JP2016153375A - Cosmetic - Google Patents
Cosmetic Download PDFInfo
- Publication number
- JP2016153375A JP2016153375A JP2015031321A JP2015031321A JP2016153375A JP 2016153375 A JP2016153375 A JP 2016153375A JP 2015031321 A JP2015031321 A JP 2015031321A JP 2015031321 A JP2015031321 A JP 2015031321A JP 2016153375 A JP2016153375 A JP 2016153375A
- Authority
- JP
- Japan
- Prior art keywords
- menthol
- spherical powder
- cosmetic
- extract
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 56
- 239000000843 powder Substances 0.000 claims abstract description 61
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 39
- 229940041616 menthol Drugs 0.000 claims abstract description 38
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 16
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000000811 xylitol Substances 0.000 claims abstract description 16
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 16
- 235000010447 xylitol Nutrition 0.000 claims abstract description 16
- 229960002675 xylitol Drugs 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 33
- 239000002245 particle Substances 0.000 claims description 26
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- 229920006037 cross link polymer Polymers 0.000 claims description 3
- 229940008099 dimethicone Drugs 0.000 claims description 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 3
- 229920002554 vinyl polymer Polymers 0.000 claims description 3
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 51
- 239000000284 extract Substances 0.000 description 29
- -1 phytosterol Chemical compound 0.000 description 14
- 230000000694 effects Effects 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 11
- 239000003921 oil Substances 0.000 description 10
- 235000019198 oils Nutrition 0.000 description 10
- 230000035597 cooling sensation Effects 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 230000002459 sustained effect Effects 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
- 239000006210 lotion Substances 0.000 description 6
- 238000002156 mixing Methods 0.000 description 5
- 230000001953 sensory effect Effects 0.000 description 5
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 5
- 239000004166 Lanolin Substances 0.000 description 4
- 206010040880 Skin irritation Diseases 0.000 description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 235000019388 lanolin Nutrition 0.000 description 4
- 229940039717 lanolin Drugs 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 210000004761 scalp Anatomy 0.000 description 4
- 230000036556 skin irritation Effects 0.000 description 4
- 231100000475 skin irritation Toxicity 0.000 description 4
- 239000001993 wax Substances 0.000 description 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 239000004359 castor oil Substances 0.000 description 3
- 235000019438 castor oil Nutrition 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
- 150000002430 hydrocarbons Chemical group 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 230000035807 sensation Effects 0.000 description 3
- 235000019615 sensations Nutrition 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 150000005846 sugar alcohols Chemical class 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- XHXUANMFYXWVNG-ADEWGFFLSA-N (-)-Menthyl acetate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O XHXUANMFYXWVNG-ADEWGFFLSA-N 0.000 description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical class OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- 240000000731 Fagus sylvatica Species 0.000 description 2
- 235000010099 Fagus sylvatica Nutrition 0.000 description 2
- 239000002211 L-ascorbic acid Substances 0.000 description 2
- 235000000069 L-ascorbic acid Nutrition 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- 239000007844 bleaching agent Substances 0.000 description 2
- 229940116229 borneol Drugs 0.000 description 2
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 2
- 239000003093 cationic surfactant Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- ZQBAKBUEJOMQEX-UHFFFAOYSA-N phenyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OC1=CC=CC=C1 ZQBAKBUEJOMQEX-UHFFFAOYSA-N 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 239000003352 sequestering agent Substances 0.000 description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 description 1
- DBSABEYSGXPBTA-RXSVEWSESA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O DBSABEYSGXPBTA-RXSVEWSESA-N 0.000 description 1
- 239000001605 (5-methyl-2-propan-2-ylcyclohexyl) acetate Substances 0.000 description 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical class C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 1
- ZXDDPOHVAMWLBH-UHFFFAOYSA-N 2,4-Dihydroxybenzophenone Chemical compound OC1=CC(O)=CC=C1C(=O)C1=CC=CC=C1 ZXDDPOHVAMWLBH-UHFFFAOYSA-N 0.000 description 1
- XATHTZNVYDUDGS-UHFFFAOYSA-N 2-octadecylpropane-1,2,3-triol Chemical compound CCCCCCCCCCCCCCCCCCC(O)(CO)CO XATHTZNVYDUDGS-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000205585 Aquilegia canadensis Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- XHXUANMFYXWVNG-UHFFFAOYSA-N D-menthyl acetate Natural products CC(C)C1CCC(C)CC1OC(C)=O XHXUANMFYXWVNG-UHFFFAOYSA-N 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- 235000009008 Eriobotrya japonica Nutrition 0.000 description 1
- 244000061508 Eriobotrya japonica Species 0.000 description 1
- 235000009419 Fagopyrum esculentum Nutrition 0.000 description 1
- 240000008620 Fagopyrum esculentum Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 241001071795 Gentiana Species 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 241000208690 Hamamelis Species 0.000 description 1
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 244000280244 Luffa acutangula Species 0.000 description 1
- 235000009814 Luffa aegyptiaca Nutrition 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N N-methylaminoacetic acid Natural products C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 229940123973 Oxygen scavenger Drugs 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- 241000269851 Sarda sarda Species 0.000 description 1
- 235000002953 Saxifraga stolonifera Nutrition 0.000 description 1
- 244000288377 Saxifraga stolonifera Species 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 235000007303 Thymus vulgaris Nutrition 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 description 1
- 229940069521 aloe extract Drugs 0.000 description 1
- 229930194270 alpha-Vitamin Natural products 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- 239000010495 camellia oil Substances 0.000 description 1
- 239000004204 candelilla wax Substances 0.000 description 1
- 235000013868 candelilla wax Nutrition 0.000 description 1
- 229940073532 candelilla wax Drugs 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 229940119217 chamomile extract Drugs 0.000 description 1
- 235000020221 chamomile extract Nutrition 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 229940105990 diglycerin Drugs 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 1
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- JZKFHQMONDVVNF-UHFFFAOYSA-N dodecyl sulfate;tris(2-hydroxyethyl)azanium Chemical compound OCCN(CCO)CCO.CCCCCCCCCCCCOS(O)(=O)=O JZKFHQMONDVVNF-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940048820 edetates Drugs 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 235000008524 evening primrose extract Nutrition 0.000 description 1
- 229940089020 evening primrose oil Drugs 0.000 description 1
- 239000010475 evening primrose oil Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 229940038487 grape extract Drugs 0.000 description 1
- 229940065115 grapefruit extract Drugs 0.000 description 1
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
- 235000020721 horse chestnut extract Nutrition 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- NFLGAXVYCFJBMK-UHFFFAOYSA-N isomenthone Natural products CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 229940069445 licorice extract Drugs 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 229940114937 microcrystalline wax Drugs 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 229940117336 parsley extract Drugs 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 229960000969 phenyl salicylate Drugs 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 description 1
- 229940077082 red pepper extract Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 229940092258 rosemary extract Drugs 0.000 description 1
- 235000020748 rosemary extract Nutrition 0.000 description 1
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 description 1
- 229940109850 royal jelly Drugs 0.000 description 1
- 229940112950 sage extract Drugs 0.000 description 1
- 235000020752 sage extract Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940043230 sarcosine Drugs 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 230000005476 size effect Effects 0.000 description 1
- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 1
- 229940037001 sodium edetate Drugs 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940082004 sodium laurate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、冷涼感が持続する化粧料に関する。 The present invention relates to a cosmetic that maintains a cool feeling.
化粧料を肌に塗布した際の冷涼感を与えるため、様々な技術が開発されている。一般にはアルコールなどの揮発性の成分と糖アルコールを配合し、アルコールが気化する際の冷感と糖アルコールの熱吸収性を利用する技術が多い。
特許文献1には、キシリトール、エタノール、液状油、分子内に炭素数10〜30の炭化水素基とカルボキシル基とを有するポリマーを、それぞれ特定の比率で含有するO/W化粧料が、べたつきがなく、みずみずしい感触で、しかも清涼感が持続する化粧料となることが開示されている(特許文献1)。
また、メントールは、冷感を引き起こす皮膚の受容体を刺激して冷涼感が得られるため、古くから化粧料に配合されてきた。しかし、少量を配合するだけでは冷涼感が持続せず、冷涼感を持続させるために多量に配合量すると、メントール臭がきつく生じたり、レセプターの刺激によって過度の冷涼感や皮膚の痛みや刺激が感じられたりすることが問題であった。このような中、皮膚や頭皮に冷涼感を付与し、その効果を持続させるために様々な技術提案がなされている。
例えば、メントールとボルネオールを含有する化粧料の技術では、メントールを多めに配合してもボルネオールがメントールの皮膚刺激を低減させ、清涼感の発現が強く、しかも発現した清涼感の持続性も優れることが開示されている(特許文献2)。
また、糖アルコールとメントールと常温で液状の油性成分と非イオン界面活性剤と水を含み乳化粒子経を400nm以下とした乳化組成物が、皮膚に塗布した時に冷涼感を与え、汗をかいたときに再び冷涼感を与えることが開示されている(特許文献3)。
さらにまた、メントール誘導体とシリコーンオイルを0.1から3.0質量%含有する皮膚化粧料に、さらに粒子径1μmから100μmの水不溶性球状粉体を含有すると、清涼感の効果及びその効果の持続性が優れたものになることが開示されている(特許文献4)。
しかしながら、これらの技術を用いても、メントールが少ない配合量の組成の場合には、十分に満足する効果が得られなかった。一方、エタノールを多量に配合すると、エタノールの揮発によって一時的に冷涼感が得られるものの、独特のエタノール臭は好まれず、また、冷涼感の持続性に欠けることが問題であった。
近年、皮膚の安全性を重視した化粧料が好まれる傾向にあり、メントールをより少なく配合した場合においても効果的に冷涼感を持続させる技術が求められている。
Various techniques have been developed to give a cool feeling when cosmetics are applied to the skin. In general, there are many techniques in which a volatile component such as alcohol and a sugar alcohol are blended, and the cooling sensation when the alcohol is vaporized and the heat absorption of the sugar alcohol are utilized.
Patent Document 1 discloses that an O / W cosmetic containing xylitol, ethanol, liquid oil, and a polymer having a hydrocarbon group having 10 to 30 carbon atoms and a carboxyl group in a molecule at a specific ratio is not sticky. However, it is disclosed that it is a cosmetic with a fresh feeling and a refreshing feeling (Patent Document 1).
In addition, menthol has been blended into cosmetics for a long time because it can cool the skin receptor that causes a cool sensation to provide a cool sensation. However, the cooling sensation cannot be sustained only by adding a small amount, but if it is added in a large amount to maintain the cooling sensation, the menthol odor will be harsh or excessive cooling sensation and skin pain and irritation may occur due to receptor stimulation. It was a problem to be felt. Under such circumstances, various technical proposals have been made to impart a cool feeling to the skin and scalp and to maintain the effect.
For example, in a cosmetic technology containing menthol and borneol, even if menthol is added in a large amount, borneol reduces the skin irritation of menthol, and the appearance of a refreshing feeling is strong, and the sustainability of the refreshing feeling that is expressed is also excellent. Is disclosed (Patent Document 2).
In addition, an emulsified composition containing sugar alcohol, menthol, an oily component that is liquid at room temperature, a nonionic surfactant, and water and having an emulsified particle size of 400 nm or less gives coolness and sweat when applied to the skin. It has been disclosed that a cool feeling is sometimes given again (Patent Document 3).
Furthermore, when the skin cosmetic containing 0.1 to 3.0% by mass of menthol derivative and silicone oil further contains a water-insoluble spherical powder having a particle size of 1 μm to 100 μm, the effect of refreshing feeling and the sustaining of the effect. It is disclosed that the property becomes excellent (Patent Document 4).
However, even if these techniques were used, a sufficiently satisfactory effect could not be obtained in the case of a composition with a small amount of menthol. On the other hand, when a large amount of ethanol is blended, although a cool feeling can be temporarily obtained by volatilization of ethanol, a unique ethanol odor is not preferred, and there is a problem that lack of sustain of the cool feeling.
In recent years, there has been a tendency to favor cosmetics that emphasize skin safety, and there is a need for a technique that effectively maintains a cool feeling even when less menthol is blended.
本発明は、メントール又はメントール誘導体の配合量を抑制しながら、メントール又はメントール誘導体の冷涼感が持続する化粧料を得ることを課題とする。 This invention makes it a subject to obtain the cosmetics with which the cool feeling of a menthol or a menthol derivative continues, suppressing the compounding quantity of a menthol or a menthol derivative.
本発明者は、水を含む化粧料において、メントールやメントール誘導体とともに、キシリトール、2種以上の性質の異なる粉体を含ませると、メントールやメントール誘導体の配合量を少なくした場合でも、塗布直後の冷涼感がそのまま長時間持続することを見出し、本発明を完成した。 In the cosmetic containing water, the present inventor, when containing xylitol and two or more kinds of powders having different properties together with menthol and menthol derivatives, even when the blending amount of menthol and menthol derivatives is reduced, The inventor found that the cool feeling lasted for a long time, and completed the present invention.
本発明の主な構成は、次のとおりである。
(1)水を含有する化粧料において、メントール及び/又はメントール誘導体と、キシリトールと、特性の異なる2種以上の球状粉体とを含有する化粧料。
(2)特性の異なる球状粉体が、親油性球状粉体と親水性球状粉体である(1)記載の化粧料。
(3)球状粉体の平均粒子経が1〜30μmである(1)又は(2)に記載の化粧料。
(4)メントール及び/又はメントール誘導体を0.045〜0.1質量%含有する(1)〜(3)のいずれかに記載の化粧料。
(5)キシリトールを0.1〜0.5質量%含有する(1)〜(4)のいずれかに記載の化粧料。
(6)親油性球状粉体を0.5〜1質量%、親水性球状粉体を0.2〜1質量%含有する(2)〜(5)のいずれかに記載の化粧料。
(7)親油性球状粉体の平均粒子経が20〜30μmである(2)〜(6)のいずれかに記載の化粧料。
(8)親油性球状粉体が(ビニルジメチコン/メチコンシルセスキオキサン)クロスポリマーである(2)〜(7)のいずれかに記載の化粧料。
(9)親水性球状粉体が無水ケイ酸である(2)〜(8)のいずれかに記載の化粧料。
(10)エタノールを含有しないことを特徴とする(1)〜(9)のいずれかに記載の化粧料。
The main configuration of the present invention is as follows.
(1) A cosmetic containing water containing menthol and / or menthol derivatives, xylitol, and two or more spherical powders having different characteristics.
(2) The cosmetic according to (1), wherein the spherical powders having different characteristics are a lipophilic spherical powder and a hydrophilic spherical powder.
(3) Cosmetics as described in (1) or (2) whose average particle diameter of spherical powder is 1-30 micrometers.
(4) The cosmetic according to any one of (1) to (3), containing 0.045 to 0.1% by mass of menthol and / or menthol derivative.
(5) The cosmetic according to any one of (1) to (4), containing xylitol in an amount of 0.1 to 0.5% by mass.
(6) The cosmetic according to any one of (2) to (5), containing 0.5 to 1% by mass of lipophilic spherical powder and 0.2 to 1% by mass of hydrophilic spherical powder.
(7) The cosmetic according to any one of (2) to (6), wherein the lipophilic spherical powder has an average particle size of 20 to 30 μm.
(8) The cosmetic according to any one of (2) to (7), wherein the lipophilic spherical powder is a (vinyl dimethicone / methicone silsesquioxane) cross polymer.
(9) The cosmetic according to any one of (2) to (8), wherein the hydrophilic spherical powder is silicic anhydride.
(10) The cosmetic according to any one of (1) to (9), which does not contain ethanol.
本発明の構成をとることで、メントール及び/又はメントール誘導体の配合量を少なくした場合でも、冷涼感が持続した化粧料が得られる。また、本発明の構成をとる化粧料は、エタノールを含まなくても冷涼感が持続し、メントール特有の刺激臭がなく、また、皮膚刺激の低減された化粧料となる。 By taking the constitution of the present invention, a cosmetic with a cool feeling can be obtained even when the amount of menthol and / or menthol derivative is reduced. In addition, the cosmetic having the configuration of the present invention has a cool feeling even without ethanol, does not have a pungent odor peculiar to menthol, and has a reduced skin irritation.
本発明でいう「化粧料」とは、水を含む液状、乳液状、クリーム状、半固形状、固形状の化粧料のことであり、皮膚や頭皮に用いることを目的とするものである。本発明において水を含むとは、化粧料中に水を1質量%以上含むことを意味している。
以下に、本発明の化粧料の構成成分について説明する。
<メントール及び/又はメントール誘導体(成分A)>
本発明に用いるメントールとしては、l−メントール、dl−メントール、ハッカ油等を例示できる。メントール誘導体としては、メントールのエステル体である乳酸メンチル、酢酸メンチル等を例示できる。メントール及び/又はメントール誘導体を化粧料全量に対し、0.045〜0.1質量%、より好ましくは0.045〜0.09質量%配合することが好ましい。0.045〜0.09質量%の範囲だと、皮膚に塗布した時にメントール及び/又はメントール誘導体特有の刺激臭が気にならないので好ましい。
“Cosmetic” as used in the present invention refers to a liquid, emulsion, cream, semi-solid, or solid cosmetic containing water, and is intended for use on the skin and scalp. In the present invention, containing water means containing 1% by mass or more of water in the cosmetic.
Below, the structural component of the cosmetics of this invention is demonstrated.
<Menthol and / or menthol derivative (component A)>
Examples of menthol used in the present invention include l-menthol, dl-menthol, and peppermint oil. Examples of menthol derivatives include menthyl lactate and menthyl acetate which are menthol esters. It is preferable to blend menthol and / or menthol derivative in an amount of 0.045 to 0.1% by mass, more preferably 0.045 to 0.09% by mass, based on the total amount of the cosmetic. When it is in the range of 0.045 to 0.09% by mass, the irritating odor peculiar to menthol and / or menthol derivatives is not a concern when applied to the skin.
<キシリトール(成分B)>
本発明に用いるキシリトールとしては、化粧料に使用できるものであればいずれも配合可能である。化粧料全量に対し0.1〜0.5質量%、より好ましくは0.2〜0.3質量%配合することが好ましい。
<Xylitol (component B)>
Any xylitol used in the present invention can be blended as long as it can be used in cosmetics. It is preferable to add 0.1 to 0.5 mass%, more preferably 0.2 to 0.3 mass% with respect to the total amount of the cosmetic.
<球状粉体(成分C・D)>
本発明には、特性の異なる球状粉体を2種以上配合することが必須である。ここで言う特性とは、球状粒子の水に対する親和性の相違である。特性が異なるとは、粉体表面が油と水のどちらに親和しやすいかにより区別する(粉体粒子表面に親油性基が存在する場合親油性粉体として挙動し、粉体粒子表面に親水性基を有する場合親水性粉体として挙動する。本発明においては、油(スクワラン)に親和しやすい(濡れやすい)球状粉体を親油性球状粉体、水に親和しやすい(濡れやすい)球状粉体を親水性球状粉体と呼ぶ。
球状粉体の粒径の調整は、その種類、使用目的、用途において、篩い、バーチカルグラニュレイターなどを用い、一般的な方法で任意に調整することができる。
本発明に用いる球状粉体の粒径は1〜30μm、より好ましくは20〜30μmの範囲のものを用いることが好ましい。この範囲のものを用いると、メントールの冷涼感が持続する効果がより一層高まる。この傾向は、特に親油性球状粉体において顕著であり、親油性球状粉体の平均粒子経が20〜30μmであることが好ましい。
本発明においては、化粧料中に親油性球状粉体を0.5〜1質量%、親水性球状粉体を0.2〜1質量%含有することが好ましい。親油性、親水性のいずれかの球状粉体の配合量が0.2質量%に満たないと冷涼感の持続効果が得られ難くなる恐れがある。本発明においては、球状粉体の配合量によってメントール及び/又はメントール誘導体の示す冷感の持続効果を増強するが、1質量%を超えて配合しても、冷涼感の持続効果が配合量に応じて強まるわけではない。各球状粉体の配合上限は、用いる剤型、使用対象、使用感等を考慮して適宜設定できる。
親油性球状粉体(成分C)としては、(ビニルジメチコン/メチコンシルセスキオキサン)クロスポリマーを用いることが好ましい。市販品としては、信越化学工業(株)製のKSP−105(平均粒子経;2μm)、KSP−100(平均粒子経;5μm)、KSP−102(平均粒子経;30μm)が例示できる。
親水性球状粉体(成分D)としては、無水ケイ酸(シリカ)を用いることが好ましい。市販品としては、鈴木油脂工業(株)製のゴッドボールE−2C(平均粒子経;1μm)、AGCエスアイテック(株)製のサンスフェアH−51(平均粒子経;5μm)、サンスフェアH−53(平均粒子経;5μm)、サンスフェアH−201(平均粒子経;20μm)が例示できる。
<Spherical powder (components C and D)>
In the present invention, it is essential to blend two or more kinds of spherical powders having different characteristics. The characteristic referred to here is a difference in affinity of spherical particles with water. Different characteristics are distinguished by whether the powder surface is more compatible with oil or water (behaves as a lipophilic powder when a lipophilic group is present on the powder particle surface and is hydrophilic on the powder particle surface. In the present invention, a spherical powder that is easily affinityd with oil (squalane) (easy to wet) is a lipophilic spherical powder, and a spherical powder that is easily compatible with water (easy to wet). The powder is called hydrophilic spherical powder.
The particle size of the spherical powder can be arbitrarily adjusted by a general method using a sieve, a vertical granulator or the like in the type, purpose of use, and application.
The particle size of the spherical powder used in the present invention is preferably 1 to 30 μm, more preferably 20 to 30 μm. Use of a material in this range further enhances the effect of maintaining the cool feeling of menthol. This tendency is particularly remarkable in the lipophilic spherical powder, and the average particle size of the lipophilic spherical powder is preferably 20 to 30 μm.
In the present invention, the cosmetic preferably contains 0.5 to 1% by mass of lipophilic spherical powder and 0.2 to 1% by mass of hydrophilic spherical powder. If the blending amount of either the lipophilic or hydrophilic spherical powder is less than 0.2% by mass, it may be difficult to obtain a cooling effect. In the present invention, the sustained effect of cooling sensation exhibited by menthol and / or menthol derivatives is enhanced by the blending amount of the spherical powder, but even if blended in excess of 1% by mass, the cooling effect continues to be blended. It does not strengthen as a result. The upper limit of blending of each spherical powder can be set as appropriate in consideration of the dosage form used, the intended use, the feeling of use, and the like.
As the lipophilic spherical powder (component C), it is preferable to use a (vinyl dimethicone / methicone silsesquioxane) cross polymer. Examples of commercially available products include KSP-105 (average particle diameter; 2 μm), KSP-100 (average particle diameter; 5 μm), and KSP-102 (average particle diameter; 30 μm) manufactured by Shin-Etsu Chemical Co., Ltd.
As the hydrophilic spherical powder (component D), it is preferable to use anhydrous silicic acid (silica). Commercially available products include God Ball E-2C (average particle diameter; 1 μm) manufactured by Suzuki Oil & Fat Co., Ltd., Sunsphere H-51 (average particle diameter; 5 μm) manufactured by AGC S-Tech Co., Ltd., Sunsphere H -53 (average particle diameter; 5 μm) and Sunsphere H-201 (average particle diameter; 20 μm).
本発明の化粧料には、本発明の効果を損なわない範囲で、植物油のような油脂類、炭化水素類、高級脂肪酸、高級アルコール、シリコーン、アニオン界面活性剤、カチオン界面活性剤、両性界面活性剤、非イオン界面活性剤、防腐剤、糖類、金属イオン封鎖剤、水溶性高分子のような高分子、増粘剤、粉体成分、紫外線吸収剤、紫外線遮断剤、ヒアルロン酸のような保湿剤、香料、pH調整剤、乾燥剤等を含有させることができる。ビタミン類、皮膚賦活剤、血行促進剤、常在菌コントロール剤、活性酸素消去剤、抗炎症剤、抗癌剤、美白剤、殺菌剤等の他の薬効成分、生理活性成分を含有させることもできる。 The cosmetics of the present invention include fats and oils such as vegetable oils, hydrocarbons, higher fatty acids, higher alcohols, silicones, anionic surfactants, cationic surfactants, and amphoteric surfactants, as long as the effects of the present invention are not impaired. , Nonionic surfactant, preservative, sugar, sequestering agent, polymer such as water-soluble polymer, thickener, powder component, UV absorber, UV blocker, moisturizing agent such as hyaluronic acid An agent, a fragrance | flavor, a pH adjuster, a desiccant, etc. can be contained. Vitamins, skin activators, blood circulation promoters, resident bacteria control agents, active oxygen scavengers, anti-inflammatory agents, anticancer agents, whitening agents, bactericides, and other medicinal components and physiologically active components can also be included.
油脂類としては、例えばツバキ油、月見草油、マカデミアナッツ油、オリーブ油、ナタネ油、トウモロコシ油、ゴマ油、ホホバ油、胚芽油、小麦胚芽油、トリオクタン酸グリセリン等の液体油脂、カカオ脂、ヤシ油、硬化ヤシ油、パーム油、パーム核油、モクロウ、モクロウ核油、硬化油、硬化ヒマシ油等の固体油脂、ミツロウ、キャンデリラロウ、綿ロウ、ヌカロウ、ラノリン、酢酸ラノリン、液状ラノリン、サトウキビロウ等のロウ類が挙げられる。 Examples of fats and oils include camellia oil, evening primrose oil, macadamia nut oil, olive oil, rapeseed oil, corn oil, sesame oil, jojoba oil, germ oil, wheat germ oil, glycerin trioctanoate, cocoa butter, coconut oil, hardened Solid oils such as coconut oil, palm oil, palm kernel oil, owl, owl kernel oil, hydrogenated oil, hydrogenated castor oil, beeswax, candelilla wax, cotton wax, nutca wax, lanolin, lanolin acetate, liquid lanolin, sugarcane wax, etc. Waxes.
炭化水素類としては、流動パラフィン、スクワレン、スクワラン、マイクロクリスタリンワックス等が挙げられる。 Examples of hydrocarbons include liquid paraffin, squalene, squalane, and microcrystalline wax.
高級脂肪酸として、例えばラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、オレイン酸、リノール酸、リノレン酸、ドコサヘキサエン酸(DHA)、エイコサペンタエン酸(EPA)等が挙げられる。 Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and the like.
高級アルコールとして、例えば、ラウリルアルコール、ステアリルアルコール、セチルアルコール、セトステアリルアルコール等の直鎖アルコール、モノステアリルグリセリンエーテル、ラノリンアルコール、コレステロール、フィトステロール、オクチルドデカノール等の分枝鎖アルコール等が挙げられる。 Examples of the higher alcohol include linear alcohols such as lauryl alcohol, stearyl alcohol, cetyl alcohol, and cetostearyl alcohol, and branched chain alcohols such as monostearyl glycerol ether, lanolin alcohol, cholesterol, phytosterol, and octyldodecanol.
シリコーンとして、例えば、鎖状ポリシロキサンのジメチルポリシロキサン、メチルフェニルポリシロキサン等、環状ポリシロキサンのデカメチルシクロペンタシロキサン等が挙げられる。 Examples of silicone include linear polysiloxanes such as dimethylpolysiloxane and methylphenylpolysiloxane, and cyclic polysiloxanes such as decamethylcyclopentasiloxane.
アニオン界面活性剤として、例えば、ラウリン酸ナトリウム等の脂肪酸塩、ラウリル硫酸ナトリウム等の高級アルキル硫酸エステル塩、POEラウリル硫酸トリエタノールアミン等のアルキルエーテル硫酸エステル塩、N−アシルサルコシン酸、スルホコハク酸塩、N−アシルアミノ酸塩等が挙げられる。 Examples of the anionic surfactant include fatty acid salts such as sodium laurate, higher alkyl sulfates such as sodium lauryl sulfate, alkyl ether sulfates such as POE lauryl sulfate triethanolamine, N-acyl sarcosine acid, sulfosuccinate , N-acyl amino acid salts and the like.
カチオン界面活性剤として、例えば、塩化ステアリルトリメチルアンモニウム等のアルキルトリメチルアンモニウム塩、塩化ベンザルコニウム、塩化ベンゼトニウム等が挙げられる。 Examples of the cationic surfactant include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride, benzalkonium chloride, and benzethonium chloride.
両性界面活性剤として、アルキルベタイン、アミドベタイン等のベタイン系界面活性剤等が挙げられる。 Examples of amphoteric surfactants include betaine surfactants such as alkyl betaines and amide betaines.
非イオン界面活性剤として、例えば、ソルビタンモノオレエート等のソルビタン脂肪酸エステル類、硬化ヒマシ油誘導体が挙げられる。 Examples of nonionic surfactants include sorbitan fatty acid esters such as sorbitan monooleate and hydrogenated castor oil derivatives.
防腐剤として、例えばメチルパラベン、エチルパラベン等を挙げることができる。 Examples of preservatives include methyl paraben and ethyl paraben.
金属イオン封鎖剤として、例えばエチレンジアミン四酢酸二ナトリウム、エデト酸、エデト酸ナトリウム塩等のエデト酸塩を挙げることができる。 Examples of the sequestering agent include edetates such as disodium ethylenediaminetetraacetate, edetic acid, and sodium edetate.
紫外線吸収剤としては、パラアミノ安息香酸、サリチル酸フェニル、パラメトキシケイ皮酸イソプロピル、パラメトキシケイ皮酸オクチル、2,4−ジヒドロキシベンゾフェノン等を挙げることができる。 Examples of the ultraviolet absorber include paraaminobenzoic acid, phenyl salicylate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2,4-dihydroxybenzophenone, and the like.
保湿剤として、コンドロイチン硫酸ナトリウム、ヒアルロン酸ナトリウム、乳酸ナトリウム、ピロリドンカルボン酸、シクロデキストリン等が挙げられる。 Examples of the humectant include sodium chondroitin sulfate, sodium hyaluronate, sodium lactate, pyrrolidone carboxylic acid, cyclodextrin and the like.
薬効成分としては、ビタミンA油、レチノール等のビタミンA類、リボフラビン等のビタミンB2類、ピリドキシン塩酸塩等のB6類、L−アスコルビン酸、L−アスコルビン酸リン酸エステル、L−アスコルビン酸モノパルミチン酸エステル、L−アスコルビン酸ジパルミチン酸エステル、L−アスコルビン酸−2−グルコシド等のビタミンC類、パントテン酸カルシウム等のパントテン酸類、ビタミンD2、コレカルシフェロール等のビタミンD類;α−トコフェロール、酢酸トコフェロール、ニコチン酸DL−α−トコフェロール等のビタミンE類等のビタミン類を挙げることができる。 Medicinal ingredients include vitamin A oil, vitamin A such as retinol, vitamin B 2 such as riboflavin, B 6 such as pyridoxine hydrochloride, L-ascorbic acid, L-ascorbic acid phosphate, L-ascorbic acid Vitamin C such as monopalmitic acid ester, L-ascorbic acid dipalmitic acid ester, L-ascorbic acid-2-glucoside, pantothenic acid such as calcium pantothenate, vitamin D such as vitamin D 2 and cholecalciferol; α -Vitamins, such as vitamin E, such as tocopherol, tocopherol acetate, and DL-α-tocopherol nicotinate.
プラセンタエキス、グルタチオン、ユキノシタ抽出物等の美白剤、ローヤルゼリー、ぶなの木エキス等の皮膚賦活剤、カプサイシン、ジンゲロン、カンタリスチンキ、イクタモール、カフェイン、タンニン酸γ−オリザノール等の血行促進剤、グリチルリチン酸誘導体、グリチルレチン酸誘導体、アズレン等の消炎剤、アルギニン、セリン、ロイシン、トリプトファン等のアミノ酸類、常在菌コントロール剤のマルトースショ糖縮合物、塩化リゾチーム等を配合することができる。 Whitening agents such as placenta extract, glutathione, and yukinoshita extract; skin activators such as royal jelly and beech tree extract; An acid derivative, a glycyrrhetinic acid derivative, an anti-inflammatory agent such as azulene, amino acids such as arginine, serine, leucine, and tryptophan, a maltose sucrose condensate of a resident bacteria control agent, and lysozyme chloride can be added.
さらに、カミツレエキス、パセリエキス、ぶなの木エキス、ワイン酵母エキス、グレープフルーツエキス、スイカズラエキス、コメエキス、ブドウエキス、ホップエキス、コメヌカエキス、ビワエキス、オウバクエキス、ヨクイニンエキス、センブリエキス、メリロートエキス、バーチエキス、カンゾウエキス、シャクヤクエキス、サボンソウエキス、ヘチマエキス、トウガラシエキス、レモンエキス、ゲンチアナエキス、シソエキス、アロエエキス、ローズマリーエキス、セージエキス、タイムエキス、茶エキス、海藻エキス、キューカンバーエキス、チョウジエキス、ニンジンエキス、マロニエエキス、ハマメリスエキス、クワエキス等の各種抽出物を配合することができる。 In addition, chamomile extract, parsley extract, beech tree extract, wine yeast extract, grapefruit extract, honeysuckle extract, rice extract, grape extract, hop extract, rice bran extract, loquat extract, buckwheat extract, yakuinin extract, assembly extract, merirot extract, birch extract, Licorice extract, peony extract, bonito extract, loofah extract, red pepper extract, lemon extract, gentian extract, perilla extract, aloe extract, rosemary extract, sage extract, thyme extract, tea extract, seaweed extract, cucumber extract, clove extract, carrot Various extracts such as an extract, a horse chestnut extract, a hamamelis extract, and a mulberry extract can be blended.
また本発明は、高分子物質を本発明の効果を損なわない範囲で配合してもよい。例えば、コラーゲン、カゼイン、ゼラチン、カルボキシビニルポリマー、ベントナイト等を挙げることができる。 Moreover, you may mix | blend a polymeric substance in the range which does not impair the effect of this invention. Examples thereof include collagen, casein, gelatin, carboxyvinyl polymer, bentonite and the like.
本発明の化粧料は、化粧水、乳液、クリーム、美容液、日焼け止め、パック剤などの顔面皮膚用化粧料、ボディローション等の身体用化粧料、頭皮用ローション、頭皮用クリーム等の毛髪用化粧料とすることができる。 The cosmetics of the present invention are for facial skin cosmetics such as lotions, emulsions, creams, cosmetics, sunscreens, packs, body cosmetics such as body lotions, scalp lotions, scalp creams and other hair. It can be a cosmetic.
本発明の化粧料は常法により製造することができる。 The cosmetic of the present invention can be produced by a conventional method.
表1、2の組成の実施例、及び比較例の化粧料を調製した。なお、組成表の数字の単位は質量%である。化粧料を皮膚に塗布した直後の冷涼感とその持続性については下記の基準により官能評価を行った。 Examples of the compositions shown in Tables 1 and 2 and comparative cosmetics were prepared. In addition, the unit of the number of a composition table | surface is the mass%. Sensory evaluation was performed on the coolness immediately after the cosmetic was applied to the skin and its sustainability according to the following criteria.
[塗布直後の冷涼感評価]
専門の官能評価員2名により、官能評価を実施した。上腕内側部に試料を0.2g塗布し、塗布時に冷涼感を感じるか評価した。
○;冷涼感を感じる
×;冷涼感を感じない
[Cool feeling evaluation immediately after application]
Sensory evaluation was conducted by two specialized sensory evaluators. 0.2 g of the sample was applied to the inner side of the upper arm, and it was evaluated whether a cool feeling was felt during application.
○: I feel a cool feeling ×; I don't feel a cool feeling
[冷涼感の持続性評価]
専門の官能評価員2名により、官能評価を実施した。上腕内側部に試料を0.2g塗布し、冷涼感を感じるか時間を追って評価した。
◎;4時間以上冷涼感が持続する
○;2時間以上4時間未満冷涼感が持続する
△;11分以上2時間未満冷涼感が持続する
×;10分以内に冷涼感が消失する
[Durability evaluation of cool feeling]
Sensory evaluation was conducted by two specialized sensory evaluators. 0.2 g of the sample was applied to the inner side of the upper arm, and whether or not a cool feeling was felt was evaluated over time.
◎; Cool feeling persists for 4 hours or more ○; Cool feeling persists for 2 hours or more and less than 4 hours Δ; Cool feeling persists for 11 minutes or more and less than 2 hours ×: Cool feeling disappears within 10 minutes
<1.メントールの持続効果に及ぼす配合成分の効果試験>
各成分相互の冷涼感に及ぼす相互作用を確認した。
<1. Effect test of compounding ingredients on sustained effect of menthol>
The interaction affecting the cool feeling of each component was confirmed.
試験結果:
表1に示すように、メントールとキシリトールと水親和性の異なる2種の球状粉体を含有させると、相互の作用により冷涼感が持続することがわかった(実施例1、2)。また、皮膚の刺激は感じなかった。
4つの成分(A、B、C、D)のいずれかを欠く組成の比較例については、メントールとキシリトールと親油性球状粉体を配合した比較例1は、皮膚に塗布した直後の冷涼感は得られたものの、10分以内に冷涼感が消失してしまい持続しなかった。比較例1の処方の親油性球状粉体を4倍量にした場合も、塗布した直後の冷涼感は得られたものの、10分以内に冷涼感が消失してしまい持続しなかった(比較例2)。
メントールとキシリトールと親水性球状粉体を配合した比較例3は皮膚に塗布した直後の冷涼感が得られなかった。
キシリトールと水親和性の異なる2種の球状粉体を配合した比較例4およびキシリトールの配合量を増量させた比較例5は、皮膚に塗布した直後の冷涼感が得られなかった。
メントールと2種の球状粉体を含有させた比較例6は、冷涼感が持続しなかった。
メントールを0.1質量%に増量して、さらに2種の球状粉体を含有させても冷涼感は持続しなかった(比較例7)。
さらにメントールとキシリトールを配合せず、エタノールと2種の球状粉体を含有させた場合も冷涼感は持続せず、また、エタノール臭が強く感じられ、好ましい評価を得られなかった(比較例8)。
Test results:
As shown in Table 1, it was found that when two kinds of spherical powders having different water affinity with menthol and xylitol were contained, the cooling sensation was sustained by mutual action (Examples 1 and 2). Also, no skin irritation was felt.
About the comparative example of a composition lacking any of the four components (A, B, C, D), the comparative example 1 in which menthol, xylitol, and lipophilic spherical powder are blended has a cool feeling immediately after being applied to the skin. Although it was obtained, the cooling sensation disappeared within 10 minutes and was not sustained. Even when the lipophilic spherical powder of the formulation of Comparative Example 1 was used in an amount of 4 times, the cool feeling immediately after application was obtained, but the cool feeling disappeared within 10 minutes and was not maintained (Comparative Example). 2).
In Comparative Example 3 in which menthol, xylitol, and hydrophilic spherical powder were blended, the cool feeling immediately after application to the skin was not obtained.
In Comparative Example 4 in which two spherical powders different in water affinity from xylitol were blended and in Comparative Example 5 in which the blended amount of xylitol was increased, the cool feeling immediately after application to the skin was not obtained.
In Comparative Example 6 containing menthol and two kinds of spherical powders, the cool feeling did not last.
Even when the amount of menthol was increased to 0.1% by mass and further two kinds of spherical powders were added, the cooling sensation did not last (Comparative Example 7).
Further, when menthol and xylitol were not blended and ethanol and two kinds of spherical powders were contained, the cooling sensation was not sustained, and the ethanol odor was felt strongly, and favorable evaluation could not be obtained (Comparative Example 8). ).
<2.メントールの持続効果に及ぼす球状粉体の粒子径の影響確認試験>
球状粉体の粒子径が冷涼感に及ぼす効果を確認した。
<2. Test to confirm the effect of particle size of spherical powder on the sustained effect of menthol>
The effect of the particle size of the spherical powder on the cool feeling was confirmed.
表2(実施例3〜7)に示すとおり、親油性球状粉体と親水性球状粉体の粒子径を変えて試験したところ、いずれも粒径が小さいもの(2μm)よりも、5μm、20μm、30μmと粒子サイズを大きくしたものの方が、清涼感を持続させる効果が高いことが分かった。特に親油性球状粉体は、この粒子径のサイズ効果が強かった。
また、実施例1と実施例5は、粒子径は同じであるが、親水性粉体としての表面特性が異なる粉体である。両者(サンスフェアH−51、サンスフェアH−53)を比較すると、無水ケイ酸の粒子径が同じ5μmで表面特性(細孔容積、細孔直径)が異なる粉体であるが、清涼感の持続性に違いは認められなかった。
さらにまた、実施例3〜7は、いずれも皮膚に対する刺激を感じさせなかった。
As shown in Table 2 (Examples 3 to 7), when the lipophilic spherical powder and the hydrophilic spherical powder were tested with different particle diameters, both were 5 μm and 20 μm smaller than those having a small particle diameter (2 μm). It was found that those having a larger particle size of 30 μm have a higher effect of maintaining a refreshing feeling. In particular, the lipophilic spherical powder had a strong size effect on the particle size.
Further, Example 1 and Example 5 are powders having the same particle diameter but different surface characteristics as hydrophilic powders. Comparing the two (Sunsphere H-51, Sunsphere H-53), although the particle size of silicic acid is the same 5 μm, the surface characteristics (pore volume, pore diameter) are different. There was no difference in persistence.
Furthermore, all of Examples 3 to 7 did not cause irritation to the skin.
以上のとおり、本発明の構成をとることで、メントール及び/又はメントール誘導体の配合量を少なくした場合でも、冷涼感が持続した化粧料が得られた。また、従来技術でしばしば配合されるエタノールを含まなくても冷涼感が持続しており、さらにメントールに由来する皮膚刺激も低減された化粧料が提供できた。 As described above, by taking the constitution of the present invention, a cosmetic having a cool feeling was obtained even when the blending amount of menthol and / or menthol derivative was reduced. Moreover, even if it does not contain ethanol often blended in the prior art, it has been possible to provide a cosmetic that has a cool sensation and has reduced skin irritation derived from menthol.
処方例
化粧水
成分 配合量(質量%)
1.メントール 0.05
2.キシリトール 0.25
3.1,2−ペンタンジオール 1.5
4.ジグリセリン 3
5.1,3−ブチレングリコール 5
6.カルボキシビニルポリマー 0.05
7.水酸化カリウム 0.015
8.KSP−102(30μm) 0.5
9.サンスフェアH−51(5μm) 0.2
10.ポリオキシエチレン硬化ヒマシ油 0.05
11.精製水 残余
Formulation example
Toner lotion component amount
1. Menthol 0.05
2. Xylitol 0.25
3. 1,2-pentanediol 1.5
4). Diglycerin 3
5.1,3-Butylene glycol 5
6). Carboxyvinyl polymer 0.05
7). Potassium hydroxide 0.015
8). KSP-102 (30 μm) 0.5
9. Sunsphere H-51 (5 μm) 0.2
10. Polyoxyethylene hydrogenated castor oil 0.05
11 Purified water residue
すべての成分を均一に混合し、化粧水とした。得られた化粧水は、皮膚に塗布してから、4時間経過後も冷涼感が感じられた。また刺激性は感じられなかった。 All ingredients were mixed uniformly to obtain a skin lotion. The obtained lotion felt cool even after 4 hours had passed since it was applied to the skin. Moreover, irritation was not felt.
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015031321A JP6470999B2 (en) | 2015-02-20 | 2015-02-20 | Cosmetics |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015031321A JP6470999B2 (en) | 2015-02-20 | 2015-02-20 | Cosmetics |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016153375A true JP2016153375A (en) | 2016-08-25 |
JP6470999B2 JP6470999B2 (en) | 2019-02-13 |
Family
ID=56760906
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015031321A Active JP6470999B2 (en) | 2015-02-20 | 2015-02-20 | Cosmetics |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP6470999B2 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001226252A (en) * | 2000-02-15 | 2001-08-21 | Lion Corp | Skin care cosmetic |
JP2004285052A (en) * | 2003-03-06 | 2004-10-14 | Lion Corp | Cosmetic composition |
JP2008297318A (en) * | 2008-07-30 | 2008-12-11 | Meisei Sansho Kk | Method for producing cosmetic sheet containing powder |
JP2014201525A (en) * | 2013-04-02 | 2014-10-27 | 日光ケミカルズ株式会社 | Cool feeling agent composition and external preparations for skin or hair |
-
2015
- 2015-02-20 JP JP2015031321A patent/JP6470999B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001226252A (en) * | 2000-02-15 | 2001-08-21 | Lion Corp | Skin care cosmetic |
JP2004285052A (en) * | 2003-03-06 | 2004-10-14 | Lion Corp | Cosmetic composition |
JP2008297318A (en) * | 2008-07-30 | 2008-12-11 | Meisei Sansho Kk | Method for producing cosmetic sheet containing powder |
JP2014201525A (en) * | 2013-04-02 | 2014-10-27 | 日光ケミカルズ株式会社 | Cool feeling agent composition and external preparations for skin or hair |
Also Published As
Publication number | Publication date |
---|---|
JP6470999B2 (en) | 2019-02-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5101808B2 (en) | Oil-in-water liquid composition | |
TWI516278B (en) | Water-in-oil type emulsifying cosmetic | |
JP6359295B2 (en) | Water-in-oil emulsified cosmetic and method for producing the same | |
JP5827079B2 (en) | Powder-containing skin external preparation | |
JP6205297B2 (en) | Water-in-oil emulsified cosmetic | |
JP6639816B2 (en) | Cosmetics | |
JP6554394B2 (en) | Cosmetics | |
JP2007137822A (en) | Skin care preparation which is suitable for massage | |
JP2006306793A (en) | Emulsion type cosmetic | |
JP2014162724A (en) | Water-in-oil emulsion composition | |
JP4468797B2 (en) | Water-in-oil emulsified cosmetic | |
JP4594661B2 (en) | Emulsified composition containing oil-soluble ascorbic acid derivative | |
JP2008297239A (en) | Water-in-oil type external preparation for skin | |
JP6470999B2 (en) | Cosmetics | |
JP6474227B2 (en) | Composition for toiletry products containing plant extract | |
JP2003306410A (en) | Powder-containing water in oil type emulsion cosmetic | |
JP2014162790A (en) | Oil-in-water type powder cosmetic | |
JP7041500B2 (en) | Skin cosmetics | |
US20200171083A1 (en) | Compositions of silver and cannabinoids | |
JP2009137909A (en) | Astringent cosmetic | |
JP2017081883A (en) | External preparation for skin | |
JP2008088092A (en) | O/w-type emulsified liquid cosmetics | |
JP2001226252A (en) | Skin care cosmetic | |
JP2013227286A (en) | Moisturizing agent and skin external preparation or cosmetic containing the same | |
JP4332468B2 (en) | Cosmetics |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20171005 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180619 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20180615 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20180809 Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180809 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20190108 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190121 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6470999 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |