JP2015529826A5 - - Google Patents
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- JP2015529826A5 JP2015529826A5 JP2015529850A JP2015529850A JP2015529826A5 JP 2015529826 A5 JP2015529826 A5 JP 2015529826A5 JP 2015529850 A JP2015529850 A JP 2015529850A JP 2015529850 A JP2015529850 A JP 2015529850A JP 2015529826 A5 JP2015529826 A5 JP 2015529826A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- antibody
- target molecule
- expressing
- phenotype
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 30
- 210000004027 cell Anatomy 0.000 claims 25
- 239000000126 substance Substances 0.000 claims 9
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 108020003175 receptors Proteins 0.000 claims 6
- 102000005962 receptors Human genes 0.000 claims 6
- 102000004127 Cytokines Human genes 0.000 claims 3
- 108090000695 Cytokines Proteins 0.000 claims 3
- 210000003527 eukaryotic cell Anatomy 0.000 claims 3
- 229940088597 hormone Drugs 0.000 claims 3
- 239000005556 hormone Substances 0.000 claims 3
- 230000001270 agonistic effect Effects 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 230000003305 autocrine Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 230000008672 reprogramming Effects 0.000 claims 2
- 102000035025 signaling receptors Human genes 0.000 claims 2
- 108091005475 signaling receptors Proteins 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 1
- 102000003951 Erythropoietin Human genes 0.000 claims 1
- 108090000394 Erythropoietin Proteins 0.000 claims 1
- 108010002352 Interleukin-1 Proteins 0.000 claims 1
- 102000000589 Interleukin-1 Human genes 0.000 claims 1
- 108700020796 Oncogene Proteins 0.000 claims 1
- 102000036693 Thrombopoietin Human genes 0.000 claims 1
- 108010041111 Thrombopoietin Proteins 0.000 claims 1
- 108700025716 Tumor Suppressor Genes Proteins 0.000 claims 1
- 102000044209 Tumor Suppressor Genes Human genes 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 230000036755 cellular response Effects 0.000 claims 1
- 230000005754 cellular signaling Effects 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229940105423 erythropoietin Drugs 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 102000006240 membrane receptors Human genes 0.000 claims 1
- 230000004766 neurogenesis Effects 0.000 claims 1
- 238000002823 phage display Methods 0.000 claims 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical group [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 210000001082 somatic cell Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261695527P | 2012-08-31 | 2012-08-31 | |
| US61/695,527 | 2012-08-31 | ||
| US201361814646P | 2013-04-22 | 2013-04-22 | |
| US61/814,646 | 2013-04-22 | ||
| PCT/US2013/055362 WO2014035693A2 (en) | 2012-08-31 | 2013-08-16 | Methods and compositions related to modulators of eukaryotic cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529826A JP2015529826A (ja) | 2015-10-08 |
| JP2015529826A5 true JP2015529826A5 (enExample) | 2018-01-18 |
| JP6590694B2 JP6590694B2 (ja) | 2019-10-16 |
Family
ID=50184579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015529850A Active JP6590694B2 (ja) | 2012-08-31 | 2013-08-16 | 真核生物細胞の調節因子に関する方法及び組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9738719B2 (enExample) |
| EP (2) | EP2966088B1 (enExample) |
| JP (1) | JP6590694B2 (enExample) |
| CN (1) | CN105452546B (enExample) |
| AU (2) | AU2013309272B2 (enExample) |
| CA (1) | CA2883454C (enExample) |
| DK (1) | DK2890836T3 (enExample) |
| IL (1) | IL237479B (enExample) |
| PT (1) | PT2890836T (enExample) |
| WO (1) | WO2014035693A2 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20210517T1 (hr) | 2012-12-05 | 2021-05-14 | Novartis Ag | Pripravci i postupci za protutijela usmjerena na epo |
| US9409139B2 (en) | 2013-08-05 | 2016-08-09 | Twist Bioscience Corporation | De novo synthesized gene libraries |
| EA201790946A8 (ru) * | 2014-12-01 | 2018-10-31 | Зе Скриппс Рисёрч Инститьют | Способы и композиции, связанные с функциональными полипептидами, встроенными в гетерологичные белковые каркасы |
| CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| CA3253836A1 (en) | 2015-02-04 | 2025-12-01 | Twist Bioscience Corp | Compositions and methods for synthetic gene assembly |
| WO2016172377A1 (en) | 2015-04-21 | 2016-10-27 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| WO2016205784A1 (en) * | 2015-06-19 | 2016-12-22 | The Scripps Research Institute | Methods and compositions for producing activated natural killer cells and related uses |
| JP2018525389A (ja) | 2015-08-12 | 2018-09-06 | ノバルティス アーゲー | 眼障害を治療する方法 |
| AU2016324296A1 (en) * | 2015-09-18 | 2018-04-12 | Twist Bioscience Corporation | Oligonucleic acid variant libraries and synthesis thereof |
| CN108698012A (zh) | 2015-09-22 | 2018-10-23 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
| CN108603307A (zh) | 2015-12-01 | 2018-09-28 | 特韦斯特生物科学公司 | 功能化表面及其制备 |
| US10233255B2 (en) | 2016-04-25 | 2019-03-19 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind STAT3 |
| WO2017214831A1 (zh) * | 2016-06-14 | 2017-12-21 | 石庆学 | 特异促进 nrg1 基因高表达的慢病毒载体及其应用 |
| WO2017214832A1 (zh) * | 2016-06-14 | 2017-12-21 | 石庆学 | 特异促进 Foxp3 基因高表达的慢病毒载体及其应用 |
| WO2017214829A1 (zh) * | 2016-06-14 | 2017-12-21 | 石庆学 | 特异促进 pd-l1 基因高表达的慢病毒表达载体及其应用 |
| WO2017214830A1 (zh) * | 2016-06-14 | 2017-12-21 | 石庆学 | 特异促进 pd-1 基因高表达的慢病毒载体及其应用 |
| WO2017214828A1 (zh) * | 2016-06-14 | 2017-12-21 | 石庆学 | 特异促进 Prkcz 基因高表达的慢病毒表达载体及其应用 |
| WO2017214910A1 (zh) * | 2016-06-15 | 2017-12-21 | 石庆学 | 特异促进Tβ4基因高表达的慢病毒表达载体及其应用 |
| WO2017214945A1 (zh) * | 2016-06-16 | 2017-12-21 | 毛侃琅 | 提升Hepcidin基因表达水平的慢病毒表达载体及其应用 |
| CA3034769A1 (en) | 2016-08-22 | 2018-03-01 | Twist Bioscience Corporation | De novo synthesized nucleic acid libraries |
| CN110248724B (zh) | 2016-09-21 | 2022-11-18 | 特韦斯特生物科学公司 | 基于核酸的数据存储 |
| CN110366613A (zh) | 2016-12-16 | 2019-10-22 | 特韦斯特生物科学公司 | 免疫突触的变体文库及其合成 |
| WO2018141058A1 (en) * | 2017-01-31 | 2018-08-09 | The Governors Of The University Of Alberta | Display of molecules on silently genetically encoded nanoscale carriers for determining synergistic molecular interactions |
| WO2018156792A1 (en) | 2017-02-22 | 2018-08-30 | Twist Bioscience Corporation | Nucleic acid based data storage |
| AU2018234624B2 (en) * | 2017-03-15 | 2023-11-16 | Twist Bioscience Corporation | De novo synthesized combinatorial nucleic acid libraries |
| CN110913865A (zh) | 2017-03-15 | 2020-03-24 | 特韦斯特生物科学公司 | 免疫突触的变体文库及其合成 |
| IL271205B2 (en) | 2017-06-12 | 2025-02-01 | Twist Bioscience Corp | Methods for assembling continuous nucleic acids |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| US11407837B2 (en) | 2017-09-11 | 2022-08-09 | Twist Bioscience Corporation | GPCR binding proteins and synthesis thereof |
| JP2020536115A (ja) | 2017-10-04 | 2020-12-10 | オプコ ファーマシューティカルズ、エルエルシー | 癌の個別化療法に関する物品および方法 |
| KR102637566B1 (ko) | 2017-10-20 | 2024-02-16 | 트위스트 바이오사이언스 코포레이션 | 폴리뉴클레오타이드 합성을 위한 가열된 나노웰 |
| AU2018383600B2 (en) | 2017-12-11 | 2025-10-02 | Abalone Bio, Inc. | Yeast display of proteins in the periplasmic space |
| CN112041438B (zh) | 2018-01-04 | 2025-05-23 | 特韦斯特生物科学公司 | 基于dna的数字信息存储 |
| CA3100739A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
| EP3827116A4 (en) | 2018-07-23 | 2022-05-11 | The Governors of the University of Alberta | Genetically-encoded bicyclic peptide libraries |
| JP7257508B2 (ja) | 2018-10-08 | 2023-04-13 | アンバーストーン・バイオサイエンシーズ・インコーポレイテッド | 二重特異性および多重特異性生物学的物質の区画化されたアッセイ |
| CA3124980A1 (en) | 2018-12-26 | 2020-07-02 | Twist Bioscience Corporation | Highly accurate de novo polynucleotide synthesis |
| KR20210143766A (ko) | 2019-02-26 | 2021-11-29 | 트위스트 바이오사이언스 코포레이션 | Glp1 수용체에 대한 변이체 핵산 라이브러리 |
| CN113785057A (zh) | 2019-02-26 | 2021-12-10 | 特韦斯特生物科学公司 | 用于抗体优化的变异核酸文库 |
| CN113544509A (zh) * | 2019-03-08 | 2021-10-22 | 牛津遗传学有限公司 | 选择抗体的方法 |
| JP2022550497A (ja) | 2019-06-21 | 2022-12-02 | ツイスト バイオサイエンス コーポレーション | バーコードに基づいた核酸配列アセンブリ |
| AU2020355027A1 (en) | 2019-09-23 | 2022-04-21 | Twist Bioscience Corporation | Antibodies that bind CD3 Epsilon |
| CA3155629A1 (en) | 2019-09-23 | 2021-04-01 | Twist Bioscience Corporation | Variant nucleic acid libraries for crth2 |
| EP4200434A4 (en) * | 2020-08-21 | 2024-10-02 | Hifibio (Shanghai) Co., Ltd. | FUNCTIONAL SCREENING USING DROPLET MICROFLUIDIC |
| EP4253417A4 (en) * | 2020-11-24 | 2024-10-23 | Daegu Gyeongbuk Institute Of Science and Technology | NEW ANTI-C-MPL ANTIBODY AND ITS USE |
| KR102579393B1 (ko) * | 2020-11-24 | 2023-09-18 | 재단법인대구경북과학기술원 | 신규한 항-c-mpl 항체 및 이의 용도 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| ATE114723T1 (de) | 1987-03-02 | 1994-12-15 | Enzon Lab Inc | Organismus als träger für ''single chain antibody domain (scad)''. |
| US6969586B1 (en) * | 1989-05-16 | 2005-11-29 | Scripps Research Institute | Method for tapping the immunological repertoire |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5401629A (en) | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
| US6300065B1 (en) | 1996-05-31 | 2001-10-09 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| US6103879A (en) * | 1996-06-21 | 2000-08-15 | Axys Pharmaceuticals, Inc. | Bivalent molecules that form an activating complex with an erythropoietin receptor |
| US5980893A (en) * | 1997-07-17 | 1999-11-09 | Beth Israel Deaconess Medical Center, Inc. | Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis |
| US6342220B1 (en) * | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
| WO2000055335A1 (en) * | 1999-03-16 | 2000-09-21 | Dana-Farber Cancer Institute, Inc. | Pseudotyped lentiviral vectors and uses thereof |
| EP1169352A4 (en) * | 1999-04-14 | 2005-05-04 | Smithkline Beecham Corp | ANTIBODY AGAINST THE ERYTHROPOIETIN RECEPTOR |
| EP1327680B1 (en) * | 2000-10-20 | 2008-04-02 | Chugai Seiyaku Kabushiki Kaisha | Modified tpo agonist antibody |
| US20030104402A1 (en) * | 2001-01-23 | 2003-06-05 | University Of Rochester | Methods of producing or identifying intrabodies in eukaryotic cells |
| CA2550933A1 (en) * | 2003-12-22 | 2005-07-14 | Amgen Inc. | Methods for identifying functional antibodies |
| US20080038265A1 (en) * | 2004-04-09 | 2008-02-14 | Reilly Edward B | Antibodies to Erythropoietin Receptor and Uses Thereof |
| HRP20110859T1 (hr) * | 2004-12-21 | 2011-12-31 | Medimmune Limited | Protutijela usmjerena na angiopoietin-2 i njihova upotreba |
| CA2625619A1 (en) * | 2005-10-14 | 2007-04-26 | Medimmune, Inc. | Cell display of antibody libraries |
| EP2006380A4 (en) * | 2006-03-23 | 2010-08-11 | Kyowa Hakko Kirin Co Ltd | AGONIST ANTIBODY AGAINST THE HUMAN THROMBOPOIETINE RECEPTOR |
| AU2007238704A1 (en) * | 2006-04-14 | 2007-10-25 | Amgen Inc. | Erythropoietin receptor agonists |
| JP5105468B2 (ja) | 2006-12-05 | 2012-12-26 | 独立行政法人産業技術総合研究所 | 細胞内で機能する抗体の創製および細胞表現型を制御するタンパク質の同定 |
| WO2008100816A2 (en) * | 2007-02-09 | 2008-08-21 | Medimmune, Llc | Antibody libray display by yeast cell plasma membrane |
| EP2604280A3 (en) * | 2008-03-27 | 2013-10-16 | ZymoGenetics, Inc. | Compositions and methods for inhibiting PDGFRBETA and VEGF-A |
-
2013
- 2013-08-16 JP JP2015529850A patent/JP6590694B2/ja active Active
- 2013-08-16 DK DK13833286.1T patent/DK2890836T3/da active
- 2013-08-16 WO PCT/US2013/055362 patent/WO2014035693A2/en not_active Ceased
- 2013-08-16 AU AU2013309272A patent/AU2013309272B2/en active Active
- 2013-08-16 PT PT13833286T patent/PT2890836T/pt unknown
- 2013-08-16 EP EP15161819.6A patent/EP2966088B1/en active Active
- 2013-08-16 CA CA2883454A patent/CA2883454C/en active Active
- 2013-08-16 US US14/424,663 patent/US9738719B2/en active Active
- 2013-08-16 EP EP13833286.1A patent/EP2890836B1/en active Active
- 2013-08-16 CN CN201380057193.8A patent/CN105452546B/zh active Active
-
2015
- 2015-03-01 IL IL237479A patent/IL237479B/en active IP Right Grant
-
2017
- 2017-04-20 AU AU2017202636A patent/AU2017202636B2/en active Active
- 2017-08-08 US US15/671,814 patent/US10494438B2/en active Active
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