JP2016505007A5 - - Google Patents
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- Publication number
- JP2016505007A5 JP2016505007A5 JP2015552046A JP2015552046A JP2016505007A5 JP 2016505007 A5 JP2016505007 A5 JP 2016505007A5 JP 2015552046 A JP2015552046 A JP 2015552046A JP 2015552046 A JP2015552046 A JP 2015552046A JP 2016505007 A5 JP2016505007 A5 JP 2016505007A5
- Authority
- JP
- Japan
- Prior art keywords
- uhplc
- methyloctanoyl
- composition
- methylheptanoyl
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 methylheptanoyl Chemical group 0.000 claims 31
- 238000001195 ultra high performance liquid chromatography Methods 0.000 claims 26
- 239000000203 mixture Substances 0.000 claims 17
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 6
- 108010040201 Polymyxins Proteins 0.000 claims 5
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 241000588724 Escherichia coli Species 0.000 claims 2
- 125000000268 heptanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000001402 nonanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 241000588626 Acinetobacter baumannii Species 0.000 claims 1
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 125000003074 decanoyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 claims 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 208000027096 gram-negative bacterial infections Diseases 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361751341P | 2013-01-11 | 2013-01-11 | |
| US61/751,341 | 2013-01-11 | ||
| US201361904793P | 2013-11-15 | 2013-11-15 | |
| US61/904,793 | 2013-11-15 | ||
| PCT/EP2014/050320 WO2014108469A1 (en) | 2013-01-11 | 2014-01-09 | Polymyxins, compositions, methods of making and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505007A JP2016505007A (ja) | 2016-02-18 |
| JP2016505007A5 true JP2016505007A5 (https=) | 2017-01-12 |
| JP6316846B2 JP6316846B2 (ja) | 2018-04-25 |
Family
ID=50101865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015552046A Active JP6316846B2 (ja) | 2013-01-11 | 2014-01-09 | ポリミキシン含有組成物 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10640536B2 (https=) |
| EP (1) | EP2943503B1 (https=) |
| JP (1) | JP6316846B2 (https=) |
| KR (1) | KR20150107793A (https=) |
| CN (1) | CN104918951B (https=) |
| AU (1) | AU2014204873B2 (https=) |
| BR (1) | BR112015016548A2 (https=) |
| CA (1) | CA2895910C (https=) |
| EA (1) | EA027067B1 (https=) |
| ES (1) | ES2641017T3 (https=) |
| HU (1) | HUE034562T2 (https=) |
| IL (1) | IL239840A (https=) |
| MX (1) | MX360905B (https=) |
| PT (1) | PT2943503T (https=) |
| RU (1) | RU2015132569A (https=) |
| SI (1) | SI2943503T1 (https=) |
| TW (1) | TWI613219B (https=) |
| UA (1) | UA117673C2 (https=) |
| WO (1) | WO2014108469A1 (https=) |
| ZA (1) | ZA201504565B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2943503B1 (en) | 2013-01-11 | 2017-08-23 | Xellia Pharmaceuticals ApS | Polymyxins, compositions, methods of making and methods of use |
| TW201522364A (zh) * | 2013-06-07 | 2015-06-16 | Xellia Pharmaceuticals Aps | 黏菌素甲磺酸鈉（ｃｍｓ）之定性方法 |
| EP3166960B1 (en) * | 2014-07-09 | 2019-08-07 | Xellia Pharmaceuticals ApS | Low substituted polymyxins and compositions thereof |
| JP6626890B2 (ja) | 2014-10-03 | 2019-12-25 | クセリア ファーマシューティカルズ エーピーエスＸｅｌｌｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ ＡｐＳ | 吸入用デバイスおよび同デバイスに含有される水溶液 |
| US10532080B2 (en) | 2014-10-03 | 2020-01-14 | Xellia Pharmaceuticals Aps | Sulfomethylated polymixin compositions |
| US9771394B2 (en) | 2014-12-16 | 2017-09-26 | Micurx Pharmaceuticals, Inc. | Antimicrobial polymyxins for treatment of bacterial infections |
| FI126143B (en) * | 2015-01-15 | 2016-07-15 | Northern Antibiotics Oy | Polymyxine derivative and its uses |
| EP3356387B1 (en) * | 2015-09-29 | 2024-06-26 | Monash University | Antimicrobial polymyxin derivative compounds |
| CN109996806B (zh) * | 2016-12-09 | 2021-11-02 | 正大天晴药业集团股份有限公司 | 高效价的多黏菌素e2甲磺酸钠 |
| WO2021150792A1 (en) | 2020-01-21 | 2021-07-29 | Micurx Pharmaceuticals, Inc. | Novel compounds and composition for targeted therapy of kidney-associated cancers |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1062895A (en) | 1962-12-13 | 1967-03-22 | Wellcome Found | Sulphomethyl derivatives of polymxin |
| DE1906699A1 (de) | 1968-02-12 | 1970-02-05 | Pfizer | Neue Polymyxinderivate und Verfahren zu deren Herstellung |
| FR1586834A (https=) * | 1968-02-12 | 1970-03-06 | ||
| JPH02504003A (ja) * | 1988-04-07 | 1990-11-22 | シャンブロム，エドワード | 非トロンボゲン形成性脈管内タイムリリースカテーテル |
| AU730546B2 (en) | 1996-11-15 | 2001-03-08 | Pathogenesis Corporation | Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections |
| US5767068A (en) | 1997-02-13 | 1998-06-16 | Pathogenesis Corporation | Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections |
| US20030143162A1 (en) | 2001-05-18 | 2003-07-31 | Speirs Robert John | Methods and unit dose formulations for the inhalation administration of aminoglycoside antibiotics |
| US20040022740A1 (en) | 2001-07-10 | 2004-02-05 | Baker William R. | Macrolide formulations for inhalation and methods of treatment of endobronchial infections |
| EP1940859A1 (en) * | 2005-10-28 | 2008-07-09 | Arch Pharmalabs Limited | An improved process for preparation of gemcitabine hydrochloride |
| WO2008025560A1 (en) | 2006-09-01 | 2008-03-06 | Pari Pharma Gmbh | Methods for taste masking of nebulised compositions for nasal and pulmonary inhalation therapy |
| US20080066739A1 (en) | 2006-09-20 | 2008-03-20 | Lemahieu Edward | Methods and systems of delivering medication via inhalation |
| WO2012168820A1 (en) | 2011-06-08 | 2012-12-13 | Pfizer Inc. | Polymyxin derivatives useful as antibacterial agents |
| EP2943503B1 (en) | 2013-01-11 | 2017-08-23 | Xellia Pharmaceuticals ApS | Polymyxins, compositions, methods of making and methods of use |
| TW201522364A (zh) | 2013-06-07 | 2015-06-16 | Xellia Pharmaceuticals Aps | 黏菌素甲磺酸鈉（ｃｍｓ）之定性方法 |
| EP3166960B1 (en) | 2014-07-09 | 2019-08-07 | Xellia Pharmaceuticals ApS | Low substituted polymyxins and compositions thereof |
| US10532080B2 (en) | 2014-10-03 | 2020-01-14 | Xellia Pharmaceuticals Aps | Sulfomethylated polymixin compositions |
-
2014
- 2014-01-09 EP EP14704292.3A patent/EP2943503B1/en active Active
- 2014-01-09 WO PCT/EP2014/050320 patent/WO2014108469A1/en not_active Ceased
- 2014-01-09 BR BR112015016548A patent/BR112015016548A2/pt not_active Application Discontinuation
- 2014-01-09 ES ES14704292.3T patent/ES2641017T3/es active Active
- 2014-01-09 KR KR1020157021592A patent/KR20150107793A/ko not_active Withdrawn
- 2014-01-09 EA EA201591280A patent/EA027067B1/ru unknown
- 2014-01-09 HU HUE14704292A patent/HUE034562T2/en unknown
- 2014-01-09 UA UAA201507907A patent/UA117673C2/uk unknown
- 2014-01-09 CN CN201480004714.8A patent/CN104918951B/zh active Active
- 2014-01-09 RU RU2015132569A patent/RU2015132569A/ru not_active Application Discontinuation
- 2014-01-09 CA CA2895910A patent/CA2895910C/en active Active
- 2014-01-09 JP JP2015552046A patent/JP6316846B2/ja active Active
- 2014-01-09 US US14/760,222 patent/US10640536B2/en active Active
- 2014-01-09 MX MX2015008878A patent/MX360905B/es active IP Right Grant
- 2014-01-09 PT PT147042923T patent/PT2943503T/pt unknown
- 2014-01-09 SI SI201430386T patent/SI2943503T1/sl unknown
- 2014-01-09 AU AU2014204873A patent/AU2014204873B2/en active Active
- 2014-01-10 TW TW103101009A patent/TWI613219B/zh active
-
2015
- 2015-06-24 ZA ZA2015/04565A patent/ZA201504565B/en unknown
- 2015-07-08 IL IL239840A patent/IL239840A/en active IP Right Grant
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