JP2016500250A5 - - Google Patents
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- Publication number
- JP2016500250A5 JP2016500250A5 JP2015543148A JP2015543148A JP2016500250A5 JP 2016500250 A5 JP2016500250 A5 JP 2016500250A5 JP 2015543148 A JP2015543148 A JP 2015543148A JP 2015543148 A JP2015543148 A JP 2015543148A JP 2016500250 A5 JP2016500250 A5 JP 2016500250A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- protein
- modified protein
- acid residues
- reference secreted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000000539 amino acid group Chemical group 0.000 claims 28
- 102000004169 proteins and genes Human genes 0.000 claims 24
- 108090000623 proteins and genes Proteins 0.000 claims 24
- 102000035118 modified proteins Human genes 0.000 claims 23
- 108091005573 modified proteins Proteins 0.000 claims 23
- 235000020776 essential amino acid Nutrition 0.000 claims 16
- 239000003797 essential amino acid Substances 0.000 claims 16
- 238000006467 substitution reaction Methods 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 244000005700 microbiome Species 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 229940024606 amino acid Drugs 0.000 claims 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 230000029087 digestion Effects 0.000 claims 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- -1 Ile amino acid Chemical class 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 210000004051 gastric juice Anatomy 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261728427P | 2012-11-20 | 2012-11-20 | |
| US61/728,427 | 2012-11-20 | ||
| PCT/US2013/071091 WO2014081884A1 (en) | 2012-11-20 | 2013-11-20 | Engineered secreted proteins and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016500250A JP2016500250A (ja) | 2016-01-12 |
| JP2016500250A5 true JP2016500250A5 (enExample) | 2017-01-19 |
Family
ID=50776536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015543148A Withdrawn JP2016500250A (ja) | 2012-11-20 | 2013-11-20 | 改変された分泌タンパク質及び方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20150307562A1 (enExample) |
| EP (1) | EP2922416A4 (enExample) |
| JP (1) | JP2016500250A (enExample) |
| CN (1) | CN104936466A (enExample) |
| CA (1) | CA2892021A1 (enExample) |
| HK (1) | HK1214739A1 (enExample) |
| WO (1) | WO2014081884A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015029580A2 (pt) * | 2013-05-31 | 2017-09-19 | Dsm Ip Assets Bv | Microrganismo recombinante, processo para a preparação de um diterpeno ou diterpeno glicosilado, diterpeno ou diterpeno glicosilado, gêneros alimentícios, alimentos para animais ou bebidas e método para converter um primeiro diterpeno glicosilado em um segundo diterpeno glicosilado |
| CN105916981A (zh) | 2013-07-29 | 2016-08-31 | 丹尼斯科美国公司 | 变体酶 |
| EP3048904A2 (en) * | 2013-09-25 | 2016-08-03 | Pronutria Biosciences, Inc. | Compositions and formulations for treatment of gastrointestinal tract malabsorption diseases and inflammatory conditions and methods of production and use thereof |
| GB201401699D0 (en) * | 2014-01-31 | 2014-03-19 | Dupont Nutrition Biosci Aps | Protein |
| CN103881994B (zh) * | 2014-04-14 | 2020-03-27 | 中国农业科学院生物技术研究所 | 一种具有高转糖苷活性的β-半乳糖苷酶突变体及其制备方法和应用 |
| FR3022558B1 (fr) | 2014-06-20 | 2019-01-25 | Proteus | Variants d'exoglucanases a activite amelioree et leurs utilisations |
| ES2896401T3 (es) * | 2014-09-22 | 2022-02-24 | Tanea Medical Ab | Proteínas recombinantes exentas de Phe para su uso en el tratamiento de la fenilcetonuria |
| CN107135653A (zh) * | 2014-10-01 | 2017-09-05 | 安迅生物制药公司 | 大肠杆菌素变体 |
| EP3217807A4 (en) * | 2014-11-11 | 2018-09-12 | Clara Foods Co. | Methods and compositions for egg white protein production |
| DK3234143T5 (da) | 2014-12-19 | 2024-10-14 | Novozymes As | Sammensætninger omfattende polypeptider med xylanaseaktivitet og polypeptider med arabinofuranosidaseaktivitet |
| GB201501565D0 (en) * | 2015-01-30 | 2015-03-18 | Dupont Nutrition Biosci Aps | Method |
| WO2016149482A2 (en) * | 2015-03-17 | 2016-09-22 | Vanderbilt University | Cs21 and lnga protein vaccines |
| DK3313193T3 (da) * | 2015-06-26 | 2021-06-07 | Novozymes As | Fremgangsmåde til fremstilling af en kaffeekstrakt |
| US10188135B2 (en) * | 2015-11-04 | 2019-01-29 | Stokley-Van Camp, Inc. | Method for inducing satiety |
| WO2017142080A1 (ja) | 2016-02-18 | 2017-08-24 | 天野エンザイム株式会社 | 腸内菌叢改善剤 |
| WO2017202997A1 (en) * | 2016-05-24 | 2017-11-30 | Novozymes A/S | Compositions comprising polypeptides having galactanase activity and polypeptides having beta-galactosidase activity |
| EP3462904B1 (en) * | 2016-05-24 | 2024-12-18 | Novozymes A/S | Gastric stable polypeptides having alpha-galactosidase activity and polynucleotides encoding same |
| WO2017202966A1 (en) | 2016-05-24 | 2017-11-30 | Novozymes A/S | Polypeptides having alpha-galactosidase activity and polynucleotides encoding same |
| US11273455B2 (en) | 2016-06-27 | 2022-03-15 | Novozymes A/S | Method of dewatering post fermentation fluids |
| DK3481948T5 (da) * | 2016-07-08 | 2024-09-02 | Novozymes As | Xylanasevarianter og polynukleotider, der koder for dem |
| JP6845244B2 (ja) * | 2016-07-19 | 2021-03-17 | サントリーホールディングス株式会社 | モグロールまたはモグロール配糖体の生産方法 |
| PT3290436T (pt) | 2016-09-01 | 2019-08-30 | Metax Inst Fuer Diaetetik Gmbh | Proteína livre de fenilalanina para o tratamento de pku |
| EA201891926A1 (ru) * | 2017-02-03 | 2019-04-30 | Киверди, Инк. | Микроорганизмы и искусственные экосистемы для производства белка, продуктов питания и полезных побочных продуктов из субстратов c1 |
| EP3592429A1 (en) * | 2017-03-06 | 2020-01-15 | DuPont Nutrition Biosciences ApS | Novel fungal fucosidases and their use in preventing and/or treating a pathogenic infection in an animal |
| EP3840582A4 (en) * | 2018-08-21 | 2022-08-03 | Clara Foods Co. | MODIFICATION OF PROTEIN GLYCOSYLATION IN MICROORGANISMS |
| EP3877519B1 (en) | 2018-11-09 | 2026-03-11 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| MX2021011361A (es) * | 2019-03-19 | 2021-10-13 | Bayer Cropscience Lp | Proteinas de fusion, bacterias recombinantes y fragmentos de exosporios para la salud de las plantas. |
| SI3997118T1 (sl) | 2019-07-11 | 2025-06-30 | Clara Foods Co. | Sestavek napitka, ki obsega rekombinantni ovomukoidni protein |
| US12096784B2 (en) | 2019-07-11 | 2024-09-24 | Clara Foods Co. | Protein compositions and consumable products thereof |
| US10927360B1 (en) | 2019-08-07 | 2021-02-23 | Clara Foods Co. | Compositions comprising digestive enzymes |
| PY2055454A (es) | 2019-09-16 | 2022-03-31 | Novozymes As | Polipéptidos que poseen actividad de beta-glucanasa y polinucleótidos que los codifican |
| EP3892290A1 (en) * | 2020-04-08 | 2021-10-13 | NUMAFERM GmbH | Variants of hlya and uses thereof |
| US12612436B2 (en) | 2020-03-18 | 2026-04-28 | Numaferm Gmbh | Variants of hlya and uses thereof |
| WO2021207679A1 (en) * | 2020-04-10 | 2021-10-14 | Liberty Biosecurity, Llc | Polypeptide compositions and uses thereof |
| CA3198703A1 (en) * | 2020-11-13 | 2022-05-19 | Timothy GEISTLINGER | Methods and compositions for producing recombinant components for use in food and other products |
| US20240117331A1 (en) * | 2021-02-10 | 2024-04-11 | Novozymes A/S | Polypeptides having pectinase activity, polynucleotides encoding same, and uses thereof |
| MX2023011028A (es) * | 2021-03-25 | 2023-09-27 | Bio Cat Inc | Mezclas de proteasas micoticas y usos de las mismas. |
| CN114015678A (zh) * | 2021-09-30 | 2022-02-08 | 中南民族大学 | 一种球形赖氨酸芽孢杆菌C3-41来源的氨肽酶Amp0279及其重组菌株和应用 |
| MX2021014268A (es) * | 2021-11-19 | 2022-02-16 | Univ Mexico Nac Autonoma | Proteina optimizada que comprende los aminoacidos esenciales para la nutricion humana. |
| US20230281444A1 (en) * | 2022-03-04 | 2023-09-07 | Cella Farms Inc | Computational system and algorithm for selecting nutritional microorganisms based on in silico protein quality determination |
| KR20250005200A (ko) | 2022-04-20 | 2025-01-09 | 노보자임스 에이/에스 | 유리 지방산을 제조하는 방법 |
| WO2023215798A1 (en) * | 2022-05-04 | 2023-11-09 | Locus Biosciences, Inc. | Phage compositions for escherichia comprising crispr-cas systems and methods of use thereof |
| US20250311734A1 (en) | 2022-05-14 | 2025-10-09 | Novozymes A/S | Compositions and Methods for Preventing, Treating, Suppressing and/or Eliminatting Phytopathogenic Infestations and Infections |
| CN115160420B (zh) * | 2022-06-24 | 2023-06-02 | 西南大学 | 盔形毕赤酵母scp类分泌蛋白及其应用 |
| WO2024220717A1 (en) * | 2023-04-20 | 2024-10-24 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| WO2025155915A1 (en) * | 2024-01-17 | 2025-07-24 | Anagram Therapeutics, Inc. | Methods and compositions for treating congenital sucrase-isomaltase deficiency |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6800726B1 (en) * | 1996-11-01 | 2004-10-05 | Pioneer Hi-Bred International, Inc. | Proteins with increased levels of essential amino acids |
| AR017831A1 (es) * | 1997-12-10 | 2001-10-24 | Pioneer Hi Bred Int | Metodo para alterar la composicion de aminoacidos de una proteina nativa de interes, proteina elaborada, y polinucleotido |
| US20060159724A1 (en) * | 2000-08-08 | 2006-07-20 | Bell Stacey J | Nutritional supplement for the management of weight |
| BR0212530A (pt) * | 2001-09-17 | 2005-04-12 | Monsanto Technology Llc | Proteìnas reforçadas e métodos para seu uso |
| US7273738B2 (en) * | 2002-10-01 | 2007-09-25 | Novozymes A/S | Family GH-61 polypeptides |
| CN1557475A (zh) * | 2004-02-04 | 2004-12-29 | 高春平 | 美容、减肥营养组合物 |
| EP2327316B1 (en) * | 2009-11-29 | 2016-11-16 | Premier Nutrition Corporation | Method of enhancing muscle protein synthesis |
| CA2786001A1 (en) * | 2009-12-31 | 2011-07-07 | Pioneer Hi-Bred International, Inc. | Engineering plant resistance to diseases caused by pathogens |
| WO2012128260A1 (ja) * | 2011-03-24 | 2012-09-27 | 旭硝子株式会社 | シゾサッカロミセス属酵母の形質転換体、該形質転換体の製造方法、β－グルコシダーゼの製造方法、およびセルロースの分解方法 |
| WO2013148329A1 (en) * | 2012-03-26 | 2013-10-03 | Pronutria, Inc. | Charged nutritive proteins and methods |
-
2013
- 2013-11-20 CA CA2892021A patent/CA2892021A1/en not_active Abandoned
- 2013-11-20 EP EP13856957.9A patent/EP2922416A4/en not_active Withdrawn
- 2013-11-20 JP JP2015543148A patent/JP2016500250A/ja not_active Withdrawn
- 2013-11-20 WO PCT/US2013/071091 patent/WO2014081884A1/en not_active Ceased
- 2013-11-20 CN CN201380070852.1A patent/CN104936466A/zh active Pending
- 2013-11-20 HK HK16102843.7A patent/HK1214739A1/zh unknown
- 2013-11-20 US US14/443,773 patent/US20150307562A1/en not_active Abandoned
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