JP2016196507A - Ophthalmic composition for silicone hydrogel contact lenses - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide ophthalmic compositions for silicone hydrogel contact lenses that can reduce the friction on the surface of a silicone hydrogel contact lens to improve a wearing feel thereof, effectively prevent generation of keratoconjunctival epithelial disorders, and allows the comfortable and safety use of silicone hydrogel contact lens.SOLUTION: An ophthalmic composition for silicone hydrogel contact lenses is prepared by combining dibutylhydroxytoluene and/or butylhydroxyanisol.SELECTED DRAWING: None

Description

  The present invention relates to an ophthalmic composition for a silicone hydrogel contact lens that can reduce friction on the surface of the silicone hydrogel contact lens, improve wearing feeling, and effectively prevent epithelial damage in the keratoconjunctiva. The present invention also relates to a method for reducing friction on the surface of a silicone hydrogel contact lens. Furthermore, this invention relates to the method of suppressing cell peeling at the time of removing a silicone hydrogel contact lens from the eyeball surface.

  In recent years, the number of wearers of contact lenses (CL) has increased, and in particular, the number of wearers of soft contact lenses (SCL) has increased. In general, it has been pointed out that when a soft contact lens is worn, the amount of oxygen supplied from the atmosphere decreases, which may result in suppression of corneal epithelial cell division and thickening of the cornea. Therefore, development of soft contact lenses having higher oxygen permeability has been advanced.

  Under such circumstances, silicone hydrogel contact lenses have been developed in recent years as soft contact lenses having high oxygen permeability. Silicone hydrogel contact lenses achieve oxygen permeability several times that of conventional hydrogel contact lenses by blending silicone with hydrogel. Therefore, it is highly expected that the oxygen supply shortage, which is a weak point of the soft contact lens, can be improved and the adverse effects on the cornea due to the oxygen shortage can be greatly suppressed.

  On the other hand, it has recently been reported that the surface of a silicone hydrogel contact lens has significant irregularities that are not found on the surface of a normal hydrogel contact lens (see Non-Patent Document 1). Such prominent irregularities are not only easier to attach biological substances and dirt than those with a smooth surface, but are also expected to increase friction, especially in sensitive eye tissues It is also fully conceivable to cause discomfort such as a foreign body feeling and a dry feeling. In addition, there is a concern that contact lenses having significant irregularities may rub against the ocular mucosa during wearing and may cause epithelial damage to the keratoconjunctiva.

  Dibutylhydroxytoluene and / or butylhydroxyanisole is well known as an antioxidant and is widely used as an additive blended in foods and pharmaceuticals (see Patent Documents 1 and 2). However, until now, it has not been known at all about the influence of dibutylhydroxytoluene and / or butylhydroxyanisole on silicone hydrogel contact lenses. In addition, from the prior art, the effect of applying dibutylhydroxytoluene and / or butylhydroxyanisole and other components to a silicone hydrogel contact lens cannot be estimated at all.

Japanese Patent No. 3021312 JP 2007-99697 A

Akemi Hariya et al., 51st Annual Meeting of the Japanese Contact Lens Society Program Abstracts, 110 pages

  As a result of various studies on the physical properties of various soft contact lenses, the present inventors have found that silicone hydrogel contact lenses (hereinafter sometimes simply referred to as “SHCL”) are compared to conventional hydrogel contact lenses. It was confirmed that the friction on the lens surface was extremely large. This large frictional force is thought to be due to the already reported significant unevenness of the surface, but such a large friction is uncomfortable (such as a foreign object or dry feeling) when using the SHCL. It may cause eye fatigue. In addition, a contact lens with high friction may cause epithelial damage to the keratoconjunctiva when the mucous membrane on the back side of the eyelid and the contact lens surface rub against each other or whenever the contact lens moves on the eyeball surface. Therefore, it is possible to reduce the friction on the surface of the silicone hydrogel contact lens, improve its feeling of wear, effectively prevent epithelial damage etc. in the keratoconjunctiva, and use the silicone hydrogel contact lens comfortably and safely. There is a need to develop a means to

  As a result of diligent studies to solve the above problems, the present inventors have found that the friction of SHCL can be greatly reduced by applying dibutylhydroxytoluene and / or butylhydroxyanisole to SHCL. The friction of this SHCL can be further reduced by applying a combination of pranoprofen and / or its salt to dibutylhydroxytoluene and / or butylhydroxyanisole. In addition, the present inventors have further investigated and found that cell detachment that occurs when SHCL is removed from the eyeball surface can be effectively suppressed by using dibutylhydroxytoluene and / or butylhydroxyanisole. The present invention has been completed by making further improvements based on such findings.

That is, the present invention provides the following ophthalmic compositions for silicone hydrogel contact lenses.
Item 1-1. An ophthalmic composition for a silicone hydrogel contact lens, comprising at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole.
Item 1-2. Item 10. The ophthalmic composition for silicone hydrogel contact lenses according to Item 1-1, which contains dibutylhydroxytoluene.
Item 1-3. Item 11. The silicone hydrogel contact lens according to Item 1-1 or 1-2, which contains 0.00005 to 0.05 w / v% in total of at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole Ophthalmic composition.
Item 1-4. Item 4. The ophthalmic composition for silicone hydrogel contact lens according to any one of Items 1-1 to 1-3, further comprising at least one selected from the group consisting of pranoprofen and a salt thereof.
Item 1-5. Item 5. The ophthalmic composition for silicone hydrogel contact lenses according to Item 1-4, which contains at least one selected from the group consisting of pranoprofen and a salt thereof in a total amount of 0.001 to 0.3 w / v%.
Item 1-6. The ophthalmic composition for silicone hydrogel contact lenses according to any one of Items 1-1 to 1-5, further comprising a surfactant.
Item 1-7. Item 7. The ophthalmic composition for silicone hydrogel contact lenses according to Item 1-6, which contains a nonionic surfactant as a surfactant.
Item 1-8. Item 8. The ophthalmic composition for silicone hydrogel contact lens according to Item 1-6 or 1-7, wherein the surfactant is contained in a total amount of 0.001 to 1.0 w / v%.
Item 1-9. Item 10. The ophthalmic composition for silicone hydrogel contact lens according to any one of Items 1-1 to 1-8, further comprising a buffer.
Item 1-10. Item 10. The ophthalmic composition for silicone hydrogel contact lenses according to Item 1-9, which contains a borate buffer as a buffer.
Item 1-11. Item 10. The ophthalmic composition for silicone hydrogel contact lenses according to Item 1-9 or 1-10, comprising a buffering agent in a total amount of 0.01 to 10 w / v%.
Item 1-12. The ophthalmic composition for silicone hydrogel contact lenses according to any one of Items 1-1 to 1-11, further comprising an isotonic agent.
Item 1-13. The ophthalmology for silicone hydrogel contact lenses according to Item 1-12, which contains at least one selected from the group consisting of glycerin, propylene glycol, sodium chloride, potassium chloride, calcium chloride, and magnesium chloride as an isotonic agent. Composition.
Item 1-14. Item 14. The ophthalmic composition for silicone hydrogel contact lens according to Item 1-12 or 1-13, which contains an isotonic agent in a total amount of 0.01 to 10 w / v%.
Item 1-15. Item 15. An ophthalmic composition for silicone hydrogel contact lenses according to any one of Items 1-1 to 1-14, which is an eye drop.
Item 1-16. Item 15. The ophthalmic composition for a silicone hydrogel contact lens according to any one of Items 1-1 to 1-15, which is used for reducing friction of the silicone hydrogel contact lens.
Item 1-17. Item 15. The ophthalmic composition for a silicone hydrogel contact lens according to any one of Items 1-1 to 1-15, which is used for suppressing cell detachment that occurs when the silicone hydrogel contact lens is removed from the surface of the eyeball.

Furthermore, this invention provides the friction reduction method of the silicone hydrogel contact lens hung up below.
Item 2-1. A method for reducing friction of a silicone hydrogel contact lens, comprising contacting a silicone hydrogel contact lens with at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole.
Item 2-2. The method according to Item 2-1, wherein the ophthalmic composition for a silicone hydrogel contact lens according to any one of Items 1-1 to 1-17 is contacted with a silicone hydrogel contact lens.

Furthermore, this invention provides the method of providing the effect | action which reduces the friction of the silicone hydrogel contact lens hung up below to an ophthalmic composition.
Item 3. The ophthalmic composition for a silicone hydrogel contact lens is blended with at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole, and has the effect of reducing friction of the silicone hydrogel contact lens. A method of applying to an ophthalmic composition.

Furthermore, this invention provides the method of suppressing the cell peeling from the eyeball surface accompanying removal of the silicone hydrogel contact lens hung up below.
Item 4-1. A cell from the surface of the eyeball associated with the removal of the silicone hydrogel contact lens, wherein the silicone hydrogel contact lens is brought into contact with at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole A method for suppressing peeling.
Item 4-2. Item 14. The method according to Item 4-1, wherein the ophthalmic composition for a silicone hydrogel contact lens according to any one of Items 1-1 to 1-17 is contacted with a silicone hydrogel contact lens.

Furthermore, this invention provides the method of providing the effect | action which suppresses the cell peeling from the eyeball surface accompanying removal of the silicone hydrogel contact lens hung up below to an ophthalmic composition.
Item 5. The ophthalmic composition for silicone hydrogel contact lenses is blended with at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole, from the surface of the eyeball accompanying removal of the silicone hydrogel contact lens A method for imparting the ophthalmic composition with an action of suppressing cell detachment.

Furthermore, the present invention also provides the uses listed below.
Item 6-1. Use of at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole for the manufacture of an ophthalmic composition for silicone hydrogel contact lenses.
Item 6-2. (A) At least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole and (B) selected from the group consisting of pranoprofen and a salt thereof for the production of an ophthalmic composition for silicone hydrogel contact lenses At least one use.
Item 6-3. The use according to Item 6-1 or 6-2, wherein the ophthalmic composition for a silicone hydrogel contact lens is the ophthalmic composition according to any one of Items 1-1 to 1-17.
Item 6-4. Use of at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole for the manufacture of an agent for reducing friction of silicone hydrogel contact lenses.
Item 6-5. (A) at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole and (B) pranoprofen and its salts for the manufacture of an agent for reducing friction of silicone hydrogel contact lenses At least one use selected from the group consisting of:
Item 6-6. Use of at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole for the manufacture of an agent for suppressing cell detachment from the surface of the eyeball accompanying removal of a silicone hydrogel contact lens.
Item 6-7. (A) at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole for the manufacture of an agent for inhibiting cell detachment from the surface of the eyeball accompanying removal of the silicone hydrogel contact lens; B) At least one use selected from the group consisting of pranoprofen and its salts.

  According to the ophthalmic composition for SHCL of the present invention, the friction of the SHCL surface can be greatly reduced. Therefore, the ophthalmic composition for SHCL of the present invention can improve the wearing feeling of SHCL, can effectively prevent the occurrence of epithelial damage in the keratoconjunctiva, and can use SHCL comfortably and safely. Realized.

  In addition, according to the ophthalmic composition for SHCL of the present invention, the risk of cell detachment that occurs when SHCL is removed from the surface of the eyeball can be greatly reduced. Therefore, according to the ophthalmic composition for SHCL of the present invention, it is possible to safely remove SHCL without damaging epithelial cells on the surface of the eyeball.

In the reference test example 1, it is a figure which shows the result of having evaluated the friction (The logarithmic attenuation factor measured by a rigid pendulum physical property test) of various soft contact lenses. In Test Example 1, it is a figure which shows the result of having evaluated the reduction effect of the friction which a test liquid (Example 1-2 and Comparative Example 1-2) exerts on SHCL (lens A). In Test Example 1, it is a figure which shows the result of having evaluated the friction reduction effect which a test liquid (Example 1-2 and Comparative Example 1) exerts on SHCL (lens C). In Test Example 1, it is a figure which shows the result of having evaluated the reduction effect of the friction which a test liquid (Example 1 and Comparative Example 1) exerts on a hydrogel lens (lens D). In Test Example 2, it is a figure which shows the result of having evaluated the friction reduction effect which a test liquid (Example 3 and Comparative Example 3) exerts on SHCL (lens A). In Test Example 3, it is a figure which shows the result of having evaluated the effect which a test liquid (Example 5 and Comparative Example 5) suppresses cell peeling accompanying removal of SHCL.

1. The ophthalmic composition for SHCL The ophthalmic composition for SHCL of the present invention comprises at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole (hereinafter sometimes simply referred to as “dibutylhydroxytoluenes”). contains. By using such dibutylhydroxytoluenes, it becomes possible to reduce the friction on the surface of the SHCL, and to suppress cell detachment that occurs when the SHCL is removed from the surface of the eyeball.

  Dibutylhydroxytoluene (chemical name 2,6-di-tert-butyl-4-methylphenol; sometimes abbreviated as BHT) and butylhydroxyanisole (chemical names 2-tert-butyl-4-methoxyphenol and 3- tert-butyl-4-methoxyphenol (sometimes abbreviated as BHA) is a compound in which a t-butyl group is substituted on the benzene ring of hydroxytoluene or hydroxyanisole, and is known as an antioxidant. Dibutylhydroxytoluene and butylhydroxyanisole may be synthesized by a known method or may be obtained as a commercial product.

  In the ophthalmic composition for SHCL of the present invention, any one of dibutylhydroxytoluene and butylhydroxyanisole may be used alone or in combination as dibutylhydroxytoluenes. Among them, dibutylhydroxytoluene can greatly reduce the friction of SHCL, and can effectively suppress cell detachment that occurs when SHCL is removed from the surface of the eyeball. From this viewpoint, dibutylhydroxytoluene can be particularly preferably used in the present invention.

  In the ophthalmic composition for SHCL of the present invention, the blending ratio of the dibutylhydroxytoluene may be appropriately set according to the type of the dibutylhydroxytoluene, the formulation form of the ophthalmic composition for SHCL, etc. From the viewpoint of effectively reducing friction, and from the viewpoint of effectively suppressing cell detachment when the SHCL is removed from the surface of the eyeball, for example, dibutylhydroxy with respect to the total amount of the ophthalmic composition for SHCL. The total amount of toluene is 0.00005 to 0.05 w / v%, preferably 0.0001 to 0.03 w / v%, more preferably 0.0005 to 0.01 w / v%, particularly preferably 0.001. -0.005 w / v% is illustrated.

  In addition to the dibutylhydroxytoluenes, the ophthalmic composition for SHCL of the present invention is at least one selected from the group consisting of pranoprofen and a salt thereof (hereinafter simply referred to as “planoprofen”). In some cases). Thus, by using the dibutylhydroxytoluenes together with pranoprofens, it is possible to enhance the friction reducing effect on the SHCL surface.

  Planoprofen is a known compound also called α-methyl-5H- [1] benzopyrano [2,3-b] pyridine-7-acetic acid, which may be synthesized by a known method and obtained as a commercial product. You can also.

  The salt of pranoprofen is not particularly limited as long as it is pharmaceutically, pharmacologically (pharmacologically) or physiologically acceptable. Specifically, a salt with an inorganic base [for example, sodium Salts, potassium salts, calcium salts, magnesium salts, aluminum salts, etc.] and salts with organic bases [eg salts with methylamine, triethylamine, diethylamine, triethanolamine, morpholine, piperazine, pyrrolidine, tripyridine, picoline, etc.] Etc. These pranoprofen salts may be used alone or in any combination of two or more.

  In the ophthalmic composition for SHCL of the present invention, as the planoprofen, one kind of pranoprofen and a salt thereof may be selected and used alone, or two or more kinds may be arbitrarily selected. You may use it in combination. Among these, pranoprofen is preferable from the viewpoint of further enhancing the effect of reducing friction on the SHCL surface by the dibutylhydroxytoluenes.

  When pranoprofen is blended in the ophthalmic composition for SHCL of the present invention, these blending ratios are appropriately set according to the type of the dibutylhydroxytoluene, the formulation form of the ophthalmic composition for SHCL, etc. For example, with respect to the total amount of the ophthalmic composition for SHCL, the total amount of pranoprofen is 0.001 to 0.3 w / v%, preferably 0.005 to 0.2 w / v%, more preferably 0. A ratio of 01 to 0.1 w / v% is exemplified.

  When pranoprofen is blended in the ophthalmic composition for SHCL of the present invention, the ratio of pranoprofen to the dibutylhydroxytoluene is not particularly limited, but the SHCL surface by the dibutylhydroxytoluene From the viewpoint of effectively enhancing the friction reducing effect, for example, per 100 parts by weight of the total amount of the dibutylhydroxytoluenes, the total amount of pranoprofen is 20 to 40,000 parts by weight, preferably 100 to 20000 parts by weight, more preferably A range of 200 to 10,000 parts by weight is exemplified.

  The ophthalmic composition for SHCL of the present invention may further contain a surfactant. The surfactant that can be blended in the ophthalmic composition for SHCL of the present invention is not particularly limited as long as it is pharmaceutically, pharmacologically (pharmaceutically) or physiologically acceptable, and is a nonionic surfactant. Any of an agent, an amphoteric surfactant, an anionic surfactant, and a cationic surfactant may be used.

  Specific examples of the nonionic surfactant that can be incorporated into the ophthalmic composition for SHCL of the present invention include monolauric acid POE (20) sorbitan (polysorbate 20) and monopalmitic acid POE (20) sorbitan (polysorbate 40). POE sorbitan fatty acid esters such as monostearic acid POE (20) sorbitan (polysorbate 60), tristearic acid POE (20) sorbitan (polysorbate 65), monooleic acid POE (20) sorbitan (polysorbate 80); POE / POP block copolymers such as poloxamer 235, poloxamer 188, poloxamer 403, poloxamer 237, poloxamer 124; POE cured castor oil such as POE (60) hydrogenated castor oil (polyoxyethylene hydrogenated castor oil 60); POE (9 ) POE alkyl ethers such as lauryl ether; POE-POP alkyl ethers such as POE (20) POP (4) cetyl ether POE (10) POE alkylphenyl ethers such as nonylphenyl ether. In the compounds exemplified above, POE is polyoxyethylene, POP is polyoxypropylene, and the numbers in parentheses indicate the number of moles added. Specific examples of the amphoteric surfactant that can be blended in the ophthalmic composition for SHCL of the present invention include alkyldiaminoethylglycine. Specific examples of the cationic surfactant that can be incorporated into the ophthalmic composition for SHCL of the present invention include benzalkonium chloride and benzethonium chloride. Specific examples of the anionic surfactant that can be incorporated into the ophthalmic composition for SHCL of the present invention include alkylbenzene sulfonate, alkyl sulfate, polyoxyethylene alkyl sulfate, and aliphatic α-sulfomethyl. Examples include esters and α-olefin sulfonic acids.

  In the ophthalmic composition for SHCL of the present invention, the surfactant may be used alone or in combination of two or more.

  Among the above surfactants, preferably nonionic surfactants; more preferably POE sorbitan fatty acid esters, POE hydrogenated castor oil, or POE / POP block copolymers; more preferably POE sorbitan fatty acid esters or POE Hardened castor oil; particularly preferably POE sorbitan fatty acid esters are used. Among the POE sorbitan fatty acid esters, polysorbate 80 is particularly preferable.

  When a surfactant is blended in the ophthalmic composition for SHCL of the present invention, the blending ratio of the surfactant is the type of the surfactant, the type and amount of other blended components, the ophthalmic composition for SHCL. It can set suitably according to a formulation form etc. As an example of the blending ratio of the surfactant, the total amount of the surfactant is 0.001 to 1.0 w / v%, preferably 0.005 to 0.7 w / relative to the total amount of the ophthalmic composition for SHCL. Examples thereof include v%, more preferably 0.01 to 0.5 w / v%, particularly preferably 0.1 to 0.5 w / v%.

  The ophthalmic composition for SHCL of the present invention may further contain a buffer. The buffer that can be incorporated into the ophthalmic composition for SHCL of the present invention is not particularly limited as long as it is pharmaceutically, pharmacologically (pharmaceutically) or physiologically acceptable. Examples of such buffers include borate buffer, phosphate buffer, carbonate buffer, citrate buffer, acetate buffer, tris buffer, epsilon-aminocaproic acid, aspartic acid, aspartate and the like. These buffering agents may be used in combination. Preferred buffering agents are borate buffer, phosphate buffer, carbonate buffer, and citrate buffer, and more preferred are borate buffer and phosphate buffer, and particularly preferred buffer. Is a borate buffer. Examples of the boric acid buffer include boric acid or boric acid salts such as alkali metal borate and alkaline earth metal borate. Examples of the phosphate buffer include phosphoric acid or phosphates such as alkali metal phosphates and alkaline earth metal phosphates. Examples of the carbonate buffer include carbonates or carbonates such as alkali metal carbonates and alkaline earth metal carbonates. Examples of the citrate buffer include citric acid, alkali metal citrate, and alkaline earth metal citrate. Moreover, you may use the borate or the hydrate of a phosphate as a borate buffer or a phosphate buffer. As a more specific example, boric acid or a salt thereof (sodium borate, potassium tetraborate, potassium metaborate, ammonium borate, borax, etc.); as a phosphate buffer, phosphoric acid or a salt thereof Salt (disodium hydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, trisodium phosphate, dipotassium phosphate, calcium monohydrogen phosphate, calcium dihydrogen phosphate, etc.); Or a salt thereof (sodium bicarbonate, sodium carbonate, ammonium carbonate, potassium carbonate, calcium carbonate, potassium bicarbonate, magnesium carbonate, etc.); citric acid or a salt thereof (sodium citrate, potassium citrate, citric acid, etc.) Calcium acetate, sodium dihydrogen citrate, disodium citrate, etc.); with acetate buffer Acetic acid or a salt thereof (ammonium acetate, potassium acetate, calcium acetate, sodium acetate, etc.); as a Tris buffer, tris (hydroxymethyl) aminomethane or a salt thereof (hydrochloride, acetate, sulfonate, etc.); Examples include aspartic acid or a salt thereof (sodium aspartate, magnesium aspartate, potassium aspartate, etc.). Among these buffering agents, boric acid buffering agents are preferably used in the ophthalmic composition for SHCL of the present invention because they are expected to exhibit the effects of the present invention more reliably. These buffering agents may be used alone or in any combination of two or more.

  When a buffering agent is blended with the ophthalmic composition for SHCL of the present invention, the blending ratio of the buffering agent depends on the type of buffering agent used, the type and amount of other blending components, the formulation form of the ophthalmic composition, etc. Depending on the total amount of the ophthalmic composition for SHCL, for example, the total amount of the buffer is 0.01 to 10 w / v%, preferably 0.1 to 5 w / Examples are v%, more preferably 0.5 to 2 w / v%.

  The ophthalmic composition for SHCL of the present invention may further contain an isotonic agent. The isotonic agent that can be incorporated into the ophthalmic composition for SHCL of the present invention is not particularly limited as long as it is pharmaceutically, pharmacologically (pharmaceutically) or physiologically acceptable. Specific examples of such isotonic agents include, for example, disodium hydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, sodium hydrogen sulfite, sodium sulfite, potassium chloride, calcium chloride, sodium chloride, magnesium chloride, acetic acid Examples include potassium, sodium acetate, sodium hydrogen carbonate, sodium carbonate, sodium thiosulfate, magnesium sulfate, glycerin, propylene glycol and the like. Among these isotonic agents, glycerin, propylene glycol, sodium chloride, potassium chloride, calcium chloride, and magnesium chloride are preferable from the viewpoint of achieving the effect of the present invention more surely, and more preferably. Examples include glycerin and sodium chloride. These isotonic agents may be used alone or in any combination of two or more.

  When an isotonic agent is blended in the ophthalmic composition for SHCL of the present invention, the blending ratio of the tonicity agent varies depending on the type of tonicity agent used and cannot be defined uniformly. However, for example, the proportion of the tonicity agent is 0.01 to 10 w / v%, preferably 0.05 to 5 w / v%, more preferably 0.1 to 3 w / v% in the total amount. .

  The pH of the ophthalmic composition for SHCL of the present invention is not particularly limited as long as it is within a pharmaceutically, pharmacologically (pharmaceutical) or physiologically acceptable range. An example of the pH of the ophthalmic composition for SHCL of the present invention is 4.0 to 9.5, preferably 5.0 to 9.0, and more preferably 5.5 to 8.5.

  Further, the osmotic pressure of the ophthalmic composition for SHCL of the present invention is not particularly limited as long as it is within a range acceptable for a living body. As an example of the osmotic pressure ratio of the ophthalmic composition for SHCL of the present invention, a range of preferably 0.5 to 5.0, more preferably 0.6 to 3.0, particularly preferably 0.7 to 2.0. Can be mentioned. The osmotic pressure can be adjusted by a method known in the art using inorganic salts, polyhydric alcohols, sugar alcohols, saccharides and the like. The osmotic pressure ratio is the ratio of the osmotic pressure of the sample to 286 mOsm (0.9 w / v% sodium chloride aqueous solution) based on the 15th revised Japanese pharmacopoeia. Measure with reference to the descent method. The standard solution for measuring the osmotic pressure ratio (0.9 w / v% sodium chloride aqueous solution) was dried in sodium chloride (Japanese Pharmacopoeia standard reagent) at 500 to 650 ° C. for 40 to 50 minutes and then released in a desiccator (silica gel). Cool and accurately measure 0.900 g and dissolve in purified water to make exactly 100 mL, or use a commercially available standard solution for osmotic pressure ratio measurement (0.9 w / v% sodium chloride aqueous solution).

The ophthalmic composition for SHCL of the present invention may contain an appropriate amount of various pharmacologically active components and physiologically active components in addition to the above components, as long as the effects of the present invention are not hindered. Such an ingredient is not particularly limited, and examples thereof include an active ingredient in an ophthalmic drug described in the over-the-counter drug manufacturing (import) approval standard 2000 edition (supervised by the Pharmaceutical Affairs Research Committee). Specifically, the following components are listed as components used in ophthalmic drugs.
Antihistamines: for example, iproheptin, diphenhydramine hydrochloride, chlorpheniramine maleate, ketotifen fumarate, pemirolast potassium and the like.
Decongestant: For example, tetrahydrozoline hydrochloride, naphazoline hydrochloride, naphazoline sulfate, epinephrine hydrochloride, ephedrine hydrochloride, methylephedrine hydrochloride, and the like.
Fungicide: For example, cetylpyridinium, benzalkonium chloride, benzethonium chloride, chlorhexidine hydrochloride, chlorhexidine gluconate, polyhexamethylene biguanide hydrochloride, and the like.
Vitamins: For example, flavin adenine dinucleotide sodium, cyanocobalamin, retinol acetate, retinol palmitate, pyridoxine hydrochloride, panthenol, calcium pantothenate, tocopherol acetate and the like.
Amino acids: For example, potassium aspartate, magnesium aspartate, aminoethylsulfonic acid and the like.
Anti-inflammatory agent: for example, dipotassium glycyrrhizinate, allantoin, azulene, sodium azulenesulfonate, guaiazulene, ε-aminocaproic acid, berberine chloride, berberine sulfate, lysozyme chloride, licorice and the like.
Astringent: For example, zinc white, zinc lactate, zinc sulfate and the like.
Other: For example, sodium cromoglycate, sodium chondroitin sulfate, sodium hyaluronate, sulfamethoxazole, sodium sulfamethoxazole and the like.

In addition, in the ophthalmic composition for SHCL of the present invention, various additives are appropriately selected according to a conventional method according to its use and form as long as they do not impair the effects of the invention, and one or more of them are selected. May be used in an appropriate amount. Examples of these additives include various additives described in Pharmaceutical Additives Encyclopedia 2007 (edited by Japan Pharmaceutical Additives Association). Typical additives include the following additives.
Carrier: An aqueous carrier such as water or hydrous ethanol.
Thickeners: for example, carboxyvinyl polymer, hydroxyethylcellulose, hydroxypropylmethylcellulose, methylcellulose, alginic acid, polyvinyl alcohol (completely or partially saponified product), polyvinylpyrrolidone, macrogol and the like.
Sugars: For example, cyclodextrins and the like.
Sugar alcohols: For example, xylitol, sorbitol, mannitol and the like. These may be d-form, l-form or dl-form.
Preservatives, bactericides or antibacterial agents: for example, alkyldiaminoethylglycine hydrochloride, sodium benzoate, ethanol, benzalkonium chloride, benzethonium chloride, chlorhexidine gluconate, chlorobutanol, sorbic acid, potassium sorbate, sodium dehydroacetate, paraoxy Methyl benzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, oxyquinoline sulfate, phenethyl alcohol, benzyl alcohol, biguanide compounds (specifically, polyhexamethylene biguanide, etc.), Glowyl (manufactured by Rhodia) Name) etc.
pH adjuster: for example, hydrochloric acid, boric acid, aminoethylsulfonic acid, epsilon-aminocaproic acid, citric acid, acetic acid, sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, sodium bicarbonate, sodium carbonate, boro Sand, triethanolamine, monoethanolamine, diisopropanolamine, sulfuric acid, phosphoric acid, polyphosphoric acid, propionic acid, oxalic acid, gluconic acid, fumaric acid, lactic acid, tartaric acid, malic acid, succinic acid, gluconolactone, ammonium acetate etc.
Stabilizers: for example, trometamol, sodium formaldehyde sulfoxylate (Longalite), tocopherol, sodium pyrosulfite, monoethanolamine, aluminum monostearate, glyceryl monostearate, etc.
Chelating agents: for example, ethylenediaminediacetic acid (EDDA), ethylenediaminetriacetic acid, ethylenediaminetetraacetic acid (edetic acid, EDTA), N- (2-hydroxyethyl) ethylenediaminetriacetic acid (HEDTA), diethylenetriaminepentaacetic acid (DTPA), and the like.
Perfume or refreshing agent: for example, menthol, anethole, eugenol, camphor, geraniol, cineol, borneol, limonene, ryuno and the like. These may be either d-form, l-form or dl-form, and are formulated as essential oils (mint oil, cool mint oil, spearmint oil, peppermint oil, fennel oil, cinnamon oil, bergamot oil, eucalyptus oil, rose oil, etc.) May be.

  The ophthalmic composition for SHCL of the present invention is prepared by adding a desired amount of the above-mentioned dibutylhydroxytoluenes and, if necessary, other ingredients to a desired concentration.

  The ophthalmic composition for SHCL of the present invention is not particularly limited as long as it can be used in the ophthalmic field, and examples thereof include liquids and ointments. Among these, liquid is preferable. Of the liquids, aqueous liquids are preferred. When the ophthalmic composition for SHCL of the present invention is made into an aqueous liquid, pharmaceutically, pharmacologically (pharmaceutically) or physiologically acceptable water may be used as an aqueous carrier. Specifically, distilled water, normal water, purified water, sterilized purified water, water for injection, distilled water for injection and the like are exemplified. These definitions are based on the 1st 5th Japanese Pharmacopoeia. Here, the aqueous liquid means a liquid form containing water, and usually 1% by weight or more, preferably 5% by weight or more, more preferably 20% by weight or more of water in the ophthalmic composition for SHCL. More preferably, it means one containing 50% by weight or more.

  The ophthalmic composition for SHCL of the present invention is not limited in its formulation form as long as it is used in the ophthalmic field and is used so as to come into contact with SHCL. For example, eye drops for SHCL (eye drops that can be used while wearing SHCL), eye drops for SHCL (eye wash that can be used while wearing SHCL), SHCL wearing liquid, SHCL care liquid (SHCL disinfectant, SHCL Storage solution, SHCL cleaning solution, SHCL cleaning storage solution, etc.). Among these, the eye drops for SHCL or the SHCL wearing liquid, especially the eye drops for SHCL are used when the SHCL is in contact with the eyeball surface or immediately before the contact (for example, within 10 minutes before the wearing action to be brought into contact). ) And is a preparation form that strongly desires to exert the friction reducing action of SHCL. In particular, in the case of eye drops, there is an advantage that when an uncomfortable feeling or tired eyes are felt during SHCL wearing, it can be used immediately on the spot. In addition, since eye drops are generally used more frequently per day than other ophthalmic compositions, there is also an advantage that the friction reducing effect of the SHCL ophthalmic composition of the present invention can be obtained more effectively. In addition, from the viewpoint of enabling safe removal of SHCL, the eye drop preparation form that can be used immediately before the removal of SHCL (for example, within 10 minutes before the removal) is convenient, and the cells when removing SHCL are convenient. Peeling can be more effectively suppressed. In view of this point of view, preferred examples of the ophthalmic composition for SHCL of the present invention include SHCL eye drops and SHCL mounting solutions, and particularly preferred examples include SHCL eye drops.

  The method for using the ophthalmic composition for SHCL of the present invention is not particularly limited as long as it is a known method having a step of bringing the ophthalmic composition for SHCL into contact with SHCL. For example, in the case of an eye drop for SHCL, an appropriate amount of the eye drop is administered before wearing SHCL (for example, immediately before wearing 10 minutes before wearing) or during wearing (for example, including immediately before removing 10 minutes before removing). Just drop it in. In the case of an eye wash for SHCL, an appropriate amount of the eye wash may be used for eye washing before (for example, just before wearing) or during (for example, just before desorption) wearing SHCL. In addition, when the ophthalmic composition for SHCL of the present invention is an eye drop for SHCL or an eye wash for SHCL, it can be used for the purpose of eye drops or eye wash even when not wearing SHCL. it can. Moreover, in the case of SHCL mounting liquid, it is used by contacting SHCL with an appropriate amount of the mounting liquid when SHCL is mounted. Furthermore, in the case of an SHCL care solution, it is used by immersing SHCL in an appropriate amount of the care solution, or by bringing SHCL into contact with the care solution and scrubbing.

  In the ophthalmic composition for SHCL of the present invention, the type of SHCL to be applied is not particularly limited, and any SHCL that is currently marketed or will be marketed in the future regardless of whether it is ionic or nonionic. Can be applied. Here, ionic refers to the content of ionic components in contact lens materials of 1 mol% or more in accordance with US FDA (US Food and Drug Administration) standards, and nonionic refers to US FDA ( According to US Food and Drug Administration standards, the content of ionic components in contact lens materials is less than 1 mol%. Further, the moisture content of the SHCL to be applied is not particularly limited, but generally the friction of the SHCL surface increases as the moisture content decreases, and cell detachment tends to occur when the SHCL is removed. According to the ophthalmic composition for SHCL of the present invention, even when the SHCL is likely to increase friction and cause cell detachment, friction can be effectively reduced and cell detachment can be effectively suppressed. In view of this viewpoint, an example of the moisture content of SHCL to be applied is specifically 90% or less, preferably 60% or less, and more preferably 50% or less. Since SHCL contains a hydrogel material, it contains at least more than 0% moisture.

  Here, the moisture content of SHCL indicates the ratio of water in SHCL, and is specifically determined by the following calculation formula.

Moisture content (%) = (weight of hydrated water / weight of hydrated SHCL) x 100
Such moisture content can be measured by a gravimetric method according to the description of ISO18369-4: 2006.

  Since the ophthalmic composition for SHCL of the present invention can reduce friction on the surface of the SHCL, it can be used for SHCL friction reduction. Furthermore, since the ophthalmic composition for SHCL of the present invention can suppress cell detachment that occurs when SHCL is removed from the surface of the eyeball, it can also be used as an SHCL removal solution (for cell detachment suppression during SHCL removal). In addition, since the epithelial cells of the eyeball also have a barrier function against allergens, epithelial disorders caused by cell detachment caused by friction of the SHCL surface as described above, or removal of SHCL, reduce the barrier function, There is a tendency to easily develop or worsen allergic diseases of the eye. Therefore, the ophthalmic composition for SHCL of the present invention is an ophthalmic disease preventive agent (for example, prevention of allergic diseases) for a person who uses SHCL to enhance and prevent various eye diseases including allergic diseases. Agent). In addition, when the ophthalmic composition for SHCL of the present invention contains pranoprofen and / or a salt thereof, it can also exert an antiallergic action based on these components, and is therefore useful as a allergy symptom reducing agent. is there.

  Moreover, this invention provides at least 1 sort (s) of use selected from the group which consists of dibutylhydroxytoluene and butylhydroxyanisole for manufacture of the ophthalmic composition for silicone hydrogel contact lenses from another viewpoint.

  Furthermore, the present invention provides (A) at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole for the production of an ophthalmic composition for silicone hydrogel contact lenses, and (B) pranoprofen and There is also provided at least one use selected from the group consisting of the salts.

2. Method of reducing friction of SHCL; and method of imparting an action of reducing the friction of SHCL to an ophthalmic composition As described above, dibutylhydroxytoluene and butylhydroxyanisole can reduce the friction of the SHCL surface. Accordingly, the present invention, from yet another aspect, comprises contacting SHCL with at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole, and reducing the friction of the SHCL I will provide a.

  Specifically, the friction reducing method may be carried out by bringing dibutylhydroxytoluenes into contact with SHCL as they are, or by bringing the above-mentioned ophthalmic composition for SHCL containing dibutylhydroxytoluenes into contact with SHCL.

  The present invention also provides the ophthalmic composition having the action of reducing friction of SHCL, characterized in that the ophthalmic composition for SHCL is blended with at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole. It also provides a method of granting.

  In addition, in the friction reduction method and the application method, the type of SHCL to be applied, the method of bringing dibutylhydroxytoluenes into contact with SHCL, and the like are the same as in “1. SHCL ophthalmic composition”.

  Furthermore, the present invention also provides at least one use selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole for the manufacture of an agent for reducing the friction of silicone hydrogel contact lenses.

3. A method for suppressing cell detachment associated with removal of SHCL; and a method for imparting an effect of inhibiting cell detachment associated with removal of SHCL to an ophthalmic composition As described above, dibutylhydroxytoluene and butylhydroxyanisole are produced from above the ocular surface Cell detachment that occurs when the SHCL is removed can be suppressed. Accordingly, the present invention, from yet another aspect, contacts at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole with SHCL, and the ocular surface associated with removal of the SHCL A method for suppressing cell detachment from above is provided.

  Specifically, the method for inhibiting cell detachment may be carried out by bringing dibutylhydroxytoluenes into contact with SHCL as they are, or by bringing the ophthalmic composition for SHCL containing dibutylhydroxytoluenes into contact with SHCL. .

  The present invention also relates to the ophthalmic composition for SHCL, wherein at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole is blended, and cell detachment from the surface of the eyeball accompanying removal of SHCL There is also provided a method of imparting an action of suppressing ophthalmic to the ophthalmic composition.

  In addition, in the cell detachment suppression method and the application method, the type of SHCL to be applied, the method of bringing dibutylhydroxytoluenes into contact with SHCL, and the like are the same as those in “1. SHCL ophthalmic composition”. .

  Furthermore, the present invention, from another viewpoint, is at least selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole for producing an agent for suppressing cell detachment from the surface of the eyeball associated with removal of SHCL. One type of use is also provided.

  Hereinafter, the present invention will be described in detail based on examples and the like, but the present invention is not limited to these examples.

Reference test example 1: Evaluation of friction on SCL surface
In order to measure the physical properties of the SCL surface, a rigid pendulum physical property tester RPT-3000W (( The frictional force of each SCL surface was evaluated using A & D Co., Ltd. Specifically, the SCL used in the test is six lenses shown in Table 1 below.

  Those obtained by immersing these SCLs in physiological saline overnight were used as test samples. The measurement was carried out under the conditions of a temperature of 25 ° C. and a relative humidity of 60% under the conditions of a pendulum weight of 200 g and a sensor diameter of 4 mm, and comparison was made between each SCL with a logarithmic decay rate 5 minutes after the start of the measurement.

  The result is shown in FIG. The logarithmic decay rate measured here indicates the magnitude of the friction on the lens surface, and the higher the logarithmic decay rate, the greater the friction. As is clear from FIG. 1, it was recognized that SHCL (lenses A to C) has a significantly high logarithmic decay rate and very large friction compared to non-silicone hydrogel lenses (lenses D to F).

Test Example 1: Evaluation of reduction effect on friction of SCL surface
Using the two types of lenses A and C used in Reference Test Example 1 as SHCL, and using the lens D used in Reference Test Example 1 as a non-silicone hydrogel lens, the friction reduction effect on the lens surface is as follows. Evaluation was performed by the method.

  First, each test solution (Comparative Example 1-2 and Example 1-2) shown in Table 2 was prepared. The surface of SHCL (lenses A and C) was sufficiently rinsed with physiological saline, and then immersed in 20 ml of each test solution and allowed to stand overnight. Separately, for the non-silicone hydrogel lens (lens D), the surface was sufficiently rinsed with physiological saline, and then immersed in 20 ml of each test solution (Comparative Example 1 and Example 1) two by two. Let stand overnight. On the next day, the moisture on the lens surface was lightly wiped, and the logarithmic decay rate was measured every 10 seconds for 3 minutes under conditions of a pendulum weight of 200 g and a sensor diameter of 4 mm under conditions of 25 ° C. and a relative humidity of 60%.

  The results are shown in FIGS. As shown in FIGS. 2 and 3, in SHCL, in any case of lenses A and C, the logarithmic decay rate is significantly reduced by the addition of dibutylhydroxytoluene (Example 1) compared to the control (Comparative Example 1). It was found that the friction was greatly reduced. In addition, although pranoprofen itself has a tendency to have little effect on friction or slightly increase compared to the control (Comparative Example 1) (Comparative Example 2), it is completely unexpected. When used in combination with dibutylhydroxytoluene (Example 2), it was observed that the friction reduction effect was further improved.

  On the other hand, as shown in FIG. 4, with the conventional hydrogel lens (non-silicone hydrogel lens), the above-mentioned friction reduction effect was not recognized at all.

  From the above results, the effect of reducing friction on the SCL surface by dibutylhydroxytoluene alone or in combination with dibutylhydroxytoluene and pranoprofen is an effect that is specifically observed when the target SCL is SHCL. It became clear.

Test Example 2: Evaluation of reduction effect on friction of SCL surface:
As the SHCL, the lens A used in Reference Test Example 1 was used, and the SHCL friction reduction effect was evaluated by the following method.

  First, the surface of SHCL (lens A) was sufficiently rinsed with physiological saline, and then pretreated by immersing in physiological saline overnight.

  Next, each test solution (Example 3-4 and Comparative Example 3-4) shown in Table 3 was prepared, and each lens after pretreatment was immersed in 10 ml of each test solution one by one, and allowed to stand for 3 days. I put it. Three days later, the moisture on the lens surface was lightly wiped, and the logarithmic decay rate was measured for 3 minutes every 10 seconds under the conditions of a pendulum weight of 200 g and a sensor diameter of 4 mm under the conditions of 25 ° C. and relative humidity of 60%.

  The result of comparing Example 3 and Comparative Example 3 is shown in FIG. As shown in FIG. 5, in the lens A, a decrease in the logarithmic decay rate was observed by using the test solution (Example 3) containing dibutylhydroxytoluene, compared to the control (Comparative Example 3). It was found that friction was reduced. Further, from the results of Example 4 and Comparative Example 4, it is recognized that the logarithmic decay rate similarly decreases even when the nonionic surfactant is changed from polysorbate 80 to polyoxyethylene hydrogenated castor oil. It was.

Test Example 3: Evaluation of cell detachment inhibitory effect
Using the lens A used in the above Reference Test Example 1 as SHCL, the effect of suppressing cell detachment accompanying the removal of SHCL from the eyeball surface was evaluated by the following method.

  First, each test solution shown in Table 4 (Comparative Example 5 and Example 5) was prepared. The lens A was hollowed out with a 6 mm diameter trepan (perforator) and immersed in 2 ml of each test solution (Comparative Example 5 and Example 5) for 24 hours. On the next day, excess muscle and conjunctival tissue were removed from the porcine eyeball (obtained from Dard Co., Ltd.) to prepare an eyeball covered only with the sclera and cornea, and this was washed with physiological saline for 5 to 10 minutes. The eyeball thus obtained was carefully wiped off with a nonwoven fabric. Next, the SHCL that had been soaked for 24 hours was taken out from each test solution, and excess water was carefully wiped off with a nonwoven fabric. Separately, the lens A immediately after opening that was not immersed in any of the test solutions was used in the test as an untreated lens group. Next, the eyeball is set on the test table so that the corneal surface is on top, and an untreated lens, a treated lens of the test liquid of Comparative Example 5, and the lens of Example 5 are placed on one eyeball (that is, one cornea). A total of three test treatment lenses were placed. The test environment was adjusted so that the temperature was 25 to 27 ° C. and the relative humidity was 62 to 68%.

  Ten minutes later, the end of the SHCL on the eyeball was gently picked with a round tweezers (ring tweezers) and gently and carefully peeled off. The peeled SHCL was washed once with physiological saline and immersed in 4% by volume paraformaldehyde solution to fix the cells attached to the SHCL. Thereafter, the cells were stained with Mayer's hematoxylin solution, and the number of stained cells (the number of corneal cells attached to SHCL and detached) was counted under a microscope. The counted number of cells was classified according to the evaluation criteria shown in Table 5, and the degree of cell detachment accompanying SHCL removal was evaluated by a score.

  The results are shown in FIG. As shown in FIG. 6, the test solution of Comparative Example 5 had almost no cell detachment inhibiting effect. On the other hand, when it was treated with the test solution of Example 5 containing dibutylhydroxytoluene, it was found that the number of cells attached to and detached from the SHCL when the SHCL was removed from the eyeball surface could be significantly reduced.

Formulation Example With the formulation described in Table 6, an eye drop for SHCL (Example 6-10) is prepared.

Claims (1)

An ophthalmic composition for a silicone hydrogel contact lens, comprising at least one selected from the group consisting of dibutylhydroxytoluene and butylhydroxyanisole.

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