JP2016508145A5 - - Google Patents
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- Publication number
- JP2016508145A5 JP2016508145A5 JP2015551200A JP2015551200A JP2016508145A5 JP 2016508145 A5 JP2016508145 A5 JP 2016508145A5 JP 2015551200 A JP2015551200 A JP 2015551200A JP 2015551200 A JP2015551200 A JP 2015551200A JP 2016508145 A5 JP2016508145 A5 JP 2016508145A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- group
- inhibitor
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 14
- 239000003446 ligand Substances 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 239000013078 crystal Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 206010022000 influenza Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 claims 2
- 101800004538 Bradykinin Proteins 0.000 claims 2
- JGLMVXWAHNTPRF-CMDGGOBGSA-N CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O Chemical compound CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O JGLMVXWAHNTPRF-CMDGGOBGSA-N 0.000 claims 2
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 claims 2
- 102100035792 Kininogen-1 Human genes 0.000 claims 2
- 239000000867 Lipoxygenase Inhibitor Substances 0.000 claims 2
- 229940122142 Lipoxygenase inhibitor Drugs 0.000 claims 2
- -1 M2 channel inhibitor Substances 0.000 claims 2
- 229940123424 Neuraminidase inhibitor Drugs 0.000 claims 2
- 229940123066 Polymerase inhibitor Drugs 0.000 claims 2
- 239000003888 alpha glucosidase inhibitor Substances 0.000 claims 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims 2
- 229930003827 cannabinoid Natural products 0.000 claims 2
- 239000003557 cannabinoid Substances 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229940125400 channel inhibitor Drugs 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 239000002911 sialidase inhibitor Substances 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- 238000003419 tautomerization reaction Methods 0.000 claims 2
- 125000001960 7 membered carbocyclic group Chemical group 0.000 claims 1
- 241000712892 Arenaviridae Species 0.000 claims 1
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- 241000711573 Coronaviridae Species 0.000 claims 1
- 102100031780 Endonuclease Human genes 0.000 claims 1
- 108010042407 Endonucleases Proteins 0.000 claims 1
- 241000711950 Filoviridae Species 0.000 claims 1
- 241000710781 Flaviviridae Species 0.000 claims 1
- 241000700586 Herpesviridae Species 0.000 claims 1
- 241000712464 Orthomyxoviridae Species 0.000 claims 1
- 241000711504 Paramyxoviridae Species 0.000 claims 1
- 241000150350 Peribunyaviridae Species 0.000 claims 1
- 241000709664 Picornaviridae Species 0.000 claims 1
- 241000712907 Retroviridae Species 0.000 claims 1
- 241000711931 Rhabdoviridae Species 0.000 claims 1
- 241000710924 Togaviridae Species 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000002866 fluorescence resonance energy transfer Methods 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical group 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361750023P | 2013-01-08 | 2013-01-08 | |
| US61/750,023 | 2013-01-08 | ||
| PCT/EP2014/050166 WO2014108407A1 (en) | 2013-01-08 | 2014-01-07 | Pyridone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016508145A JP2016508145A (ja) | 2016-03-17 |
| JP2016508145A5 true JP2016508145A5 (en:Method) | 2017-02-16 |
Family
ID=50070508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015551200A Pending JP2016508145A (ja) | 2013-01-08 | 2014-01-07 | ピリドン誘導体及びウイルス性疾患の治療、改善又は予防におけるそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8952039B2 (en:Method) |
| EP (1) | EP2943469A1 (en:Method) |
| JP (1) | JP2016508145A (en:Method) |
| KR (1) | KR20150103034A (en:Method) |
| CN (1) | CN104903294A (en:Method) |
| BR (1) | BR112015016184A2 (en:Method) |
| CA (1) | CA2894452A1 (en:Method) |
| HK (2) | HK1211287A1 (en:Method) |
| MX (1) | MX2015008288A (en:Method) |
| RU (1) | RU2015125570A (en:Method) |
| WO (1) | WO2014108407A1 (en:Method) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ736259A (en) | 2015-04-28 | 2019-09-27 | Shionogi & Co | Substituted polycyclic pyridone derivative and prodrugs thereof |
| LT3290424T (lt) | 2015-04-28 | 2023-03-10 | Shionogi & Co., Ltd | Pakeisto policiklinio piridono dariniai ir jo provaistas |
| KR102084109B1 (ko) | 2015-12-15 | 2020-03-03 | 시오노기세야쿠 가부시키가이샤 | 캡 의존적 엔도뉴클레아제 저해제 및 항인플루엔자 약을 조합하는 것을 특징으로 하는 인플루엔자 치료용 의약 |
| WO2017106820A1 (en) | 2015-12-17 | 2017-06-22 | Thomas Jefferson University | Antiviral agents for drug-resistant influenza a |
| US10889556B2 (en) * | 2016-03-08 | 2021-01-12 | The Regents Of The University Of California | Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease |
| CR20190123A (es) | 2016-08-10 | 2019-04-30 | Shionogi & Co | Composiciones farmacéuticas que contienen derivados de piridona policíclicos sustituídos y profármacos de los mismos |
| BR112022010924A2 (pt) | 2019-12-06 | 2022-09-06 | Vertex Pharma | Tetra-hidrofuranos substituídos como moduladores de canais de sódio |
| KR20240031300A (ko) | 2021-06-04 | 2024-03-07 | 버텍스 파마슈티칼스 인코포레이티드 | 나트륨 채널 조절제로서의 n-(하이드록시알킬 (헤테로)아릴) 테트라하이드로푸란 카르복스아미드 |
| TW202404969A (zh) | 2022-04-22 | 2024-02-01 | 美商維泰克斯製藥公司 | 用於治療疼痛之雜芳基化合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5475109A (en) | 1994-10-17 | 1995-12-12 | Merck & Co., Inc. | Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease |
| US20070155744A1 (en) | 2004-01-30 | 2007-07-05 | Istituto Di Ricerche Di Biologia Molecolare P, Angeletti S.P.A. | N-benzyl-3,4-dihyroxypyridine-2-carboxamide and n-benzyl-2,3-dihydroxypyridine-4- carboxamide compounds useful as hiv integrase inhibitors |
| EP1790638B1 (en) | 2004-09-15 | 2013-04-03 | Shionogi Co., Ltd. | Carbamoylpyridone derivative having hiv integrase inhibitory activity |
| US20070072831A1 (en) | 2005-05-16 | 2007-03-29 | Gilead Sciences, Inc. | Integrase inhibitor compounds |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| JP5697163B2 (ja) * | 2009-03-26 | 2015-04-08 | 塩野義製薬株式会社 | 置換された３−ヒドロキシ−４−ピリドン誘導体 |
| WO2011000566A2 (en) | 2009-06-30 | 2011-01-06 | Savira Pharmaceuticals Gmbh | Compounds and pharmaceutical compositions for the treatment of negative-sense ssrna virus infections |
-
2014
- 2014-01-07 BR BR112015016184A patent/BR112015016184A2/pt not_active IP Right Cessation
- 2014-01-07 KR KR1020157017812A patent/KR20150103034A/ko not_active Withdrawn
- 2014-01-07 CA CA2894452A patent/CA2894452A1/en not_active Abandoned
- 2014-01-07 US US14/149,218 patent/US8952039B2/en not_active Expired - Fee Related
- 2014-01-07 HK HK15112096.1A patent/HK1211287A1/xx unknown
- 2014-01-07 CN CN201480004181.3A patent/CN104903294A/zh active Pending
- 2014-01-07 MX MX2015008288A patent/MX2015008288A/es unknown
- 2014-01-07 RU RU2015125570A patent/RU2015125570A/ru not_active Application Discontinuation
- 2014-01-07 WO PCT/EP2014/050166 patent/WO2014108407A1/en not_active Ceased
- 2014-01-07 JP JP2015551200A patent/JP2016508145A/ja active Pending
- 2014-01-07 EP EP14703276.7A patent/EP2943469A1/en not_active Withdrawn
- 2014-01-07 HK HK16100551.3A patent/HK1212688A1/zh unknown
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