JP2016508504A - 対象に対する抗アクチビン−a化合物の投与 - Google Patents
対象に対する抗アクチビン−a化合物の投与 Download PDFInfo
- Publication number
- JP2016508504A JP2016508504A JP2015556210A JP2015556210A JP2016508504A JP 2016508504 A JP2016508504 A JP 2016508504A JP 2015556210 A JP2015556210 A JP 2015556210A JP 2015556210 A JP2015556210 A JP 2015556210A JP 2016508504 A JP2016508504 A JP 2016508504A
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- Prior art keywords
- residue
- activin
- sequence
- polypeptide
- subject
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1796—Receptors; Cell surface antigens; Cell surface determinants for hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Analytical Chemistry (AREA)
- Dermatology (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361759961P | 2013-02-01 | 2013-02-01 | |
US61/759,961 | 2013-02-01 | ||
US201361815220P | 2013-04-23 | 2013-04-23 | |
US61/815,220 | 2013-04-23 | ||
PCT/US2014/014490 WO2014121221A1 (en) | 2013-02-01 | 2014-02-03 | Administration of an anti-activin-a compound to a subject |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016508504A true JP2016508504A (ja) | 2016-03-22 |
JP2016508504A5 JP2016508504A5 (zh) | 2017-03-09 |
Family
ID=51263035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015556210A Pending JP2016508504A (ja) | 2013-02-01 | 2014-02-03 | 対象に対する抗アクチビン−a化合物の投与 |
Country Status (15)
Country | Link |
---|---|
US (3) | US20150359850A1 (zh) |
EP (2) | EP3985024A1 (zh) |
JP (1) | JP2016508504A (zh) |
KR (1) | KR20150136061A (zh) |
CN (1) | CN105431455A (zh) |
AU (1) | AU2014212014A1 (zh) |
CA (1) | CA2899889A1 (zh) |
CL (1) | CL2015002116A1 (zh) |
EA (1) | EA201591423A1 (zh) |
HK (1) | HK1218553A1 (zh) |
IL (1) | IL240139A0 (zh) |
MX (1) | MX2015009901A (zh) |
PH (1) | PH12015501709A1 (zh) |
SG (2) | SG11201505960VA (zh) |
WO (1) | WO2014121221A1 (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2780368T3 (en) | 2011-11-14 | 2018-02-05 | Regeneron Pharma | COMPOSITIONS AND PROCEDURES FOR INCREASING MUSCLE MASS AND MUSCLE STRENGTH BY SPECIFIC ANTAGONIZATION OF GDF8 AND / OR ACTIVIN A |
MX2015009901A (es) | 2013-02-01 | 2016-04-06 | Santa Maria Biotherapeutics Inc | Administración de un compuesto de antiactivina a a un sujeto. |
TWI655207B (zh) | 2013-07-30 | 2019-04-01 | 再生元醫藥公司 | 抗活化素a之抗體及其用途 |
EA201692568A1 (ru) * | 2014-06-13 | 2017-05-31 | Санта Мария Биотерапевтикс, Инк. | Составы с полипептидами-рецепторами и связанные с ними способы |
PL3286206T3 (pl) * | 2015-04-22 | 2021-09-13 | Biogen Ma Inc. | Nowe hybrydowe białka pułapki na ligand actriib do leczenia chorób powodujących zanik mięśni |
US11357851B2 (en) * | 2015-11-11 | 2022-06-14 | Novartis Ag | Uses of myostatin antagonists, combinations containing them and uses thereof |
EA201992350A1 (ru) | 2017-04-05 | 2020-03-23 | Симфоген А/С | Комбинированные лекарственные средства, нацеленные на pd-1, tim-3 и lag-3 |
MA52417A (fr) | 2018-03-01 | 2021-01-06 | Regeneron Pharma | Procédés de modification de composition corporelle |
CN116948028B (zh) * | 2023-09-20 | 2023-11-28 | 北京合源汇丰医药科技有限公司 | 一种抗抑制素抗体及其应用 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009506791A (ja) * | 2005-09-07 | 2009-02-19 | アムジェン フレモント インコーポレイティッド | アクチビン受容体様キナーゼ−1に対するヒトモノクローナル抗体 |
JP2010502740A (ja) * | 2006-09-08 | 2010-01-28 | アムジエン・インコーポレーテツド | 抗アクチビンa抗体およびその使用 |
JP2010519931A (ja) * | 2007-03-06 | 2010-06-10 | アムジェン インコーポレイテッド | バリアントアクチビン受容体ポリペプチドおよびその使用 |
JP2010539236A (ja) * | 2007-09-18 | 2010-12-16 | アクセルロン ファーマ, インコーポレイテッド | アクチビン−ActRIIa拮抗薬およびFSH分泌を低減または阻害するための使用 |
JP2012509687A (ja) * | 2008-11-26 | 2012-04-26 | アムジエン・インコーポレーテツド | アクチビンiib受容体ポリペプチドの変異体及びその使用 |
WO2012064771A1 (en) * | 2010-11-08 | 2012-05-18 | Acceleron Pharma, Inc. | Actriia binding agents and uses thereof |
US20120328595A1 (en) * | 2007-03-06 | 2012-12-27 | Jeonghoon Sun | Variant activin receptor polypeptides and uses thereof |
JP2015505859A (ja) * | 2011-12-19 | 2015-02-26 | アムジエン・インコーポレーテツド | 単独でのまたは化学療法と組み合わされた変異アクチビン受容体ポリペプチド、およびその使用 |
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CA2899889A1 (en) | 2014-08-07 |
EP2951205B1 (en) | 2021-08-11 |
US20230201231A1 (en) | 2023-06-29 |
CN105431455A (zh) | 2016-03-23 |
MX2015009901A (es) | 2016-04-06 |
AU2014212014A1 (en) | 2015-08-27 |
WO2014121221A1 (en) | 2014-08-07 |
EA201591423A1 (ru) | 2016-01-29 |
US11541070B2 (en) | 2023-01-03 |
EP3985024A1 (en) | 2022-04-20 |
HK1218553A1 (zh) | 2017-02-24 |
IL240139A0 (en) | 2015-09-24 |
KR20150136061A (ko) | 2015-12-04 |
EP2951205A4 (en) | 2016-09-07 |
PH12015501709A1 (en) | 2015-10-19 |
EP2951205A1 (en) | 2015-12-09 |
US20200108085A1 (en) | 2020-04-09 |
WO2014121221A8 (en) | 2015-12-23 |
CL2015002116A1 (es) | 2016-05-27 |
SG10201706148WA (en) | 2017-08-30 |
US20150359850A1 (en) | 2015-12-17 |
SG11201505960VA (en) | 2015-08-28 |
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