JP2016506933A5 - - Google Patents
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- JP2016506933A5 JP2016506933A5 JP2015555445A JP2015555445A JP2016506933A5 JP 2016506933 A5 JP2016506933 A5 JP 2016506933A5 JP 2015555445 A JP2015555445 A JP 2015555445A JP 2015555445 A JP2015555445 A JP 2015555445A JP 2016506933 A5 JP2016506933 A5 JP 2016506933A5
- Authority
- JP
- Japan
- Prior art keywords
- item
- composition
- treatment
- use according
- naltrexone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000011282 treatment Methods 0.000 claims description 49
- 230000001430 anti-depressive effect Effects 0.000 claims description 46
- 239000000935 antidepressant agent Substances 0.000 claims description 42
- 229940005513 antidepressants Drugs 0.000 claims description 42
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims description 36
- 229960003086 naltrexone Drugs 0.000 claims description 36
- 208000024714 major depressive disease Diseases 0.000 claims description 8
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical group C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 claims description 5
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 claims description 5
- 229960004372 aripiprazole Drugs 0.000 claims description 5
- 229960001058 bupropion Drugs 0.000 claims description 5
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical group CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims description 5
- 229960003089 pramipexole Drugs 0.000 claims description 5
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical group C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 claims description 5
- 229960002073 sertraline Drugs 0.000 claims description 5
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims description 5
- 239000003136 dopamine receptor stimulating agent Substances 0.000 claims 7
- 229940005501 dopaminergic agent Drugs 0.000 claims 7
- DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical group C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 claims 1
- 229960001344 methylphenidate Drugs 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 93
- 230000003291 dopaminomimetic effect Effects 0.000 description 24
- 230000002265 prevention Effects 0.000 description 20
- 229940121991 Serotonin and norepinephrine reuptake inhibitor Drugs 0.000 description 19
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 19
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 19
- 239000003775 serotonin noradrenalin reuptake inhibitor Substances 0.000 description 19
- 208000028552 Treatment-Resistant Depressive disease Diseases 0.000 description 14
- 239000003623 enhancer Substances 0.000 description 11
- 102000015554 Dopamine receptor Human genes 0.000 description 8
- 108050004812 Dopamine receptor Proteins 0.000 description 8
- 229960001653 citalopram Drugs 0.000 description 8
- -1 s-citalopram Chemical compound 0.000 description 8
- 239000002552 dosage form Substances 0.000 description 6
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 description 4
- GJJFMKBJSRMPLA-HIFRSBDPSA-N (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecarboxamide Chemical compound C=1C=CC=CC=1[C@@]1(C(=O)N(CC)CC)C[C@@H]1CN GJJFMKBJSRMPLA-HIFRSBDPSA-N 0.000 description 4
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 description 4
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 description 4
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 description 4
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 description 4
- USRHYDPUVLEVMC-FQEVSTJZSA-N dapoxetine Chemical compound C1([C@H](CCOC=2C3=CC=CC=C3C=CC=2)N(C)C)=CC=CC=C1 USRHYDPUVLEVMC-FQEVSTJZSA-N 0.000 description 4
- 229960005217 dapoxetine Drugs 0.000 description 4
- 238000000586 desensitisation Methods 0.000 description 4
- 229960002866 duloxetine Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229960002464 fluoxetine Drugs 0.000 description 4
- 229960004038 fluvoxamine Drugs 0.000 description 4
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 description 4
- 229960000600 milnacipran Drugs 0.000 description 4
- 229960001800 nefazodone Drugs 0.000 description 4
- VRBKIVRKKCLPHA-UHFFFAOYSA-N nefazodone Chemical compound O=C1N(CCOC=2C=CC=CC=2)C(CC)=NN1CCCN(CC1)CCN1C1=CC=CC(Cl)=C1 VRBKIVRKKCLPHA-UHFFFAOYSA-N 0.000 description 4
- 229960002296 paroxetine Drugs 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 229960001879 ropinirole Drugs 0.000 description 4
- UHSKFQJFRQCDBE-UHFFFAOYSA-N ropinirole Chemical compound CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 UHSKFQJFRQCDBE-UHFFFAOYSA-N 0.000 description 4
- 238000011269 treatment regimen Methods 0.000 description 4
- 229960004688 venlafaxine Drugs 0.000 description 4
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 4
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000006186 oral dosage form Substances 0.000 description 2
- 239000006203 subcutaneous dosage form Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- 229940126570 serotonin reuptake inhibitor Drugs 0.000 description 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361758551P | 2013-01-30 | 2013-01-30 | |
| US61/758,551 | 2013-01-30 | ||
| US201361814476P | 2013-04-22 | 2013-04-22 | |
| US61/814,476 | 2013-04-22 | ||
| PCT/US2014/013874 WO2014120936A2 (en) | 2013-01-30 | 2014-01-30 | Treatments for depression and other diseases with a low dose agent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016506933A JP2016506933A (ja) | 2016-03-07 |
| JP2016506933A5 true JP2016506933A5 (https=) | 2017-02-16 |
| JP6406713B2 JP6406713B2 (ja) | 2018-10-17 |
Family
ID=51263114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015555445A Expired - Fee Related JP6406713B2 (ja) | 2013-01-30 | 2014-01-30 | 低用量薬剤によるうつ病および他の疾患の処置 |
Country Status (7)
| Country | Link |
|---|---|
| US (7) | US20150342946A1 (https=) |
| EP (1) | EP2950799B1 (https=) |
| JP (1) | JP6406713B2 (https=) |
| CN (1) | CN104955483A (https=) |
| CA (1) | CA2899455C (https=) |
| HK (1) | HK1212254A1 (https=) |
| WO (1) | WO2014120936A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2694352T3 (es) | 2013-12-20 | 2018-12-20 | H. Lundbeck A/S | Uso de un antagonista del receptor opioide con actividad kappa, y vortioxetina para el tratamiento del trastorno depresivo con características melancólicas |
| MX2016013889A (es) | 2014-04-22 | 2017-03-09 | Otsuka Pharma Co Ltd | Medicamento. |
| US9616068B2 (en) | 2014-10-27 | 2017-04-11 | Pohela LLC | Animal training using cognitive enhancement |
| EP3939570A1 (en) * | 2016-02-18 | 2022-01-19 | Immune Therapeutics, Inc. | Naltrexone for treating or preventing autoimmune and inflammatory diseases |
| WO2018200381A1 (en) * | 2017-04-25 | 2018-11-01 | Temple Otorongo Llc | Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| KR20210110654A (ko) * | 2019-01-07 | 2021-09-08 | 안테씨프 바이오벤쳐스 투 엘엘씨 | 우울증 치료를 위한 덱스트로메토르판과 부프로피온의 조합 |
| WO2020168337A1 (en) | 2019-02-17 | 2020-08-20 | Magid Abraham | Compositions and methods for treatment of depression and other disorders |
| EP3999058A4 (en) | 2019-07-19 | 2023-05-03 | Bioxcel Therapeutics, Inc. | NON-SEDATIVE DEXMEDETOMIDINE-BASED TREATMENT REGIMEN |
| IL303117A (en) * | 2020-11-27 | 2023-07-01 | Trexapharm Pty Ltd | Preparations containing flumazenil and naltrexone and methods of using them |
| GB202109022D0 (en) * | 2021-06-23 | 2021-08-04 | Ldn Pharma Ltd | Compositions comprising an agonist of 5-hydroxytryptamine (5-ht) receptor subtype 2a, 2b or 2c |
| CA3224257A1 (en) * | 2021-07-02 | 2023-01-05 | Michael De Vivo | Methods for treating depressive states |
| US12156914B2 (en) * | 2022-06-30 | 2024-12-03 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising bupropion and cysteine |
| US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
| US12565478B1 (en) | 2025-01-21 | 2026-03-03 | Axsome Therapeutics, Inc. | (S)-2-((S)-(2-ethoxyphenoxy)(phenyl)methyl)-4-nitrosomorpholine |
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| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
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-
2014
- 2014-01-30 WO PCT/US2014/013874 patent/WO2014120936A2/en not_active Ceased
- 2014-01-30 CA CA2899455A patent/CA2899455C/en active Active
- 2014-01-30 US US14/410,551 patent/US20150342946A1/en not_active Abandoned
- 2014-01-30 HK HK16100404.2A patent/HK1212254A1/xx unknown
- 2014-01-30 JP JP2015555445A patent/JP6406713B2/ja not_active Expired - Fee Related
- 2014-01-30 EP EP14746250.1A patent/EP2950799B1/en active Active
- 2014-01-30 CN CN201480006714.1A patent/CN104955483A/zh active Pending
-
2015
- 2015-03-05 US US14/639,797 patent/US9278094B2/en active Active
-
2016
- 2016-01-28 US US15/009,415 patent/US20160310484A1/en not_active Abandoned
-
2018
- 2018-07-10 US US16/031,662 patent/US20180318289A1/en not_active Abandoned
-
2019
- 2019-04-09 US US16/379,042 patent/US20190231772A1/en not_active Abandoned
- 2019-07-23 US US16/519,638 patent/US20190343829A1/en not_active Abandoned
-
2020
- 2020-03-05 US US16/810,188 patent/US20200197388A1/en not_active Abandoned
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