JP2015529462A5 - - Google Patents
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- Publication number
- JP2015529462A5 JP2015529462A5 JP2015530066A JP2015530066A JP2015529462A5 JP 2015529462 A5 JP2015529462 A5 JP 2015529462A5 JP 2015530066 A JP2015530066 A JP 2015530066A JP 2015530066 A JP2015530066 A JP 2015530066A JP 2015529462 A5 JP2015529462 A5 JP 2015529462A5
- Authority
- JP
- Japan
- Prior art keywords
- pressure
- bar
- high pressure
- microorganisms
- inactivation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 244000005700 microbiome Species 0.000 claims 12
- 239000012530 fluid Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 230000002779 inactivation Effects 0.000 claims 8
- 210000003000 inclusion body Anatomy 0.000 claims 8
- 239000006285 cell suspension Substances 0.000 claims 7
- 241000588724 Escherichia coli Species 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 241000588832 Bordetella pertussis Species 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
- 239000004202 carbamide Substances 0.000 claims 4
- 244000052769 pathogen Species 0.000 claims 4
- 230000000415 inactivating effect Effects 0.000 claims 3
- 238000012544 monitoring process Methods 0.000 claims 3
- 230000001717 pathogenic effect Effects 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- 230000005847 immunogenicity Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229940066827 pertussis vaccine Drugs 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 230000035899 viability Effects 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 241000206602 Eukaryota Species 0.000 claims 1
- 241000589902 Leptospira Species 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 238000007599 discharging Methods 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000002504 physiological saline solution Substances 0.000 claims 1
- 238000003825 pressing Methods 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 230000003381 solubilizing effect Effects 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261694968P | 2012-08-30 | 2012-08-30 | |
| US61/694,968 | 2012-08-30 | ||
| US201361830425P | 2013-06-03 | 2013-06-03 | |
| US61/830,425 | 2013-06-03 | ||
| PCT/US2013/057426 WO2014036345A2 (en) | 2012-08-30 | 2013-08-30 | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529462A JP2015529462A (ja) | 2015-10-08 |
| JP2015529462A5 true JP2015529462A5 (OSRAM) | 2016-09-15 |
| JP6438396B2 JP6438396B2 (ja) | 2018-12-12 |
Family
ID=49162270
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530066A Active JP6438396B2 (ja) | 2012-08-30 | 2013-08-30 | 不活化ワクチンを作製するための、ならびに組換えタンパク質をリフォールディング／可溶化させるための高圧デバイスおよび方法 |
| JP2015530070A Expired - Fee Related JP6405308B2 (ja) | 2012-08-30 | 2013-08-30 | キメラｋｓａｃタンパク質の発現及び高圧により可溶性タンパク質を製造する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530070A Expired - Fee Related JP6405308B2 (ja) | 2012-08-30 | 2013-08-30 | キメラｋｓａｃタンパク質の発現及び高圧により可溶性タンパク質を製造する方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9169302B2 (OSRAM) |
| EP (2) | EP2890392B1 (OSRAM) |
| JP (2) | JP6438396B2 (OSRAM) |
| KR (1) | KR102208844B1 (OSRAM) |
| CN (3) | CN104717976A (OSRAM) |
| AP (1) | AP2015008331A0 (OSRAM) |
| AU (4) | AU2013308627B2 (OSRAM) |
| BR (1) | BR112015004463B8 (OSRAM) |
| CA (2) | CA2883296A1 (OSRAM) |
| EA (1) | EA031988B1 (OSRAM) |
| ES (1) | ES2744709T3 (OSRAM) |
| HK (1) | HK1211874A1 (OSRAM) |
| MD (1) | MD4608C1 (OSRAM) |
| MX (3) | MX381717B (OSRAM) |
| NZ (3) | NZ705790A (OSRAM) |
| PH (1) | PH12015500700B1 (OSRAM) |
| RU (1) | RU2647568C2 (OSRAM) |
| WO (2) | WO2014036345A2 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8968749B2 (en) * | 2006-07-21 | 2015-03-03 | Universidade Federal De Minas Gerais—Ufmg | Vaccine composition and immunization method |
| ZA201501696B (en) | 2012-08-30 | 2016-01-27 | Merial Ltd | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
| AU2013308627B2 (en) | 2012-08-30 | 2016-10-27 | Boehringer Ingelheim Animal Health USA Inc. | Expression of chimeric KSAC protein and method of producing soluble proteins by high pressure |
| BR112015024860B1 (pt) | 2013-03-28 | 2023-11-07 | Access To Advanced Health Institute | Polipeptídeo de fusão, polinucleotídeo isolado, composição compreendendo dito polipeptídeo, uso da dita composição para estimular uma resposta imune contra leishmania e método in vitro e kit de diagnóstico para detectar infecção por leishmania em uma amostra biológica |
| CN104758944B (zh) | 2015-04-02 | 2017-11-28 | 中国科学院过程工程研究所 | 一种疫苗制剂及其制备方法和用途 |
| JP2018082987A (ja) * | 2016-11-25 | 2018-05-31 | 株式会社日立製作所 | ウイルス不活化方法及びウイルス不活化装置 |
| JP2020152644A (ja) * | 2019-03-18 | 2020-09-24 | 国立大学法人愛媛大学 | Ｖｎａｒのリフォールディング方法およびｖｎａｒの製造方法 |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| CN112120012B (zh) * | 2020-09-30 | 2022-03-22 | 广东康盾创新产业集团股份公司 | 一种car-t细胞冻存方法 |
| BR102021000794A2 (pt) * | 2021-01-15 | 2022-07-26 | Fundação Oswaldo Cruz | Proteína quimérica, kit, método para diagnóstico de leishmaniose, uso de uma proteína quimérica, composição vacinal contra leishmaniose visceral, e, uso de uma composição vacinal |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0138854B1 (en) | 1983-03-08 | 1992-11-04 | Chiron Mimotopes Pty. Ltd. | Antigenically active amino acid sequences |
| JP2743177B2 (ja) * | 1987-04-24 | 1998-04-22 | 財団法人阪大微生物病研究会 | 百日咳菌の培養方法、及び百日咳トキソイドとその混合ワクチン |
| JP4111403B2 (ja) | 1996-10-11 | 2008-07-02 | ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア | 免疫刺激ポリヌクレオチド／免疫調節分子複合体 |
| US5980912A (en) | 1997-03-25 | 1999-11-09 | Zonagen, Inc. | Chitosan induced immunopotentiation |
| FR2771011B1 (fr) | 1997-11-17 | 2000-01-28 | Hippocampe | Obtention de vaccins destines a prevenir les effets pathogenes associes a une infection retrovirale |
| FR2775601B1 (fr) | 1998-03-03 | 2001-09-21 | Merial Sas | Vaccins vivants recombines et adjuves |
| FR2776928B1 (fr) | 1998-04-03 | 2000-06-23 | Merial Sas | Vaccins adn adjuves |
| WO2000002901A1 (en) | 1998-07-09 | 2000-01-20 | University Technology Corporation | High pressure refolding of protein aggregates and inclusion bodies |
| WO2000072703A1 (en) | 1999-05-28 | 2000-12-07 | UNIVERSITé LAVAL | Inactivation of food spoilage and pathogenic microorganisms by dynamic high pressure |
| US6645740B1 (en) | 1999-06-10 | 2003-11-11 | Merial Limited | Nucleic acids encodings equine GM-CSF |
| KR100863630B1 (ko) | 1999-09-25 | 2008-10-15 | 유니버시티 오브 아이오와 리써치 파운데이션 | 면역자극성 핵산 |
| US7615617B2 (en) | 1999-10-25 | 2009-11-10 | University Of Delaware | Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding |
| WO2002056824A2 (en) | 2000-08-10 | 2002-07-25 | Boston Biomedica, Inc. | Pressure cycling inactivation of pathogens in biological materials used for therapeutics or vaccines |
| US6635223B2 (en) * | 2000-10-25 | 2003-10-21 | Andreas Maerz | Method for inactivating micro-organisms using high pressure processing |
| DK1434789T3 (da) * | 2000-10-31 | 2008-07-07 | Barofold Inc | Forbedret proteindisaggregering og refoldning under tryk |
| WO2004024027A2 (en) | 2002-06-07 | 2004-03-25 | University Of Florida | Endodontic files made using bulk metallic glasses |
| SE525457C2 (sv) | 2002-06-24 | 2005-02-22 | Flow Holdings Sagl | Förfarande för åstadkommande av en tryckändring mellan två trycktillstånd, högtryckspressanordning samt användning av förfarande eller högtryckspressanordning |
| AU2004287284B2 (en) * | 2003-11-05 | 2009-11-12 | C.B.F. Leti, S.L. Unipersonal | Use of specific histones for the treatment of parasitic diseases |
| US7993580B2 (en) | 2004-08-24 | 2011-08-09 | Baxter International Inc. | Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors |
| WO2007062174A2 (en) | 2005-11-21 | 2007-05-31 | Barofold, Inc. | Devices and methods for high-pressure refolding of proteins |
| CN200945252Y (zh) * | 2006-09-01 | 2007-09-12 | 天津市华泰森淼生物工程技术有限公司 | 手动开启式小型超高压生物处理设备 |
| WO2008033556A2 (en) * | 2006-09-15 | 2008-03-20 | Barofold, Inc. | High pressure treatment of proteins for reduced immunogenicity |
| WO2008124134A2 (en) | 2007-04-05 | 2008-10-16 | Barofold, Inc. | High-pressure refolding of proteins in the presence of binding partners |
| US7829681B2 (en) * | 2007-04-05 | 2010-11-09 | Barofold Inc. | High-pressure inclusion body solubilization and protease clipping of recombinant fusion proteins |
| EP2207890A4 (en) | 2007-10-05 | 2010-12-15 | Barofold Inc | HIGH PRESSURE PROCESSING OF AGGREGATED INTERFERONS |
| RU2440137C1 (ru) * | 2007-12-21 | 2012-01-20 | Пфайзер Инк. | Термообработанные бактерины и эмульсионные вакцины, полученные из таких термообработанных бактеринов |
| BRPI0800357A2 (pt) | 2008-03-10 | 2009-10-27 | Fundacao Oswaldo Cruz | método para produção de uma vacina estabilizada |
| US8603808B2 (en) | 2008-05-08 | 2013-12-10 | Merial Limited | Leishmania vaccine using sand fly salivary immunogen |
| US8410258B2 (en) * | 2008-05-21 | 2013-04-02 | Infections Disease Research Institute | Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis |
| AR073170A1 (es) | 2008-05-21 | 2010-10-20 | Infectious Disease Res Inst | Vacunas de poliproteinas recombinantes para el tratamiento y diagnostico de leishmaniasis |
| US20100112660A1 (en) | 2008-05-30 | 2010-05-06 | Barofold, Inc. | Method for Derivatization of Proteins Using Hydrostatic Pressure |
| US20110070219A1 (en) | 2009-04-27 | 2011-03-24 | Seefeldt Matthew B | High pressure protein crystallization |
| US20120304872A1 (en) * | 2010-02-01 | 2012-12-06 | Avure Technologies Ab | High-pressure arrangement with locking element preventing rotation of load basket |
| CN201781934U (zh) * | 2010-04-14 | 2011-04-06 | 中国农业大学 | 一种小型框架自动式超高压设备 |
| EP2600843B9 (en) | 2010-07-19 | 2020-03-11 | Pressure BioSciences, Inc. | Therapeutic protein compositions having reduced immunogenicity and/or improved efficacy |
| AU2013308627B2 (en) * | 2012-08-30 | 2016-10-27 | Boehringer Ingelheim Animal Health USA Inc. | Expression of chimeric KSAC protein and method of producing soluble proteins by high pressure |
| ZA201501696B (en) * | 2012-08-30 | 2016-01-27 | Merial Ltd | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
-
2013
- 2013-08-30 AU AU2013308627A patent/AU2013308627B2/en not_active Ceased
- 2013-08-30 AU AU2013308623A patent/AU2013308623B2/en active Active
- 2013-08-30 AP AP2015008331A patent/AP2015008331A0/xx unknown
- 2013-08-30 MD MDA20150031A patent/MD4608C1/ro active IP Right Revival
- 2013-08-30 CA CA2883296A patent/CA2883296A1/en not_active Abandoned
- 2013-08-30 HK HK16100050.9A patent/HK1211874A1/xx unknown
- 2013-08-30 MX MX2015002701A patent/MX381717B/es unknown
- 2013-08-30 EA EA201500275A patent/EA031988B1/ru unknown
- 2013-08-30 KR KR1020157008190A patent/KR102208844B1/ko active Active
- 2013-08-30 US US14/014,434 patent/US9169302B2/en active Active
- 2013-08-30 WO PCT/US2013/057426 patent/WO2014036345A2/en not_active Ceased
- 2013-08-30 NZ NZ705790A patent/NZ705790A/en unknown
- 2013-08-30 RU RU2015111255A patent/RU2647568C2/ru active
- 2013-08-30 CA CA2883303A patent/CA2883303A1/en not_active Abandoned
- 2013-08-30 BR BR112015004463A patent/BR112015004463B8/pt active IP Right Grant
- 2013-08-30 CN CN201380053720.8A patent/CN104717976A/zh active Pending
- 2013-08-30 NZ NZ706288A patent/NZ706288A/en not_active IP Right Cessation
- 2013-08-30 ES ES13760212T patent/ES2744709T3/es active Active
- 2013-08-30 MX MX2015002699A patent/MX358782B/es active IP Right Grant
- 2013-08-30 EP EP13760212.4A patent/EP2890392B1/en not_active Not-in-force
- 2013-08-30 JP JP2015530066A patent/JP6438396B2/ja active Active
- 2013-08-30 CN CN201810318137.XA patent/CN108578679A/zh active Pending
- 2013-08-30 NZ NZ715459A patent/NZ715459A/en unknown
- 2013-08-30 US US14/014,437 patent/US9315553B2/en active Active
- 2013-08-30 EP EP13766420.7A patent/EP2890393A2/en active Pending
- 2013-08-30 CN CN201380054922.4A patent/CN104768577B/zh active Active
- 2013-08-30 JP JP2015530070A patent/JP6405308B2/ja not_active Expired - Fee Related
- 2013-08-30 WO PCT/US2013/057430 patent/WO2014036349A1/en not_active Ceased
-
2015
- 2015-02-27 MX MX2021004478A patent/MX2021004478A/es unknown
- 2015-03-27 PH PH12015500700A patent/PH12015500700B1/en unknown
-
2016
- 2016-02-05 US US15/017,486 patent/US10364274B2/en active Active
-
2017
- 2017-01-17 AU AU2017200301A patent/AU2017200301A1/en not_active Abandoned
- 2017-03-14 AU AU2017201724A patent/AU2017201724B2/en active Active
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