JP2015533126A - ヒト抗vegfr2/kdr抗体 - Google Patents
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- JP2015533126A JP2015533126A JP2015535881A JP2015535881A JP2015533126A JP 2015533126 A JP2015533126 A JP 2015533126A JP 2015535881 A JP2015535881 A JP 2015535881A JP 2015535881 A JP2015535881 A JP 2015535881A JP 2015533126 A JP2015533126 A JP 2015533126A
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Abstract
Description
(i)CDR‐1H配列はGFTFSWYX1MX2(SEQ ID NO:185)であり、ここで、X1はVまたはI、X2はGまたはLであり、
(ii)CDR‐2H配列はSIX1X2SGGX3TX4YADSVKG(SEQ ID NO:186)であり、ここで、X1はYまたはGであり、X2はPまたはSであり、X3はAまたはFであり、X4はNまたはDであり、
(iii)CDR‐3H配列はGNYFDY(SEQ ID NO:3)またはGLAAPRS(SEQ ID NO:11)である。
(i)CDR‐1L配列は、X1GX2X3LX4X5X6X7X8S(SEQ ID NO:187)であり、ここで、X1はS、QまたはTであり、X2はD、EまたはQであり、X3はK、S、N、IまたはAであり、X4はGまたはRであり、X5はD、S、H、EまたはNであり、X6はE、Y、Q、RまたはNであり、X7はY、FまたはSであり、X8はAまたはSであり、もしくはSGSX1SNX2X3X4X5X6X7X8(SEQ ID NO:188)であり、ここで、X1はSまたはTであり、X2はIまたはLであり、X3はEまたはGであり、X4はT、SまたはNであり、X5はNまたはYであり、X6はT、P、AまたはYであり、X7はVまたはLであり、X8はN、IまたはYであり、もしくはX1GX2SX3DX4GX5YDYVS(SEQ ID NO:189)であり、ここで、X1はAまたはTであり、X2はSまたはTであり、X3はH、SまたはNであり、X4はIまたはVであり、X5はSまたはAであり、
(ii)CDR‐2L配列は、X1X2X3X4X5PS(SEQ ID NO:190)であり、ここで、X1はQ、D、T、Y、SまたはAであり、X2はD、N、S、T、VまたはVであり、X3はD、N、S、TまたはYであり、X4はQ、K、NまたはLであり、X5はRまたはLであり、
(iii)CDR‐3L配列は、QX1WX2X3X4X5X6X7X8(SEQ ID NO:191)であり、ここで、X1はAまたはTであり、X2はDまたはGであり、X3はRでありまたはアミノ酸を含まず、X4はS、FまたはNであり、X5はS、TまたはNであり、X6はS、TまたはPであり、X7はA、V、L、IまたはYであり、X8はVまたはLであり、もしくはAX1WDDX2LX3X4X5X6(SEQ ID NO:192)であり、ここで、X1はA、SまたはTであり、X2はNまたはSであり、X3はN、IまたはGであり、X4はGまたはSであり、X5はP、WまたはVであり、X6はVまたはLであり、もしくはMYSTITX1LL(SEQ ID NO:193)であり、ここで、X1はAまたはTである。
(i)CDR‐1L配列は、RASX1X2X3X4X5X6X7YX8X9(SEQ ID NO:194)であり、ここで、X1はQ、EまたはHであり、X2はS、RまたはNであり、X3はV、IまたはLであり、X4はS、R、GまたはNであり、X5はSまたはNであり、X6はS、N、WまたはDであり、X7はGでありまたはアミノ酸を含まず、X8はLまたはFであり、X9はA、G、MまたはSであり、
(ii)CDR‐2L配列は、GASX1RAT(SEQ ID NO:195)であり、ここで、X1はS、T、IまたはNであり、
(iii)CDR‐3L配列は、QQX1X2X3X4X5X6X7X8(SEQ ID NO:196)であり、ここで、X1はFまたはYであり、X2はD、GまたはYであり、X3はS、TまたはNであり、X4はS、LまたはWであり、X5はPでありまたはアミノ酸を含まず、X6はPまたはTであり、X7はL、I、V、P、WまたはYであり、X8はTまたはSである。
(i)CDR‐1H配列はGFTFSWYX1MX2(SEQ ID NO:185)であり、ここで、X1はVまたはIであり、X2はGまたはLであり、
(ii)CDR‐2H配列はSIX1X2SGGX3TX4YADSVKG(SEQ ID NO:186)であり、ここで、X1はYまたはGであり、X2はPまたはSであり、X3はAまたはFであり、X4はNまたはDであり、
(iii)CDR‐3H配列はGNYFDY(SEQ ID NO:3)またはGLAAPRS(SEQ ID NO:11)である。
(i)CDR‐L1配列は、X1GX2X3LX4X5X6X7X8S(SEQ ID NO:187)であり、ここで、X1はS、QまたはTであり、X2はD、EまたはQであり、X3はK、S、N、IまたはAであり、X4はGまたはRであり、X5はD、S、H、EまたはNであり、X6はE、Y、Q、RまたはNであり、X7はY、FまたはSであり、X8はAまたはSであり、もしくは、SGSX1SNX2X3X4X5X6X7X8(SEQ ID NO:188)であり、ここで、X1はSまたはTであり、X2はIまたはLであり、X3はEまたはGであり、X4はT、SまたはNであり、X5はNまたはYであり、X6はT、P、AまたはYであり、X7はVまたはLであり、X8はN、IまたはYであり、もしくは、X1GX2SX3DX4GX5YDYVS(SEQ ID NO:189)であり、ここで、X1はAまたはTであり、X2はSまたはTであり、X3はH、SまたはNであり、X4はIまたはVであり、X5はSまたはAであり、
(ii)CDR‐L2配列は、X1X2X3X4X5PS(SEQ ID NO:190)であり、ここで、X1はQ、D、T、Y、SまたはAであり、X2はD、N、S、TまたはVであり、X3はD、N、S、TまたはYであり、X4はQ、K、NまたはLであり、X5はRまたはLであり、
(iii)CDR‐L3配列は、QX1WX2X3X4X5X6X7X8(SEQ ID NO:191)であり、ここで、X1はAまたはTであり、X2はDまたはGであり、X3はRでありまたはアミノ酸を含まず、X4はS、FまたはNであり、X5はS、TまたはNであり、X6はS、TまたはPであり、X7はA、V、L、IまたはYであり、X8はVまたはLであり、もしくは、AX1WDDX2LX3X4X5X6(SEQ ID NO:192)であり、ここで、X1はA、SまたはTであり、X2はNまたはSであり、X3はN、IまたはGであり、X4はGまたはSであり、X5はP、WまたはVであり、X6はVまたはLであり、もしくは、MYSTITX1LL(SEQ ID NO:193)であり、ここで、X1はAまたはTである。
(i)CDR‐L1配列は、RASX1X2X3X4X5X6X7YX8X9(SEQ ID NO:194)であり、ここで、X1はQ、EまたはHであり、X2はS、RまたはNであり、X3はV、IまたはLであり、X4はS、R、GまたはNであり、X5はSまたはNであり、X6はS、N、WまたはDであり、X7はGでありまたはアミノ酸を含まず、X8はLまたはFであり、X9はA、G、MまたはSであり、
(ii)CDR‐L2配列は、GASX1RAT(SEQ ID NO:195)であり、ここで、X1はS、T、IまたはNであり、
(iii)CDR‐L3配列は、QQX1X2X3X4X5X6X7X8(SEQ ID NO:196)であり、ここで、X1はFまたはYであり、X2はD、GまたはYであり、X3はS、TまたはNであり、X4はS、LまたはWであり、X5はPでありまたはアミノ酸を含まず、X6はPまたはTであり、X7はL、I、V、P、WまたはYであり、X8はTまたはSである。
VEGFRドメイン2および3を結合して、リガンド結合を遮断する抗体の同定
実施例2
生体内腫瘍成長の阻止
実施例3
人間の患者における結腸癌の治療
Claims (24)
- CDR‐1H、CDR‐2HおよびCDR‐3H配列を有する、重鎖可変ドメインを有するヒトVEGFR2を結合する、単離された抗体または該抗体の断片であって、
(i)前記CDR‐1H配列はGFTFSWYX1MX2(SEQ ID NO:185)であり、ここで、X1はVであり、X2はGまたはLであり、
(ii)CDR‐2H配列はSIX1X2SGGX3TX4YADSVKG(SEQ ID NO:186)であり、ここで、X1はYまたはGであり、X2はPまたはSであり、X3はAまたはFであり、X4はNまたはDであり、
(iii)CDR‐3H配列はGNYFDY(SEQ ID NO:3)またはGLAAPRS(SEQ ID NO:11)である
前記抗体。 - 前記抗体は、CDR‐1L、CDR‐2LおよびCDR‐3Lを有し、
(i)CDR‐1L配列は、X1GX2X3LX4X5X6X7X8S(SEQ ID NO:187)であり、ここで、X1はS、QまたはTであり、X2はD、EまたはQであり、X3はK、S、N、IまたはAであり、X4はGまたはRであり、X5はD、S、H、EまたはNであり、X6はE、Y、Q、RまたはNであり、X7はY、FまたはSであり、X8はAまたはSであり、もしくはSGSX1SNX2X3X4X5X6X7X8(SEQ ID NO:188)であり、ここで、X1はSまたはTであり、X2はIまたはLであり、X3はEまたはGであり、X4はT、SまたはNであり、X5はNまたはYであり、X6はT、P、AまたはYであり、X7はVまたはLであり、X8はN、IまたはYであり、もしくはX1GX2SX3DX4GX5YDYVS(SEQ ID NO:189)であり、ここで、X1はAまたはTであり、X2はSまたはTであり、X3はH、SまたはNであり、X4はIまたはVであり、X5はSまたはAであり、
(ii)CDR‐2L配列は、X1X2X3X4X5PS(SEQ ID NO:190)であり、ここで、X1はQ、D、T、Y、SまたはAであり、X2はD、N、S、T、VまたはVであり、X3はD、N、S、TまたはYであり、X4はQ、K、NまたはLであり、X5はRまたはLであり、
(iii)CDR‐3L配列は、QX1WX2X3X4X5X6X7X8(SEQ ID NO:191)であり、ここで、X1はAまたはTであり、X2はDまたはGであり、X3はRでありまたはアミノ酸を含まず、X4はS、FまたはNであり、X5はS、TまたはNであり、X6はS、TまたはPであり、X7はA、V、L、IまたはYであり、X8はVまたはLであり、もしくはAX1WDDX2LX3X4X5X6(SEQ ID NO:192)であり、ここで、X1はA、SまたはTであり、X2はNまたはSであり、X3はN、IまたはGであり、X4はGまたはSであり、X5はP、WまたはVであり、X6はVまたはLであり、もしくはMYSTITX1LL(SEQ ID NO:193)であり、ここで、X1はAまたはTである
請求項1に記載の前記抗体。 - 前記抗体は、CDR‐1L、CDR‐2LおよびCDR‐3Lを有し、
(i)CDR‐1L配列は、RASX1X2X3X4X5X6X7YX8X9(SEQ ID NO:194)であり、ここで、X1はQ、EまたはHであり、X2はS、RまたはNであり、X3はV、IまたはLであり、X4はS、R、GまたはNであり、X5はSまたはNであり、X6はS、N、WまたはDであり、X7はGでありまたはアミノ酸を含まず、X8はLまたはFであり、X9はA、G、MまたはSであり、
(ii)CDR‐2L配列は、GASX1RAT(SEQ ID NO:195)であり、ここで、X1はS、T、IまたはNであり、
(iii)CDR‐3L配列は、QQX1X2X3X4X5X6X7X8(SEQ ID NO:196)であり、ここで、X1はFまたはYであり、X2はD、GまたはYであり、X3はS、TまたはNであり、X4はS、LまたはWであり、X5はPでありまたはアミノ酸を含まず、X6はPまたはTであり、X7はL、I、V、P、WまたはYであり、X8はTまたはSである
請求項1に記載の前記抗体。 - 前記抗体は、SEQ ID NO:1を有するCDR‐1Hと、SEQ ID NO:2を有するCDR‐2Hと、SEQ ID NO:3を有するCDR‐3Hとを有する、請求項1に記載の前記抗体。
- 前記抗体は、SEQ ID NO:5を有するCDR‐1Lと、SEQ ID NO:6を有するCDR‐2Lと、SEQ ID NO:7を有するCDR‐3Lとを有する、請求項1に記載の前記抗体。
- 前記抗体は、SEQ ID NO:4を有する重鎖可変ドメインを有する、請求項1に記載の前記抗体。
- 前記抗体は、SEQ ID NO:8を有する軽鎖可変ドメインを有する、請求項1に記載の前記抗体。
- 前記抗体は、SEQ ID NO:9を有するCDR‐1Hと、SEQ ID NO:10を有するCDR‐2Hと、SEQ ID NO:11を有するCDR‐3Hとを有する、請求項1に記載の抗体。
- 前記抗体は、SEQ ID NO:13を有するCDR‐1Lと、SEQ ID NO:14を有するCDR‐2Lと、SEQ ID NO:15を有するCDR‐3Lとを有する、請求項1に記載の前記抗体。
- 前記抗体は、SEQ ID NO:12を有する重鎖可変ドメインを有する、請求項1に記載の前記抗体。
- 前記抗体は、SEQ ID NO:16を有する軽鎖可変ドメインを有する、請求項1に記載の前記抗体。
- 前記抗体は、表2に示す抗体の一である、請求項1に記載の前記抗体。
- 前記抗体は、SEQ ID NO:25を有するCDR‐1Lと、SEQ ID NO:26を有するCDR‐2Lと、SEQ ID NO:27を有するCDR‐3Lとを有する、請求項1に記載の前記抗体。
- 前記抗体は、SEQ ID NO:28を有する軽鎖可変ドメインを有する、請求項1に記載の前記抗体。
- 前記抗体は、SEQ ID NO:29を有するCDR‐1Lと、SEQ ID NO:30を有するCDR‐2Lと、SEQ ID NO:31を有するCDR‐3Lとを有する、請求項1に記載の前記抗体。
- 前記抗体は、SEQ ID NO:32を有する軽鎖可変ドメインを有する、請求項1に記載の前記抗体。
- 前記抗体は、hVEGFR2へのVEGFの結合を遮断する、請求項1乃至16のいずれか一項に記載のすべての前記抗体。
- 請求項1乃至16の何れか一項に記載の抗体の有効量を有する細胞に接することを含むVEGFR2の活性化を中和する方法。
- 請求項1乃至16の何れか一項に記載の抗体の有効量を投与することを含む血管新生を阻止する方法。
- 請求項1乃至16の何れか一項に記載の抗体の有効量を投与することを含む腫瘍成長を低減する方法。
- 表皮成長因子受容体(EGFR)アンタゴニストの有効量を投与することをさらに含む、請求項20に記載の方法。
- fms様チロシンキナーゼ受容体(flt‐1)アンタゴニストの有効量を投与することをさらに含む、請求項20に記載の方法。
- rho関連キナーゼ2(ROCK2)アンタゴニストの有効量を投与することをさらに有する、請求項20に記載の方法。
- マトリックスメタロプロテアーゼアンタゴニストの有効量を投与することをさらに有する、請求項20に記載の方法。
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EA039595B1 (ru) | 2022-02-15 |
EP3685855B1 (en) | 2023-11-22 |
EA032679B1 (ru) | 2019-07-31 |
JP6449772B2 (ja) | 2019-01-09 |
ES2781974T3 (es) | 2020-09-09 |
EP3685855C0 (en) | 2023-11-22 |
CA2926386A1 (en) | 2014-04-10 |
US10364291B2 (en) | 2019-07-30 |
EA201500363A8 (ru) | 2016-04-29 |
ES2966030T3 (es) | 2024-04-18 |
EA201500363A1 (ru) | 2015-11-30 |
CN116003600A (zh) | 2023-04-25 |
WO2014055998A1 (en) | 2014-04-10 |
EP3685855A1 (en) | 2020-07-29 |
US20180346579A1 (en) | 2018-12-06 |
CN109160950B (zh) | 2022-10-04 |
CN105007939A (zh) | 2015-10-28 |
EA201990403A1 (ru) | 2019-07-31 |
EP2903647B1 (en) | 2020-01-01 |
PL3685855T3 (pl) | 2024-04-08 |
EP2903647A1 (en) | 2015-08-12 |
CN109160950A (zh) | 2019-01-08 |
CN105007939B (zh) | 2018-10-19 |
EP2903647A4 (en) | 2016-08-17 |
US20150284464A1 (en) | 2015-10-08 |
US10023640B2 (en) | 2018-07-17 |
CA2926386C (en) | 2021-11-09 |
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