HK1214739A1 - 工程化的分泌蛋白质和方法 - Google Patents

工程化的分泌蛋白质和方法 Download PDF

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Publication number
HK1214739A1
HK1214739A1 HK16102843.7A HK16102843A HK1214739A1 HK 1214739 A1 HK1214739 A1 HK 1214739A1 HK 16102843 A HK16102843 A HK 16102843A HK 1214739 A1 HK1214739 A1 HK 1214739A1
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HK
Hong Kong
Prior art keywords
proteins
amino acids
engineered
methods
amino acid
Prior art date
Application number
HK16102843.7A
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English (en)
Chinese (zh)
Inventor
‧巴薩
S‧巴萨
‧戈拉
K‧G‧戈拉
‧陳
Y-J‧陈
‧楊
D‧M‧杨
‧希爾弗
N‧W‧希尔弗
‧哈米爾
M‧哈米尔
‧貝瑞
D‧A‧贝瑞
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Axcella Health Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axcella Health Inc. filed Critical Axcella Health Inc.
Publication of HK1214739A1 publication Critical patent/HK1214739A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C12N9/2428—Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2445—Beta-glucosidase (3.2.1.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2477—Hemicellulases not provided in a preceding group
    • C12N9/248—Xylanases
    • C12N9/2482—Endo-1,4-beta-xylanase (3.2.1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK16102843.7A 2012-11-20 2013-11-20 工程化的分泌蛋白质和方法 HK1214739A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261728427P 2012-11-20 2012-11-20
US61/728,427 2012-11-20
PCT/US2013/071091 WO2014081884A1 (en) 2012-11-20 2013-11-20 Engineered secreted proteins and methods

Publications (1)

Publication Number Publication Date
HK1214739A1 true HK1214739A1 (zh) 2016-09-30

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Country Link
US (1) US20150307562A1 (enExample)
EP (1) EP2922416A4 (enExample)
JP (1) JP2016500250A (enExample)
CN (1) CN104936466A (enExample)
CA (1) CA2892021A1 (enExample)
HK (1) HK1214739A1 (enExample)
WO (1) WO2014081884A1 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105452476B (zh) 2013-05-31 2020-08-14 帝斯曼知识产权资产管理有限公司 用于二萜生产的微生物
AU2014296573A1 (en) 2013-07-29 2016-02-18 Danisco Us Inc. Variant enzymes
JP2016537302A (ja) * 2013-09-25 2016-12-01 アクセラ・ヘルス・インコーポレイテッドＡｘｃｅｌｌａ Ｈｅａｌｔｈ Ｉｎｃ． グルコースおよびカロリーの制限における、糖尿病および肥満の予防および処置のための組成物および配合物、ならびにその生成方法および使用方法
GB201401699D0 (en) * 2014-01-31 2014-03-19 Dupont Nutrition Biosci Aps Protein
CN103881994B (zh) * 2014-04-14 2020-03-27 中国农业科学院生物技术研究所 一种具有高转糖苷活性的β-半乳糖苷酶突变体及其制备方法和应用
FR3022558B1 (fr) * 2014-06-20 2019-01-25 Proteus Variants d'exoglucanases a activite amelioree et leurs utilisations
LT3197472T (lt) * 2014-09-22 2021-11-10 Tanea Medical Ab Rekombinantinių baltymų be fenilalanino naudojimas gydant fenilketonuriją
EP3201214A4 (en) * 2014-10-01 2018-04-04 Ansun Biopharma, Inc. Ecotin variants
HK1244185A1 (zh) * 2014-11-11 2018-08-03 Clara Foods Co. 用於生成卵清蛋白的方法和组合物
BR112017011271A2 (pt) 2014-12-19 2018-04-03 Novozymes As composição, polipeptídeo isolado, aditivo de ração animal, ração animal, métodos de melhoria de um ou mais parâmetros de desempenho de um animal, de solubilização de xilose de material à base de plantas, de liberação de amido de material à base de plantas, de melhoria do valor nutricional de uma ração animal, de preparação de uma ração animal e de produção do polipeptídeo, uso de uma composição, polinucleotídeo, construto de ácido nucleico ou vetor de expressão, e, célula hospedeira recombinante.
GB201501565D0 (en) * 2015-01-30 2015-03-18 Dupont Nutrition Biosci Aps Method
US20180243392A1 (en) * 2015-03-17 2018-08-30 Vanderbilt University Cs21 and lnga protein vaccines
EP3313193B1 (en) * 2015-06-26 2021-03-24 Novozymes A/S Method for producing a coffee extract
US10188135B2 (en) * 2015-11-04 2019-01-29 Stokley-Van Camp, Inc. Method for inducing satiety
US11167016B2 (en) 2016-02-18 2021-11-09 Amanoenzyme Inc. Intestinal flora improvement agent
AU2017270269A1 (en) * 2016-05-24 2018-11-15 Novozymes A/S Compositions comprising polypeptides having galactanase activity and polypeptides having beta-galactosidase activity
US10808268B2 (en) 2016-05-24 2020-10-20 Novozymes A/S Polypeptides having alpha-galactosidase activity and polynucleotides encoding same
WO2017202979A1 (en) * 2016-05-24 2017-11-30 Novozymes A/S Polypeptides having alpha-galactosidase activity and polynucleotides encoding same
WO2018005035A1 (en) 2016-06-27 2018-01-04 Novozymes A/S Method of dewatering post fermentation fluids
BR112019000089A2 (pt) * 2016-07-08 2019-07-09 Novozymes As variante de xilanase, composição, grânulo, aditivo de ração animal, formulação líquida, ração animal, métodos para aprimorar um ou mais parâmetros de desempenho de um animal, para solubilizar xilana a partir do material à base de planta, para liberar amido do material à base de planta, para aprimorar o valor nutricional de uma ração animal, para preparar uma massa ou um produto assado preparado a partir da massa, de produção de uma variante de xilanase e para obter uma variante de xilanase, uso de uma variante de xilanase, processo de produção de um produto de fermentação, polinucleotídeo isolado, construto de ácido nucleico ou vetor de expressão, e, célula hospedeira recombinante.
JP6845244B2 (ja) * 2016-07-19 2021-03-17 サントリーホールディングス株式会社 モグロールまたはモグロール配糖体の生産方法
PL3290436T3 (pl) 2016-09-01 2020-01-31 Metax Institut Für Diätetik Gmbh Białko wolne od fenyloalaniny do leczenia pku
EA201891926A1 (ru) * 2017-02-03 2019-04-30 Киверди, Инк. Микроорганизмы и искусственные экосистемы для производства белка, продуктов питания и полезных побочных продуктов из субстратов c1
EP3592429A1 (en) * 2017-03-06 2020-01-15 DuPont Nutrition Biosciences ApS Novel fungal fucosidases and their use in preventing and/or treating a pathogenic infection in an animal
EP3840582A4 (en) * 2018-08-21 2022-08-03 Clara Foods Co. MODIFICATION OF PROTEIN GLYCOSYLATION IN MICROORGANISMS
CA3118924A1 (en) 2018-11-09 2020-05-14 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
US20220169999A1 (en) * 2019-03-19 2022-06-02 Bayer Cropscience Lp Fusion proteins, recombinant bacteria, and exosporium fragements for plant health
EP4613765A1 (en) 2019-07-11 2025-09-10 Clara Foods Co. Protein compositions and consumable products thereof
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
EP4031661A1 (en) 2019-09-16 2022-07-27 Novozymes A/S Polypeptides having beta-glucanase activity and polynucleotides encoding same
WO2021185969A1 (en) * 2020-03-18 2021-09-23 Numaferm Gmbh Variants of hlya and uses thereof
EP3892290A1 (en) * 2020-04-08 2021-10-13 NUMAFERM GmbH Variants of hlya and uses thereof
WO2021207679A1 (en) * 2020-04-10 2021-10-14 Liberty Biosecurity, Llc Polypeptide compositions and uses thereof
EP4291634A4 (en) * 2021-02-10 2025-01-01 Novozymes A/S POLYPEPTIDES HAVING PECTINASE ACTIVITY, POLYNUCLEOTIDES FOR ENCODING THEM AND USES THEREOF
WO2022204576A1 (en) * 2021-03-25 2022-09-29 Bio-Cat, Inc. Fungal protease mixtures and uses thereof
CN114015678A (zh) * 2021-09-30 2022-02-08 中南民族大学 一种球形赖氨酸芽孢杆菌C3-41来源的氨肽酶Amp0279及其重组菌株和应用
MX2021014268A (es) * 2021-11-19 2022-02-16 Univ Mexico Nac Autonoma Proteina optimizada que comprende los aminoacidos esenciales para la nutricion humana.
US20230281444A1 (en) * 2022-03-04 2023-09-07 Cella Farms Inc Computational system and algorithm for selecting nutritional microorganisms based on in silico protein quality determination
CA3253720A1 (en) 2022-04-20 2023-10-26 Novozymes As PROCESS FOR PRODUCING FREE FATTY ACIDS
EP4519287A1 (en) * 2022-05-04 2025-03-12 Locus Biosciences, Inc. Phage compositions for escherichia comprising crispr-cas systems and methods of use thereof
CN119630280A (zh) 2022-05-14 2025-03-14 诺维信公司 用于预防、处理、抑制和/或消除植物病原性侵染和感染的组合物和方法
CN115160420B (zh) * 2022-06-24 2023-06-02 西南大学 盔形毕赤酵母scp类分泌蛋白及其应用
WO2024220717A1 (en) * 2023-04-20 2024-10-24 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
WO2025155915A1 (en) * 2024-01-17 2025-07-24 Anagram Therapeutics, Inc. Methods and compositions for treating congenital sucrase-isomaltase deficiency

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800726B1 (en) * 1996-11-01 2004-10-05 Pioneer Hi-Bred International, Inc. Proteins with increased levels of essential amino acids
AR017831A1 (es) * 1997-12-10 2001-10-24 Pioneer Hi Bred Int Metodo para alterar la composicion de aminoacidos de una proteina nativa de interes, proteina elaborada, y polinucleotido
US20060159724A1 (en) * 2000-08-08 2006-07-20 Bell Stacey J Nutritional supplement for the management of weight
CN100537600C (zh) * 2001-09-17 2009-09-09 孟山都技术公司 增强型蛋白及其应用方法
US7273738B2 (en) * 2002-10-01 2007-09-25 Novozymes A/S Family GH-61 polypeptides
CN1557475A (zh) * 2004-02-04 2004-12-29 高春平 美容、减肥营养组合物
EP2327316B1 (en) * 2009-11-29 2016-11-16 Premier Nutrition Corporation Method of enhancing muscle protein synthesis
US20110191903A1 (en) * 2009-12-31 2011-08-04 Pioneer Hi-Bred International, Inc. Engineering plant resistance to diseases caused by pathogens
WO2012128260A1 (ja) * 2011-03-24 2012-09-27 旭硝子株式会社 シゾサッカロミセス属酵母の形質転換体、該形質転換体の製造方法、β－グルコシダーゼの製造方法、およびセルロースの分解方法
BR112014023869A2 (pt) * 2012-03-26 2017-07-18 Pronutria Inc proteínas nutritivas carregadas e métodos

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JP2016500250A (ja) 2016-01-12
CA2892021A1 (en) 2014-05-30
EP2922416A1 (en) 2015-09-30
WO2014081884A9 (en) 2015-05-21
EP2922416A4 (en) 2016-07-20
CN104936466A (zh) 2015-09-23
WO2014081884A1 (en) 2014-05-30
US20150307562A1 (en) 2015-10-29

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