JP2016169203A - Calcium absorption promoter - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide pulverized powder of foliage of barley that can be used daily and has the effect of promoting calcium absorption.SOLUTION: A calcium absorption promoter according to the present invention contains at least one pulverized powder selected from the group consisting of specific varieties of barley as an active ingredient.SELECTED DRAWING: None

Description

The present invention relates to a calcium absorption promoter.

Calcium is a major mineral that forms bones and teeth, and is a divalent cation that plays an important role in living organisms. For example, in bone, calcium that is absorbed in the intestine and enters the blood is used for bone formation to form new bone. On the other hand, in bone, bone resorption that absorbs old bone is observed. In a healthy state, there is a bone metabolism that balances bone resorption and bone formation. However, when bone metabolism abnormalities occur due to a decrease in calcium intake or the like, bone mass is reduced, and bone-related diseases such as osteoporosis and fractures occur.

A part of calcium in the body is present at a constant concentration in cells and blood other than bones and teeth, and plays an important role in terms of nerve and muscle excitement, blood coagulation and the like. Therefore, when calcium in the blood is insufficient, diseases based on abnormalities such as nerves, muscles, blood, etc., bone-related diseases due to progress of bone resorption, and the like are observed.

By the way, calcium ingested from food is absorbed in the intestinal tract by two routes of active transport due to the action of active vitamin D and passive transport depending on the soluble calcium concentration, and is used for bone formation via blood. .

Active vitamin D3 preparations containing calcitriol, alphacalcidol, eldecalcitol and the like as active ingredients are known as substances that improve active transport due to the action of active vitamin D. When such an active vitamin D3 preparation is used, calcium absorption from the intestinal tract is promoted.

For example, the present applicant has proposed a calcium absorbent containing barley young leaf powder, lactose and sugar alcohol (Patent Document 1). However, since the invention requires lactose and sugar alcohol in addition to the young barley leaves, problems such as the limitation of the components to be mixed and the cost of production occur, so even if barley foliage is used alone It was necessary to search for barley varieties with high calcium absorption promoting effect.

On the other hand, popular varieties of barley change on the basis of yield, disease and insect damage resistance standards, and thus problems such as difficulty in obtaining seeds and difficulty in stable supply of barley stems and leaves arise. Furthermore, an enormous number of varieties of 30,000 or more are known for barley (Non-Patent Document 1), and it has not been easy to search for specific barley varieties that can solve the above problems.

JP 2002-142721 A

Search results for barley scientific name "Hordeum vulgare" in the Germplasm Resources Information Network under the jurisdiction of the US Department of Agriculture <https://npgsweb.ars-grin.gov/gringlobal/view2.aspx?dv=web_taxonomyspecies_view_accessionlist&params=: taxonomyid = 19333>

An object of the present invention is to provide a calcium absorption enhancer containing a substance exhibiting a more excellent faecal calcium absorption promoting action than a substance having a conventional calcium absorption promoting action. .

In order to solve the above-mentioned problems, the present applicant has conducted intensive studies on various substances. Surprisingly, the applicant has not been able to use Shunrai, Shunrai, Fiber Snow, Ichiban Boshi, and Silky Snow (hereinafter referred to as “specific varieties”). Compared to those containing no crushed powder of barley stalks and leaves and crushed powder of Nishinohoshi which is a variety of barley. The present inventors have found that the calcium absorption promoting action is particularly excellent. The present invention is a completed invention based on such successful examples and knowledge.

The gist of the present invention is as follows.
[1] A calcium absorption promoter containing at least one barley stem and / or leaf pulverized powder selected from the group consisting of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow.
[2] The content of the barley stem and / or leaf pulverized powder in the solid content of the calcium absorption promoter is 20% by mass or more in terms of dry mass, as described in [1] Calcium absorption promoter.
[3] The content of the pulverized powder of the barley stem and / or leaf in the solid content of the calcium absorption promoter is 80% by mass or less in terms of dry mass, [1] or [2 ] The calcium absorption promoter in any one of.

According to the calcium absorption promoter of the present invention, calcium absorption into the body can be efficiently promoted by containing the pulverized powder of barley stems and leaves of a specific variety. In addition, since the calcium absorption enhancer of the present invention can exhibit a calcium absorption promoting action even by oral administration, the calcium absorption enhancer of the present invention can be used in a daily use mode.

The calcium absorption enhancer of the present invention can be expected to prevent or treat diseases associated with calcium deficiency, such as bone-related diseases, neurological diseases, arteriosclerosis, hypertension, and overeating.

FIG. 1 is a graph showing changes over time in blood calcium concentration in a control group according to an example of a calcium absorption promoter and a test group using a test substance. The numerical value represents an average value. FIG. 2 is a diagram showing the AUC of the blood calcium concentration in the control group and the test group using the test substance according to the example of the calcium absorption promoter. Numbers and bars represent mean ± standard deviation.

Hereinafter, the present invention will be described in detail.

[1. Barley Stem and / or Leaf Crush Powder]
As it is known that there are actually more than 30,000 varieties as barley varieties, in the present invention, at least one selected from Fiber Snow, Silky Snow, Shunrai, Ichibanboshi, and Harushizuku (specific varieties). Use the barley stem and / or leaf grind powder. In the present specification, “stems and / or leaves” may be called stems and leaves.

Specific varieties of barley are, for example, generally used as raw materials for wheat, such as barley miso, barley tea, shochu, and beer. In the present invention, one of these varieties can be used alone, or two or more can be used in combination. The pulverized powder of barley stalks and leaves may be barley leaves, stems, or both, and the leaves and stems may be part or all of them.

The barley stalks and leaves of a specific variety are preferably harvested before the maturity period, that is, from the beginning of the splitting to the early stage of heading. Barley foliage is preferably processed immediately after harvesting. When processing takes time, it is stored by storage means commonly used by those skilled in the art, such as low-temperature storage, to prevent barley foliage alteration.

A conventionally known method can be used to pulverize barley foliage. As such a method, a method combining drying treatment and pulverization treatment on barley foliage can be used. Either the drying process or the pulverization process may be performed first, but the drying process is preferably performed first. For pulverization, this method may be combined with one or more treatments selected from treatments such as blanching treatment and sterilization treatment as necessary. In addition, the number of times of pulverization may be one time or a combination of two or more processes, but it is preferable to combine a fine pulverization process that finely pulverizes after the coarse pulverization process.

The blanching process is a process for keeping the green color of the foliage vivid, and examples of the blanching process include a hot water process and a steaming process.

Examples of the hot water treatment include a method of treating barley foliage in hot water or steam at 80 to 100 ° C., preferably 90 to 100 ° C. for 60 to 180 seconds, preferably 90 to 120 seconds. Further, in the hot water treatment, it is preferable to use a carbonate such as magnesium carbonate or a hydrogen carbonate such as sodium hydrogen carbonate. By dissolving the hydrogen carbonate salt in hot water, the green color of the barley foliage is more vivid. can do.

The steaming treatment is preferably an intermittent steaming treatment in which barley stems and leaves are steamed and steamed under normal pressure or pressure. In the intermittent steaming process, the steaming process is performed, for example, for 20 to 40 seconds, preferably 30 seconds. The cooling treatment after the steaming treatment is preferably performed immediately, and the method is not particularly limited, but it is immersed in cold water, refrigerated, cooling with cold air, evaporative cooling with hot air, evaporative cooling combining hot air and cold air Etc. are used. Among these, evaporative cooling combining hot air and cold air is preferable. Such cooling treatment is performed such that the barley foliage has an article temperature of preferably 60 ° C. or lower, more preferably 50 ° C. or lower, and even more preferably 40 ° C. or lower. In order to produce barley stalk and leaf powder rich in nutrients such as vitamins, minerals, and chlorophyll, it is preferable to repeat the intermittent steaming treatment 2 to 5 times.

The sterilization treatment is not particularly limited as long as it is a treatment generally known to those skilled in the art. For example, the sterilization treatment is a treatment that physically or chemically kills microorganisms using temperature, pressure, electromagnetic waves, chemicals, or the like. it can. When the branching process is performed in addition to the drying process and the pulverization process, the branching process is preferably performed before the drying process. Moreover, when performing a sterilization treatment in addition to the drying treatment and the pulverization treatment, the sterilization treatment is preferably performed after the drying treatment or before or after the pulverization treatment.

Although a drying process is not specifically limited, For example, the process dried so that the moisture content of barley foliage may be 10% or less, Preferably it is 5% or less is mentioned. The drying treatment can be performed by any method known to those skilled in the art, such as hot air drying, high pressure steam drying, electromagnetic wave drying, freeze drying, and the like. Drying by heating can be performed, for example, at a temperature and a time at which the foliage is not discolored by heating at 40 ° C to 140 ° C, preferably 80 ° C to 130 ° C.

The pulverization process is not particularly limited, and examples thereof include a process of pulverizing a plant body by an arbitrary method commonly used by those skilled in the art using a crusher, a mill, a blender, a millstone, or the like. The crushed barley foliage is sieved as necessary. For example, it is preferable to use a barley foliage powder that passes through 30 to 250 mesh. By making the particle size below 250 mesh, the barley foliage powder becomes easier to handle during further processing, and by making the particle size above 30 mesh, the barley foliage powder and other materials Uniform mixing with is easy.

As a specific method for producing a pulverized powder, for example, after cutting barley foliage, it is subjected to a blanching treatment, and then dried so that the water content is 10% by mass or less, preferably 5% by mass or less. The method of grind | pulverizing is mentioned (refer Unexamined-Japanese-Patent No. 2004-000210). In addition to this, for example, after cutting barley stalks and leaves, a branching treatment is performed, followed by twisting, and then drying and pulverization (see Japanese Patent Application Laid-Open No. 2002-0665204 and Japanese Patent No. 3428956). A method in which barley foliage is dried and coarsely pulverized, heated at 110 ° C. or higher, and further finely pulverized (see Japanese Patent Application Laid-Open Nos. 2003-033151 and 3277181).

Although the characteristics of the pulverized powder of barley foliage are not particularly limited, for example, the angle of repose is preferably 20 ° to 80 °, more preferably 30 ° to 70 °, still more preferably 40 ° to 60 °, and more preferably 45 ° to Even more preferred is 55 °. The angle of repose is measured using an angle of repose measuring instrument (As One, ASK-01) by dropping about 50 g of sample into the center of a petri dish having an altitude of 12 cm to a radius of 4.3 cm, and then depositing the sample in a mountain shape. After measuring the height, the angle of repose can be calculated by the following formula from the radius of the petri dish and the height of the deposited sample.
Angle of repose = tan−1 (b / a) × 180 ÷ π (where, a = the petri dish radius, b = the height of the deposited sample)

The pulverized powder of barley stalks of a specific variety used in the present invention may contain water-insoluble dietary fiber. The water-insoluble dietary fiber contained in the pulverized powder is contained in an amount of 20% by mass or more, preferably 30% by mass or more in terms of dry mass, preferably 20 to 80% by mass, preferably 30 to 70% by mass, more preferably 35%. It is more preferable to contain -60 mass%.

[2. Calcium absorption promoter]
The present invention relates to a calcium absorption enhancer containing ground powder of barley foliage.

The calcium absorption enhancer of the present invention is a substance having the calcium absorption promoting action of the present invention, which includes any one of barley of at least one of fiber snow, silky snow, shunrai, ichibanboshi and harushizuku (specific varieties). It contains at least the ground powder of the foliage.

The calcium absorption promoting action is not particularly limited as long as it is an action as commonly known. For example, the action of increasing or improving the absorption of calcium in a living body is specifically mentioned. The calcium concentration is increased or maintained, or the decrease in calcium concentration in the blood is suppressed or alleviated.

The calcium absorption enhancer of the present invention contains not only a calcium absorption promoting action by containing a pulverized powder of barley stems and leaves of a specific variety, but also has a beautiful appearance and a good flavor due to vivid colors. It is possible to achieve both.

The calcium absorption enhancer of the present invention can exhibit a calcium absorption promoting action by containing pulverized powder of barley stems and leaves of a specific variety. The degree of the calcium absorption promoting action is not particularly limited, and can be evaluated, for example, by measuring and comparing the blood calcium concentration as described in Examples described later. The calcium absorption promoting action of the calcium absorption promoter of the present invention is 200 mg for the user as measured by the MXB method based on the principle that calcium binds to MXB under alkaline conditions and exhibits a blue color. -The amount of change in blood calcium concentration (= [blood calcium concentration in 2, 3 or 5 hours after administration]-[blood calcium concentration immediately before administration]) after administration at calcium / kg for 2, 3 or 5 hours , Calcium absorption enhancement to a degree greater than the amount of change in blood calcium concentration when using the same amount of crushed powder of Nishinohoshi stalks and leaves of barley stems and leaves of a specific variety contained in the calcium absorption promoter of the present invention It is an action.

Specifically, the calcium absorption promoting action of the calcium absorption promoter of the present invention is, for example, that the amount of change in blood calcium concentration after 2 hours of administration is 1.8 mg / dL or more, preferably 2.0 mg / dL. dL or more, more preferably 2.2 mg / dL or more, still more preferably 2.3 mg / dL or more; similarly, the change in blood calcium concentration after 3 hours of administration is 2.4 mg / dL or more. Yes, preferably at least 2.5 mg / dL, more preferably at least 2.6 mg / dL, even more preferably at least 2.7 mg / dL; or, similarly, blood calcium concentration at 5 hours after administration The amount of change is 1.2 mg / dL or more, preferably 1.3 mg / dL or more, more preferably 1.4 mg / dL or more, and further preferably 1.5 mg / dL. It is a top. In addition, it is preferable that the blood calcium concentration is maintained at 8.0-10.0 mg / mL by using the calcium absorption promoter of this invention.

In addition, the calcium absorption promoting action of the calcium absorption promoter of the present invention is measured using, for example, the MXB method, and is administered to the user at 200 mg-calcium / kg, 0, 0.5, 1, 2, It can be expressed using AUC (area under the blood concentration-time curve) calculated based on blood calcium concentrations at 3 and 5 hours. From the viewpoint of AUC, the calcium absorption promoting action of the calcium absorption promoter of the present invention is, for example, that of the same amount of Nishinohoshi foliage as the ground powder of the barley foliage of a specific variety contained in the calcium absorption promoter of the present invention. Calcium absorption promotion effect to a degree greater than AUC of blood calcium concentration when using pulverized powder, specifically 8.1 mg / dL · hr, preferably 8.5 mg / dL · hr, More preferably, it is 9.0 mg / dL · hr, and even more preferably 9.5 mg / dL · hr.

The calcium absorption enhancer of the present invention can be used in various forms for the purpose of obtaining a calcium absorption promoting action. For example, it may be used for various purposes without adding special processing. In addition, the calcium absorption enhancer of the present invention depends not only on calcium absorption by calcium components such as calcium and calcium-containing materials used at the same time, but also by calcium components used before or after the use of the calcium absorption enhancer of the present invention. It can be expected to promote calcium absorption.

In the solid content of the calcium absorption promoter of the present invention, the content of barley stalks and leaves is dry mass, and the lower limit is preferably 0.1% by mass or more, more preferably 0.5% by mass or more. 1 mass% or more is more preferable, 10 mass% or more is still more preferable, 20 mass% or more is especially preferable, As an upper limit, 99.9 mass% or less is preferable, 90 mass% or less is more preferable, 80 mass% % Or less is more preferable. In order to sufficiently exert the calcium absorption promoting action, the content of the barley stalks and leaves is preferably 0.1% by mass.

The daily use amount of the calcium absorption promoter of the present invention is not particularly limited, and can be appropriately set according to the use mode and the use contents of the user, for example, in terms of the mass of the pulverized powder of barley foliage, Based on the weight of the user, it is 1 to 6000 mg / kg, preferably 1 to 4000 mg / kg, more preferably 10 to 3000 mg / kg, and further preferably 10 to 2000 mg / kg. Similarly, there is no particular limitation on the amount of the calcium absorption promoter of the present invention used once. For example, it is 0.5 to 3000 mg / kg on the basis of the weight of the user in terms of mass of the pulverized powder of barley foliage. Preferably, it is 1-2000 mg / kg, More preferably, it is 5-1000 mg / kg.

Moreover, the usage-amount of the calcium absorption promoter of this invention once is 0.01-30 g in conversion of the mass of the pulverized powder of barley foliage, for example, Preferably it is 0.05-20 g, More preferably, it is 0.1. -10 g, particularly preferably 0.3-7 g. Similarly, the daily use amount of the calcium absorption enhancer of the present invention is, for example, 0.01 to 100 g, preferably 0.05 to 70 g, more preferably 0. It can be 5 to 50 g, particularly preferably 1 to 30 g.

The calcium absorption promoter of the present invention may contain only the pulverized powder of barley foliage, or may contain other components in addition to the pulverized powder of barley foliage. Examples of other components include various excipients, binders, lubricants, stabilizers, diluents, extenders, thickeners, emulsifiers, colorants, fragrances, additives, and the like. The content of the other components can be appropriately selected according to the usage form of the calcium absorption promoter of the present invention.

The calcium absorption enhancer of the present invention can be used in various forms for the purpose of obtaining a calcium absorption promoting action. The calcium absorption enhancer of the present invention can be, for example, an oral or parenteral calcium absorption enhancer.

The form of the calcium absorption promoter of the present invention is not particularly limited and can be any form. As a form of oral calcium absorption promoter, for example, a form suitable for oral use, specifically, powder, granule, granule, tablet, liquid, paste, hard capsule, soft capsule and the like Examples include capsule, caplet, and tablet forms.

The packaging form of the calcium absorption promoter of the present invention is not particularly limited, and can be appropriately selected depending on the dosage form. For example, blister packs such as PTP; strip packaging; heat sealing; aluminum pouches; Examples include film packaging used; glass containers such as vials; plastic containers such as ampoules.

The calcium absorption enhancer of the present invention is in the form of powder (powder, granule, etc.) and is a form in which a mixture mixed with water is used orally, because it prevents spoilage and is suitable for long-term storage. preferable. When the calcium absorption promoter of the present invention is in a solid form such as powder or tablet, as described above, it can be mixed with water to form a liquid, which can be used orally. Depending on the user's preference, it may be used orally as a solid.

The calcium absorption promoter of the present invention is preferably used in combination with a calcium component. The combined use in this case means that a calcium component is used for the purpose of ingesting calcium simultaneously with or before or after the calcium absorption promoter of the present invention.

A calcium component is not specifically limited, For example, calcium and its salt, a natural and synthetic calcium containing material, a calcium agent, a calcium adjuvant etc. are mentioned. Examples of the natural calcium-containing material include, but are not limited to, bones of mammals, birds, fish and the like, shells of shellfish, shells of shellfish, eggshells, and the like. The amount of the calcium component used is not particularly limited, and can be appropriately set in consideration of, for example, the degree of calcium shortage by the user. The daily usage of the calcium component is, for example, 200 to 2,000 mg per calcium, preferably 400 to 1,500 mg.

The calcium absorption enhancer of the present invention has a calcium absorption promoting action, and its use is useful for maintaining health for those who have calcium deficiency or calcium deficiency disease and those who are at risk thereof, Especially those with bone-related diseases such as osteoporosis and rickets, hypocalcemia, neurological diseases, arteriosclerosis, hypertension, bulimia, etc. and those who are over 40 years of age, middle-aged and middle-aged and elderly It is very useful for maintaining the health of the elderly.

Another aspect of the present invention is for the prevention and treatment of calcium deficiency diseases such as osteoporosis, rickets, hypocalcemia, arteriosclerosis, hypertension, bulimia and the like, which contain a powder of barley foliage of a specific variety. It is a pharmaceutical composition. In particular, a kit containing the calcium absorption promoter of the present invention and a calcium component is useful as a kit for the purpose of use such as treatment and prevention of the above calcium deficiency diseases.

Further, the calcium absorption enhancer of the present invention contains a large amount of vitamins, minerals and the like derived from the pulverized powder of barley foliage of specific varieties, in addition to the calcium absorption promoting action of the conventional barley shoot powder. Therefore, it produces secondary effects based on these and contributes to maintaining the health of the user.

Hereinafter, the present invention will be described in more detail with reference to examples. However, the present invention is not limited to these examples, and the present invention can take various modes as long as the problems of the present invention can be solved. .

It was demonstrated as follows that the ground powder of barley stalks of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow show a remarkable calcium absorption promoting action.

1. As Test Substance Examples 1 to 5, Harushizuku, Shunrai, Fiber Snow, Ichibanboshi, and Silky Snow were used. Moreover, Nishinohoshi was used as Comparative Example 1.

2. Preparation of test sample The barley foliage of the above Examples and Comparative Examples was used as a test sample. This was washed with water to remove adhering mud and the like, and a pretreatment was performed to cut it to a size of about 5 to 10 cm. The pretreated stalks and leaves were blanched only once with hot water at 90 to 100 ° C. for 90 to 120 seconds, and then cooled with cold water. Subsequently, the obtained foliage was dried with warm air at 80 ° C. to 130 ° C. for 20 minutes to 180 minutes in a dryer until the water content became 5% by mass or less. The dried foliage was pulverized to a size of about 1 mm using a mixer. The obtained barley stalks and leaves were pulverized using a pulverizer such that 90% or more of the 200 mesh sections passed through to obtain pulverized powder of barley stalks and leaves.

According to the composition shown in Table 1 below, each component of the crushed powder of barley foliage and the non-fiber high-fat diet (NFHF) based on AIN-76 is used in each feed using a pestle and mortar. The ingredients were prepared to be uniform to obtain a barley foliage-containing NFHF powder feed. Moreover, the NFHF powder feed was obtained as what does not contain barley foliage.

3. Preparation of Calcium Solution Using pure water as a solvent, DL-calcium lactate pentahydrate (Wako Pure Chemical Industries, Ltd.) was prepared to a calcium concentration of 20 mg / mL to obtain a calcium solution.

4). Test animals 6-week-old male Wistar rats (Kudo Co., Ltd.) were allowed to freely ingest MF solid feed (Oriental Yeast Co., Ltd.) and water for 5 days. For the 7-week-old male Wistar rats after acclimatization, they were grouped as shown in Table 2 below so that the average value of the body weight was almost uniform. Breeding freely. However, in grouping, it was considered that there was no significant difference in the number of feces before the start of the test (from -1 to 0 days) in each group (priority order: body weight value> number of feces).

5. After 22 days or more from the start of feeding the calcium solution, the test animals of each group fasted for 16 hours or more from the previous day were used with a sonde so that the calcium solution was 10 mL / kg (200 mg-Ca / kg). Forced oral administration.

6). Evaluation method Before administration of calcium solution (0 hour), 0.5, 1, 2, 3, 5 hours after administration, a certain amount of blood was collected over time from the vein. After blood collection, the blood sample was allowed to stand at room temperature for 30 minutes or more, and then subjected to centrifugation (8000 rpm, 20 minutes, 4 ° C.) to collect serum. Serum was stored at −30 ° C. until subjected to calcium concentration measurements. Using the obtained serum, the blood calcium concentration was measured using a commercially available kit, Calcium E-Test Wako (Wako Pure Chemical Industries, Ltd.). FIG. 1 is a graph showing the amount of change in blood calcium concentration with time (= [measured value at each time] − [measured value at 0 hour]), and AUC (blood concentration−). A diagram showing the area under the time curve is shown in FIG.

7). As a result of the evaluation of the calcium absorption promoting effect, the blood calcium concentration was higher in the test group using the test substance than in the control group in both time-dependent changes and AUC. Surprisingly, the example group (Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow) showed a tendency that the blood calcium concentration was higher than that of the Comparative Example group (Nishino Hoshi). Therefore, when pulverized powdered leaves of harushizuku, shunrai, fiber snow, ichibanboshi and silky snow are ingested, it is shown to have an effect of increasing blood calcium concentration and thus promoting calcium absorption. It was.

From the above results, it became clear that Shunrai, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow have a calcium absorption promoting action. In other words, crushed powder of barley stalks of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi and Silky Snow is a useful material as a calcium absorption promoter. Thus, it was revealed that calcium can be efficiently absorbed into the body via blood.

The calcium absorption enhancer of the present invention can be expected to have a calcium absorption promoting action depending on daily use by containing a pulverized powder of barley stems and leaves of a specific variety, and has a calcium deficiency disease or its risk. It is useful for maintaining the health of the elderly. Therefore, the calcium absorption promoter of the present invention prevents or treats calcium deficiency diseases such as bone-related diseases such as osteoporosis and rickets, hypocalcemia, neurological diseases, arteriosclerosis, hypertension, bulimia and the like. Therefore, it contributes to the entire national economy, such as reduction of medical expenses related to these diseases and reduction of labor force.

The present invention includes specific health foods and drinks, nutritional foods and drinks, health functional foods and drinks, special purpose foods and drinks, nutritional supplements and foods, health supplements and foods, supplements, beauty foods and beverages, other health foods and beverages, and pharmaceutical parts. It can be used as foreign products, cosmetics, and pharmaceuticals.

Claims (3)

A calcium absorption promoter containing at least one barley stem and / or leaf pulverized powder selected from the group consisting of Harushizuku, Shunrai, Fiber Snow, Ichibanboshi, and Silky Snow. 2. The calcium absorption promotion according to claim 1, wherein the content of the barley stem and / or leaf pulverized powder in the solid content of the calcium absorption promoter is 20% by mass or more in terms of dry mass. Agent. The content of the pulverized powder of the barley stem and / or leaves in the solid content of the calcium absorption promoter is 80% by mass or less in terms of dry mass. The calcium absorption promoter as described.

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