNYHSKFW-RCTAOEEJSA-N 0.000 claims 1
UVNPQAHWPUSOHZ-MBDNFAEBSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-(3-hydroxypropyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C([C@H](CCCO)O2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 UVNPQAHWPUSOHZ-MBDNFAEBSA-N 0.000 claims 1
NGKDSMRXYILHBJ-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-(3-morpholin-4-ylpropyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)CCN1CCOCC1 NGKDSMRXYILHBJ-ZJSPYRCASA-N 0.000 claims 1
LBKMRYPTFPFDCU-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(2-cyano-4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1C#N LBKMRYPTFPFDCU-RAVGUYNFSA-N 0.000 claims 1
PWBYWLZBUHMMDL-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(2-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1C#N PWBYWLZBUHMMDL-RAVGUYNFSA-N 0.000 claims 1
NPPZSLNNEJILGK-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(2-fluoro-4-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(C)(=O)=O)C=C1F NPPZSLNNEJILGK-RAVGUYNFSA-N 0.000 claims 1
AMKMOSMZFSCUOD-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(2-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1F AMKMOSMZFSCUOD-ZJSPYRCASA-N 0.000 claims 1
PEUMHKJNNDMFQQ-PTJMHOJZSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(2-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1S(C)(=O)=O PEUMHKJNNDMFQQ-PTJMHOJZSA-N 0.000 claims 1
SPYIFURQACUIAM-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(3-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC(C#N)=C1 SPYIFURQACUIAM-RAVGUYNFSA-N 0.000 claims 1
AHQBKWGBBRACRW-PTJMHOJZSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(3-fluoro-4-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(C)(=O)=O)C(F)=C1 AHQBKWGBBRACRW-PTJMHOJZSA-N 0.000 claims 1
JGVKIUWTWNCOIK-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(3-methoxyphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC(OC)=C1 JGVKIUWTWNCOIK-RAVGUYNFSA-N 0.000 claims 1
LSNLEJWOTADEBZ-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(3-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC(S(C)(=O)=O)=C1 LSNLEJWOTADEBZ-RAVGUYNFSA-N 0.000 claims 1
AKQJJTYNRDWUSK-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-chlorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 AKQJJTYNRDWUSK-ZJSPYRCASA-N 0.000 claims 1
SOQTZEGEPNFLOH-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyano-2-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1F SOQTZEGEPNFLOH-RAVGUYNFSA-N 0.000 claims 1
OOPXZKSDSRPLBN-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyano-3-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C(F)=C1 OOPXZKSDSRPLBN-RAVGUYNFSA-N 0.000 claims 1
IVUMCPDLSMRPHW-PTJMHOJZSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluoro-2-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1S(C)(=O)=O IVUMCPDLSMRPHW-PTJMHOJZSA-N 0.000 claims 1
SXEUXSPFRBDCHM-KGWIZABPSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-2-methyl-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2N(C([C@H](CC=3C=CC(F)=CC=3)O[C@@]2(C)C=2C=CC(Cl)=CC=2)=O)[C@H](CCC)C(O)=O)=CC=C(Cl)C=C1 SXEUXSPFRBDCHM-KGWIZABPSA-N 0.000 claims 1
ROAXJFVTHGLTIQ-AUAHOFGGSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-(3-chlorophenyl)acetic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](C(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 ROAXJFVTHGLTIQ-AUAHOFGGSA-N 0.000 claims 1
QYBDMSRKFASBLX-AUAHOFGGSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-(4-chlorophenyl)acetic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](C(=O)O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 QYBDMSRKFASBLX-AUAHOFGGSA-N 0.000 claims 1
TVTKMFRTMDPMSM-AUAHOFGGSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-phenylacetic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](C(=O)O)C=1C=CC=CC=1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 TVTKMFRTMDPMSM-AUAHOFGGSA-N 0.000 claims 1
MWHYTIMDFDUUCL-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]hexanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 MWHYTIMDFDUUCL-RAVGUYNFSA-N 0.000 claims 1
FFYWGOJJTFJPLJ-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pent-4-enoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CC=C)C(=O)O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 FFYWGOJJTFJPLJ-ZJSPYRCASA-N 0.000 claims 1
YFKWSSUWEXWUQR-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-iodophenyl)methyl]-5-oxomorpholin-4-yl]pentanenitrile Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](C#N)CCC)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 YFKWSSUWEXWUQR-RAVGUYNFSA-N 0.000 claims 1
RSPPZOGCJOGKJV-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-iodophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 RSPPZOGCJOGKJV-ZJSPYRCASA-N 0.000 claims 1
JJOOVSOTAJEJLF-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-methoxyphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(OC)C=C1 JJOOVSOTAJEJLF-RAVGUYNFSA-N 0.000 claims 1
OMHYTCBDMJATCG-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[2-(4-methylpiperazin-1-yl)ethyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)CN1CCN(C)CC1 OMHYTCBDMJATCG-ZJSPYRCASA-N 0.000 claims 1
GYSDXBKUMJAGEH-ACESQOTJSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[2-(dimethylamino)ethyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C([C@H](CCN(C)C)O2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 GYSDXBKUMJAGEH-ACESQOTJSA-N 0.000 claims 1
VWWCPRURKNDDAR-DMNJWKMDSA-N (2r)-2-[(2s,3r,6s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-[(4-fluorophenyl)methyl]pentanoic acid Chemical compound C([C@@](CCC)(N1C([C@H](CC=2C=CC(F)=CC=2)O[C@H]([C@H]1C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)=O)C(O)=O)C1=CC=C(F)C=C1 VWWCPRURKNDDAR-DMNJWKMDSA-N 0.000 claims 1
YYFBIAHAZGHHSV-QUMGSSFMSA-N (2r)-2-[(2s,3r,6s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound C1([C@H](C(=O)O)N2C([C@H](CC=3C=CC(F)=CC=3)O[C@H]([C@H]2C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)=O)CC1 YYFBIAHAZGHHSV-QUMGSSFMSA-N 0.000 claims 1
LOBJSWXKCWZHRU-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)C1=CC=C(F)C=C1 LOBJSWXKCWZHRU-ZJSPYRCASA-N 0.000 claims 1
UVXJEGSLASNFDS-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2-(4-chloro-2-methylphenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C(=CC(Cl)=CC=1)C)C1=CC=C(F)C=C1 UVXJEGSLASNFDS-RAVGUYNFSA-N 0.000 claims 1
JGSDUUHREWFLDE-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2-(4-chloro-3-fluorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(F)C(Cl)=CC=1)C1=CC=C(F)C=C1 JGSDUUHREWFLDE-ZJSPYRCASA-N 0.000 claims 1
TVGRZWHDCBETPU-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C(=CC(Cl)=CC=1)Cl)C1=CC=C(F)C=C1 TVGRZWHDCBETPU-ZJSPYRCASA-N 0.000 claims 1
BZLYRIZTBQBHRB-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C(Cl)=CC=1)C1=CC=C(F)C=C1 BZLYRIZTBQBHRB-ZJSPYRCASA-N 0.000 claims 1
LWKLJVWPVADUAQ-JYRKZWEQSA-N (2r)-2-[(2s,5r,6s)-2-(2-amino-2-oxoethyl)-5,6-bis(4-chlorophenyl)-3-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C([C@H](CC(N)=O)O2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 LWKLJVWPVADUAQ-JYRKZWEQSA-N 0.000 claims 1
SCIHNVZRVLKGMQ-ZJSPYRCASA-N (2r)-2-[(2s,5r,6s)-2-benzyl-5,6-bis(4-chlorophenyl)-3-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 SCIHNVZRVLKGMQ-ZJSPYRCASA-N 0.000 claims 1
RNOUYZSZHKHMEU-ZJSPYRCASA-N (2r)-2-[(2s,5r,6s)-5-(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-3-oxo-6-phenylmorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC=CC=1)C1=CC=C(F)C=C1 RNOUYZSZHKHMEU-ZJSPYRCASA-N 0.000 claims 1
CWAUKFZHSRAVQL-MGEHJEIGSA-N (2r)-2-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]propanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)N[C@H](C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 CWAUKFZHSRAVQL-MGEHJEIGSA-N 0.000 claims 1
CWAUKFZHSRAVQL-AQPBRFSRSA-N (2r)-2-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]propanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)N[C@H](C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 CWAUKFZHSRAVQL-AQPBRFSRSA-N 0.000 claims 1
HHCOGKKNQCRCGF-RQKPWJHBSA-N (2r)-2-amino-3-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]propanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NC[C@@H](N)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 HHCOGKKNQCRCGF-RQKPWJHBSA-N 0.000 claims 1
HHCOGKKNQCRCGF-FYYQJAJYSA-N (2r)-2-amino-3-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]propanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)NC[C@@H](N)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 HHCOGKKNQCRCGF-FYYQJAJYSA-N 0.000 claims 1
NVRKHLCRIFHQOK-RUYTYSJGSA-N (2r)-3-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-2-methylpropanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NC[C@@H](C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 NVRKHLCRIFHQOK-RUYTYSJGSA-N 0.000 claims 1
IRPCEHWYFCBCLC-IUHCWXKNSA-N (2r)-3-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)NC[C@@H](NC(=O)OC(C)(C)C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 IRPCEHWYFCBCLC-IUHCWXKNSA-N 0.000 claims 1
NVRKHLCRIFHQOK-XYVGLUNFSA-N (2r)-3-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-2-methylpropanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)NC[C@@H](C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 NVRKHLCRIFHQOK-XYVGLUNFSA-N 0.000 claims 1
BCOHFAVJXIGODD-WOJBJXKFSA-N (2r,3r)-3-(4-chlorophenyl)-4-(cyclopropylmethyl)-n-(2-hydroxyphenyl)-5-oxomorpholine-2-carboxamide Chemical compound OC1=CC=CC=C1NC(=O)[C@H]1[C@@H](C=2C=CC(Cl)=CC=2)N(CC2CC2)C(=O)CO1 BCOHFAVJXIGODD-WOJBJXKFSA-N 0.000 claims 1
GDCLCJXRLOPXOZ-LQAWEQHXSA-N (2r,5r,6s)-5,6-bis(4-bromophenyl)-2,4-dimethylmorpholin-3-one Chemical compound C1([C@@H]2[C@@H](O[C@@H](C(N2C)=O)C)C=2C=CC(Br)=CC=2)=CC=C(Br)C=C1 GDCLCJXRLOPXOZ-LQAWEQHXSA-N 0.000 claims 1
NKGNWIMUMHTIQK-PFBJBMPXSA-N (2r,5r,6s)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-pyridin-3-ylmorpholin-3-one Chemical compound C1=CC(F)=CC=C1C[C@@H]1C(=O)N(C=2C=NC=CC=2)[C@H](C=2C=CC(Cl)=CC=2)[C@H](C=2C=CC(Cl)=CC=2)O1 NKGNWIMUMHTIQK-PFBJBMPXSA-N 0.000 claims 1
WPBLGWRJZYKVJT-HLLBOEOZSA-N (2r,5r,6s)-5,6-bis(4-chlorophenyl)-2-hydroxy-4-methylmorpholin-3-one Chemical compound C1([C@H]2[C@H](N(C([C@H](O)O2)=O)C)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 WPBLGWRJZYKVJT-HLLBOEOZSA-N 0.000 claims 1
DFHXIDFJPXBWRW-TZRRMPRUSA-N (2r,5s,6r)-2-[[4-(aminomethyl)phenyl]methyl]-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(CN)C=C1 DFHXIDFJPXBWRW-TZRRMPRUSA-N 0.000 claims 1
AYEZCABKRRTTPU-DSNGMDLFSA-N (2r,5s,6r)-2-benzyl-5,6-bis(4-bromophenyl)-4-cyclopropylmorpholin-3-one Chemical compound C1=CC(Br)=CC=C1[C@@H]1[C@H](C=2C=CC(Br)=CC=2)N(C2CC2)C(=O)[C@@H](CC=2C=CC=CC=2)O1 AYEZCABKRRTTPU-DSNGMDLFSA-N 0.000 claims 1
YYVYIVSNIAMIER-XPWALMASSA-N (2r,5s,6r)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)C1=CC=CC=C1 YYVYIVSNIAMIER-XPWALMASSA-N 0.000 claims 1
NFFXQTHZDQEVMP-XPWALMASSA-N (2r,5s,6r)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 NFFXQTHZDQEVMP-XPWALMASSA-N 0.000 claims 1
FFWXYSDZASUBHP-XPWALMASSA-N (2r,5s,6r)-2-benzyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-methylmorpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)C1=CC=CC=C1 FFWXYSDZASUBHP-XPWALMASSA-N 0.000 claims 1
LTDIAJLOLCVPIG-YYGZZXRFSA-N (2r,5s,6r)-4-[(2s)-1-aminopentan-2-yl]-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CN)CCC)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 LTDIAJLOLCVPIG-YYGZZXRFSA-N 0.000 claims 1
FCOPQZKTHYVUEK-TZRRMPRUSA-N (2r,5s,6r)-5,6-bis(4-bromophenyl)-2-[(3-methoxyphenyl)methyl]-4-methylmorpholin-3-one Chemical compound COC1=CC=CC(C[C@@H]2C(N(C)[C@H]([C@H](O2)C=2C=CC(Br)=CC=2)C=2C=CC(Br)=CC=2)=O)=C1 FCOPQZKTHYVUEK-TZRRMPRUSA-N 0.000 claims 1
RHWGELPEQKFUHE-XPWALMASSA-N (2r,5s,6r)-5,6-bis(4-bromophenyl)-2-[(4-bromophenyl)methyl]-4-methylmorpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)C1=CC=C(Br)C=C1 RHWGELPEQKFUHE-XPWALMASSA-N 0.000 claims 1
ZOPUXVMFTFLAOX-XPWALMASSA-N (2r,5s,6r)-5,6-bis(4-bromophenyl)-2-[(4-fluorophenyl)methyl]-4-methylmorpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)C1=CC=C(F)C=C1 ZOPUXVMFTFLAOX-XPWALMASSA-N 0.000 claims 1
JQFPMGMYKYPPLI-TZRRMPRUSA-N (2r,5s,6r)-5,6-bis(4-bromophenyl)-2-[(4-methoxyphenyl)methyl]-4-methylmorpholin-3-one Chemical compound C1=CC(OC)=CC=C1C[C@@H]1C(=O)N(C)[C@@H](C=2C=CC(Br)=CC=2)[C@@H](C=2C=CC(Br)=CC=2)O1 JQFPMGMYKYPPLI-TZRRMPRUSA-N 0.000 claims 1
JNWVIZMYBCAVNA-QHAWAJNXSA-N (2r,5s,6r)-5,6-bis(4-bromophenyl)-4-methyl-2-(3-methylbut-2-enyl)morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C([C@@H](CC=C(C)C)O2)=O)C)C=2C=CC(Br)=CC=2)=CC=C(Br)C=C1 JNWVIZMYBCAVNA-QHAWAJNXSA-N 0.000 claims 1
HYNGBJAFVPKRRJ-XPWALMASSA-N (2r,5s,6r)-5,6-bis(4-bromophenyl)-4-methyl-2-[[4-(trifluoromethoxy)phenyl]methyl]morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)C1=CC=C(OC(F)(F)F)C=C1 HYNGBJAFVPKRRJ-XPWALMASSA-N 0.000 claims 1
KBJUZOFBLZGYEP-BHDDXSALSA-N (2r,5s,6r)-5,6-bis(4-bromophenyl)-4-methyl-2-phenylmorpholin-3-one Chemical compound C1([C@H]2O[C@@H]([C@@H](N(C2=O)C)C=2C=CC(Br)=CC=2)C=2C=CC(Br)=CC=2)=CC=CC=C1 KBJUZOFBLZGYEP-BHDDXSALSA-N 0.000 claims 1
VHKIGKDLGUTETJ-CEXWTWQISA-N (2r,5s,6r)-5,6-bis(4-bromophenyl)-4-methyl-2-prop-2-enylmorpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C([C@@H](CC=C)O2)=O)C)C=2C=CC(Br)=CC=2)=CC=C(Br)C=C1 VHKIGKDLGUTETJ-CEXWTWQISA-N 0.000 claims 1
BFBUGOGWCKRJJC-FGTMMUONSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-(2-hydroxyethyl)-4-methylmorpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C([C@@H](CCO)O2)=O)C)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 BFBUGOGWCKRJJC-FGTMMUONSA-N 0.000 claims 1
FPKXWYRDEQIPKH-OZNIXHKMSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(2-fluoro-4-methylsulfonylphenyl)methyl]-4-pyridin-3-ylmorpholin-3-one Chemical compound FC1=CC(S(=O)(=O)C)=CC=C1C[C@@H]1C(=O)N(C=2C=NC=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)O1 FPKXWYRDEQIPKH-OZNIXHKMSA-N 0.000 claims 1
IPJCFRDZXMOROQ-AKHDSKFASA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(2r)-2,3-dihydroxypropyl]-4-methylmorpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C([C@@H](C[C@@H](O)CO)O2)=O)C)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 IPJCFRDZXMOROQ-AKHDSKFASA-N 0.000 claims 1
KAWBFOLKWOWQNK-ROXDYWFKSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(1s)-1-(2h-tetrazol-5-yl)butyl]morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C1=NNN=N1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 KAWBFOLKWOWQNK-ROXDYWFKSA-N 0.000 claims 1
OZZCSOBIPVVGCN-JVYGEBFASA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2r)-1-hydroxypentan-2-yl]morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CO)CCC)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 OZZCSOBIPVVGCN-JVYGEBFASA-N 0.000 claims 1
TWSBSLQNMNNFDV-OZNIXHKMSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-phenylmorpholin-3-one Chemical compound C1=CC(F)=CC=C1C[C@@H]1C(=O)N(C=2C=CC=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)O1 TWSBSLQNMNNFDV-OZNIXHKMSA-N 0.000 claims 1
VPGKHHKAWPXNLG-KWXIBIRDSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-pyridin-4-ylmorpholin-3-one Chemical compound C1=CC(F)=CC=C1C[C@@H]1C(=O)N(C=2C=CN=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)O1 VPGKHHKAWPXNLG-KWXIBIRDSA-N 0.000 claims 1
NNHHVXDUFOZJBY-BHIFYINESA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]morpholin-3-one Chemical compound C1=CC(F)=CC=C1C[C@@H]1C(=O)N[C@@H](C=2C=CC(Cl)=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)O1 NNHHVXDUFOZJBY-BHIFYINESA-N 0.000 claims 1
HCAYISRYXICNRK-ROXDYWFKSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(4-iodophenyl)methyl]-4-[(1s)-1-(2h-tetrazol-5-yl)butyl]morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C1=NNN=N1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 HCAYISRYXICNRK-ROXDYWFKSA-N 0.000 claims 1
ZOHISOPDHUSNHZ-OZNIXHKMSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(4-methylsulfonylphenyl)methyl]-4-pyridin-3-ylmorpholin-3-one Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C[C@@H]1C(=O)N(C=2C=NC=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)O1 ZOHISOPDHUSNHZ-OZNIXHKMSA-N 0.000 claims 1
GTBIGGRMISCXCW-UODIDJSMSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[[4-[(dimethylamino)methyl]phenyl]methyl]-4-methylmorpholin-3-one Chemical compound C1=CC(CN(C)C)=CC=C1C[C@@H]1C(=O)N(C)[C@@H](C=2C=CC(Cl)=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)O1 GTBIGGRMISCXCW-UODIDJSMSA-N 0.000 claims 1
KDMZQPXBRXKOKS-FXVJXKIMSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-(2-chloropyridin-4-yl)-2-[(4-fluorophenyl)methyl]morpholin-3-one Chemical compound C1=CC(F)=CC=C1C[C@@H]1C(=O)N(C=2C=C(Cl)N=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)O1 KDMZQPXBRXKOKS-FXVJXKIMSA-N 0.000 claims 1
LNNGRKMUIHMFPX-YUMYIRISSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[(2r)-2,3-dihydroxypropyl]morpholin-3-one Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)C[C@@H](O)CO)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 LNNGRKMUIHMFPX-YUMYIRISSA-N 0.000 claims 1
LNNGRKMUIHMFPX-LNRXMEIDSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[(2s)-2,3-dihydroxypropyl]morpholin-3-one Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)C[C@H](O)CO)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 LNNGRKMUIHMFPX-LNRXMEIDSA-N 0.000 claims 1
ISEMFQGMTRGCLK-BHIFYINESA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-methyl-2-(2-morpholin-4-ylethyl)morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)CN1CCOCC1 ISEMFQGMTRGCLK-BHIFYINESA-N 0.000 claims 1
FRJPQPIZOAFJPH-BPQIPLTHSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-methyl-2-(2h-tetrazol-5-ylmethyl)morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C=1N=NNN=1 FRJPQPIZOAFJPH-BPQIPLTHSA-N 0.000 claims 1
OGHYKDRSHULZRE-BHIFYINESA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-methyl-2-(pyridin-4-ylmethyl)morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=NC=C1 OGHYKDRSHULZRE-BHIFYINESA-N 0.000 claims 1
OPOUULYBDDBEGY-TZRRMPRUSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-methyl-2-[(4-methylsulfonylphenyl)methyl]morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(C)(=O)=O)C=C1 OPOUULYBDDBEGY-TZRRMPRUSA-N 0.000 claims 1
BTFDOQOPNARQSS-QHAWAJNXSA-N (2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-(2-hydroxyethyl)morpholin-3-one Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CCO)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 BTFDOQOPNARQSS-QHAWAJNXSA-N 0.000 claims 1
SBIUCEQISUZNJO-PZUNEJSGSA-N (2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-(2-morpholin-4-yl-2-oxoethyl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1N(CC2CC2)C(=O)[C@@H](CC(=O)N2CCOCC2)O[C@@H]1C1=CC=CC(Cl)=C1 SBIUCEQISUZNJO-PZUNEJSGSA-N 0.000 claims 1
PMULZUULMROOQM-BHIFYINESA-N (2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-(3-hydroxypropyl)morpholin-3-one Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CCCO)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 PMULZUULMROOQM-BHIFYINESA-N 0.000 claims 1
QUGAINMJPTZFKB-AKIFATBCSA-N (2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]morpholin-3-one Chemical compound O1C(C)=NN=C1C[C@@H]1C(=O)N(CC2CC2)[C@@H](C=2C=CC(Cl)=CC=2)[C@@H](C=2C=C(Cl)C=CC=2)O1 QUGAINMJPTZFKB-AKIFATBCSA-N 0.000 claims 1
FODTWMGUVKCBDV-BHIFYINESA-N (2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[2-(methylamino)ethyl]morpholin-3-one Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CCNC)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 FODTWMGUVKCBDV-BHIFYINESA-N 0.000 claims 1
YFIAXOHWIQXCTA-RCZSKKKRSA-N (2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-2-methyl-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2N(C(CO[C@]2(C)C=2C=CC(Cl)=CC=2)=O)[C@@H](CCC)C(O)=O)=CC=C(Cl)C=C1 YFIAXOHWIQXCTA-RCZSKKKRSA-N 0.000 claims 1
MRDGLMFSEFPRMJ-RJGXRXQPSA-N (2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-2-(4-chlorophenyl)acetic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](C(=O)O)C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 MRDGLMFSEFPRMJ-RJGXRXQPSA-N 0.000 claims 1
CIHVZMMIYHRVQW-RJGXRXQPSA-N (2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-2-phenylacetic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](C(=O)O)C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 CIHVZMMIYHRVQW-RJGXRXQPSA-N 0.000 claims 1
CNFXEWFDZZINFW-SLFFLAALSA-N (2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-3-methylbutanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](C(C)C)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 CNFXEWFDZZINFW-SLFFLAALSA-N 0.000 claims 1
XJWXASPVMUYFHO-SESVDKBCSA-N (2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-4-methylpentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CC(C)C)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 XJWXASPVMUYFHO-SESVDKBCSA-N 0.000 claims 1
AEBYGXOLYVPIPA-ILWGZMRPSA-N (2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-n,n-dimethylpentanamide Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(=O)N(C)C)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 AEBYGXOLYVPIPA-ILWGZMRPSA-N 0.000 claims 1
BAMQKGWVIVISCO-SESVDKBCSA-N (2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-n-methylpentanamide Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(=O)NC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 BAMQKGWVIVISCO-SESVDKBCSA-N 0.000 claims 1
NMDQLMUYNFLIHG-ACIOBRDBSA-N (2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-n-propylpentanamide Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(=O)NCCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 NMDQLMUYNFLIHG-ACIOBRDBSA-N 0.000 claims 1
IHLREHZHMFDKGL-YTQUADARSA-N (2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]butanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 IHLREHZHMFDKGL-YTQUADARSA-N 0.000 claims 1
NHDJKSJILSOCFS-YSIASYRMSA-N (2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 NHDJKSJILSOCFS-YSIASYRMSA-N 0.000 claims 1
XUKXVBWPEVYIRP-FJNPEDAXSA-N (2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]propanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](C)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 XUKXVBWPEVYIRP-FJNPEDAXSA-N 0.000 claims 1
UQASTWWEIVFSHY-RCZSKKKRSA-N (2s)-2-[(2r,3s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-2-methyl-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2N(C(CO[C@]2(C)C=2C=C(Cl)C=CC=2)=O)[C@@H](CCC)C(O)=O)=CC=C(Cl)C=C1 UQASTWWEIVFSHY-RCZSKKKRSA-N 0.000 claims 1
LOBJSWXKCWZHRU-QYIJMHBESA-N (2s)-2-[(2r,3s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound O([C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)C1CC1=CC=C(F)C=C1 LOBJSWXKCWZHRU-QYIJMHBESA-N 0.000 claims 1
VPLIEYIAKCWJBX-SESVDKBCSA-N (2s)-2-[(2r,3s)-2-(4-chloro-2-methylphenyl)-3-(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1C VPLIEYIAKCWJBX-SESVDKBCSA-N 0.000 claims 1
HQRAQGJHPUFZPL-ILWGZMRPSA-N (2s)-2-[(2r,3s)-2-(4-chlorophenyl)-3-(1h-indol-2-yl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2NC3=CC=CC=C3C=2)=CC=C(Cl)C=C1 HQRAQGJHPUFZPL-ILWGZMRPSA-N 0.000 claims 1
ZAWNFLSCDKKZCP-YSIASYRMSA-N (2s)-2-[(2r,3s)-2-(4-chlorophenyl)-3-(3,4-dichlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2C=C(Cl)C(Cl)=CC=2)=CC=C(Cl)C=C1 ZAWNFLSCDKKZCP-YSIASYRMSA-N 0.000 claims 1
IIIKIXKRUIFYHN-ACIOBRDBSA-N (2s)-2-[(2r,3s)-2-(4-chlorophenyl)-3-(4-cyclopropylphenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2C=CC(=CC=2)C2CC2)=CC=C(Cl)C=C1 IIIKIXKRUIFYHN-ACIOBRDBSA-N 0.000 claims 1
BUGVQKZOFPGGOD-YSIASYRMSA-N (2s)-2-[(2r,3s)-3-(4-bromophenyl)-2-(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2C=CC(Br)=CC=2)=CC=C(Cl)C=C1 BUGVQKZOFPGGOD-YSIASYRMSA-N 0.000 claims 1
KSNIEWKPHUKWIK-YSIASYRMSA-N (2s)-2-[(2r,3s)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1Cl KSNIEWKPHUKWIK-YSIASYRMSA-N 0.000 claims 1
MJJBTJKKAKENBZ-SESVDKBCSA-N (2s)-2-[(2r,3s)-3-(4-chlorophenyl)-2-(4-cyanophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(C#N)C=C1 MJJBTJKKAKENBZ-SESVDKBCSA-N 0.000 claims 1
FSCVIBLJKPENPF-FQUZAXHOSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-5-oxo-6-(pyridin-4-ylmethyl)morpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=NC=C1 FSCVIBLJKPENPF-FQUZAXHOSA-N 0.000 claims 1
NOBZFGZQPIWTKF-MLMSKLGMSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-5-oxo-6-[(4-phenylphenyl)methyl]morpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1C1=CC=CC=C1 NOBZFGZQPIWTKF-MLMSKLGMSA-N 0.000 claims 1
JDASRZQWSYKDDN-ICYKMPLBSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-5-oxo-6-[(4-pyrazol-1-ylphenyl)methyl]morpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N1C=CC=N1 JDASRZQWSYKDDN-ICYKMPLBSA-N 0.000 claims 1
MCUYMYIUXMDUGR-RRGQHJHPSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-5-oxo-6-[(4-pyrrol-1-ylphenyl)methyl]morpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N1C=CC=C1 MCUYMYIUXMDUGR-RRGQHJHPSA-N 0.000 claims 1
FIHSOWJVKMUORE-ZVBOOHQUSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-5-oxo-6-[[4-(1,2,4-triazol-1-yl)phenyl]methyl]morpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N1C=NC=N1 FIHSOWJVKMUORE-ZVBOOHQUSA-N 0.000 claims 1
NPPZSLNNEJILGK-YYGZZXRFSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(2-fluoro-4-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(C)(=O)=O)C=C1F NPPZSLNNEJILGK-YYGZZXRFSA-N 0.000 claims 1
AKQJJTYNRDWUSK-ROXDYWFKSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-chlorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 AKQJJTYNRDWUSK-ROXDYWFKSA-N 0.000 claims 1
SOQTZEGEPNFLOH-YYGZZXRFSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyano-2-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1F SOQTZEGEPNFLOH-YYGZZXRFSA-N 0.000 claims 1
AKVZPAVYTSBNGJ-YYGZZXRFSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 AKVZPAVYTSBNGJ-YYGZZXRFSA-N 0.000 claims 1
SXEUXSPFRBDCHM-XWDJFTLGSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-2-methyl-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2N(C([C@@H](CC=3C=CC(F)=CC=3)O[C@]2(C)C=2C=CC(Cl)=CC=2)=O)[C@@H](CCC)C(O)=O)=CC=C(Cl)C=C1 SXEUXSPFRBDCHM-XWDJFTLGSA-N 0.000 claims 1
ROAXJFVTHGLTIQ-GIFPIDKJSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-(3-chlorophenyl)acetic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](C(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 ROAXJFVTHGLTIQ-GIFPIDKJSA-N 0.000 claims 1
QYBDMSRKFASBLX-GIFPIDKJSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-(4-chlorophenyl)acetic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](C(=O)O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 QYBDMSRKFASBLX-GIFPIDKJSA-N 0.000 claims 1
TVTKMFRTMDPMSM-GIFPIDKJSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-phenylacetic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](C(=O)O)C=1C=CC=CC=1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 TVTKMFRTMDPMSM-GIFPIDKJSA-N 0.000 claims 1
MWHYTIMDFDUUCL-YYGZZXRFSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]hexanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 MWHYTIMDFDUUCL-YYGZZXRFSA-N 0.000 claims 1
FFYWGOJJTFJPLJ-ROXDYWFKSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pent-4-enoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CC=C)C(=O)O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 FFYWGOJJTFJPLJ-ROXDYWFKSA-N 0.000 claims 1
YFKWSSUWEXWUQR-YYGZZXRFSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-iodophenyl)methyl]-5-oxomorpholin-4-yl]pentanenitrile Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](C#N)CCC)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 YFKWSSUWEXWUQR-YYGZZXRFSA-N 0.000 claims 1
RSPPZOGCJOGKJV-ROXDYWFKSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-iodophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 RSPPZOGCJOGKJV-ROXDYWFKSA-N 0.000 claims 1
JJOOVSOTAJEJLF-YYGZZXRFSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-methoxyphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(OC)C=C1 JJOOVSOTAJEJLF-YYGZZXRFSA-N 0.000 claims 1
SOTSYTXAFGARSV-YYGZZXRFSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(C)(=O)=O)C=C1 SOTSYTXAFGARSV-YYGZZXRFSA-N 0.000 claims 1
GYSDXBKUMJAGEH-GSPCLOLRSA-N (2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[2-(dimethylamino)ethyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C([C@@H](CCN(C)C)O2)=O)[C@@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 GYSDXBKUMJAGEH-GSPCLOLRSA-N 0.000 claims 1
VCHJPDFVEKENPJ-TVYALGDOSA-N (2s)-2-[(2r,3s,6r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(2-morpholin-4-yl-2-oxoethyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)C(=O)N1CCOCC1 VCHJPDFVEKENPJ-TVYALGDOSA-N 0.000 claims 1
VWWCPRURKNDDAR-OFYIWSMMSA-N (2s)-2-[(2r,3s,6r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-[(4-fluorophenyl)methyl]pentanoic acid Chemical compound C([C@](CCC)(N1C([C@@H](CC=2C=CC(F)=CC=2)O[C@@H]([C@@H]1C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)=O)C(O)=O)C1=CC=C(F)C=C1 VWWCPRURKNDDAR-OFYIWSMMSA-N 0.000 claims 1
YYFBIAHAZGHHSV-KEVKATSASA-N (2s)-2-[(2r,3s,6r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound C1([C@@H](C(=O)O)N2C([C@@H](CC=3C=CC(F)=CC=3)O[C@@H]([C@@H]2C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)=O)CC1 YYFBIAHAZGHHSV-KEVKATSASA-N 0.000 claims 1
LOBJSWXKCWZHRU-ROXDYWFKSA-N (2s)-2-[(2r,3s,6r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)C1=CC=C(F)C=C1 LOBJSWXKCWZHRU-ROXDYWFKSA-N 0.000 claims 1
UVXJEGSLASNFDS-YYGZZXRFSA-N (2s)-2-[(2r,3s,6r)-2-(4-chloro-2-methylphenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C(=CC(Cl)=CC=1)C)C1=CC=C(F)C=C1 UVXJEGSLASNFDS-YYGZZXRFSA-N 0.000 claims 1
JGSDUUHREWFLDE-ROXDYWFKSA-N (2s)-2-[(2r,3s,6r)-2-(4-chloro-3-fluorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(F)C(Cl)=CC=1)C1=CC=C(F)C=C1 JGSDUUHREWFLDE-ROXDYWFKSA-N 0.000 claims 1
TVGRZWHDCBETPU-ROXDYWFKSA-N (2s)-2-[(2r,3s,6r)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C(=CC(Cl)=CC=1)Cl)C1=CC=C(F)C=C1 TVGRZWHDCBETPU-ROXDYWFKSA-N 0.000 claims 1
BZLYRIZTBQBHRB-ROXDYWFKSA-N (2s)-2-[(2r,3s,6r)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C(Cl)=CC=1)C1=CC=C(F)C=C1 BZLYRIZTBQBHRB-ROXDYWFKSA-N 0.000 claims 1
LWKLJVWPVADUAQ-IZZBFERCSA-N (2s)-2-[(2r,5s,6r)-2-(2-amino-2-oxoethyl)-5,6-bis(4-chlorophenyl)-3-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C([C@@H](CC(N)=O)O2)=O)[C@@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 LWKLJVWPVADUAQ-IZZBFERCSA-N 0.000 claims 1
OUUJJKDFCKFTJR-ROXDYWFKSA-N (2s)-2-[(2r,5s,6r)-2-[(4-carbamoylphenyl)methyl]-5,6-bis(4-chlorophenyl)-3-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C(N)=O)C=C1 OUUJJKDFCKFTJR-ROXDYWFKSA-N 0.000 claims 1
RNOUYZSZHKHMEU-ROXDYWFKSA-N (2s)-2-[(2r,5s,6r)-5-(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-3-oxo-6-phenylmorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC=CC=1)C1=CC=C(F)C=C1 RNOUYZSZHKHMEU-ROXDYWFKSA-N 0.000 claims 1
MRDGLMFSEFPRMJ-VJBWXMMDSA-N (2s)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-2-(4-chlorophenyl)acetic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](C(=O)O)C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 MRDGLMFSEFPRMJ-VJBWXMMDSA-N 0.000 claims 1
CIHVZMMIYHRVQW-VJBWXMMDSA-N (2s)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-2-phenylacetic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](C(=O)O)C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 CIHVZMMIYHRVQW-VJBWXMMDSA-N 0.000 claims 1
CNFXEWFDZZINFW-ZCNNSNEGSA-N (2s)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-3-methylbutanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](C(C)C)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 CNFXEWFDZZINFW-ZCNNSNEGSA-N 0.000 claims 1
XJWXASPVMUYFHO-TYPHKJRUSA-N (2s)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-4-methylpentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CC(C)C)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 XJWXASPVMUYFHO-TYPHKJRUSA-N 0.000 claims 1
AEBYGXOLYVPIPA-NNWRFLSQSA-N (2s)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-n,n-dimethylpentanamide Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CCC)C(=O)N(C)C)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 AEBYGXOLYVPIPA-NNWRFLSQSA-N 0.000 claims 1
BAMQKGWVIVISCO-TYPHKJRUSA-N (2s)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-n-methylpentanamide Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CCC)C(=O)NC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 BAMQKGWVIVISCO-TYPHKJRUSA-N 0.000 claims 1
NMDQLMUYNFLIHG-WWNPGLIZSA-N (2s)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-n-propylpentanamide Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CCC)C(=O)NCCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 NMDQLMUYNFLIHG-WWNPGLIZSA-N 0.000 claims 1
IHLREHZHMFDKGL-UHOSZYNNSA-N (2s)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]butanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 IHLREHZHMFDKGL-UHOSZYNNSA-N 0.000 claims 1
NHDJKSJILSOCFS-SXLOBPIMSA-N (2s)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 NHDJKSJILSOCFS-SXLOBPIMSA-N 0.000 claims 1
XUKXVBWPEVYIRP-PDSMFRHLSA-N (2s)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]propanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](C)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 XUKXVBWPEVYIRP-PDSMFRHLSA-N 0.000 claims 1
UQASTWWEIVFSHY-DWLFOUALSA-N (2s)-2-[(2s,3r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-2-methyl-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2N(C(CO[C@@]2(C)C=2C=C(Cl)C=CC=2)=O)[C@@H](CCC)C(O)=O)=CC=C(Cl)C=C1 UQASTWWEIVFSHY-DWLFOUALSA-N 0.000 claims 1
DELFMJQSZBLXHR-SXLOBPIMSA-N (2s)-2-[(2s,3r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 DELFMJQSZBLXHR-SXLOBPIMSA-N 0.000 claims 1
LOBJSWXKCWZHRU-QKYIYPHDSA-N (2s)-2-[(2s,3r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound O([C@H]([C@H](N(C1=O)[C@@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)C1CC1=CC=C(F)C=C1 LOBJSWXKCWZHRU-QKYIYPHDSA-N 0.000 claims 1
VPLIEYIAKCWJBX-TYPHKJRUSA-N (2s)-2-[(2s,3r)-2-(4-chloro-2-methylphenyl)-3-(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1C VPLIEYIAKCWJBX-TYPHKJRUSA-N 0.000 claims 1
ZAWNFLSCDKKZCP-SXLOBPIMSA-N (2s)-2-[(2s,3r)-2-(4-chlorophenyl)-3-(3,4-dichlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2C=C(Cl)C(Cl)=CC=2)=CC=C(Cl)C=C1 ZAWNFLSCDKKZCP-SXLOBPIMSA-N 0.000 claims 1
IIIKIXKRUIFYHN-WWNPGLIZSA-N (2s)-2-[(2s,3r)-2-(4-chlorophenyl)-3-(4-cyclopropylphenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2C=CC(=CC=2)C2CC2)=CC=C(Cl)C=C1 IIIKIXKRUIFYHN-WWNPGLIZSA-N 0.000 claims 1
BUGVQKZOFPGGOD-SXLOBPIMSA-N (2s)-2-[(2s,3r)-3-(4-bromophenyl)-2-(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2C=CC(Br)=CC=2)=CC=C(Cl)C=C1 BUGVQKZOFPGGOD-SXLOBPIMSA-N 0.000 claims 1
KSNIEWKPHUKWIK-SXLOBPIMSA-N (2s)-2-[(2s,3r)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1Cl KSNIEWKPHUKWIK-SXLOBPIMSA-N 0.000 claims 1
MJJBTJKKAKENBZ-TYPHKJRUSA-N (2s)-2-[(2s,3r)-3-(4-chlorophenyl)-2-(4-cyanophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(C#N)C=C1 MJJBTJKKAKENBZ-TYPHKJRUSA-N 0.000 claims 1
NPPZSLNNEJILGK-NFGXINMFSA-N (2s)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(2-fluoro-4-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(C)(=O)=O)C=C1F NPPZSLNNEJILGK-NFGXINMFSA-N 0.000 claims 1
SXEUXSPFRBDCHM-QNVWVOQGSA-N (2s)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-2-methyl-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2N(C([C@H](CC=3C=CC(F)=CC=3)O[C@@]2(C)C=2C=CC(Cl)=CC=2)=O)[C@@H](CCC)C(O)=O)=CC=C(Cl)C=C1 SXEUXSPFRBDCHM-QNVWVOQGSA-N 0.000 claims 1
ROAXJFVTHGLTIQ-CRNKYVSFSA-N (2s)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-(3-chlorophenyl)acetic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](C(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 ROAXJFVTHGLTIQ-CRNKYVSFSA-N 0.000 claims 1
QYBDMSRKFASBLX-CRNKYVSFSA-N (2s)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-(4-chlorophenyl)acetic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](C(=O)O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 QYBDMSRKFASBLX-CRNKYVSFSA-N 0.000 claims 1
TVTKMFRTMDPMSM-CRNKYVSFSA-N (2s)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-phenylacetic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](C(=O)O)C=1C=CC=CC=1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 TVTKMFRTMDPMSM-CRNKYVSFSA-N 0.000 claims 1
MWHYTIMDFDUUCL-NFGXINMFSA-N (2s)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]hexanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CCCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 MWHYTIMDFDUUCL-NFGXINMFSA-N 0.000 claims 1
FFYWGOJJTFJPLJ-SSUZURRFSA-N (2s)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pent-4-enoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CC=C)C(=O)O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 FFYWGOJJTFJPLJ-SSUZURRFSA-N 0.000 claims 1
BPTXICQAEGSTHS-SSUZURRFSA-N (2s)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 BPTXICQAEGSTHS-SSUZURRFSA-N 0.000 claims 1
SOTSYTXAFGARSV-NFGXINMFSA-N (2s)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(C)(=O)=O)C=C1 SOTSYTXAFGARSV-NFGXINMFSA-N 0.000 claims 1
VCHJPDFVEKENPJ-HFOXQMJASA-N (2s)-2-[(2s,3r,6s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(2-morpholin-4-yl-2-oxoethyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)C(=O)N1CCOCC1 VCHJPDFVEKENPJ-HFOXQMJASA-N 0.000 claims 1
VWWCPRURKNDDAR-AIPQGOBWSA-N (2s)-2-[(2s,3r,6s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-[(4-fluorophenyl)methyl]pentanoic acid Chemical compound C([C@](CCC)(N1C([C@H](CC=2C=CC(F)=CC=2)O[C@H]([C@H]1C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)=O)C(O)=O)C1=CC=C(F)C=C1 VWWCPRURKNDDAR-AIPQGOBWSA-N 0.000 claims 1
YYFBIAHAZGHHSV-QYOOZWMWSA-N (2s)-2-[(2s,3r,6s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound C1([C@@H](C(=O)O)N2C([C@H](CC=3C=CC(F)=CC=3)O[C@H]([C@H]2C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)=O)CC1 YYFBIAHAZGHHSV-QYOOZWMWSA-N 0.000 claims 1
LOBJSWXKCWZHRU-SSUZURRFSA-N (2s)-2-[(2s,3r,6s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)C1=CC=C(F)C=C1 LOBJSWXKCWZHRU-SSUZURRFSA-N 0.000 claims 1
UVXJEGSLASNFDS-NFGXINMFSA-N (2s)-2-[(2s,3r,6s)-2-(4-chloro-2-methylphenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C(=CC(Cl)=CC=1)C)C1=CC=C(F)C=C1 UVXJEGSLASNFDS-NFGXINMFSA-N 0.000 claims 1
JGSDUUHREWFLDE-SSUZURRFSA-N (2s)-2-[(2s,3r,6s)-2-(4-chloro-3-fluorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(F)C(Cl)=CC=1)C1=CC=C(F)C=C1 JGSDUUHREWFLDE-SSUZURRFSA-N 0.000 claims 1
TVGRZWHDCBETPU-SSUZURRFSA-N (2s)-2-[(2s,3r,6s)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C(=CC(Cl)=CC=1)Cl)C1=CC=C(F)C=C1 TVGRZWHDCBETPU-SSUZURRFSA-N 0.000 claims 1
BZLYRIZTBQBHRB-SSUZURRFSA-N (2s)-2-[(2s,3r,6s)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C(Cl)=CC=1)C1=CC=C(F)C=C1 BZLYRIZTBQBHRB-SSUZURRFSA-N 0.000 claims 1
RNOUYZSZHKHMEU-SSUZURRFSA-N (2s)-2-[(2s,5r,6s)-5-(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-3-oxo-6-phenylmorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC=CC=1)C1=CC=C(F)C=C1 RNOUYZSZHKHMEU-SSUZURRFSA-N 0.000 claims 1
NVRKHLCRIFHQOK-HSTJWYMLSA-N (2s)-3-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-2-methylpropanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NC[C@H](C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 NVRKHLCRIFHQOK-HSTJWYMLSA-N 0.000 claims 1
NVRKHLCRIFHQOK-RVCDUGNCSA-N (2s)-3-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-2-methylpropanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)NC[C@H](C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 NVRKHLCRIFHQOK-RVCDUGNCSA-N 0.000 claims 1
HRSXFSXFUMVJFU-QBHLCAJUSA-N (2s)-4-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-2-hydroxybutanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NCC[C@H](O)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 HRSXFSXFUMVJFU-QBHLCAJUSA-N 0.000 claims 1
HRSXFSXFUMVJFU-FVYAUOJASA-N (2s)-4-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-2-hydroxybutanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)NCC[C@H](O)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 HRSXFSXFUMVJFU-FVYAUOJASA-N 0.000 claims 1
DFHXIDFJPXBWRW-VXNXHJTFSA-N (2s,5r,6s)-2-[[4-(aminomethyl)phenyl]methyl]-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(CN)C=C1 DFHXIDFJPXBWRW-VXNXHJTFSA-N 0.000 claims 1
AYEZCABKRRTTPU-GVAUOCQISA-N (2s,5r,6s)-2-benzyl-5,6-bis(4-bromophenyl)-4-cyclopropylmorpholin-3-one Chemical compound C1=CC(Br)=CC=C1[C@H]1[C@@H](C=2C=CC(Br)=CC=2)N(C2CC2)C(=O)[C@H](CC=2C=CC=CC=2)O1 AYEZCABKRRTTPU-GVAUOCQISA-N 0.000 claims 1
YYVYIVSNIAMIER-ZRBLBEILSA-N (2s,5r,6s)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)C1=CC=CC=C1 YYVYIVSNIAMIER-ZRBLBEILSA-N 0.000 claims 1
NFFXQTHZDQEVMP-ZRBLBEILSA-N (2s,5r,6s)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 NFFXQTHZDQEVMP-ZRBLBEILSA-N 0.000 claims 1
FFWXYSDZASUBHP-ZRBLBEILSA-N (2s,5r,6s)-2-benzyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-methylmorpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)C1=CC=CC=C1 FFWXYSDZASUBHP-ZRBLBEILSA-N 0.000 claims 1
FCOPQZKTHYVUEK-VXNXHJTFSA-N (2s,5r,6s)-5,6-bis(4-bromophenyl)-2-[(3-methoxyphenyl)methyl]-4-methylmorpholin-3-one Chemical compound COC1=CC=CC(C[C@H]2C(N(C)[C@@H]([C@@H](O2)C=2C=CC(Br)=CC=2)C=2C=CC(Br)=CC=2)=O)=C1 FCOPQZKTHYVUEK-VXNXHJTFSA-N 0.000 claims 1
RHWGELPEQKFUHE-ZRBLBEILSA-N (2s,5r,6s)-5,6-bis(4-bromophenyl)-2-[(4-bromophenyl)methyl]-4-methylmorpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)C1=CC=C(Br)C=C1 RHWGELPEQKFUHE-ZRBLBEILSA-N 0.000 claims 1
ZOPUXVMFTFLAOX-ZRBLBEILSA-N (2s,5r,6s)-5,6-bis(4-bromophenyl)-2-[(4-fluorophenyl)methyl]-4-methylmorpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)C1=CC=C(F)C=C1 ZOPUXVMFTFLAOX-ZRBLBEILSA-N 0.000 claims 1
JQFPMGMYKYPPLI-VXNXHJTFSA-N (2s,5r,6s)-5,6-bis(4-bromophenyl)-2-[(4-methoxyphenyl)methyl]-4-methylmorpholin-3-one Chemical compound C1=CC(OC)=CC=C1C[C@H]1C(=O)N(C)[C@H](C=2C=CC(Br)=CC=2)[C@H](C=2C=CC(Br)=CC=2)O1 JQFPMGMYKYPPLI-VXNXHJTFSA-N 0.000 claims 1
JNWVIZMYBCAVNA-HBMCJLEFSA-N (2s,5r,6s)-5,6-bis(4-bromophenyl)-4-methyl-2-(3-methylbut-2-enyl)morpholin-3-one Chemical compound C1([C@H]2[C@H](N(C([C@H](CC=C(C)C)O2)=O)C)C=2C=CC(Br)=CC=2)=CC=C(Br)C=C1 JNWVIZMYBCAVNA-HBMCJLEFSA-N 0.000 claims 1
HYNGBJAFVPKRRJ-ZRBLBEILSA-N (2s,5r,6s)-5,6-bis(4-bromophenyl)-4-methyl-2-[[4-(trifluoromethoxy)phenyl]methyl]morpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)C1=CC=C(OC(F)(F)F)C=C1 HYNGBJAFVPKRRJ-ZRBLBEILSA-N 0.000 claims 1
KBJUZOFBLZGYEP-FSSWDIPSSA-N (2s,5r,6s)-5,6-bis(4-bromophenyl)-4-methyl-2-phenylmorpholin-3-one Chemical compound C1([C@@H]2O[C@H]([C@H](N(C2=O)C)C=2C=CC(Br)=CC=2)C=2C=CC(Br)=CC=2)=CC=CC=C1 KBJUZOFBLZGYEP-FSSWDIPSSA-N 0.000 claims 1
VHKIGKDLGUTETJ-OTWHNJEPSA-N (2s,5r,6s)-5,6-bis(4-bromophenyl)-4-methyl-2-prop-2-enylmorpholin-3-one Chemical compound C1([C@H]2[C@H](N(C([C@H](CC=C)O2)=O)C)C=2C=CC(Br)=CC=2)=CC=C(Br)C=C1 VHKIGKDLGUTETJ-OTWHNJEPSA-N 0.000 claims 1
BFBUGOGWCKRJJC-KSZLIROESA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-(2-hydroxyethyl)-4-methylmorpholin-3-one Chemical compound C1([C@H]2[C@H](N(C([C@H](CCO)O2)=O)C)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 BFBUGOGWCKRJJC-KSZLIROESA-N 0.000 claims 1
FPKXWYRDEQIPKH-IARZGTGTSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-[(2-fluoro-4-methylsulfonylphenyl)methyl]-4-pyridin-3-ylmorpholin-3-one Chemical compound FC1=CC(S(=O)(=O)C)=CC=C1C[C@H]1C(=O)N(C=2C=NC=CC=2)[C@H](C=2C=CC(Cl)=CC=2)[C@H](C=2C=CC(Cl)=CC=2)O1 FPKXWYRDEQIPKH-IARZGTGTSA-N 0.000 claims 1
IPJCFRDZXMOROQ-HCXYKTFWSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-[(2r)-2,3-dihydroxypropyl]-4-methylmorpholin-3-one Chemical compound C1([C@H]2[C@H](N(C([C@H](C[C@@H](O)CO)O2)=O)C)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 IPJCFRDZXMOROQ-HCXYKTFWSA-N 0.000 claims 1
IPJCFRDZXMOROQ-OKYOBFRVSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-[(2s)-2,3-dihydroxypropyl]-4-methylmorpholin-3-one Chemical compound C1([C@H]2[C@H](N(C([C@H](C[C@H](O)CO)O2)=O)C)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 IPJCFRDZXMOROQ-OKYOBFRVSA-N 0.000 claims 1
YZXNLAQFGPTWEK-DMDYGQEQSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-(1-methylimidazol-4-yl)morpholin-3-one Chemical compound CN1C=NC(N2C([C@H](CC=3C=CC(F)=CC=3)O[C@H]([C@H]2C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)=O)=C1 YZXNLAQFGPTWEK-DMDYGQEQSA-N 0.000 claims 1
GAQCTUBQELXKFM-GVAUOCQISA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-(1h-pyrazol-4-yl)morpholin-3-one Chemical compound C1=CC(F)=CC=C1C[C@H]1C(=O)N(C2=CNN=C2)[C@H](C=2C=CC(Cl)=CC=2)[C@H](C=2C=CC(Cl)=CC=2)O1 GAQCTUBQELXKFM-GVAUOCQISA-N 0.000 claims 1
KAWBFOLKWOWQNK-ZJSPYRCASA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(1r)-1-(2h-tetrazol-5-yl)butyl]morpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C1=NNN=N1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 KAWBFOLKWOWQNK-ZJSPYRCASA-N 0.000 claims 1
NNHHVXDUFOZJBY-BDTNDASRSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]morpholin-3-one Chemical compound C1=CC(F)=CC=C1C[C@H]1C(=O)N[C@H](C=2C=CC(Cl)=CC=2)[C@H](C=2C=CC(Cl)=CC=2)O1 NNHHVXDUFOZJBY-BDTNDASRSA-N 0.000 claims 1
HCAYISRYXICNRK-ZJSPYRCASA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-[(4-iodophenyl)methyl]-4-[(1r)-1-(2h-tetrazol-5-yl)butyl]morpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C1=NNN=N1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 HCAYISRYXICNRK-ZJSPYRCASA-N 0.000 claims 1
ZOHISOPDHUSNHZ-IARZGTGTSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-[(4-methylsulfonylphenyl)methyl]-4-pyridin-3-ylmorpholin-3-one Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C[C@H]1C(=O)N(C=2C=NC=CC=2)[C@H](C=2C=CC(Cl)=CC=2)[C@H](C=2C=CC(Cl)=CC=2)O1 ZOHISOPDHUSNHZ-IARZGTGTSA-N 0.000 claims 1
GTBIGGRMISCXCW-NXCFDTQHSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-[[4-[(dimethylamino)methyl]phenyl]methyl]-4-methylmorpholin-3-one Chemical compound C1=CC(CN(C)C)=CC=C1C[C@H]1C(=O)N(C)[C@H](C=2C=CC(Cl)=CC=2)[C@H](C=2C=CC(Cl)=CC=2)O1 GTBIGGRMISCXCW-NXCFDTQHSA-N 0.000 claims 1
KDMZQPXBRXKOKS-OIKPOIBNSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-(2-chloropyridin-4-yl)-2-[(4-fluorophenyl)methyl]morpholin-3-one Chemical compound C1=CC(F)=CC=C1C[C@H]1C(=O)N(C=2C=C(Cl)N=CC=2)[C@H](C=2C=CC(Cl)=CC=2)[C@H](C=2C=CC(Cl)=CC=2)O1 KDMZQPXBRXKOKS-OIKPOIBNSA-N 0.000 claims 1
LNNGRKMUIHMFPX-MBDNFAEBSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[(2r)-2,3-dihydroxypropyl]morpholin-3-one Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)C[C@@H](O)CO)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 LNNGRKMUIHMFPX-MBDNFAEBSA-N 0.000 claims 1
LNNGRKMUIHMFPX-KJJMTIBFSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[(2s)-2,3-dihydroxypropyl]morpholin-3-one Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)C[C@H](O)CO)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 LNNGRKMUIHMFPX-KJJMTIBFSA-N 0.000 claims 1
ISEMFQGMTRGCLK-BDTNDASRSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-methyl-2-(2-morpholin-4-ylethyl)morpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)CN1CCOCC1 ISEMFQGMTRGCLK-BDTNDASRSA-N 0.000 claims 1
FRJPQPIZOAFJPH-JQHSSLGASA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-methyl-2-(2h-tetrazol-5-ylmethyl)morpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C=1N=NNN=1 FRJPQPIZOAFJPH-JQHSSLGASA-N 0.000 claims 1
OGHYKDRSHULZRE-BDTNDASRSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-methyl-2-(pyridin-4-ylmethyl)morpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=NC=C1 OGHYKDRSHULZRE-BDTNDASRSA-N 0.000 claims 1
OPOUULYBDDBEGY-VXNXHJTFSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-methyl-2-[(4-methylsulfonylphenyl)methyl]morpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(C)(=O)=O)C=C1 OPOUULYBDDBEGY-VXNXHJTFSA-N 0.000 claims 1
BTFDOQOPNARQSS-HBMCJLEFSA-N (2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-(2-hydroxyethyl)morpholin-3-one Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)CCO)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 BTFDOQOPNARQSS-HBMCJLEFSA-N 0.000 claims 1
UXPNGKJMGNJWPS-MBDNFAEBSA-N (2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[(2r)-2,3-dihydroxypropyl]morpholin-3-one Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)C[C@@H](O)CO)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 UXPNGKJMGNJWPS-MBDNFAEBSA-N 0.000 claims 1
UXPNGKJMGNJWPS-KJJMTIBFSA-N (2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[(2s)-2,3-dihydroxypropyl]morpholin-3-one Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)C[C@H](O)CO)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 UXPNGKJMGNJWPS-KJJMTIBFSA-N 0.000 claims 1
QUGAINMJPTZFKB-WWNPGLIZSA-N (2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]morpholin-3-one Chemical compound O1C(C)=NN=C1C[C@H]1C(=O)N(CC2CC2)[C@H](C=2C=CC(Cl)=CC=2)[C@H](C=2C=C(Cl)C=CC=2)O1 QUGAINMJPTZFKB-WWNPGLIZSA-N 0.000 claims 1
FODTWMGUVKCBDV-BDTNDASRSA-N (2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[2-(methylamino)ethyl]morpholin-3-one Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)CCNC)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 FODTWMGUVKCBDV-BDTNDASRSA-N 0.000 claims 1
NKGNWIMUMHTIQK-GMQQYTKMSA-N (2s,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-pyridin-3-ylmorpholin-3-one Chemical compound C1=CC(F)=CC=C1C[C@H]1C(=O)N(C=2C=NC=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)O1 NKGNWIMUMHTIQK-GMQQYTKMSA-N 0.000 claims 1
WPBLGWRJZYKVJT-UXLLHSPISA-N (2s,5s,6r)-5,6-bis(4-chlorophenyl)-2-hydroxy-4-methylmorpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C([C@@H](O)O2)=O)C)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 WPBLGWRJZYKVJT-UXLLHSPISA-N 0.000 claims 1
UXPNGKJMGNJWPS-CLAROIROSA-N (2s,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[(2r)-2,3-dihydroxypropyl]morpholin-3-one Chemical compound N1([C@H]([C@H](O[C@H](C1=O)C[C@@H](O)CO)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 UXPNGKJMGNJWPS-CLAROIROSA-N 0.000 claims 1
UXPNGKJMGNJWPS-MYGLTJDJSA-N (2s,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[(2s)-2,3-dihydroxypropyl]morpholin-3-one Chemical compound N1([C@H]([C@H](O[C@H](C1=O)C[C@H](O)CO)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 UXPNGKJMGNJWPS-MYGLTJDJSA-N 0.000 claims 1
ZCOWGZXYZFNWSM-QKBZBAIHSA-N (3r)-3-[(2r,3s,6r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]hexanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CC(O)=O)CCC)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)C1=CC=C(F)C=C1 ZCOWGZXYZFNWSM-QKBZBAIHSA-N 0.000 claims 1
ZCOWGZXYZFNWSM-PSXRRJEGSA-N (3r)-3-[(2s,3r,6s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]hexanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CC(O)=O)CCC)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)C1=CC=C(F)C=C1 ZCOWGZXYZFNWSM-PSXRRJEGSA-N 0.000 claims 1
ZEXPYFGDNAYGIW-LJLJYUEBSA-N (3r)-4-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-3-hydroxybutanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NC[C@H](O)CC(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 ZEXPYFGDNAYGIW-LJLJYUEBSA-N 0.000 claims 1
ZEXPYFGDNAYGIW-WUWGLDPXSA-N (3r)-4-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-3-hydroxybutanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)NC[C@H](O)CC(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 ZEXPYFGDNAYGIW-WUWGLDPXSA-N 0.000 claims 1
VFQSDHHWNIJHMY-NRSPTQNISA-N (3r,4s,8ar)-4-(3-chlorophenyl)-3-(4-chlorophenyl)-2-propan-2-yl-4,7,8,8a-tetrahydro-3h-pyrrolo[1,2-a]pyrazine-1,6-dione Chemical compound C1([C@H]2[C@H](N(C([C@@H]3N2C(CC3)=O)=O)C(C)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 VFQSDHHWNIJHMY-NRSPTQNISA-N 0.000 claims 1
VFQSDHHWNIJHMY-TYPHKJRUSA-N (3r,4s,8as)-4-(3-chlorophenyl)-3-(4-chlorophenyl)-2-propan-2-yl-4,7,8,8a-tetrahydro-3h-pyrrolo[1,2-a]pyrazine-1,6-dione Chemical compound C1([C@H]2[C@H](N(C([C@H]3N2C(CC3)=O)=O)C(C)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 VFQSDHHWNIJHMY-TYPHKJRUSA-N 0.000 claims 1
ZCOWGZXYZFNWSM-XKXQUDOTSA-N (3s)-3-[(2r,3s,6r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]hexanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CC(O)=O)CCC)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)C1=CC=C(F)C=C1 ZCOWGZXYZFNWSM-XKXQUDOTSA-N 0.000 claims 1
ZCOWGZXYZFNWSM-KWNVVKLJSA-N (3s)-3-[(2s,3r,6s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]hexanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CC(O)=O)CCC)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)C1=CC=C(F)C=C1 ZCOWGZXYZFNWSM-KWNVVKLJSA-N 0.000 claims 1
ZEXPYFGDNAYGIW-NCJVALPZSA-N (3s)-4-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-3-hydroxybutanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NC[C@@H](O)CC(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 ZEXPYFGDNAYGIW-NCJVALPZSA-N 0.000 claims 1
ZEXPYFGDNAYGIW-WOOLYZHOSA-N (3s)-4-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-3-hydroxybutanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)NC[C@@H](O)CC(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 ZEXPYFGDNAYGIW-WOOLYZHOSA-N 0.000 claims 1
ORQJVLFEYQMTKF-WTIAFYNJSA-N (4r)-4-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]heptanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC(O)=O)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 ORQJVLFEYQMTKF-WTIAFYNJSA-N 0.000 claims 1
ORQJVLFEYQMTKF-PTUXOGIPSA-N (4r)-4-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]heptanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CCC(O)=O)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 ORQJVLFEYQMTKF-PTUXOGIPSA-N 0.000 claims 1
PTHOVXLFQNARAG-GEEWNISJSA-N (4r)-4-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]heptanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CCC(O)=O)CCC)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 PTHOVXLFQNARAG-GEEWNISJSA-N 0.000 claims 1
ORQJVLFEYQMTKF-AJSBUHFISA-N (4s)-4-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]heptanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC(O)=O)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 ORQJVLFEYQMTKF-AJSBUHFISA-N 0.000 claims 1
PTHOVXLFQNARAG-IXGYBEARSA-N (4s)-4-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]heptanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CCC(O)=O)CCC)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 PTHOVXLFQNARAG-IXGYBEARSA-N 0.000 claims 1
ORQJVLFEYQMTKF-PMOQBDJRSA-N (4s)-4-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]heptanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC(O)=O)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 ORQJVLFEYQMTKF-PMOQBDJRSA-N 0.000 claims 1
HVSJWQOMQAUZJJ-NRSPTQNISA-N (5R,6S)-4-[(2R)-1-aminopentan-2-yl]-5,6-bis(4-chlorophenyl)morpholin-3-one Chemical compound CCC[C@H](CN)N1[C@@H]([C@@H](OCC1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1 HVSJWQOMQAUZJJ-NRSPTQNISA-N 0.000 claims 1
CUWALWMUMSNASC-UXHICEINSA-N (5R,6S)-5,6-bis(4-chlorophenyl)-4-(2-methylsulfanylpyrimidin-4-yl)morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@@H]1[C@@H](OCC(N1C1=NC(=NC=C1)SC)=O)C1=CC=C(C=C1)Cl CUWALWMUMSNASC-UXHICEINSA-N 0.000 claims 1
QKPDERJMFUEBJZ-QTJGBDASSA-N (5R,6S)-5,6-bis(4-chlorophenyl)-4-[(1R)-1-(4-chlorophenyl)-2-hydroxyethyl]morpholin-3-one Chemical compound OC[C@H](N1[C@@H]([C@@H](OCC1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1ccc(Cl)cc1 QKPDERJMFUEBJZ-QTJGBDASSA-N 0.000 claims 1
KYLOCVMOIHNQQJ-QTJGBDASSA-N (5R,6S)-5,6-bis(4-chlorophenyl)-4-[(1R)-2-hydroxy-1-phenylethyl]morpholin-3-one Chemical compound OC[C@H](N1[C@@H]([C@@H](OCC1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1ccccc1 KYLOCVMOIHNQQJ-QTJGBDASSA-N 0.000 claims 1
KYLOCVMOIHNQQJ-JRFVFWCSSA-N (5R,6S)-5,6-bis(4-chlorophenyl)-4-[(1S)-2-hydroxy-1-phenylethyl]morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@@H]1[C@@H](OCC(N1[C@H](CO)C1=CC=CC=C1)=O)C1=CC=C(C=C1)Cl KYLOCVMOIHNQQJ-JRFVFWCSSA-N 0.000 claims 1
NRDRYAOWCKDLIG-GPXOXTDOSA-N (5R,6S)-5,6-bis(4-chlorophenyl)-4-[(2R)-1-morpholin-4-ylpentan-2-yl]morpholin-3-one Chemical compound CCC[C@H](CN1CCOCC1)N1[C@@H]([C@@H](OCC1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1 NRDRYAOWCKDLIG-GPXOXTDOSA-N 0.000 claims 1
NPUKNXUSVLKLGA-TYPHKJRUSA-N (5R,6S)-5,6-bis(4-chlorophenyl)-4-[(2S)-1-hydroxypentan-2-yl]morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@@H]1[C@@H](OCC(N1[C@@H](CCC)CO)=O)C1=CC=C(C=C1)Cl NPUKNXUSVLKLGA-TYPHKJRUSA-N 0.000 claims 1
CURGNKBSEFRFQJ-FCEUIQTBSA-N (5R,6S)-5,6-bis(4-chlorophenyl)-4-[(3R)-2-hydroxy-2-methylhexan-3-yl]morpholin-3-one Chemical compound CCC[C@@H](N1[C@@H]([C@@H](OCC1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)O CURGNKBSEFRFQJ-FCEUIQTBSA-N 0.000 claims 1
BDLWENAIRDHLMN-MOPGFXCFSA-N (5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-1,1-dioxo-4-propan-2-yl-1,4-thiazinan-3-one Chemical compound ClC=1C=C(C=CC1)[C@@H]1S(CC(N([C@@H]1C1=CC=C(C=C1)Cl)C(C)C)=O)(=O)=O BDLWENAIRDHLMN-MOPGFXCFSA-N 0.000 claims 1
GRGQOQRBLAYQQK-PWSRMUCDSA-N (5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[[(1R,2R)-2-methylcyclopropyl]methyl]morpholin-3-one Chemical compound C[C@@H]1C[C@H]1CN1[C@@H]([C@@H](OCC1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 GRGQOQRBLAYQQK-PWSRMUCDSA-N 0.000 claims 1
HVSJWQOMQAUZJJ-SESVDKBCSA-N (5S,6R)-4-[(2S)-1-aminopentan-2-yl]-5,6-bis(4-chlorophenyl)morpholin-3-one Chemical compound NC[C@H](CCC)N1C(CO[C@@H]([C@@H]1C1=CC=C(C=C1)Cl)C1=CC=C(C=C1)Cl)=O HVSJWQOMQAUZJJ-SESVDKBCSA-N 0.000 claims 1
GRGQOQRBLAYQQK-NUVQDNJRSA-N (5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[[(1R,2R)-2-methylcyclopropyl]methyl]morpholin-3-one Chemical compound C[C@@H]1C[C@H]1CN1[C@H]([C@H](OCC1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 GRGQOQRBLAYQQK-NUVQDNJRSA-N 0.000 claims 1
UBQFROVZCWMDOT-UGKGYDQZSA-N (5S,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2,2,6-trimethyl-1,1-dioxo-4-propan-2-yl-1,4-thiazinan-3-one Chemical compound ClC=1C=C(C=CC1)[C@@]1(S(C(C(N([C@H]1C1=CC=C(C=C1)Cl)C(C)C)=O)(C)C)(=O)=O)C UBQFROVZCWMDOT-UGKGYDQZSA-N 0.000 claims 1
UBQFROVZCWMDOT-DENIHFKCSA-N (5r,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2,2,6-trimethyl-1,1-dioxo-4-propan-2-yl-1,4-thiazinan-3-one Chemical compound C1([C@H]2N(C(C(C)(C)S(=O)(=O)[C@@]2(C=2C=C(Cl)C=CC=2)C)=O)C(C)C)=CC=C(Cl)C=C1 UBQFROVZCWMDOT-DENIHFKCSA-N 0.000 claims 1
NFFXQTHZDQEVMP-NRSZHQCHSA-N (5r,6s)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one Chemical compound O([C@H]([C@H](N(C1=O)C)C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C1CC1=CC=CC=C1 NFFXQTHZDQEVMP-NRSZHQCHSA-N 0.000 claims 1
HVSJWQOMQAUZJJ-TYPHKJRUSA-N (5r,6s)-4-[(2s)-1-aminopentan-2-yl]-5,6-bis(4-chlorophenyl)morpholin-3-one Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CN)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 HVSJWQOMQAUZJJ-TYPHKJRUSA-N 0.000 claims 1
XAMBKCQKHCNJRN-BJKOFHAPSA-N (5r,6s)-4-benzyl-5,6-bis(4-bromophenyl)-1-methylpiperazin-2-one Chemical compound N1([C@@H]([C@@H](N(C(C1)=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)CC1=CC=CC=C1 XAMBKCQKHCNJRN-BJKOFHAPSA-N 0.000 claims 1
DALLVBVMPULHMF-XZOQPEGZSA-N (5r,6s)-4-benzyl-5,6-bis(4-bromophenyl)piperazin-2-one Chemical compound C1=CC(Br)=CC=C1[C@H]1[C@@H](C=2C=CC(Br)=CC=2)N(CC=2C=CC=CC=2)CC(=O)N1 DALLVBVMPULHMF-XZOQPEGZSA-N 0.000 claims 1
DQQKKQGUCKEHFP-MOPGFXCFSA-N (5r,6s)-5,6-bis(4-bromophenyl)-4-cyclopropylmorpholin-3-one Chemical compound C1=CC(Br)=CC=C1[C@H]1[C@@H](C=2C=CC(Br)=CC=2)N(C2CC2)C(=O)CO1 DQQKKQGUCKEHFP-MOPGFXCFSA-N 0.000 claims 1
WAJRLDXLGCDAQX-MSOLQXFVSA-N (5r,6s)-5,6-bis(4-bromophenyl)-4-ethylmorpholin-3-one Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)CC)C=2C=CC(Br)=CC=2)=CC=C(Br)C=C1 WAJRLDXLGCDAQX-MSOLQXFVSA-N 0.000 claims 1
KWJNDERVFPWYAJ-MOPGFXCFSA-N (5r,6s)-5,6-bis(4-bromophenyl)-4-propan-2-ylmorpholin-3-one Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)C(C)C)C=2C=CC(Br)=CC=2)=CC=C(Br)C=C1 KWJNDERVFPWYAJ-MOPGFXCFSA-N 0.000 claims 1
VTVJMRFHIGHVTQ-RTWAWAEBSA-N (5r,6s)-5,6-bis(4-chlorophenyl)-4-(2,6-dichloropyridin-4-yl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1[C@@H](C=2C=CC(Cl)=CC=2)N(C=2C=C(Cl)N=C(Cl)C=2)C(=O)CO1 VTVJMRFHIGHVTQ-RTWAWAEBSA-N 0.000 claims 1
IZCQHQAAXLBWGS-RTWAWAEBSA-N (5r,6s)-5,6-bis(4-chlorophenyl)-4-(2-chloropyridin-4-yl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1[C@@H](C=2C=CC(Cl)=CC=2)N(C=2C=C(Cl)N=CC=2)C(=O)CO1 IZCQHQAAXLBWGS-RTWAWAEBSA-N 0.000 claims 1
RZBOZYNANYNPDY-UXHICEINSA-N (5r,6s)-5,6-bis(4-chlorophenyl)-4-(cyclopropylmethyl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1[C@@H](C=2C=CC(Cl)=CC=2)N(CC2CC2)C(=O)CO1 RZBOZYNANYNPDY-UXHICEINSA-N 0.000 claims 1
QKPDERJMFUEBJZ-JRFVFWCSSA-N (5r,6s)-5,6-bis(4-chlorophenyl)-4-[(1s)-1-(4-chlorophenyl)-2-hydroxyethyl]morpholin-3-one Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CO)C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 QKPDERJMFUEBJZ-JRFVFWCSSA-N 0.000 claims 1
NPUKNXUSVLKLGA-NRSPTQNISA-N (5r,6s)-5,6-bis(4-chlorophenyl)-4-[(2r)-1-hydroxypentan-2-yl]morpholin-3-one Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CO)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 NPUKNXUSVLKLGA-NRSPTQNISA-N 0.000 claims 1
CURGNKBSEFRFQJ-NNWRFLSQSA-N (5r,6s)-5,6-bis(4-chlorophenyl)-4-[(3s)-2-hydroxy-2-methylhexan-3-yl]morpholin-3-one Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CCC)C(C)(C)O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 CURGNKBSEFRFQJ-NNWRFLSQSA-N 0.000 claims 1
BUVTWCVIMGDTMT-SJORKVTESA-N (5r,6s)-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)C)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 BUVTWCVIMGDTMT-SJORKVTESA-N 0.000 claims 1
YVGIGWRUHLIOQO-YADHBBJMSA-N (5r,6s)-5,6-bis(4-chlorophenyl)-4-phenylmorpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1[C@@H](C=2C=CC(Cl)=CC=2)N(C=2C=CC=CC=2)C(=O)CO1 YVGIGWRUHLIOQO-YADHBBJMSA-N 0.000 claims 1
JTNLQIKYPHDYIG-UXHICEINSA-N (5r,6s)-5,6-bis(4-chlorophenyl)-4-pyrazin-2-ylmorpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1[C@@H](C=2C=CC(Cl)=CC=2)N(C=2N=CC=NC=2)C(=O)CO1 JTNLQIKYPHDYIG-UXHICEINSA-N 0.000 claims 1
LTHTVCXIZFFMEH-RTWAWAEBSA-N (5r,6s)-5,6-bis(4-chlorophenyl)-4-pyridin-3-ylmorpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1[C@@H](C=2C=CC(Cl)=CC=2)N(C=2C=NC=CC=2)C(=O)CO1 LTHTVCXIZFFMEH-RTWAWAEBSA-N 0.000 claims 1
NFUIRTFPUSSSBU-RTWAWAEBSA-N (5r,6s)-5,6-bis(4-chlorophenyl)-4-pyridin-4-ylmorpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1[C@@H](C=2C=CC(Cl)=CC=2)N(C=2C=CN=CC=2)C(=O)CO1 NFUIRTFPUSSSBU-RTWAWAEBSA-N 0.000 claims 1
UDRAKFVWDQNKFE-SJORKVTESA-N (5r,6s)-5,6-bis(4-chlorophenyl)-6-methylmorpholin-3-one Chemical compound C1([C@H]2NC(=O)CO[C@@]2(C)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 UDRAKFVWDQNKFE-SJORKVTESA-N 0.000 claims 1
UBQFROVZCWMDOT-KNQAVFIVSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2,2,6-trimethyl-1,1-dioxo-4-propan-2-yl-1,4-thiazinan-3-one Chemical compound C1([C@H]2N(C(C(C)(C)S(=O)(=O)[C@]2(C=2C=C(Cl)C=CC=2)C)=O)C(C)C)=CC=C(Cl)C=C1 UBQFROVZCWMDOT-KNQAVFIVSA-N 0.000 claims 1
FGWXAEQUAWMQJO-UXHICEINSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(1,3-thiazol-4-ylmethyl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1N(CC=2N=CSC=2)C(=O)CO[C@H]1C1=CC=CC(Cl)=C1 FGWXAEQUAWMQJO-UXHICEINSA-N 0.000 claims 1
SPMXUJWZKOUETJ-MOPGFXCFSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(2-hydroxy-2-methylpropyl)morpholin-3-one Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)CC(C)(O)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 SPMXUJWZKOUETJ-MOPGFXCFSA-N 0.000 claims 1
JGNOFMCABZIOJJ-MOPGFXCFSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(2-methoxyethyl)morpholin-3-one Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)CCOC)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 JGNOFMCABZIOJJ-MOPGFXCFSA-N 0.000 claims 1
YEADITPTMUCVLJ-UXHICEINSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(2-methylpropyl)morpholin-3-one Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)CC(C)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 YEADITPTMUCVLJ-UXHICEINSA-N 0.000 claims 1
OIVHXUNAHLCSTH-RTWAWAEBSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclobutylmethyl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1N(CC2CCC2)C(=O)CO[C@H]1C1=CC=CC(Cl)=C1 OIVHXUNAHLCSTH-RTWAWAEBSA-N 0.000 claims 1
SUKADUYCYVAULK-UXHICEINSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-1,1-dioxo-1,4-thiazinan-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1N(CC2CC2)C(=O)CS(=O)(=O)[C@H]1C1=CC=CC(Cl)=C1 SUKADUYCYVAULK-UXHICEINSA-N 0.000 claims 1
HVHAGGDWFLSMMK-UXHICEINSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2,2-dimethyl-1,1-dioxo-1,4-thiazinan-3-one Chemical compound O=S(=O)([C@@H](C=1C=C(Cl)C=CC=1)[C@H]1C=2C=CC(Cl)=CC=2)C(C)(C)C(=O)N1CC1CC1 HVHAGGDWFLSMMK-UXHICEINSA-N 0.000 claims 1
QZJQNDKBBCUNAC-UXHICEINSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)thiomorpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1N(CC2CC2)C(=O)CS[C@H]1C1=CC=CC(Cl)=C1 QZJQNDKBBCUNAC-UXHICEINSA-N 0.000 claims 1
GRGQOQRBLAYQQK-OUMIMPDCSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[[(1s,2s)-2-methylcyclopropyl]methyl]morpholin-3-one Chemical compound C[C@H]1C[C@@H]1CN1C(=O)CO[C@@H](C=2C=C(Cl)C=CC=2)[C@H]1C1=CC=C(Cl)C=C1 GRGQOQRBLAYQQK-OUMIMPDCSA-N 0.000 claims 1
ABCMHMRIGRRYJN-RTWAWAEBSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-cyclopentylmorpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1N(C2CCCC2)C(=O)CO[C@H]1C1=CC=CC(Cl)=C1 ABCMHMRIGRRYJN-RTWAWAEBSA-N 0.000 claims 1
YUCPGGRZBHWSOS-MOPGFXCFSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-cyclopropylsulfonylmorpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1N(S(=O)(=O)C2CC2)C(=O)CO[C@H]1C1=CC=CC(Cl)=C1 YUCPGGRZBHWSOS-MOPGFXCFSA-N 0.000 claims 1
ZUYDNBDMQAEZPD-SJORKVTESA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-methylmorpholin-3-one Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 ZUYDNBDMQAEZPD-SJORKVTESA-N 0.000 claims 1
VKUFOQXIICORFX-MOPGFXCFSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-propan-2-ylthiomorpholin-3-one Chemical compound C1([C@H]2[C@H](N(C(CS2)=O)C(C)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 VKUFOQXIICORFX-MOPGFXCFSA-N 0.000 claims 1
HVSJWQOMQAUZJJ-HLAWJBBLSA-N (5s,6r)-4-[(2r)-1-aminopentan-2-yl]-5,6-bis(4-chlorophenyl)morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CN)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 HVSJWQOMQAUZJJ-HLAWJBBLSA-N 0.000 claims 1
XAMBKCQKHCNJRN-RPWUZVMVSA-N (5s,6r)-4-benzyl-5,6-bis(4-bromophenyl)-1-methylpiperazin-2-one Chemical compound N1([C@H]([C@H](N(C(C1)=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)CC1=CC=CC=C1 XAMBKCQKHCNJRN-RPWUZVMVSA-N 0.000 claims 1
DALLVBVMPULHMF-PKTZIBPZSA-N (5s,6r)-4-benzyl-5,6-bis(4-bromophenyl)piperazin-2-one Chemical compound C1=CC(Br)=CC=C1[C@@H]1[C@H](C=2C=CC(Br)=CC=2)N(CC=2C=CC=CC=2)CC(=O)N1 DALLVBVMPULHMF-PKTZIBPZSA-N 0.000 claims 1
WAJRLDXLGCDAQX-ZWKOTPCHSA-N (5s,6r)-5,6-bis(4-bromophenyl)-4-ethylmorpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)CC)C=2C=CC(Br)=CC=2)=CC=C(Br)C=C1 WAJRLDXLGCDAQX-ZWKOTPCHSA-N 0.000 claims 1
KWJNDERVFPWYAJ-RBUKOAKNSA-N (5s,6r)-5,6-bis(4-bromophenyl)-4-propan-2-ylmorpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)C(C)C)C=2C=CC(Br)=CC=2)=CC=C(Br)C=C1 KWJNDERVFPWYAJ-RBUKOAKNSA-N 0.000 claims 1
VTVJMRFHIGHVTQ-LEWJYISDSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-(2,6-dichloropyridin-4-yl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1[C@H](C=2C=CC(Cl)=CC=2)N(C=2C=C(Cl)N=C(Cl)C=2)C(=O)CO1 VTVJMRFHIGHVTQ-LEWJYISDSA-N 0.000 claims 1
IZCQHQAAXLBWGS-LEWJYISDSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-(2-chloropyridin-4-yl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1[C@H](C=2C=CC(Cl)=CC=2)N(C=2C=C(Cl)N=CC=2)C(=O)CO1 IZCQHQAAXLBWGS-LEWJYISDSA-N 0.000 claims 1
CUWALWMUMSNASC-VQTJNVASSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-(2-methylsulfanylpyrimidin-4-yl)morpholin-3-one Chemical compound CSC1=NC=CC(N2C(CO[C@@H]([C@@H]2C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)=O)=N1 CUWALWMUMSNASC-VQTJNVASSA-N 0.000 claims 1
RZBOZYNANYNPDY-VQTJNVASSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-(cyclopropylmethyl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1[C@H](C=2C=CC(Cl)=CC=2)N(CC2CC2)C(=O)CO1 RZBOZYNANYNPDY-VQTJNVASSA-N 0.000 claims 1
QKPDERJMFUEBJZ-OEMFJLHTSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-[(1r)-1-(4-chlorophenyl)-2-hydroxyethyl]morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CO)C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 QKPDERJMFUEBJZ-OEMFJLHTSA-N 0.000 claims 1
KYLOCVMOIHNQQJ-OEMFJLHTSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-[(1r)-2-hydroxy-1-phenylethyl]morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CO)C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 KYLOCVMOIHNQQJ-OEMFJLHTSA-N 0.000 claims 1
QKPDERJMFUEBJZ-YFNKSVMNSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-[(1s)-1-(4-chlorophenyl)-2-hydroxyethyl]morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CO)C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 QKPDERJMFUEBJZ-YFNKSVMNSA-N 0.000 claims 1
KYLOCVMOIHNQQJ-YFNKSVMNSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-[(1s)-2-hydroxy-1-phenylethyl]morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CO)C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 KYLOCVMOIHNQQJ-YFNKSVMNSA-N 0.000 claims 1
NPUKNXUSVLKLGA-HLAWJBBLSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-[(2r)-1-hydroxypentan-2-yl]morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CO)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 NPUKNXUSVLKLGA-HLAWJBBLSA-N 0.000 claims 1
NPUKNXUSVLKLGA-SESVDKBCSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-[(2s)-1-hydroxypentan-2-yl]morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CO)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 NPUKNXUSVLKLGA-SESVDKBCSA-N 0.000 claims 1
NRDRYAOWCKDLIG-ZKMPZPQNSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-[(2s)-1-morpholin-4-ylpentan-2-yl]morpholin-3-one Chemical compound C([C@H](CCC)N1C(CO[C@@H]([C@@H]1C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)=O)N1CCOCC1 NRDRYAOWCKDLIG-ZKMPZPQNSA-N 0.000 claims 1
CURGNKBSEFRFQJ-BAGYTPMASA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-[(3r)-2-hydroxy-2-methylhexan-3-yl]morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(C)(C)O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 CURGNKBSEFRFQJ-BAGYTPMASA-N 0.000 claims 1
CURGNKBSEFRFQJ-ILWGZMRPSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-[(3s)-2-hydroxy-2-methylhexan-3-yl]morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(C)(C)O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 CURGNKBSEFRFQJ-ILWGZMRPSA-N 0.000 claims 1
YVGIGWRUHLIOQO-FCHUYYIVSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-phenylmorpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1[C@H](C=2C=CC(Cl)=CC=2)N(C=2C=CC=CC=2)C(=O)CO1 YVGIGWRUHLIOQO-FCHUYYIVSA-N 0.000 claims 1
JTNLQIKYPHDYIG-VQTJNVASSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-pyrazin-2-ylmorpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1[C@H](C=2C=CC(Cl)=CC=2)N(C=2N=CC=NC=2)C(=O)CO1 JTNLQIKYPHDYIG-VQTJNVASSA-N 0.000 claims 1
LTHTVCXIZFFMEH-LEWJYISDSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-pyridin-3-ylmorpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1[C@H](C=2C=CC(Cl)=CC=2)N(C=2C=NC=CC=2)C(=O)CO1 LTHTVCXIZFFMEH-LEWJYISDSA-N 0.000 claims 1
NFUIRTFPUSSSBU-LEWJYISDSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-pyridin-4-ylmorpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1[C@H](C=2C=CC(Cl)=CC=2)N(C=2C=CN=CC=2)C(=O)CO1 NFUIRTFPUSSSBU-LEWJYISDSA-N 0.000 claims 1
UBQFROVZCWMDOT-SIKLNZKXSA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2,2,6-trimethyl-1,1-dioxo-4-propan-2-yl-1,4-thiazinan-3-one Chemical compound C1([C@@H]2N(C(C(C)(C)S(=O)(=O)[C@@]2(C=2C=C(Cl)C=CC=2)C)=O)C(C)C)=CC=C(Cl)C=C1 UBQFROVZCWMDOT-SIKLNZKXSA-N 0.000 claims 1
FGWXAEQUAWMQJO-VQTJNVASSA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(1,3-thiazol-4-ylmethyl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1N(CC=2N=CSC=2)C(=O)CO[C@@H]1C1=CC=CC(Cl)=C1 FGWXAEQUAWMQJO-VQTJNVASSA-N 0.000 claims 1
SPMXUJWZKOUETJ-RBUKOAKNSA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(2-hydroxy-2-methylpropyl)morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)CC(C)(O)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 SPMXUJWZKOUETJ-RBUKOAKNSA-N 0.000 claims 1
JGNOFMCABZIOJJ-RBUKOAKNSA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(2-methoxyethyl)morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)CCOC)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 JGNOFMCABZIOJJ-RBUKOAKNSA-N 0.000 claims 1
YEADITPTMUCVLJ-VQTJNVASSA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(2-methylpropyl)morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)CC(C)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 YEADITPTMUCVLJ-VQTJNVASSA-N 0.000 claims 1
OIVHXUNAHLCSTH-LEWJYISDSA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclobutylmethyl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1N(CC2CCC2)C(=O)CO[C@@H]1C1=CC=CC(Cl)=C1 OIVHXUNAHLCSTH-LEWJYISDSA-N 0.000 claims 1
GRGQOQRBLAYQQK-MWYMOKJQSA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[[(1s,2s)-2-methylcyclopropyl]methyl]morpholin-3-one Chemical compound C[C@H]1C[C@@H]1CN1C(=O)CO[C@H](C=2C=C(Cl)C=CC=2)[C@@H]1C1=CC=C(Cl)C=C1 GRGQOQRBLAYQQK-MWYMOKJQSA-N 0.000 claims 1
ABCMHMRIGRRYJN-LEWJYISDSA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-cyclopentylmorpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1N(C2CCCC2)C(=O)CO[C@@H]1C1=CC=CC(Cl)=C1 ABCMHMRIGRRYJN-LEWJYISDSA-N 0.000 claims 1
YUCPGGRZBHWSOS-RBUKOAKNSA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-cyclopropylsulfonylmorpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1N(S(=O)(=O)C2CC2)C(=O)CO[C@@H]1C1=CC=CC(Cl)=C1 YUCPGGRZBHWSOS-RBUKOAKNSA-N 0.000 claims 1
ZUYDNBDMQAEZPD-DLBZAZTESA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-methylmorpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 ZUYDNBDMQAEZPD-DLBZAZTESA-N 0.000 claims 1
IAXQDFUNSAJUPQ-GPXOXTDOSA-N 1-[(2R)-2-[(2S,3R)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoyl]piperidine-4-carboxylic acid Chemical compound ClC1=CC=C(C=C1)[C@H]1[C@H](N(C(CO1)=O)[C@@H](C(=O)N1CCC(CC1)C(=O)O)CCC)C1=CC=C(C=C1)Cl IAXQDFUNSAJUPQ-GPXOXTDOSA-N 0.000 claims 1
ODHVFUZLPHKYAU-ATIZSFMBSA-N 1-[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]azetidine-3-carboxylic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)N1CC(C1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 ODHVFUZLPHKYAU-ATIZSFMBSA-N 0.000 claims 1
CAAWFBFPQTYVGS-AIQXTLEGSA-N 1-[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]azetidine-3-carboxylic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)N1CC(C1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 CAAWFBFPQTYVGS-AIQXTLEGSA-N 0.000 claims 1
DCKDPLFEFIVNLL-IQLXHWPESA-N 1-[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentyl]piperidine-4-carboxylic acid Chemical compound C([C@@H](CCC)N1C([C@H](CC=2C=CC(F)=CC=2)O[C@H]([C@H]1C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)=O)N1CCC(C(O)=O)CC1 DCKDPLFEFIVNLL-IQLXHWPESA-N 0.000 claims 1
NANBAGSGGMNGDK-ITGKQZKFSA-N 1-[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-iodophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]piperidine-4-carboxylic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)N1CCC(CC1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 NANBAGSGGMNGDK-ITGKQZKFSA-N 0.000 claims 1
IAXQDFUNSAJUPQ-ZKMPZPQNSA-N 1-[(2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoyl]piperidine-4-carboxylic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(=O)N2CCC(CC2)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 IAXQDFUNSAJUPQ-ZKMPZPQNSA-N 0.000 claims 1
ODHVFUZLPHKYAU-RRGQHJHPSA-N 1-[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]azetidine-3-carboxylic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)N1CC(C1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 ODHVFUZLPHKYAU-RRGQHJHPSA-N 0.000 claims 1
CAAWFBFPQTYVGS-ICYKMPLBSA-N 1-[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]azetidine-3-carboxylic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)N1CC(C1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 CAAWFBFPQTYVGS-ICYKMPLBSA-N 0.000 claims 1
DCKDPLFEFIVNLL-MLMSKLGMSA-N 1-[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentyl]piperidine-4-carboxylic acid Chemical compound C([C@H](CCC)N1C([C@@H](CC=2C=CC(F)=CC=2)O[C@@H]([C@@H]1C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)=O)N1CCC(C(O)=O)CC1 DCKDPLFEFIVNLL-MLMSKLGMSA-N 0.000 claims 1
NANBAGSGGMNGDK-XFBWMNOSSA-N 1-[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-iodophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)N1CCC(CC1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 NANBAGSGGMNGDK-XFBWMNOSSA-N 0.000 claims 1
AXLFRXXLVUJAFX-RMVXJAJNSA-N 2-[(2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxo-4-[(1R)-1-(2H-tetrazol-5-yl)butyl]morpholin-2-yl]acetic acid Chemical compound N1N=NN=C1[C@@H](CCC)N1C([C@H](O[C@@H]([C@@H]1C1=CC=C(C=C1)Cl)C1=CC(=CC=C1)Cl)CC(=O)O)=O AXLFRXXLVUJAFX-RMVXJAJNSA-N 0.000 claims 1
AXLFRXXLVUJAFX-IZZBFERCSA-N 2-[(2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxo-4-[(1S)-1-(2H-tetrazol-5-yl)butyl]morpholin-2-yl]acetic acid Chemical compound N1N=NN=C1[C@H](CCC)N1C([C@H](O[C@@H]([C@@H]1C1=CC=C(C=C1)Cl)C1=CC(=CC=C1)Cl)CC(=O)O)=O AXLFRXXLVUJAFX-IZZBFERCSA-N 0.000 claims 1
XKUYNNZACAGYEX-KRXUUXHPSA-N 2-[(2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(1R)-1-cyanobutyl]-3-oxomorpholin-2-yl]acetic acid Chemical compound ClC=1C=C(C=CC1)[C@H]1O[C@@H](C(N([C@H]1C1=CC=C(C=C1)Cl)[C@H](CCC)C#N)=O)CC(=O)O XKUYNNZACAGYEX-KRXUUXHPSA-N 0.000 claims 1
XKUYNNZACAGYEX-YUVXSKOASA-N 2-[(2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(1S)-1-cyanobutyl]-3-oxomorpholin-2-yl]acetic acid Chemical compound ClC=1C=C(C=CC1)[C@H]1O[C@@H](C(N([C@H]1C1=CC=C(C=C1)Cl)[C@@H](CCC)C#N)=O)CC(=O)O XKUYNNZACAGYEX-YUVXSKOASA-N 0.000 claims 1
AXLFRXXLVUJAFX-JYRKZWEQSA-N 2-[(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxo-4-[(1R)-1-(2H-tetrazol-5-yl)butyl]morpholin-2-yl]acetic acid Chemical compound N1N=NN=C1[C@@H](CCC)N1C([C@@H](O[C@H]([C@H]1C1=CC=C(C=C1)Cl)C1=CC(=CC=C1)Cl)CC(=O)O)=O AXLFRXXLVUJAFX-JYRKZWEQSA-N 0.000 claims 1
AXLFRXXLVUJAFX-MMKMLUHNSA-N 2-[(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxo-4-[(1S)-1-(2H-tetrazol-5-yl)butyl]morpholin-2-yl]acetic acid Chemical compound N1N=NN=C1[C@H](CCC)N1C([C@@H](O[C@H]([C@H]1C1=CC=C(C=C1)Cl)C1=CC(=CC=C1)Cl)CC(=O)O)=O AXLFRXXLVUJAFX-MMKMLUHNSA-N 0.000 claims 1
XKUYNNZACAGYEX-KIZRIRGWSA-N 2-[(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(1R)-1-cyanobutyl]-3-oxomorpholin-2-yl]acetic acid Chemical compound ClC=1C=C(C=CC1)[C@@H]1O[C@H](C(N([C@@H]1C1=CC=C(C=C1)Cl)[C@H](CCC)C#N)=O)CC(=O)O XKUYNNZACAGYEX-KIZRIRGWSA-N 0.000 claims 1
QDILNQYTSNQECW-RMVXJAJNSA-N 2-[(2r,5s,6r)-4-[(2r)-1-amino-1-oxopentan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound C1([C@@H]2[C@@H](N(C([C@@H](CC(O)=O)O2)=O)[C@H](CCC)C(N)=O)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 QDILNQYTSNQECW-RMVXJAJNSA-N 0.000 claims 1
QDILNQYTSNQECW-IZZBFERCSA-N 2-[(2r,5s,6r)-4-[(2s)-1-amino-1-oxopentan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound C1([C@@H]2[C@@H](N(C([C@@H](CC(O)=O)O2)=O)[C@@H](CCC)C(N)=O)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 QDILNQYTSNQECW-IZZBFERCSA-N 0.000 claims 1
FWZPXOOPTXRDSU-YFNKSVMNSA-N 2-[(2r,5s,6r)-4-benzyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1=CC=CC=C1 FWZPXOOPTXRDSU-YFNKSVMNSA-N 0.000 claims 1
FFLUYTXQAXBHJM-BAGYTPMASA-N 2-[(2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclobutylmethyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CCC1 FFLUYTXQAXBHJM-BAGYTPMASA-N 0.000 claims 1
VPRNCQLEQWUMOF-YFNKSVMNSA-N 2-[(2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclohexylmethyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CCCCC1 VPRNCQLEQWUMOF-YFNKSVMNSA-N 0.000 claims 1
FTMBFKSFLLFQNY-AKIFATBCSA-N 2-[(2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]-n,n-dimethylacetamide Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CC(=O)N(C)C)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 FTMBFKSFLLFQNY-AKIFATBCSA-N 0.000 claims 1
QDILNQYTSNQECW-JYRKZWEQSA-N 2-[(2s,5r,6s)-4-[(2r)-1-amino-1-oxopentan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound C1([C@H]2[C@H](N(C([C@H](CC(O)=O)O2)=O)[C@H](CCC)C(N)=O)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 QDILNQYTSNQECW-JYRKZWEQSA-N 0.000 claims 1
QDILNQYTSNQECW-MMKMLUHNSA-N 2-[(2s,5r,6s)-4-[(2s)-1-amino-1-oxopentan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound C1([C@H]2[C@H](N(C([C@H](CC(O)=O)O2)=O)[C@@H](CCC)C(N)=O)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 QDILNQYTSNQECW-MMKMLUHNSA-N 0.000 claims 1
FWZPXOOPTXRDSU-QTJGBDASSA-N 2-[(2s,5r,6s)-4-benzyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)CC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1=CC=CC=C1 FWZPXOOPTXRDSU-QTJGBDASSA-N 0.000 claims 1
FFLUYTXQAXBHJM-NNWRFLSQSA-N 2-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclobutylmethyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)CC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CCC1 FFLUYTXQAXBHJM-NNWRFLSQSA-N 0.000 claims 1
VPRNCQLEQWUMOF-QTJGBDASSA-N 2-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclohexylmethyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)CC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CCCCC1 VPRNCQLEQWUMOF-QTJGBDASSA-N 0.000 claims 1
FTMBFKSFLLFQNY-WWNPGLIZSA-N 2-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]-n,n-dimethylacetamide Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)CC(=O)N(C)C)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 FTMBFKSFLLFQNY-WWNPGLIZSA-N 0.000 claims 1
KSWKEATWRRWERE-IEIRFRATSA-N 2-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-5-methyl-3-oxomorpholin-2-yl]acetic acid Chemical compound O=C([C@H](CC(O)=O)O[C@H]([C@@]1(C)C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)N1CC1CC1 KSWKEATWRRWERE-IEIRFRATSA-N 0.000 claims 1
XKUYNNZACAGYEX-MPJJRAAHSA-N 2-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(1s)-1-cyanobutyl]-3-oxomorpholin-2-yl]acetic acid Chemical compound C1([C@H]2[C@H](N(C([C@H](CC(O)=O)O2)=O)[C@H](C#N)CCC)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 XKUYNNZACAGYEX-MPJJRAAHSA-N 0.000 claims 1
VQBIJVGCPBDOQG-RCXJIHSJSA-N 2-[4-[(2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoyl]piperazin-1-yl]acetic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(=O)N2CCN(CC(O)=O)CC2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 VQBIJVGCPBDOQG-RCXJIHSJSA-N 0.000 claims 1
IJRDKLRHAXUUKI-IZSFFQSRSA-N 2-[4-[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]piperazin-1-yl]acetic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)N1CCN(CC(O)=O)CC1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 IJRDKLRHAXUUKI-IZSFFQSRSA-N 0.000 claims 1
VQBIJVGCPBDOQG-UCGXPXSYSA-N 2-[4-[(2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoyl]piperazin-1-yl]acetic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(=O)N2CCN(CC(O)=O)CC2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 VQBIJVGCPBDOQG-UCGXPXSYSA-N 0.000 claims 1
IJRDKLRHAXUUKI-NTQAFHMMSA-N 2-[4-[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]piperazin-1-yl]acetic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)N1CCN(CC(O)=O)CC1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 IJRDKLRHAXUUKI-NTQAFHMMSA-N 0.000 claims 1
NJPCNMAIFNVBLQ-GEEWNISJSA-N 2-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]-methylamino]acetic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)N(C)CC(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 NJPCNMAIFNVBLQ-GEEWNISJSA-N 0.000 claims 1
MMWOGKGDLMPDNR-TZRRMPRUSA-N 2-[[(2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxomorpholin-2-yl]methyl]benzonitrile Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1C#N MMWOGKGDLMPDNR-TZRRMPRUSA-N 0.000 claims 1
NJPCNMAIFNVBLQ-IXGYBEARSA-N 2-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]-methylamino]acetic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)N(C)CC(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 NJPCNMAIFNVBLQ-IXGYBEARSA-N 0.000 claims 1
MMWOGKGDLMPDNR-VXNXHJTFSA-N 2-[[(2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxomorpholin-2-yl]methyl]benzonitrile Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1C#N MMWOGKGDLMPDNR-VXNXHJTFSA-N 0.000 claims 1
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
XABBNPPXNJCCLT-LEWJYISDSA-N 3-[(2r,3s)-3-(4-chlorophenyl)-4-(cyclopropylmethyl)-5-oxomorpholin-2-yl]benzonitrile Chemical compound C1=CC(Cl)=CC=C1[C@@H]1N(CC2CC2)C(=O)CO[C@@H]1C1=CC=CC(C#N)=C1 XABBNPPXNJCCLT-LEWJYISDSA-N 0.000 claims 1
IYPPDCFULNNMSW-BHIFYINESA-N 3-[(2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]propanenitrile Chemical compound C1=CC(Cl)=CC=C1[C@@H]1N(CC2CC2)C(=O)[C@@H](CCC#N)O[C@@H]1C1=CC=CC(Cl)=C1 IYPPDCFULNNMSW-BHIFYINESA-N 0.000 claims 1
RTDZBLVTLREENZ-BAGYTPMASA-N 3-[(2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]propanoic acid Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CCC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 RTDZBLVTLREENZ-BAGYTPMASA-N 0.000 claims 1
XABBNPPXNJCCLT-RTWAWAEBSA-N 3-[(2s,3r)-3-(4-chlorophenyl)-4-(cyclopropylmethyl)-5-oxomorpholin-2-yl]benzonitrile Chemical compound C1=CC(Cl)=CC=C1[C@H]1N(CC2CC2)C(=O)CO[C@H]1C1=CC=CC(C#N)=C1 XABBNPPXNJCCLT-RTWAWAEBSA-N 0.000 claims 1
IYPPDCFULNNMSW-BDTNDASRSA-N 3-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]propanenitrile Chemical compound C1=CC(Cl)=CC=C1[C@H]1N(CC2CC2)C(=O)[C@H](CCC#N)O[C@H]1C1=CC=CC(Cl)=C1 IYPPDCFULNNMSW-BDTNDASRSA-N 0.000 claims 1
RTDZBLVTLREENZ-NNWRFLSQSA-N 3-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]propanoic acid Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)CCC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 RTDZBLVTLREENZ-NNWRFLSQSA-N 0.000 claims 1
DLHUKVSGVNYFLF-MVNQZMKCSA-N 3-[4-[(2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoyl]piperazin-1-yl]propanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(=O)N2CCN(CCC(O)=O)CC2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 DLHUKVSGVNYFLF-MVNQZMKCSA-N 0.000 claims 1
DLHUKVSGVNYFLF-MSLLRLGPSA-N 3-[4-[(2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoyl]piperazin-1-yl]propanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(=O)N2CCN(CCC(O)=O)CC2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 DLHUKVSGVNYFLF-MSLLRLGPSA-N 0.000 claims 1
BTJPJTMEFRMSFV-FOVJLYNBSA-N 3-[[(2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentyl]amino]-3-oxopropanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CNC(=O)CC(O)=O)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 BTJPJTMEFRMSFV-FOVJLYNBSA-N 0.000 claims 1
ZDMBTZRSVDIRDM-ATIZSFMBSA-N 3-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-2,2-dimethylpropanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NCC(C)(C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 ZDMBTZRSVDIRDM-ATIZSFMBSA-N 0.000 claims 1
HCLAPAZXKFMQQR-ZIMFAVFZSA-N 3-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-iodophenyl)methyl]-5-oxomorpholin-4-yl]pentyl]amino]-3-oxopropanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CNC(=O)CC(O)=O)CCC)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 HCLAPAZXKFMQQR-ZIMFAVFZSA-N 0.000 claims 1
GFOZQYQHUOXZGF-XPWALMASSA-N 3-[[(2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxomorpholin-2-yl]methyl]benzoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC(C(O)=O)=C1 GFOZQYQHUOXZGF-XPWALMASSA-N 0.000 claims 1
RVNLWHXLSQTBHF-TZRRMPRUSA-N 3-[[(2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxomorpholin-2-yl]methyl]benzonitrile Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC(C#N)=C1 RVNLWHXLSQTBHF-TZRRMPRUSA-N 0.000 claims 1
BTJPJTMEFRMSFV-WDJPJFJCSA-N 3-[[(2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentyl]amino]-3-oxopropanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CNC(=O)CC(O)=O)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 BTJPJTMEFRMSFV-WDJPJFJCSA-N 0.000 claims 1
ZDMBTZRSVDIRDM-RRGQHJHPSA-N 3-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-2,2-dimethylpropanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)NCC(C)(C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 ZDMBTZRSVDIRDM-RRGQHJHPSA-N 0.000 claims 1
HCLAPAZXKFMQQR-FKPPXMAGSA-N 3-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-iodophenyl)methyl]-5-oxomorpholin-4-yl]pentyl]amino]-3-oxopropanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CNC(=O)CC(O)=O)CCC)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 HCLAPAZXKFMQQR-FKPPXMAGSA-N 0.000 claims 1
GFOZQYQHUOXZGF-ZRBLBEILSA-N 3-[[(2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxomorpholin-2-yl]methyl]benzoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC(C(O)=O)=C1 GFOZQYQHUOXZGF-ZRBLBEILSA-N 0.000 claims 1
RVNLWHXLSQTBHF-VXNXHJTFSA-N 3-[[(2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxomorpholin-2-yl]methyl]benzonitrile Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC(C#N)=C1 RVNLWHXLSQTBHF-VXNXHJTFSA-N 0.000 claims 1
125000006275 3-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C([H])C(*)=C1[H] 0.000 claims 1
ZSPKXEAKOCYIAX-UHFFFAOYSA-N 4-[(4-iodophenyl)methyl]morpholin-3-one Chemical compound C1=CC(I)=CC=C1CN1C(=O)COCC1 ZSPKXEAKOCYIAX-UHFFFAOYSA-N 0.000 claims 1
ATFUGFUUNIXVJV-RAVGUYNFSA-N 4-[[(2S,5R,6S)-5,6-bis(4-chlorophenyl)-3-oxo-4-[(1R)-1-(2H-tetrazol-5-yl)butyl]morpholin-2-yl]methyl]benzonitrile Chemical compound CCC[C@@H](N1[C@@H]([C@@H](O[C@@H](Cc2ccc(cc2)C#N)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1nnn[nH]1 ATFUGFUUNIXVJV-RAVGUYNFSA-N 0.000 claims 1
IOBJPQJJXSHZBT-HUAAZGBFSA-N 4-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]butanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NCCCC(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 IOBJPQJJXSHZBT-HUAAZGBFSA-N 0.000 claims 1
YUHWFYBTXQQXNJ-JJILFORISA-N 4-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-iodophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]butanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NCCCC(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 YUHWFYBTXQQXNJ-JJILFORISA-N 0.000 claims 1
ILWAHSOWRYCOHU-HUAAZGBFSA-N 4-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]butanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NCCCC(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(C)(=O)=O)C=C1 ILWAHSOWRYCOHU-HUAAZGBFSA-N 0.000 claims 1
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JP2015558205A 2013-02-19 2014-02-18 癌の治療のためのｍｄｍ２阻害剤としてのシス−モルホリノン及び他の化合物 Active JP6417338B2 (ja)