JP2016505247A5 - - Google Patents
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- JP2016505247A5 JP2016505247A5 JP2015544190A JP2015544190A JP2016505247A5 JP 2016505247 A5 JP2016505247 A5 JP 2016505247A5 JP 2015544190 A JP2015544190 A JP 2015544190A JP 2015544190 A JP2015544190 A JP 2015544190A JP 2016505247 A5 JP2016505247 A5 JP 2016505247A5
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- gene
- tissue sample
- thyroid tissue
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 claims description 106
- 210000001685 thyroid gland Anatomy 0.000 claims description 65
- 239000000523 sample Substances 0.000 claims description 62
- 238000000034 method Methods 0.000 claims description 54
- 230000014509 gene expression Effects 0.000 claims description 52
- 108010031374 Tissue Inhibitor of Metalloproteinase-1 Proteins 0.000 claims description 26
- 101150058049 car gene Proteins 0.000 claims description 26
- 101150037720 CCR7 gene Proteins 0.000 claims description 24
- 101150077124 CXCL10 gene Proteins 0.000 claims description 22
- 239000003153 chemical reaction reagent Substances 0.000 claims description 22
- 101150019010 CCR3 gene Proteins 0.000 claims description 18
- 101150004010 CXCR3 gene Proteins 0.000 claims description 14
- 108091034117 Oligonucleotide Proteins 0.000 claims description 14
- 101000892366 Homo sapiens Actin filament-associated protein 1-like 2 Proteins 0.000 claims description 12
- 101150051753 gene 7 gene Proteins 0.000 claims description 11
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 10
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 9
- 201000002510 thyroid cancer Diseases 0.000 claims description 9
- 108010018924 Heme Oxygenase-1 Proteins 0.000 claims description 8
- 102100028006 Heme oxygenase 1 Human genes 0.000 claims description 8
- 101000998011 Homo sapiens Keratin, type I cytoskeletal 19 Proteins 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 238000002512 chemotherapy Methods 0.000 claims description 4
- 238000001794 hormone therapy Methods 0.000 claims description 4
- 238000001959 radiotherapy Methods 0.000 claims description 4
- 238000012360 testing method Methods 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- 102100036301 C-C chemokine receptor type 7 Human genes 0.000 claims description 2
- 101150022250 CXCL11 gene Proteins 0.000 claims description 2
- 101150115558 CXCL9 gene Proteins 0.000 claims description 2
- 101150066398 CXCR4 gene Proteins 0.000 claims description 2
- 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 claims description 2
- 101000582950 Homo sapiens Platelet factor 4 Proteins 0.000 claims description 2
- 101710183399 Keratin, type I cytoskeletal 19 Proteins 0.000 claims description 2
- 108060005251 Nectin Proteins 0.000 claims description 2
- 238000004458 analytical method Methods 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 claims description 2
- 230000002380 cytological effect Effects 0.000 claims description 2
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- 229920001184 polypeptide Polymers 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 230000035945 sensitivity Effects 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 description 5
- 201000011510 cancer Diseases 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
- 238000001574 biopsy Methods 0.000 description 3
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- 238000003745 diagnosis Methods 0.000 description 2
- 238000002493 microarray Methods 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 238000002944 PCR assay Methods 0.000 description 1
- 238000011529 RT qPCR Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 238000011273 incision biopsy Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 108091070501 miRNA Proteins 0.000 description 1
- 239000002679 microRNA Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000013188 needle biopsy Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000007388 punch biopsy Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- -1 rRNA Proteins 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261730391P | 2012-11-27 | 2012-11-27 | |
| US61/730,391 | 2012-11-27 | ||
| US201361775419P | 2013-03-08 | 2013-03-08 | |
| US61/775,419 | 2013-03-08 | ||
| PCT/US2013/071970 WO2014085434A1 (en) | 2012-11-27 | 2013-11-26 | Compositions and methods for diagnosing thyroid tumors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505247A JP2016505247A (ja) | 2016-02-25 |
| JP2016505247A5 true JP2016505247A5 (https=) | 2016-12-22 |
| JP6309019B2 JP6309019B2 (ja) | 2018-04-11 |
Family
ID=49880965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015544190A Active JP6309019B2 (ja) | 2012-11-27 | 2013-11-26 | 甲状腺腫瘍を診断するための組成物および方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10260103B2 (https=) |
| EP (1) | EP2925886B1 (https=) |
| JP (1) | JP6309019B2 (https=) |
| KR (1) | KR102174578B1 (https=) |
| CN (1) | CN104937111B (https=) |
| AU (1) | AU2013352339B2 (https=) |
| BR (1) | BR112015012239B1 (https=) |
| CA (1) | CA2892822C (https=) |
| MX (1) | MX367366B (https=) |
| NZ (1) | NZ709167A (https=) |
| WO (1) | WO2014085434A1 (https=) |
| ZA (1) | ZA201504663B (https=) |
Families Citing this family (44)
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| US8338109B2 (en) | 2006-11-02 | 2012-12-25 | Mayo Foundation For Medical Education And Research | Predicting cancer outcome |
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| US10407731B2 (en) | 2008-05-30 | 2019-09-10 | Mayo Foundation For Medical Education And Research | Biomarker panels for predicting prostate cancer outcomes |
| US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
| US9495515B1 (en) | 2009-12-09 | 2016-11-15 | Veracyte, Inc. | Algorithms for disease diagnostics |
| US9074258B2 (en) | 2009-03-04 | 2015-07-07 | Genomedx Biosciences Inc. | Compositions and methods for classifying thyroid nodule disease |
| US8669057B2 (en) | 2009-05-07 | 2014-03-11 | Veracyte, Inc. | Methods and compositions for diagnosis of thyroid conditions |
| US10446272B2 (en) | 2009-12-09 | 2019-10-15 | Veracyte, Inc. | Methods and compositions for classification of samples |
| US20130267443A1 (en) | 2010-11-19 | 2013-10-10 | The Regents Of The University Of Michigan | ncRNA AND USES THEREOF |
| EP2791359B1 (en) | 2011-12-13 | 2020-01-15 | Decipher Biosciences, Inc. | Cancer diagnostics using non-coding transcripts |
| DK3435084T3 (da) | 2012-08-16 | 2023-05-30 | Mayo Found Medical Education & Res | Prostatakræftprognose under anvendelse af biomarkører |
| US10260103B2 (en) | 2012-11-27 | 2019-04-16 | Pontificia Universidad Catolica De Chile | Compositions and methods for diagnosing thyroid tumors |
| EP3626308A1 (en) | 2013-03-14 | 2020-03-25 | Veracyte, Inc. | Methods for evaluating copd status |
| US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| US12297505B2 (en) | 2014-07-14 | 2025-05-13 | Veracyte, Inc. | Algorithms for disease diagnostics |
| EP3215170A4 (en) | 2014-11-05 | 2018-04-25 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
| JP6144314B2 (ja) * | 2015-10-30 | 2017-06-07 | 株式会社Ｕｂｉｃ | データ分類システム，方法，プログラムおよびその記録媒体 |
| US11053542B2 (en) | 2015-12-31 | 2021-07-06 | Quest Diagnostics Investments Llc | Compositions and methods for screening mutations in thyroid cancer |
| US11486873B2 (en) | 2016-03-31 | 2022-11-01 | Ontera Inc. | Multipore determination of fractional abundance of polynucleotide sequences in a sample |
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| CN113834869B (zh) | 2016-09-02 | 2024-12-06 | 得克萨斯大学体系董事会 | 收集探针及其使用方法 |
| AU2017348009B2 (en) | 2016-10-24 | 2019-10-10 | Ontera Inc. | Fractional abundance of polynucleotide sequences in a sample |
| EP3571322B9 (en) | 2017-01-20 | 2023-10-04 | VERACYTE SD, Inc. | Molecular subtyping, prognosis, and treatment of bladder cancer |
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| CA3062716A1 (en) | 2017-05-12 | 2018-11-15 | Decipher Biosciences, Inc. | Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness |
| US11217329B1 (en) | 2017-06-23 | 2022-01-04 | Veracyte, Inc. | Methods and systems for determining biological sample integrity |
| WO2019028285A2 (en) | 2017-08-04 | 2019-02-07 | Genomedx, Inc. | USE OF SPECIFIC GENE EXPRESSION OF IMMUNE CELLS FOR THE PROGNOSIS OF PROSTATE CANCER AND THE PREDICTION OF SENSITIVITY TO RADIOTHERAPY |
| IL319255A (en) | 2017-08-07 | 2025-04-01 | Univ Johns Hopkins | Methods and materials for cancer assessment and treatment |
| EP3717901A4 (en) | 2017-11-27 | 2021-08-25 | Board Of Regents, The University Of Texas System | MINIMALLY INVASIVE DETECTION PROBE AND METHOD OF USING IT |
| US20210033623A1 (en) * | 2018-02-23 | 2021-02-04 | Board Of Regents, The University Of Texas System | Tissue analysis by mass spectrometry |
| CN109457032B (zh) * | 2018-12-20 | 2022-04-12 | 北京优迅医学检验实验室有限公司 | 甲状腺癌分子诊断试剂盒 |
| EP3914891B1 (en) | 2019-01-25 | 2026-04-01 | Board of Regents, The University of Texas System | Apparatus for cleaning and/or exchanging medical devices |
| CN109847072A (zh) * | 2019-02-27 | 2019-06-07 | 四川大学华西医院 | 一种甲状旁腺血供检测试剂盒 |
| RU2712080C1 (ru) * | 2019-05-14 | 2020-01-24 | Федеральное государственное автономное образовательное учреждение высшего образования "Дальневосточный федеральный университет" (ДВФУ) | Способ проведения цитологического исследования при дифференциальной диагностике узловых образований щитовидной железы |
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| US20230105011A1 (en) * | 2020-01-03 | 2023-04-06 | The University Of Toledo | Stratifying risk of malignancy in indeterminate thyroid nodules and immuno-genomic markers for early detection of thyroid cancer |
| KR102639140B1 (ko) * | 2020-08-14 | 2024-02-20 | 연세대학교 산학협력단 | 조직 검사 방법 및 조직 검사 장치 |
| WO2022133621A1 (es) | 2020-12-24 | 2022-06-30 | Pontificia Universidad Católica De Chile | Método in vitro para el diagnóstico y predicción de la agresividad de cáncer de tiroides, las posibilidades y tipo de cirugía de precisión para la remoción del tumor en un sujeto; kit; reactivos para conformar dicho kit; uso de los reactivos y uso de marcadores moleculares parte del método |
| EP4023770A1 (en) | 2021-01-05 | 2022-07-06 | Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Oddzial w Gliwicach | A method of examining genes for the diagnosis of thyroid tumors, a set for the diagnosis of thyroid tumors and application |
| JP2024511277A (ja) | 2021-02-19 | 2024-03-13 | メビオン・メディカル・システムズ・インコーポレーテッド | 粒子線治療システムのためのガントリー |
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| CN115807081A (zh) * | 2021-09-15 | 2023-03-17 | 江苏鹍远生物技术有限公司 | 诊断甲状腺癌的基因标志物及其用途 |
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| EP4303323B1 (en) | 2022-07-05 | 2025-02-19 | Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Oddzial w Gliwicach | A method differentiating benign and malignant tyroid nodules |
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