JP2016505010A5 - - Google Patents
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- Publication number
- JP2016505010A5 JP2016505010A5 JP2015552726A JP2015552726A JP2016505010A5 JP 2016505010 A5 JP2016505010 A5 JP 2016505010A5 JP 2015552726 A JP2015552726 A JP 2015552726A JP 2015552726 A JP2015552726 A JP 2015552726A JP 2016505010 A5 JP2016505010 A5 JP 2016505010A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- dihydro
- formula
- pharmaceutically acceptable
- salt according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- ILOFWCAZDNILKY-UHFFFAOYSA-N 1-[2-(2,3-dihydro-1h-inden-2-ylamino)-5,7-dihydropyrrolo[3,4-d]pyrimidin-6-yl]-2-[2-(2h-triazol-4-yl)ethoxy]ethanone Chemical compound C1C2=CN=C(NC3CC4=CC=CC=C4C3)N=C2CN1C(=O)COCCC1=CNN=N1 ILOFWCAZDNILKY-UHFFFAOYSA-N 0.000 claims 1
- BZXBCSVQKRJOET-UHFFFAOYSA-N 1-[2-(2,3-dihydro-1h-inden-2-ylamino)-7,8-dihydro-5h-pyrido[4,3-d]pyrimidin-6-yl]-2-[2-(2h-triazol-4-yl)ethoxy]ethanone Chemical compound C1CC2=NC(NC3CC4=CC=CC=C4C3)=NC=C2CN1C(=O)COCCC1=CNN=N1 BZXBCSVQKRJOET-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 0 CC(C)C(N*)=*N=* Chemical compound CC(C)C(N*)=*N=* 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361751363P | 2013-01-11 | 2013-01-11 | |
| US61/751,363 | 2013-01-11 | ||
| US201361777201P | 2013-03-12 | 2013-03-12 | |
| US61/777,201 | 2013-03-12 | ||
| PCT/US2014/010400 WO2014110000A1 (en) | 2013-01-11 | 2014-01-07 | Pyrido- or pyrrolo-fused pyrimidine derivatives as autotaxin inhibitors for treating pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505010A JP2016505010A (ja) | 2016-02-18 |
| JP2016505010A5 true JP2016505010A5 (en:Method) | 2017-02-16 |
| JP6285461B2 JP6285461B2 (ja) | 2018-02-28 |
Family
ID=50031555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015552726A Expired - Fee Related JP6285461B2 (ja) | 2013-01-11 | 2014-01-07 | 二環式ピリミジン化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8969555B2 (en:Method) |
| EP (1) | EP2943494B1 (en:Method) |
| JP (1) | JP6285461B2 (en:Method) |
| KR (1) | KR101757997B1 (en:Method) |
| CN (1) | CN104903327B (en:Method) |
| AU (1) | AU2014205642B2 (en:Method) |
| BR (1) | BR112015015812A2 (en:Method) |
| CA (1) | CA2893253C (en:Method) |
| EA (1) | EA025106B1 (en:Method) |
| ES (1) | ES2636248T3 (en:Method) |
| MX (1) | MX2015008971A (en:Method) |
| TW (1) | TWI499591B (en:Method) |
| WO (1) | WO2014110000A1 (en:Method) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201500356A (zh) * | 2013-04-12 | 2015-01-01 | Lilly Co Eli | 二氫吡啶并嘧啶化合物 |
| WO2015077503A1 (en) | 2013-11-22 | 2015-05-28 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| IL280863B2 (en) | 2015-05-27 | 2024-07-01 | Sabre Therapeutics Llc | Autotaxin inhibitors and uses thereof |
| EP3302465A1 (en) | 2015-06-05 | 2018-04-11 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| KR101798840B1 (ko) | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
| US10961242B2 (en) | 2017-05-17 | 2021-03-30 | Legochem Biosciences, Inc. | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same |
| US11679108B2 (en) | 2018-05-24 | 2023-06-20 | Guangzhou Henovcom Bioscience Co., Ltd. | Aromatic heterocyclic compound, and pharmaceutical composition and use thereof |
| US20220081400A1 (en) * | 2018-07-16 | 2022-03-17 | The Scripps Research Institute | Opioid haptens, conjugates, vaccines, and methods of generating antibodies |
| AU2020213569B2 (en) * | 2019-02-01 | 2022-10-13 | Wuhan Humanwell Innovative Drug Research and Development Center Limited Company | Pyrrolopyrimidine derivative and use thereof |
| IL291114B2 (en) | 2019-09-06 | 2025-09-01 | Wuhan Humanwell Innovative Drug Res And Development Center Limited Company | Pyrimidine compound and method for preparing same |
| CA3150700A1 (en) * | 2019-09-17 | 2021-03-25 | Renato T. Skerlj | IMIDAZOLE SUBSTITUTE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| WO2021088957A1 (zh) * | 2019-11-07 | 2021-05-14 | 广州市恒诺康医药科技有限公司 | 芳杂环化合物、其药物组合物及其应用 |
| KR20220113731A (ko) * | 2019-12-11 | 2022-08-16 | 스촨 하이스코 파마수티컬 씨오., 엘티디 | 질소-함유 헤테로사이클릭 오토택신 억제제, 및 이를 함유하는 조성물 및 이의 용도 |
| CN113943296B (zh) * | 2020-07-16 | 2025-07-04 | 武汉人福创新药物研发中心有限公司 | 吡咯并嘧啶衍生物及其应用 |
| CN113943295B (zh) * | 2020-07-16 | 2025-08-12 | 武汉人福创新药物研发中心有限公司 | 吡咯并嘧啶类化合物及其用途 |
| WO2022022570A1 (zh) | 2020-07-28 | 2022-02-03 | 武汉人福创新药物研发中心有限公司 | 含氮杂环化合物的盐及其盐的固体形式、药物组合物和用途 |
| TW202214644A (zh) * | 2020-07-28 | 2022-04-16 | 大陸商武漢人福創新藥物研發中心有限公司 | 含氮雜環化合物的固體形式及其藥物組合物和用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1071301A (en) * | 1999-11-01 | 2001-05-14 | Eli Lilly And Company | Pharmaceutical compounds |
| JPWO2003104230A1 (ja) | 2002-06-07 | 2005-10-06 | 協和醗酵工業株式会社 | 二環性ピリミジン誘導体 |
| DE102004020908A1 (de) | 2004-04-28 | 2005-11-17 | Grünenthal GmbH | Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen |
| US7745451B2 (en) * | 2005-05-04 | 2010-06-29 | Renovis, Inc. | Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds and compositions thereof useful in the treatment of conditions associated with neurological and inflammatory disorders and dysfunctions |
| WO2010063352A1 (en) * | 2008-12-01 | 2010-06-10 | Merck Patent Gmbh | 2, 5-diamino-substituted pyrido [4, 3-d] pyrimidines as autotaxin inhibitors against cancer |
| WO2012009258A2 (en) * | 2010-07-13 | 2012-01-19 | Edward Roberts | Peptidomimetic galanin receptor modulators |
| WO2012024620A2 (en) | 2010-08-20 | 2012-02-23 | Amira Pharmaceuticals, Inc. | Autotaxin inhibitors and uses thereof |
| WO2012085167A1 (en) * | 2010-12-22 | 2012-06-28 | Merz Pharma Gmbh & Co. Kgaa | Metabotropic glutamate receptor modulators |
| WO2013054185A1 (en) | 2011-10-13 | 2013-04-18 | Pfizer, Inc. | Pyrimidine and pyridine derivatives useful in therapy |
| EP3243815B1 (en) * | 2011-10-28 | 2019-07-10 | Inhibitaxin Limited | Pyridazine derivatives useful in therapy |
| TW201520219A (zh) * | 2013-03-12 | 2015-06-01 | Lilly Co Eli | 咪唑並吡啶化合物 |
| TW201500356A (zh) * | 2013-04-12 | 2015-01-01 | Lilly Co Eli | 二氫吡啶并嘧啶化合物 |
-
2013
- 2013-12-30 TW TW102149122A patent/TWI499591B/zh active
-
2014
- 2014-01-07 CN CN201480004482.6A patent/CN104903327B/zh not_active Expired - Fee Related
- 2014-01-07 CA CA2893253A patent/CA2893253C/en not_active Expired - Fee Related
- 2014-01-07 KR KR1020157018295A patent/KR101757997B1/ko not_active Expired - Fee Related
- 2014-01-07 WO PCT/US2014/010400 patent/WO2014110000A1/en not_active Ceased
- 2014-01-07 AU AU2014205642A patent/AU2014205642B2/en not_active Ceased
- 2014-01-07 JP JP2015552726A patent/JP6285461B2/ja not_active Expired - Fee Related
- 2014-01-07 US US14/148,775 patent/US8969555B2/en active Active
- 2014-01-07 ES ES14702336.0T patent/ES2636248T3/es active Active
- 2014-01-07 EP EP14702336.0A patent/EP2943494B1/en active Active
- 2014-01-07 BR BR112015015812A patent/BR112015015812A2/pt not_active IP Right Cessation
- 2014-01-07 EA EA201591098A patent/EA025106B1/ru not_active IP Right Cessation
- 2014-01-07 MX MX2015008971A patent/MX2015008971A/es unknown
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