CA2900776C - Method for evaluating an immunorepertoire - Google Patents

Method for evaluating an immunorepertoire Download PDF

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Publication number
CA2900776C
CA2900776C CA2900776A CA2900776A CA2900776C CA 2900776 C CA2900776 C CA 2900776C CA 2900776 A CA2900776 A CA 2900776A CA 2900776 A CA2900776 A CA 2900776A CA 2900776 C CA2900776 C CA 2900776C
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Prior art keywords
cells
immunoprofile
subject
disease
library
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CA2900776A
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English (en)
French (fr)
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CA2900776A1 (en
Inventor
Chunlin Wang
Jian Han
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Irepertoire Inc
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Irepertoire Inc
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00ICT programming tools or database systems specially adapted for bioinformatics
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/30Data warehousing; Computing architectures
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60In silico combinatorial chemistry
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10Signal processing, e.g. from mass spectrometry [MS] or from PCR

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Theoretical Computer Science (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Databases & Information Systems (AREA)
  • Bioethics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Evolutionary Computation (AREA)
  • Epidemiology (AREA)
  • Data Mining & Analysis (AREA)
  • Software Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Artificial Intelligence (AREA)
  • Computing Systems (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Library & Information Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2900776A 2013-02-11 2014-02-11 Method for evaluating an immunorepertoire Active CA2900776C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361763451P 2013-02-11 2013-02-11
US61/763,451 2013-02-11
PCT/US2014/015841 WO2014124451A1 (en) 2013-02-11 2014-02-11 Method for evaluating an immunorepertoire

Publications (2)

Publication Number Publication Date
CA2900776A1 CA2900776A1 (en) 2014-08-14
CA2900776C true CA2900776C (en) 2023-08-15

Family

ID=51300201

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2900776A Active CA2900776C (en) 2013-02-11 2014-02-11 Method for evaluating an immunorepertoire

Country Status (9)

Country Link
US (1) US20160034637A1 (enExample)
EP (1) EP2954070B1 (enExample)
JP (1) JP6460343B2 (enExample)
KR (1) KR102228488B1 (enExample)
CN (1) CN105164277B (enExample)
CA (1) CA2900776C (enExample)
ES (1) ES2798119T3 (enExample)
PT (1) PT2954070T (enExample)
WO (1) WO2014124451A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016144776A1 (en) * 2015-03-06 2016-09-15 Cb Biotechnologies, Inc. Method for measuring a change in an individual's immunorepertoire
US20160333409A1 (en) * 2015-03-09 2016-11-17 Cb Biotechnologies, Inc. Method for identifying disease-associated cdr3 patterns in an immune repertoire
US11047011B2 (en) * 2015-09-29 2021-06-29 iRepertoire, Inc. Immunorepertoire normality assessment method and its use
WO2017193097A1 (en) 2016-05-06 2017-11-09 Girihlet Inc. Methods and compositions for determining specifc tcr and bcr chain pairings
CN106283201B (zh) * 2016-09-20 2019-08-06 中国医学科学院肿瘤医院 基于高通量测序的tcr多样性检测和文库构建
US20200199650A1 (en) * 2017-05-18 2020-06-25 Geneplus-Beijing Analysis system for peripheral blood-based non-invasive detection of lesion immune repertoire diversity and uses of system
WO2019046817A1 (en) * 2017-09-01 2019-03-07 Life Technologies Corporation COMPOSITIONS AND METHODS FOR IMMUNOLOGICAL REPERTOIRE SEQUENCING
EP3824103A1 (en) 2018-07-18 2021-05-26 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
WO2020236745A1 (en) * 2019-05-17 2020-11-26 iRepertoire, Inc. Immunorepertoire wellness assessment systems and methods

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2257152C (en) * 1996-06-03 2009-01-27 Linda M. Pilarski Methods for detection of rearranged dna
CN107385040B (zh) 2008-04-03 2022-02-15 艾瑞普特公司 用于扩增多个靶标的扩增子拯救多重聚合酶链式反应
CN102066578B (zh) * 2008-04-16 2016-07-06 哈森阿尔法生物技术研究院 用于评价和比较免疫组库的方法
GB2483810B (en) * 2008-11-07 2012-09-05 Sequenta Inc Methods for correlating clonotypes with diseases in a population
US8691510B2 (en) * 2008-11-07 2014-04-08 Sequenta, Inc. Sequence analysis of complex amplicons
EP3456847B1 (en) 2010-05-06 2024-12-25 Adaptive Biotechnologies Corporation Monitoring solid transplant rejection using clonotype profiles
CA2796822C (en) * 2010-05-07 2021-10-05 The Board Of Trustees Of The Leland Standford Junior University Measurement and comparison of immune diversity by high-throughput sequencing
US20120183969A1 (en) 2011-01-14 2012-07-19 Jian Han Immunodiversity Assessment Method and Its Use
KR20200003235A (ko) * 2011-09-28 2020-01-08 씨비 바이오테크놀로지스, 인크. arm-PCR 및 고속 처리 서열 분석을 이용한 항원 특이적 후천성 면역 반응의 확인
CN106103711A (zh) * 2013-11-21 2016-11-09 组库创世纪株式会社 T细胞受体和b细胞受体库分析系统及其在治疗和诊断中的应用

Also Published As

Publication number Publication date
US20160034637A1 (en) 2016-02-04
ES2798119T3 (es) 2020-12-09
HK1212735A1 (zh) 2016-06-17
EP2954070A1 (en) 2015-12-16
CN105164277B (zh) 2021-05-28
JP6460343B2 (ja) 2019-01-30
KR102228488B1 (ko) 2021-03-15
KR20150141939A (ko) 2015-12-21
JP2016506750A (ja) 2016-03-07
EP2954070A4 (en) 2016-10-26
CA2900776A1 (en) 2014-08-14
EP2954070B1 (en) 2020-04-01
PT2954070T (pt) 2020-06-22
CN105164277A (zh) 2015-12-16
WO2014124451A1 (en) 2014-08-14

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