JP2016505637A5 - - Google Patents
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- Publication number
- JP2016505637A5 JP2016505637A5 JP2015555214A JP2015555214A JP2016505637A5 JP 2016505637 A5 JP2016505637 A5 JP 2016505637A5 JP 2015555214 A JP2015555214 A JP 2015555214A JP 2015555214 A JP2015555214 A JP 2015555214A JP 2016505637 A5 JP2016505637 A5 JP 2016505637A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- alkyl
- cycloalkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361756778P | 2013-01-25 | 2013-01-25 | |
| US61/756,778 | 2013-01-25 | ||
| PCT/US2014/012356 WO2014116593A1 (en) | 2013-01-25 | 2014-01-21 | Novel traps in the treatment of macular degeneration |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505637A JP2016505637A (ja) | 2016-02-25 |
| JP2016505637A5 true JP2016505637A5 (show.php) | 2017-02-23 |
| JP6266023B2 JP6266023B2 (ja) | 2018-01-24 |
Family
ID=51227964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015555214A Expired - Fee Related JP6266023B2 (ja) | 2013-01-25 | 2014-01-21 | 黄斑変性症の処置における新規トラップ |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10111862B2 (show.php) |
| EP (1) | EP2948436A4 (show.php) |
| JP (1) | JP6266023B2 (show.php) |
| KR (1) | KR20150120380A (show.php) |
| CN (1) | CN105228989A (show.php) |
| AU (1) | AU2014209585A1 (show.php) |
| CA (1) | CA2898869A1 (show.php) |
| HK (1) | HK1217490A1 (show.php) |
| IL (1) | IL239736A0 (show.php) |
| MX (1) | MX2015009444A (show.php) |
| RU (1) | RU2015126015A (show.php) |
| SG (1) | SG11201505599YA (show.php) |
| WO (1) | WO2014116593A1 (show.php) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7973025B2 (en) | 2005-05-26 | 2011-07-05 | Neuron Systems, Inc. | Compositions and methods of treating retinal disease |
| CA2782015C (en) | 2009-12-11 | 2020-08-25 | Neuron Systems, Inc. | Topical ophthalmic compositions and methods for the treatment of macular degeneration |
| KR20150118106A (ko) | 2012-12-20 | 2015-10-21 | 알데이라 테라퓨틱스, 아이엔씨. | 페리-카르비놀 |
| HK1217439A1 (zh) | 2013-01-23 | 2017-01-13 | Aldeyra Therapeutics, Inc. | 与毒性醛相关的疾病和治疗 |
| US20170298081A1 (en) * | 2014-08-08 | 2017-10-19 | Kasuma Partners Inc. | Condensed heterocyclic compound |
| MX2018002155A (es) * | 2015-08-21 | 2018-06-08 | Aldeyra Therapeutics Inc | Compuestos deuterados y usos de los mismos. |
| WO2017147617A1 (en) | 2016-02-28 | 2017-08-31 | Aldeyra Therapeutics, Inc. | Treatment of allergic eye conditions with cyclodextrins |
| CA3022665A1 (en) | 2016-05-09 | 2017-11-16 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
| ES2968462T3 (es) | 2017-03-16 | 2024-05-09 | Aldeyra Therapeutics Inc | Sal polimórfica de 6-cloro-3-amino-2(2-hidroxiprolil) quinolina y usos de la misma |
| JP7311162B2 (ja) | 2017-10-10 | 2023-07-19 | アルデイラ セラピューティクス， インコーポレイテッド | 炎症性障害の処置 |
| WO2020033344A1 (en) | 2018-08-06 | 2020-02-13 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| CN115869258A (zh) | 2018-09-25 | 2023-03-31 | 奥尔德拉医疗公司 | 用于治疗干眼病的调配物 |
| US11786518B2 (en) | 2019-03-26 | 2023-10-17 | Aldeyra Therapeutics, Inc. | Ophthalmic formulations and uses thereof |
| WO2020223685A1 (en) | 2019-05-02 | 2020-11-05 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| US12098132B2 (en) | 2019-05-02 | 2024-09-24 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| CN114828857B (zh) * | 2019-09-09 | 2024-11-12 | 联邦高等教育系统-匹兹堡大学 | 通过激活tfeb恢复视网膜色素上皮细胞的溶酶体功能的方法 |
| CN113767090B (zh) * | 2019-12-30 | 2024-05-28 | 中国医药研究开发中心有限公司 | 三环化合物及其制备方法和医药用途 |
| WO2021231792A1 (en) | 2020-05-13 | 2021-11-18 | Aldeyra Therapeutics, Inc. | Pharmaceutical formulations and uses thereof |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2086186A (en) | 1933-10-10 | 1937-07-06 | Us Rubber Co | Treatment of rubber |
| GB1435721A (en) | 1972-05-18 | 1976-05-12 | Lilly Industries Ltd | Benzoxazole derivatives |
| SU509046A1 (ru) | 1975-02-21 | 1984-06-23 | Всесоюзный научно-исследовательский химико-фармацевтический институт им.Серго Орджоникидзе | Производные 2-карбэтокси-3-аминоиндола,про вл ющие противовоспалительную активность, и способ их получени |
| US4675332A (en) | 1984-12-10 | 1987-06-23 | Warner-Lambert Company | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents |
| GB8610981D0 (en) | 1986-05-06 | 1986-06-11 | Ici America Inc | Quinoline amides |
| AU641052B2 (en) | 1990-11-02 | 1993-09-09 | Aventisub Ii Inc. | 3-amidoindolyl derivatives |
| US5668117A (en) | 1991-02-22 | 1997-09-16 | Shapiro; Howard K. | Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments |
| US6444221B1 (en) | 1992-06-30 | 2002-09-03 | Howard K. Shapiro | Methods of treating chronic inflammatory diseases using carbonyl trapping agents |
| US20050090553A1 (en) | 1992-06-30 | 2005-04-28 | Shapiro Howard K. | Compositions and method for treatment of chronic inflammatory diseases |
| US5472954A (en) | 1992-07-14 | 1995-12-05 | Cyclops H.F. | Cyclodextrin complexation |
| US5493027A (en) | 1993-01-22 | 1996-02-20 | Board Of Regents, The University Of Texas System | Anticonvulsive agents and uses thereof |
| US5597823A (en) | 1995-01-27 | 1997-01-28 | Abbott Laboratories | Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists |
| US5742954A (en) | 1996-11-22 | 1998-04-28 | Softub, Inc. | Electrically powered spa jet unit |
| ATE336485T1 (de) | 1997-05-02 | 2006-09-15 | Schering Ag | Substituierte heterocyclen und deren verwendung in arzneimitteln |
| EP1080068A1 (en) | 1998-03-12 | 2001-03-07 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases |
| US6498154B1 (en) | 1999-05-04 | 2002-12-24 | Wyeth | Cyclic regimens using quinazolinone and benzoxazine derivatives |
| WO2001041757A1 (en) | 1999-12-10 | 2001-06-14 | Senju Pharmaceutical Co., Ltd. | Cyclodextrin-containing pharmaceutical composition |
| US6569879B2 (en) * | 2000-02-18 | 2003-05-27 | Merck & Co., Inc. | Aryloxyacetic acids for diabetes and lipid disorders |
| FR2827599A1 (fr) | 2001-07-20 | 2003-01-24 | Neuro3D | Composes derives de quinoleine et quinoxaline,preparation et utilisations |
| UA83620C2 (ru) | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
| CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| EP2324823A3 (en) | 2003-03-14 | 2011-11-16 | University of Washington | Retinoid replacements and opsin agonists and methods for the use thereof |
| JP4564920B2 (ja) | 2003-04-18 | 2010-10-20 | 株式会社最先端医学研究所 | 眼に適用する疾患治療剤 |
| US20060111318A1 (en) | 2003-04-18 | 2006-05-25 | Advanced Medicine Research Institute | Agent for treating eye diseases |
| US7297709B2 (en) * | 2003-05-22 | 2007-11-20 | Abbott Laboratories | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors |
| US20040235892A1 (en) | 2003-05-22 | 2004-11-25 | Yujia Dai | Indazole and benzisoxazole kinase inhibitors |
| EP2468729B1 (en) | 2003-10-15 | 2013-12-25 | Ube Industries, Ltd. | Novel indazole derivative |
| EP2052720A3 (en) | 2003-11-20 | 2009-05-06 | Othera Holding, Inc. | Use of at least one hydroxylamine compound for the treatment of eye disease |
| US20050197292A1 (en) | 2004-01-30 | 2005-09-08 | Glennda Smithson | Compositions and methods for treating T-cell mediated pathological conditions |
| PL380611A1 (pl) | 2004-02-17 | 2007-02-19 | President And Fellows Of Harvard College | Postępowanie z zaburzeniami oftalmologicznymi, włącznie ze zwyrodnieniem plamki |
| US20050234018A1 (en) | 2004-04-15 | 2005-10-20 | Allergan, Inc. | Drug delivery to the back of the eye |
| WO2006002473A1 (en) | 2004-07-02 | 2006-01-12 | Adelaide Research & Innovation Pty Ltd | Method of controlling damage mediated by alpha, beta-unsaturated aldehydes |
| WO2006049968A1 (en) | 2004-10-28 | 2006-05-11 | Merck & Co., Inc. | Pyrimidine and quinoline potentiators of metabotropic glutamate receptors |
| TW200640443A (en) * | 2005-02-23 | 2006-12-01 | Alcon Inc | Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors |
| US7973025B2 (en) * | 2005-05-26 | 2011-07-05 | Neuron Systems, Inc. | Compositions and methods of treating retinal disease |
| EP2012789B1 (en) | 2006-04-14 | 2013-09-25 | Prana Biotechnology Limited | Method of treatment of age-related macular degeneration (AMD) |
| CA2658793A1 (en) | 2006-07-25 | 2008-02-07 | Daniel Dumas | Quinoline derivatives |
| RU2541430C2 (ru) | 2007-10-05 | 2015-02-10 | Акусела Инк. | Композиции и способы лечения нейродегенеративных заболеваний |
| CN102177157A (zh) * | 2008-08-12 | 2011-09-07 | 西特里斯药业公司 | 作为沉默调节蛋白调节剂的苯并*唑类、苯并噻唑类和相关的类似物 |
| WO2010133672A1 (en) | 2009-05-20 | 2010-11-25 | Clanotech Ab | Derivatives of quinoline-3-carboxylic acid and their medical use |
| WO2011008202A1 (en) | 2009-07-15 | 2011-01-20 | Vanderbilt University | Isoketal scavengers and mitigation of disorders involving oxidative injury |
| CA2783699C (en) | 2009-12-08 | 2019-01-15 | Case Western Reserve University | Primary amine compounds for treating ocular disorders |
| CA2782015C (en) * | 2009-12-11 | 2020-08-25 | Neuron Systems, Inc. | Topical ophthalmic compositions and methods for the treatment of macular degeneration |
| DK2663550T3 (en) | 2011-01-12 | 2017-03-27 | Ventirx Pharmaceuticals Inc | SUBSTITUTED BENZOAZEPINS AS MODULATORS OF TOLL-LIKE RECEPTORS |
| EP2670439B1 (en) | 2011-01-31 | 2019-03-13 | PVAC Medical Technologies Ltd. | Active principle for mitigating undesired medical conditions |
| KR20150118106A (ko) | 2012-12-20 | 2015-10-21 | 알데이라 테라퓨틱스, 아이엔씨. | 페리-카르비놀 |
| HK1217439A1 (zh) * | 2013-01-23 | 2017-01-13 | Aldeyra Therapeutics, Inc. | 与毒性醛相关的疾病和治疗 |
-
2014
- 2014-01-21 MX MX2015009444A patent/MX2015009444A/es unknown
- 2014-01-21 AU AU2014209585A patent/AU2014209585A1/en not_active Abandoned
- 2014-01-21 CN CN201480005973.2A patent/CN105228989A/zh active Pending
- 2014-01-21 JP JP2015555214A patent/JP6266023B2/ja not_active Expired - Fee Related
- 2014-01-21 HK HK16105524.6A patent/HK1217490A1/zh unknown
- 2014-01-21 SG SG11201505599YA patent/SG11201505599YA/en unknown
- 2014-01-21 EP EP14743787.5A patent/EP2948436A4/en not_active Withdrawn
- 2014-01-21 RU RU2015126015A patent/RU2015126015A/ru not_active Application Discontinuation
- 2014-01-21 US US14/760,041 patent/US10111862B2/en active Active
- 2014-01-21 WO PCT/US2014/012356 patent/WO2014116593A1/en not_active Ceased
- 2014-01-21 CA CA2898869A patent/CA2898869A1/en not_active Abandoned
- 2014-01-21 KR KR1020157022937A patent/KR20150120380A/ko not_active Withdrawn
-
2015
- 2015-07-01 IL IL239736A patent/IL239736A0/en unknown
-
2018
- 2018-10-23 US US16/168,309 patent/US20190125729A1/en not_active Abandoned
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