JP2016506750A5 - - Google Patents
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- JP2016506750A5 JP2016506750A5 JP2015557201A JP2015557201A JP2016506750A5 JP 2016506750 A5 JP2016506750 A5 JP 2016506750A5 JP 2015557201 A JP2015557201 A JP 2015557201A JP 2015557201 A JP2015557201 A JP 2015557201A JP 2016506750 A5 JP2016506750 A5 JP 2016506750A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- shared
- library
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 35
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 20
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 18
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 16
- 230000003321 amplification Effects 0.000 claims description 16
- 201000010099 disease Diseases 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 16
- 210000000265 leukocyte Anatomy 0.000 claims description 14
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 12
- 210000004027 cell Anatomy 0.000 claims description 11
- 108091093088 Amplicon Proteins 0.000 claims description 10
- 230000008707 rearrangement Effects 0.000 claims description 6
- 229960005486 vaccine Drugs 0.000 claims description 6
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims description 4
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 4
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 4
- 210000003519 mature b lymphocyte Anatomy 0.000 claims description 4
- 210000001806 memory b lymphocyte Anatomy 0.000 claims description 4
- 210000003071 memory t lymphocyte Anatomy 0.000 claims description 4
- 238000005070 sampling Methods 0.000 claims description 4
- 238000012163 sequencing technique Methods 0.000 claims description 4
- 108091008874 T cell receptors Proteins 0.000 claims description 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 2
- 230000001186 cumulative effect Effects 0.000 claims description 2
- 238000000684 flow cytometry Methods 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 108091033319 polynucleotide Proteins 0.000 claims description 2
- 102000040430 polynucleotide Human genes 0.000 claims description 2
- 239000002157 polynucleotide Substances 0.000 claims description 2
- 108020003175 receptors Proteins 0.000 claims description 2
- 238000003757 reverse transcription PCR Methods 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361763451P | 2013-02-11 | 2013-02-11 | |
| US61/763,451 | 2013-02-11 | ||
| PCT/US2014/015841 WO2014124451A1 (en) | 2013-02-11 | 2014-02-11 | Method for evaluating an immunorepertoire |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016506750A JP2016506750A (ja) | 2016-03-07 |
| JP2016506750A5 true JP2016506750A5 (enExample) | 2017-03-09 |
| JP6460343B2 JP6460343B2 (ja) | 2019-01-30 |
Family
ID=51300201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015557201A Active JP6460343B2 (ja) | 2013-02-11 | 2014-02-11 | 免疫レパートリーを評価するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20160034637A1 (enExample) |
| EP (1) | EP2954070B1 (enExample) |
| JP (1) | JP6460343B2 (enExample) |
| KR (1) | KR102228488B1 (enExample) |
| CN (1) | CN105164277B (enExample) |
| CA (1) | CA2900776C (enExample) |
| ES (1) | ES2798119T3 (enExample) |
| PT (1) | PT2954070T (enExample) |
| WO (1) | WO2014124451A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016144776A1 (en) * | 2015-03-06 | 2016-09-15 | Cb Biotechnologies, Inc. | Method for measuring a change in an individual's immunorepertoire |
| US20160333409A1 (en) * | 2015-03-09 | 2016-11-17 | Cb Biotechnologies, Inc. | Method for identifying disease-associated cdr3 patterns in an immune repertoire |
| US11047011B2 (en) * | 2015-09-29 | 2021-06-29 | iRepertoire, Inc. | Immunorepertoire normality assessment method and its use |
| WO2017193097A1 (en) | 2016-05-06 | 2017-11-09 | Girihlet Inc. | Methods and compositions for determining specifc tcr and bcr chain pairings |
| CN106283201B (zh) * | 2016-09-20 | 2019-08-06 | 中国医学科学院肿瘤医院 | 基于高通量测序的tcr多样性检测和文库构建 |
| US20200199650A1 (en) * | 2017-05-18 | 2020-06-25 | Geneplus－Beijing | Analysis system for peripheral blood-based non-invasive detection of lesion immune repertoire diversity and uses of system |
| WO2019046817A1 (en) * | 2017-09-01 | 2019-03-07 | Life Technologies Corporation | COMPOSITIONS AND METHODS FOR IMMUNOLOGICAL REPERTOIRE SEQUENCING |
| EP3824103A1 (en) | 2018-07-18 | 2021-05-26 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
| WO2020236745A1 (en) * | 2019-05-17 | 2020-11-26 | iRepertoire, Inc. | Immunorepertoire wellness assessment systems and methods |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2257152C (en) * | 1996-06-03 | 2009-01-27 | Linda M. Pilarski | Methods for detection of rearranged dna |
| CN107385040B (zh) | 2008-04-03 | 2022-02-15 | 艾瑞普特公司 | 用于扩增多个靶标的扩增子拯救多重聚合酶链式反应 |
| CN102066578B (zh) * | 2008-04-16 | 2016-07-06 | 哈森阿尔法生物技术研究院 | 用于评价和比较免疫组库的方法 |
| GB2483810B (en) * | 2008-11-07 | 2012-09-05 | Sequenta Inc | Methods for correlating clonotypes with diseases in a population |
| US8691510B2 (en) * | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
| EP3456847B1 (en) | 2010-05-06 | 2024-12-25 | Adaptive Biotechnologies Corporation | Monitoring solid transplant rejection using clonotype profiles |
| CA2796822C (en) * | 2010-05-07 | 2021-10-05 | The Board Of Trustees Of The Leland Standford Junior University | Measurement and comparison of immune diversity by high-throughput sequencing |
| US20120183969A1 (en) | 2011-01-14 | 2012-07-19 | Jian Han | Immunodiversity Assessment Method and Its Use |
| KR20200003235A (ko) * | 2011-09-28 | 2020-01-08 | 씨비 바이오테크놀로지스, 인크. | arm-PCR 및 고속 처리 서열 분석을 이용한 항원 특이적 후천성 면역 반응의 확인 |
| CN106103711A (zh) * | 2013-11-21 | 2016-11-09 | 组库创世纪株式会社 | T细胞受体和b细胞受体库分析系统及其在治疗和诊断中的应用 |
-
2014
- 2014-02-11 US US14/767,178 patent/US20160034637A1/en not_active Abandoned
- 2014-02-11 KR KR1020157023530A patent/KR102228488B1/ko active Active
- 2014-02-11 CN CN201480020810.1A patent/CN105164277B/zh active Active
- 2014-02-11 CA CA2900776A patent/CA2900776C/en active Active
- 2014-02-11 JP JP2015557201A patent/JP6460343B2/ja active Active
- 2014-02-11 PT PT147490957T patent/PT2954070T/pt unknown
- 2014-02-11 EP EP14749095.7A patent/EP2954070B1/en active Active
- 2014-02-11 ES ES14749095T patent/ES2798119T3/es active Active
- 2014-02-11 WO PCT/US2014/015841 patent/WO2014124451A1/en not_active Ceased
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