CN105164277B - 用于评估免疫组库的方法 - Google Patents

用于评估免疫组库的方法 Download PDF

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CN105164277B
CN105164277B CN201480020810.1A CN201480020810A CN105164277B CN 105164277 B CN105164277 B CN 105164277B CN 201480020810 A CN201480020810 A CN 201480020810A CN 105164277 B CN105164277 B CN 105164277B
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cdr3
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CN105164277A (zh
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王春林
韩建
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CB BIOTECHNOLOGIES Inc
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/30—Data warehousing; Computing architectures
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR

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CN201480020810.1A 2013-02-11 2014-02-11 用于评估免疫组库的方法 Active CN105164277B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361763451P 2013-02-11 2013-02-11
US61/763,451 2013-02-11
PCT/US2014/015841 WO2014124451A1 (en) 2013-02-11 2014-02-11 Method for evaluating an immunorepertoire

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CN105164277A CN105164277A (zh) 2015-12-16
CN105164277B true CN105164277B (zh) 2021-05-28

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US (1) US20160034637A1 (enExample)
EP (1) EP2954070B1 (enExample)
JP (1) JP6460343B2 (enExample)
KR (1) KR102228488B1 (enExample)
CN (1) CN105164277B (enExample)
CA (1) CA2900776C (enExample)
ES (1) ES2798119T3 (enExample)
PT (1) PT2954070T (enExample)
WO (1) WO2014124451A1 (enExample)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
WO2016144776A1 (en) * 2015-03-06 2016-09-15 Cb Biotechnologies, Inc. Method for measuring a change in an individual's immunorepertoire
US20160333409A1 (en) * 2015-03-09 2016-11-17 Cb Biotechnologies, Inc. Method for identifying disease-associated cdr3 patterns in an immune repertoire
US11047011B2 (en) * 2015-09-29 2021-06-29 iRepertoire, Inc. Immunorepertoire normality assessment method and its use
WO2017193097A1 (en) 2016-05-06 2017-11-09 Girihlet Inc. Methods and compositions for determining specifc tcr and bcr chain pairings
CN106283201B (zh) * 2016-09-20 2019-08-06 中国医学科学院肿瘤医院 基于高通量测序的tcr多样性检测和文库构建
US20200199650A1 (en) * 2017-05-18 2020-06-25 Geneplus－Beijing Analysis system for peripheral blood-based non-invasive detection of lesion immune repertoire diversity and uses of system
WO2019046817A1 (en) * 2017-09-01 2019-03-07 Life Technologies Corporation COMPOSITIONS AND METHODS FOR IMMUNOLOGICAL REPERTOIRE SEQUENCING
EP3824103A1 (en) 2018-07-18 2021-05-26 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
WO2020236745A1 (en) * 2019-05-17 2020-11-26 iRepertoire, Inc. Immunorepertoire wellness assessment systems and methods

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WO2011139371A1 (en) * 2010-05-06 2011-11-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
WO2012097374A1 (en) * 2011-01-14 2012-07-19 Cb Biotechnologies, Inc. Immunodiversity assessment method and its use

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CA2257152C (en) * 1996-06-03 2009-01-27 Linda M. Pilarski Methods for detection of rearranged dna
CN107385040B (zh) 2008-04-03 2022-02-15 艾瑞普特公司 用于扩增多个靶标的扩增子拯救多重聚合酶链式反应
CN102066578B (zh) * 2008-04-16 2016-07-06 哈森阿尔法生物技术研究院 用于评价和比较免疫组库的方法
GB2483810B (en) * 2008-11-07 2012-09-05 Sequenta Inc Methods for correlating clonotypes with diseases in a population
US8691510B2 (en) * 2008-11-07 2014-04-08 Sequenta, Inc. Sequence analysis of complex amplicons
CA2796822C (en) * 2010-05-07 2021-10-05 The Board Of Trustees Of The Leland Standford Junior University Measurement and comparison of immune diversity by high-throughput sequencing
KR20200003235A (ko) * 2011-09-28 2020-01-08 씨비 바이오테크놀로지스, 인크. arm-PCR 및 고속 처리 서열 분석을 이용한 항원 특이적 후천성 면역 반응의 확인
CN106103711A (zh) * 2013-11-21 2016-11-09 组库创世纪株式会社 T细胞受体和b细胞受体库分析系统及其在治疗和诊断中的应用

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2011139371A1 (en) * 2010-05-06 2011-11-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
WO2012097374A1 (en) * 2011-01-14 2012-07-19 Cb Biotechnologies, Inc. Immunodiversity assessment method and its use

Non-Patent Citations (1)

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Title
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US20160034637A1 (en) 2016-02-04
ES2798119T3 (es) 2020-12-09
HK1212735A1 (zh) 2016-06-17
CA2900776C (en) 2023-08-15
EP2954070A1 (en) 2015-12-16
JP6460343B2 (ja) 2019-01-30
KR102228488B1 (ko) 2021-03-15
KR20150141939A (ko) 2015-12-21
JP2016506750A (ja) 2016-03-07
EP2954070A4 (en) 2016-10-26
CA2900776A1 (en) 2014-08-14
EP2954070B1 (en) 2020-04-01
PT2954070T (pt) 2020-06-22
CN105164277A (zh) 2015-12-16
WO2014124451A1 (en) 2014-08-14

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