HK1214739A1 - 工程化的分泌蛋白质和方法 - Google Patents

工程化的分泌蛋白质和方法 Download PDF

Info

Publication number
HK1214739A1
HK1214739A1 HK16102843.7A HK16102843A HK1214739A1 HK 1214739 A1 HK1214739 A1 HK 1214739A1 HK 16102843 A HK16102843 A HK 16102843A HK 1214739 A1 HK1214739 A1 HK 1214739A1
Authority
HK
Hong Kong
Prior art keywords
proteins
amino acids
engineered
methods
amino acid
Prior art date
Application number
HK16102843.7A
Other languages
English (en)
Chinese (zh)
Inventor
‧巴薩
S‧巴萨
‧戈拉
K‧G‧戈拉
‧陳
Y-J‧陈
‧楊
D‧M‧杨
‧希爾弗
N‧W‧希尔弗
‧哈米爾
M‧哈米尔
‧貝瑞
D‧A‧贝瑞
Original Assignee
Axcella Health Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axcella Health Inc. filed Critical Axcella Health Inc.
Publication of HK1214739A1 publication Critical patent/HK1214739A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C12N9/2428—Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2445—Beta-glucosidase (3.2.1.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2477—Hemicellulases not provided in a preceding group
    • C12N9/248—Xylanases
    • C12N9/2482—Endo-1,4-beta-xylanase (3.2.1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK16102843.7A 2012-11-20 2013-11-20 工程化的分泌蛋白质和方法 HK1214739A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261728427P 2012-11-20 2012-11-20
US61/728,427 2012-11-20
PCT/US2013/071091 WO2014081884A1 (en) 2012-11-20 2013-11-20 Engineered secreted proteins and methods

Publications (1)

Publication Number Publication Date
HK1214739A1 true HK1214739A1 (zh) 2016-09-30

Family

ID=50776536

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16102843.7A HK1214739A1 (zh) 2012-11-20 2013-11-20 工程化的分泌蛋白质和方法

Country Status (7)

Country Link
US (1) US20150307562A1 (enExample)
EP (1) EP2922416A4 (enExample)
JP (1) JP2016500250A (enExample)
CN (1) CN104936466A (enExample)
CA (1) CA2892021A1 (enExample)
HK (1) HK1214739A1 (enExample)
WO (1) WO2014081884A1 (enExample)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015029580A2 (pt) * 2013-05-31 2017-09-19 Dsm Ip Assets Bv Microrganismo recombinante, processo para a preparação de um diterpeno ou diterpeno glicosilado, diterpeno ou diterpeno glicosilado, gêneros alimentícios, alimentos para animais ou bebidas e método para converter um primeiro diterpeno glicosilado em um segundo diterpeno glicosilado
CN105916981A (zh) 2013-07-29 2016-08-31 丹尼斯科美国公司 变体酶
EP3048904A2 (en) * 2013-09-25 2016-08-03 Pronutria Biosciences, Inc. Compositions and formulations for treatment of gastrointestinal tract malabsorption diseases and inflammatory conditions and methods of production and use thereof
GB201401699D0 (en) * 2014-01-31 2014-03-19 Dupont Nutrition Biosci Aps Protein
CN103881994B (zh) * 2014-04-14 2020-03-27 中国农业科学院生物技术研究所 一种具有高转糖苷活性的β-半乳糖苷酶突变体及其制备方法和应用
FR3022558B1 (fr) 2014-06-20 2019-01-25 Proteus Variants d'exoglucanases a activite amelioree et leurs utilisations
ES2896401T3 (es) * 2014-09-22 2022-02-24 Tanea Medical Ab Proteínas recombinantes exentas de Phe para su uso en el tratamiento de la fenilcetonuria
CN107135653A (zh) * 2014-10-01 2017-09-05 安迅生物制药公司 大肠杆菌素变体
EP3217807A4 (en) * 2014-11-11 2018-09-12 Clara Foods Co. Methods and compositions for egg white protein production
DK3234143T5 (da) 2014-12-19 2024-10-14 Novozymes As Sammensætninger omfattende polypeptider med xylanaseaktivitet og polypeptider med arabinofuranosidaseaktivitet
GB201501565D0 (en) * 2015-01-30 2015-03-18 Dupont Nutrition Biosci Aps Method
WO2016149482A2 (en) * 2015-03-17 2016-09-22 Vanderbilt University Cs21 and lnga protein vaccines
DK3313193T3 (da) * 2015-06-26 2021-06-07 Novozymes As Fremgangsmåde til fremstilling af en kaffeekstrakt
US10188135B2 (en) * 2015-11-04 2019-01-29 Stokley-Van Camp, Inc. Method for inducing satiety
WO2017142080A1 (ja) 2016-02-18 2017-08-24 天野エンザイム株式会社 腸内菌叢改善剤
WO2017202997A1 (en) * 2016-05-24 2017-11-30 Novozymes A/S Compositions comprising polypeptides having galactanase activity and polypeptides having beta-galactosidase activity
EP3462904B1 (en) * 2016-05-24 2024-12-18 Novozymes A/S Gastric stable polypeptides having alpha-galactosidase activity and polynucleotides encoding same
WO2017202966A1 (en) 2016-05-24 2017-11-30 Novozymes A/S Polypeptides having alpha-galactosidase activity and polynucleotides encoding same
US11273455B2 (en) 2016-06-27 2022-03-15 Novozymes A/S Method of dewatering post fermentation fluids
DK3481948T5 (da) * 2016-07-08 2024-09-02 Novozymes As Xylanasevarianter og polynukleotider, der koder for dem
JP6845244B2 (ja) * 2016-07-19 2021-03-17 サントリーホールディングス株式会社 モグロールまたはモグロール配糖体の生産方法
PT3290436T (pt) 2016-09-01 2019-08-30 Metax Inst Fuer Diaetetik Gmbh Proteína livre de fenilalanina para o tratamento de pku
EA201891926A1 (ru) * 2017-02-03 2019-04-30 Киверди, Инк. Микроорганизмы и искусственные экосистемы для производства белка, продуктов питания и полезных побочных продуктов из субстратов c1
EP3592429A1 (en) * 2017-03-06 2020-01-15 DuPont Nutrition Biosciences ApS Novel fungal fucosidases and their use in preventing and/or treating a pathogenic infection in an animal
EP3840582A4 (en) * 2018-08-21 2022-08-03 Clara Foods Co. MODIFICATION OF PROTEIN GLYCOSYLATION IN MICROORGANISMS
EP3877519B1 (en) 2018-11-09 2026-03-11 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
MX2021011361A (es) * 2019-03-19 2021-10-13 Bayer Cropscience Lp Proteinas de fusion, bacterias recombinantes y fragmentos de exosporios para la salud de las plantas.
SI3997118T1 (sl) 2019-07-11 2025-06-30 Clara Foods Co. Sestavek napitka, ki obsega rekombinantni ovomukoidni protein
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
PY2055454A (es) 2019-09-16 2022-03-31 Novozymes As Polipéptidos que poseen actividad de beta-glucanasa y polinucleótidos que los codifican
EP3892290A1 (en) * 2020-04-08 2021-10-13 NUMAFERM GmbH Variants of hlya and uses thereof
US12612436B2 (en) 2020-03-18 2026-04-28 Numaferm Gmbh Variants of hlya and uses thereof
WO2021207679A1 (en) * 2020-04-10 2021-10-14 Liberty Biosecurity, Llc Polypeptide compositions and uses thereof
CA3198703A1 (en) * 2020-11-13 2022-05-19 Timothy GEISTLINGER Methods and compositions for producing recombinant components for use in food and other products
US20240117331A1 (en) * 2021-02-10 2024-04-11 Novozymes A/S Polypeptides having pectinase activity, polynucleotides encoding same, and uses thereof
MX2023011028A (es) * 2021-03-25 2023-09-27 Bio Cat Inc Mezclas de proteasas micoticas y usos de las mismas.
CN114015678A (zh) * 2021-09-30 2022-02-08 中南民族大学 一种球形赖氨酸芽孢杆菌C3-41来源的氨肽酶Amp0279及其重组菌株和应用
MX2021014268A (es) * 2021-11-19 2022-02-16 Univ Mexico Nac Autonoma Proteina optimizada que comprende los aminoacidos esenciales para la nutricion humana.
US20230281444A1 (en) * 2022-03-04 2023-09-07 Cella Farms Inc Computational system and algorithm for selecting nutritional microorganisms based on in silico protein quality determination
KR20250005200A (ko) 2022-04-20 2025-01-09 노보자임스 에이/에스 유리 지방산을 제조하는 방법
WO2023215798A1 (en) * 2022-05-04 2023-11-09 Locus Biosciences, Inc. Phage compositions for escherichia comprising crispr-cas systems and methods of use thereof
US20250311734A1 (en) 2022-05-14 2025-10-09 Novozymes A/S Compositions and Methods for Preventing, Treating, Suppressing and/or Eliminatting Phytopathogenic Infestations and Infections
CN115160420B (zh) * 2022-06-24 2023-06-02 西南大学 盔形毕赤酵母scp类分泌蛋白及其应用
WO2024220717A1 (en) * 2023-04-20 2024-10-24 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
WO2025155915A1 (en) * 2024-01-17 2025-07-24 Anagram Therapeutics, Inc. Methods and compositions for treating congenital sucrase-isomaltase deficiency

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800726B1 (en) * 1996-11-01 2004-10-05 Pioneer Hi-Bred International, Inc. Proteins with increased levels of essential amino acids
AR017831A1 (es) * 1997-12-10 2001-10-24 Pioneer Hi Bred Int Metodo para alterar la composicion de aminoacidos de una proteina nativa de interes, proteina elaborada, y polinucleotido
US20060159724A1 (en) * 2000-08-08 2006-07-20 Bell Stacey J Nutritional supplement for the management of weight
BR0212530A (pt) * 2001-09-17 2005-04-12 Monsanto Technology Llc Proteìnas reforçadas e métodos para seu uso
US7273738B2 (en) * 2002-10-01 2007-09-25 Novozymes A/S Family GH-61 polypeptides
CN1557475A (zh) * 2004-02-04 2004-12-29 高春平 美容、减肥营养组合物
EP2327316B1 (en) * 2009-11-29 2016-11-16 Premier Nutrition Corporation Method of enhancing muscle protein synthesis
CA2786001A1 (en) * 2009-12-31 2011-07-07 Pioneer Hi-Bred International, Inc. Engineering plant resistance to diseases caused by pathogens
WO2012128260A1 (ja) * 2011-03-24 2012-09-27 旭硝子株式会社 シゾサッカロミセス属酵母の形質転換体、該形質転換体の製造方法、β－グルコシダーゼの製造方法、およびセルロースの分解方法
WO2013148329A1 (en) * 2012-03-26 2013-10-03 Pronutria, Inc. Charged nutritive proteins and methods

Also Published As

Publication number Publication date
JP2016500250A (ja) 2016-01-12
WO2014081884A9 (en) 2015-05-21
US20150307562A1 (en) 2015-10-29
WO2014081884A1 (en) 2014-05-30
EP2922416A4 (en) 2016-07-20
EP2922416A1 (en) 2015-09-30
CA2892021A1 (en) 2014-05-30
CN104936466A (zh) 2015-09-23

Similar Documents

Publication Publication Date Title
HK1206761A1 (en) Nutritive fragments, proteins and methods
HK1206764A1 (en) Nutritive proteins and methods
HK1206370A1 (en) Charged nutritive proteins and methods
WO2015048339A3 (en) Compositions and formulations for non-human nutrition and methods of production and use thereof
WO2015048332A3 (en) Secreted nutritive polypeptides and formulations thereof, and methods of production and use thereof
WO2010120514A3 (en) Antigen-binding proteins comprising recombinant protein scaffolds
HK1206765A1 (en) Nutritive fragments, proteins and methods
WO2013040093A3 (en) Glucagon-like peptide-2 compositions and methods of making and using same
IN2014CN00414A (enExample)
HK1216894A1 (zh) 多價結合蛋白組合物
WO2011146891A3 (en) High-affinity fully functional soluble single-domain human cd4, antibodies, and related fusion proteins
WO2012135805A3 (en) Delivery and formulation of engineered nucleic acids
AU2012257942A8 (en) Amino acid sequences directed against IL-17A, IL-17F and/or IL17-A/F and polypeptides comprising the same
WO2017058892A3 (en) Methods and compositions for antibody-evading virus vectors
TN2012000167A1 (en) Human il-23 antigen binding proteins
EP4276180A3 (en) Clostridium histolyticum enzyme
HK1206763A1 (en) Charged nutritive fragments, proteins and methods
WO2016022377A3 (en) Methods for modulating the glycosylation profile of recombinant proteins using dissolved oxygen
MY180953A (en) Acyl-acp thioesterase
HK1207881A1 (en) Improved enzyme variants
JP2016500250A5 (enExample)
HK1206762A1 (en) Nutritive fragments and proteins with low or no phenylalanine and methods
WO2014097113A3 (en) Production of therapeutic proteins in genetically modified mammalian cells
WO2009137778A3 (en) Methods and compositions for genetically engineering clostridia species
WO2013189972A3 (en) Use of polypeptides having protease activity in animal feed and detergents