JP2016501266A5 - - Google Patents

Info

Publication number

JP2016501266A5

JP2016501266A5 JP2015547006A JP2015547006A JP2016501266A5 JP 2016501266 A5 JP2016501266 A5 JP 2016501266A5 JP 2015547006 A JP2015547006 A JP 2015547006A JP 2015547006 A JP2015547006 A JP 2015547006A JP 2016501266 A5 JP2016501266 A5 JP 2016501266A5

Authority

JP

Japan

Prior art keywords

protein

modified

protein according

seq

antigen

Prior art date

2013-12-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 102000004169 proteins and genes Human genes 0.000 claims 19
• 108090000623 proteins and genes Proteins 0.000 claims 19
• 239000000427 antigen Substances 0.000 claims 17
• 102000036639 antigens Human genes 0.000 claims 17
• 108091007433 antigens Proteins 0.000 claims 17
• 108091005573 modified proteins Proteins 0.000 claims 14
• 102000035118 modified proteins Human genes 0.000 claims 14
• 108020001507 fusion proteins Proteins 0.000 claims 12
• 102000037865 fusion proteins Human genes 0.000 claims 12
• 108090000765 processed proteins & peptides Proteins 0.000 claims 12
• 206010022000 influenza Diseases 0.000 claims 8
• 238000000034 method Methods 0.000 claims 8
• 102000014914 Carrier Proteins Human genes 0.000 claims 6
• 108010078791 Carrier Proteins Proteins 0.000 claims 6
• 150000001413 amino acids Chemical class 0.000 claims 6
• 239000000203 mixture Substances 0.000 claims 5
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 108020004707 nucleic acids Proteins 0.000 claims 4
• 150000007523 nucleic acids Chemical class 0.000 claims 4
• 102000004196 processed proteins & peptides Human genes 0.000 claims 4
• 239000004475 Arginine Substances 0.000 claims 3
• 239000004472 Lysine Substances 0.000 claims 3
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
• 102000011931 Nucleoproteins Human genes 0.000 claims 3
• 108010061100 Nucleoproteins Proteins 0.000 claims 3
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
• 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 3
• 230000002708 enhancing effect Effects 0.000 claims 3
• 230000005847 immunogenicity Effects 0.000 claims 3
• 102100037084 C4b-binding protein alpha chain Human genes 0.000 claims 2
• 101710159767 C4b-binding protein alpha chain Proteins 0.000 claims 2
• 101710154606 Hemagglutinin Proteins 0.000 claims 2
• 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 2
• 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 2
• 101710176177 Protein A56 Proteins 0.000 claims 2
• 101800001690 Transmembrane protein gp41 Proteins 0.000 claims 2
• 241000219094 Vitaceae Species 0.000 claims 2
• 230000004927 fusion Effects 0.000 claims 2
• 235000021021 grapes Nutrition 0.000 claims 2
• 230000002163 immunogen Effects 0.000 claims 2
• 230000003834 intracellular effect Effects 0.000 claims 2
• 239000003446 ligand Substances 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• -1 preferably SpA Proteins 0.000 claims 2
• 108090000250 sortase A Proteins 0.000 claims 2
• 238000011282 treatment Methods 0.000 claims 2
• 229960005486 vaccine Drugs 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241000606660 Bartonella Species 0.000 claims 1
• 101000971127 Bartonella henselae Autotransporter adhesin BadA Proteins 0.000 claims 1
• 108010088468 Ebola virus envelope glycoprotein Proteins 0.000 claims 1
• 108090000288 Glycoproteins Proteins 0.000 claims 1
• 102000003886 Glycoproteins Human genes 0.000 claims 1
• NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 claims 1
• 208000031886 HIV Infections Diseases 0.000 claims 1
• 241000630665 Hada Species 0.000 claims 1
• 241000606768 Haemophilus influenzae Species 0.000 claims 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
• 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 1
• 241000713340 Human immunodeficiency virus 2 Species 0.000 claims 1
• 241000588655 Moraxella catarrhalis Species 0.000 claims 1
• 241000725643 Respiratory syncytial virus Species 0.000 claims 1
• 229920002684 Sepharose Polymers 0.000 claims 1
• 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 claims 1
• 206010041925 Staphylococcal infections Diseases 0.000 claims 1
• 241000191967 Staphylococcus aureus Species 0.000 claims 1
• 241000607447 Yersinia enterocolitica Species 0.000 claims 1
• 238000004587 chromatography analysis Methods 0.000 claims 1
• 229940047650 haemophilus influenzae Drugs 0.000 claims 1
• 239000000185 hemagglutinin Substances 0.000 claims 1
• 229960002897 heparin Drugs 0.000 claims 1
• 229920000669 heparin Polymers 0.000 claims 1
• 230000036039 immunity Effects 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 244000144977 poultry Species 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 238000011321 prophylaxis Methods 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000013638 trimer Substances 0.000 claims 1
• 229940098232 yersinia enterocolitica Drugs 0.000 claims 1