JP2015528801A - Ｉｒａｋ阻害剤およびその使用 - Google Patents

Ｉｒａｋ阻害剤およびその使用 Download PDF

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Publication number
JP2015528801A
JP2015528801A JP2015521817A JP2015521817A JP2015528801A JP 2015528801 A JP2015528801 A JP 2015528801A JP 2015521817 A JP2015521817 A JP 2015521817A JP 2015521817 A JP2015521817 A JP 2015521817A JP 2015528801 A JP2015528801 A JP 2015528801A
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Prior art keywords
disease
compound
irak
ring
compounds
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JP2015521817A
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Japanese (ja)
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JP2015528801A5 (cg-RX-API-DMAC7.html
Inventor
ジェラルディーン シー． ハリマン，
ジェラルディーン シー． ハリマン，
ロナルド ティー． ウェスタ—，
ロナルド ティー． ウェスタ―，
ドナ エル． ロメロ，
ドナ エル． ロメロ，
クレッグ イー． マッス，
クレッグ イー． マッス，
ショーネッシー ロビンソン，
ショーネッシー ロビンソン，
ジェレミー ロバート グリーンウッド，
ジェレミー ロバート グリーンウッド，
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ニンバス アイリス， インコーポレイテッド
ニンバス アイリス， インコーポレイテッド
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Publication of JP2015528801A publication Critical patent/JP2015528801A/ja
Publication of JP2015528801A5 publication Critical patent/JP2015528801A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Psychology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
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JP2015521817A 2012-07-11 2013-07-11 Ｉｒａｋ阻害剤およびその使用 Pending JP2015528801A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261670380P 2012-07-11 2012-07-11
US61/670,380 2012-07-11
US201261682622P 2012-08-13 2012-08-13
US61/682,622 2012-08-13
PCT/US2013/050113 WO2014011906A2 (en) 2012-07-11 2013-07-11 Irak inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
JP2015528801A true JP2015528801A (ja) 2015-10-01
JP2015528801A5 JP2015528801A5 (cg-RX-API-DMAC7.html) 2016-09-08

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JP2015521817A Pending JP2015528801A (ja) 2012-07-11 2013-07-11 Ｉｒａｋ阻害剤およびその使用

Country Status (10)

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US (2) US9067948B2 (cg-RX-API-DMAC7.html)
EP (1) EP2872518A4 (cg-RX-API-DMAC7.html)
JP (1) JP2015528801A (cg-RX-API-DMAC7.html)
CN (1) CN104902959A (cg-RX-API-DMAC7.html)
AU (1) AU2013290080A1 (cg-RX-API-DMAC7.html)
BR (1) BR112015000561A2 (cg-RX-API-DMAC7.html)
CA (1) CA2878040A1 (cg-RX-API-DMAC7.html)
HK (1) HK1210732A1 (cg-RX-API-DMAC7.html)
IN (1) IN2015DN00127A (cg-RX-API-DMAC7.html)
WO (1) WO2014011906A2 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021529751A (ja) * 2018-06-25 2021-11-04 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドChia Tai Tianqing Pharmaceutical Group Co., Ltd. ＩＲＡＫ４阻害薬としてのイソチアゾロ［５，４−ｄ］ピリミジン化合物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2663312B1 (en) 2011-01-10 2017-10-11 Nimbus Iris, Inc. Irak inhibitors and uses thereof
HK1209632A1 (en) 2012-01-10 2016-04-08 林伯士艾瑞斯公司 Irak inhibitors and uses thereof
CN104902959A (zh) 2012-07-11 2015-09-09 林伯士艾瑞斯公司 Irak抑制剂和其用途
EP2872144A4 (en) 2012-07-11 2015-12-02 Nimbus Iris Inc IRAQ INHIBITOR AND USES THEREOF
BR112015014034A2 (pt) 2013-01-10 2017-07-11 Nimbus Iris Inc inibidores de irak e usos dos mesmos
US8778365B1 (en) 2013-01-31 2014-07-15 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
KR102280614B1 (ko) 2013-03-15 2021-07-21 글로벌 블러드 테라퓨틱스, 인크. 헤모글로빈 조정을 위한 화합물 및 이의 용도
EP3049086A4 (en) 2013-09-27 2017-02-22 Nimbus Iris, Inc. Irak inhibitors and uses thereof
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
AR102849A1 (es) * 2015-03-09 2017-03-29 Astellas Pharma Inc Compuesto de piridina bicíclica
MX382156B (es) 2015-08-28 2025-03-13 Chdi Foundation Inc Sondas para formar imagenes de proteina de huntingtina.
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
JP7366031B2 (ja) 2017-09-22 2023-10-20 カイメラ セラピューティクス， インコーポレイテッド タンパク質分解剤およびそれらの使用
WO2019060693A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. CRBN LIGANDS AND USES THEREOF
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
WO2019140387A1 (en) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Crbn ligands and uses thereof
WO2019140380A1 (en) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Protein degraders and uses thereof
EP3817822A4 (en) 2018-07-06 2022-07-27 Kymera Therapeutics, Inc. PROTEIN DEGRADANTS AND USES THEREOF
US11292792B2 (en) 2018-07-06 2022-04-05 Kymera Therapeutics, Inc. Tricyclic CRBN ligands and uses thereof
TWI721483B (zh) 2018-07-13 2021-03-11 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
KR20250167680A (ko) 2018-11-30 2025-12-01 카이메라 쎄라퓨틱스 인코포레이티드 Irak 분해제 및 이의 용도
WO2021127190A1 (en) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof
US11591332B2 (en) 2019-12-17 2023-02-28 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
JP2024503300A (ja) 2020-12-30 2024-01-25 カイメラ セラピューティクス， インコーポレイテッド Ｉｒａｋ分解剤およびそれらの使用
TW202245788A (zh) 2021-02-15 2022-12-01 美商凱麥拉醫療公司 Irak4降解劑及其用途
WO2022236058A1 (en) 2021-05-07 2022-11-10 Kymera Therapeutics, Inc. Cdk2 degraders and uses thereof
AU2022378630A1 (en) 2021-10-29 2024-05-09 Kymera Therapeutics, Inc. Irak4 degraders and synthesis thereof
JP2025504059A (ja) 2022-01-31 2025-02-06 カイメラ セラピューティクス， インコーポレイテッド Ｉｒａｋデグレーダー及びその使用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006081072A1 (en) * 2005-01-24 2006-08-03 Abbott Laboratories Antagonists of the mglu receptor and uses thereof
JP2008502693A (ja) * 2004-06-15 2008-01-31 シェーリング　コーポレイション 三環式化合物およびｍｇｌｕｒ１アンタゴニストとしてのそれらの使用
JP2009504755A (ja) * 2005-08-19 2009-02-05 シェーリング コーポレイション 治療剤としての縮合三環式ｍＧｌｕＲ１アンタゴニスト
JP2009504752A (ja) * 2005-08-19 2009-02-05 シェーリング コーポレイション 治療剤としての縮合三環式ｍＧｌｕＲ１アンタゴニスト
JP2009519337A (ja) * 2005-12-13 2009-05-14 シェーリング コーポレイション 治療剤としてのｍＧｌｕＲ１アンタゴニスト

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1323719A1 (en) 1999-03-30 2003-07-02 Nippon Soda Co., Ltd. Thienopyrimidine compounds and salts thereof and process for the preparation of the same
WO2002088138A1 (en) 2001-04-30 2002-11-07 Bayer Corporation Novel 4-amino-5,6-substituted thiopheno[2,3-d]pyrimidines
AU2002360774A1 (en) 2001-12-28 2003-07-24 Bayer Corporation 4-substituted fused heteropyrimidines and fused hetero-4-pyrimidones
US20030225098A1 (en) 2002-03-21 2003-12-04 Hirst Gavin C. Kinase inhibitors
JP2006512313A (ja) 2002-10-31 2006-04-13 アムジェン インコーポレイテッド 抗炎症剤
EP1773840B1 (de) 2004-07-23 2010-01-20 The Medicines Company (Leipzig) GmbH Substituierte pyrido[3',2':4,5]thieno[3,2-d]pyrimidine und pyrido[3',2':4,5]furo[3,2-d]-pyrimidine zur verwendung als inhibitoren der pda-4 und/oder tnf-alpha freisetzung
EP1619196A1 (de) * 2004-07-23 2006-01-25 Curacyte Discovery GmbH Substituierte Pyrido[3',2':4,5]thieno[3,2-d]pyrimidine und Pyrido[3',2':4,5]furo[3,2-d]-pyrimidine zur Verwendung als Inhibitoren der PDA-4 und/oder TNF-alpha Freisetzung
JP5301986B2 (ja) * 2005-06-22 2013-09-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 医薬組成物用のチエノピリミジン類
CA2668997C (en) 2006-11-09 2012-10-09 Ardea Biosciences, Inc. 4-cyanophenylamino-substituted bicyclic heterocyclic compounds as hiv inhibitors
US20100227853A1 (en) 2008-04-18 2010-09-09 Trustees Of Boston College Inhibitors of cyclic amp phosphodiesterases
US20100063047A1 (en) 2008-09-10 2010-03-11 Kalypsys, Inc. Aminopyrimidine inhibitors of histamine receptors for the treatment of disease
EP2473054B1 (en) 2009-09-04 2017-06-14 The Regents of the University of Michigan Compositions and methods for treatment of leukemia
MX358682B (es) 2010-07-13 2018-08-31 Hoffmann La Roche Derivados de pirazolo [1,5a]pirimidina y de tieno[3,2b] pirimidina como moduladores de la cinasa asociada al receptor de la interleucina 4 (irak4).
EP2595993B1 (en) 2010-07-23 2018-04-18 President and Fellows of Harvard College Tricyclic proteasome activity enhancing compounds
EP2663312B1 (en) 2011-01-10 2017-10-11 Nimbus Iris, Inc. Irak inhibitors and uses thereof
IN2014CN04558A (cg-RX-API-DMAC7.html) 2011-11-23 2015-09-18 Cancer Rec Tech Ltd
HK1209632A1 (en) 2012-01-10 2016-04-08 林伯士艾瑞斯公司 Irak inhibitors and uses thereof
CN104902959A (zh) 2012-07-11 2015-09-09 林伯士艾瑞斯公司 Irak抑制剂和其用途
EP2872144A4 (en) 2012-07-11 2015-12-02 Nimbus Iris Inc IRAQ INHIBITOR AND USES THEREOF
WO2014011911A2 (en) 2012-07-11 2014-01-16 Nimbus Iris, Inc. Irak inhibitors and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008502693A (ja) * 2004-06-15 2008-01-31 シェーリング　コーポレイション 三環式化合物およびｍｇｌｕｒ１アンタゴニストとしてのそれらの使用
WO2006081072A1 (en) * 2005-01-24 2006-08-03 Abbott Laboratories Antagonists of the mglu receptor and uses thereof
JP2009504755A (ja) * 2005-08-19 2009-02-05 シェーリング コーポレイション 治療剤としての縮合三環式ｍＧｌｕＲ１アンタゴニスト
JP2009504752A (ja) * 2005-08-19 2009-02-05 シェーリング コーポレイション 治療剤としての縮合三環式ｍＧｌｕＲ１アンタゴニスト
JP2009519337A (ja) * 2005-12-13 2009-05-14 シェーリング コーポレイション 治療剤としてのｍＧｌｕＲ１アンタゴニスト

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, JPN6017014818, 2012, pages 1575 - 1578, ISSN: 0003704508 *
CURRENT ENZYME INHIBITION, vol. 8, JPN6017014822, 2012, pages 22 - 46, ISSN: 0003704511 *
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, JPN6017014819, 2008, pages 1025 - 1034, ISSN: 0003704509 *
JOURNAL OF MEDICINAL CHEMISTRY, vol. 48(23), JPN6017014821, 2005, pages 7374 - 7388, ISSN: 0003704510 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021529751A (ja) * 2018-06-25 2021-11-04 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドChia Tai Tianqing Pharmaceutical Group Co., Ltd. ＩＲＡＫ４阻害薬としてのイソチアゾロ［５，４−ｄ］ピリミジン化合物
JP7511489B2 (ja) 2018-06-25 2024-07-05 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド ＩＲＡＫ４阻害薬としてのイソチアゾロ［５，４－ｄ］ピリミジン化合物

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