JP2016121171A5 - - Google Patents

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Publication number

JP2016121171A5

JP2016121171A5 JP2016015912A JP2016015912A JP2016121171A5 JP 2016121171 A5 JP2016121171 A5 JP 2016121171A5 JP 2016015912 A JP2016015912 A JP 2016015912A JP 2016015912 A JP2016015912 A JP 2016015912A JP 2016121171 A5 JP2016121171 A5 JP 2016121171A5

Authority

JP

Japan

Prior art keywords

group

alkyl

infection

pharmaceutically acceptable

nitrogen

Prior art date

2016-01-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 28
• 229920006395 saturated elastomer Polymers 0.000 claims 27
• 125000000217 alkyl group Chemical group 0.000 claims 26
• 150000003839 salts Chemical class 0.000 claims 21
• 150000001875 compounds Chemical class 0.000 claims 19
• 229910052757 nitrogen Inorganic materials 0.000 claims 19
• 125000005842 heteroatom Chemical group 0.000 claims 17
• 238000006467 substitution reaction Methods 0.000 claims 16
• 208000015181 infectious disease Diseases 0.000 claims 15
• 229910052739 hydrogen Inorganic materials 0.000 claims 14
• 239000001257 hydrogen Substances 0.000 claims 14
• 125000003118 aryl group Chemical group 0.000 claims 12
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 10
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 10
• 229910052760 oxygen Inorganic materials 0.000 claims 10
• 239000001301 oxygen Chemical group 0.000 claims 10
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 8
• 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 8
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 8
• 229910052717 sulfur Inorganic materials 0.000 claims 8
• 239000011593 sulfur Substances 0.000 claims 8
• 238000006902 nitrogenation reaction Methods 0.000 claims 6
• 238000006213 oxygenation reaction Methods 0.000 claims 6
• 125000004432 carbon atom Chemical group C* 0.000 claims 5
• 239000000203 mixture Substances 0.000 claims 5
• 241001465754 Metazoa Species 0.000 claims 4
• 206010035664 Pneumonia Diseases 0.000 claims 4
• 125000003342 alkenyl group Chemical group 0.000 claims 4
• 230000000813 microbial effect Effects 0.000 claims 4
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
• 206010040872 skin infection Diseases 0.000 claims 4
• 206010062255 Soft tissue infection Diseases 0.000 claims 3
• 150000002431 hydrogen Chemical class 0.000 claims 3
• 206010057190 Respiratory tract infections Diseases 0.000 claims 2
• 125000003725 azepanyl group Chemical group 0.000 claims 2
• 229910052799 carbon Inorganic materials 0.000 claims 2
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
• 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
• 125000003678 cyclohexadienyl group Chemical group C1(=CC=CCC1)* 0.000 claims 2
• 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims 2
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
• 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 125000003386 piperidinyl group Chemical group 0.000 claims 2
• 125000004076 pyridyl group Chemical group 0.000 claims 2
• 125000005942 tetrahydropyridyl group Chemical group 0.000 claims 2
• 206010056519 Abdominal infection Diseases 0.000 claims 1
• 206010060968 Arthritis infective Diseases 0.000 claims 1
• 208000031729 Bacteremia Diseases 0.000 claims 1
• 206010018612 Gonorrhoea Diseases 0.000 claims 1
• 208000008745 Healthcare-Associated Pneumonia Diseases 0.000 claims 1
• 241000282412 Homo Species 0.000 claims 1
• 208000036209 Intraabdominal Infections Diseases 0.000 claims 1
• 201000009906 Meningitis Diseases 0.000 claims 1
• 208000037942 Methicillin-resistant Staphylococcus aureus infection Diseases 0.000 claims 1
• 206010031252 Osteomyelitis Diseases 0.000 claims 1
• 206010058674 Pelvic Infection Diseases 0.000 claims 1
• 206010035148 Plague Diseases 0.000 claims 1
• 206010035737 Pneumonia viral Diseases 0.000 claims 1
• 208000032826 Ring chromosome 3 syndrome Diseases 0.000 claims 1
• 206010040047 Sepsis Diseases 0.000 claims 1
• 206010058028 Shunt infection Diseases 0.000 claims 1
• 206010041925 Staphylococcal infections Diseases 0.000 claims 1
• 108010059993 Vancomycin Proteins 0.000 claims 1
• 208000009470 Ventilator-Associated Pneumonia Diseases 0.000 claims 1
• 241000607479 Yersinia pestis Species 0.000 claims 1
• 230000001154 acute effect Effects 0.000 claims 1
• 208000022338 anthrax infection Diseases 0.000 claims 1
• 125000002393 azetidinyl group Chemical group 0.000 claims 1
• 230000001580 bacterial effect Effects 0.000 claims 1
• 150000001717 carbocyclic compounds Chemical class 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 206010014665 endocarditis Diseases 0.000 claims 1
• 125000002541 furyl group Chemical group 0.000 claims 1
• 208000001786 gonorrhea Diseases 0.000 claims 1
• 125000000623 heterocyclic group Chemical group 0.000 claims 1
• TYZROVQLWOKYKF-ZDUSSCGKSA-N linezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 claims 1
• 229960003907 linezolid Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 206010034674 peritonitis Diseases 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
• 210000004872 soft tissue Anatomy 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1
• 201000008827 tuberculosis Diseases 0.000 claims 1
• 208000019206 urinary tract infection Diseases 0.000 claims 1
• 229960003165 vancomycin Drugs 0.000 claims 1
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 1
• MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 claims 1
• 230000002792 vascular Effects 0.000 claims 1
• 208000009421 viral pneumonia Diseases 0.000 claims 1
• LZLIMYASODBPNN-UHFFFAOYSA-N CS(CCCNCc(cc1)ccc1C1=CNC(NC(Nc2ccccc2OC(F)(F)F)=O)=NC1=O)=O Chemical compound CS(CCCNCc(cc1)ccc1C1=CNC(NC(Nc2ccccc2OC(F)(F)F)=O)=NC1=O)=O LZLIMYASODBPNN-UHFFFAOYSA-N 0.000 description 1