JP2015528284A5 - - Google Patents
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- JP2015528284A5 JP2015528284A5 JP2015527637A JP2015527637A JP2015528284A5 JP 2015528284 A5 JP2015528284 A5 JP 2015528284A5 JP 2015527637 A JP2015527637 A JP 2015527637A JP 2015527637 A JP2015527637 A JP 2015527637A JP 2015528284 A5 JP2015528284 A5 JP 2015528284A5
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- JP
- Japan
- Prior art keywords
- item
- mep
- culturing
- ahr
- conditions sufficient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 176
- 238000012258 culturing Methods 0.000 claims description 106
- 210000000135 megakaryocyte-erythroid progenitor cell Anatomy 0.000 claims description 103
- 102000003984 Aryl Hydrocarbon Receptors Human genes 0.000 claims description 66
- 108090000448 Aryl Hydrocarbon Receptors Proteins 0.000 claims description 66
- 210000003743 erythrocyte Anatomy 0.000 claims description 61
- LKTNEXPODAWWFM-UHFFFAOYSA-N 2-methyl-N-[2-methyl-4-(2-methylphenyl)azophenyl]-3-pyrazolecarboxamide Chemical compound CC1=CC=CC=C1N=NC(C=C1C)=CC=C1NC(=O)C1=CC=NN1C LKTNEXPODAWWFM-UHFFFAOYSA-N 0.000 claims description 47
- 239000000556 agonist Substances 0.000 claims description 25
- 238000004519 manufacturing process Methods 0.000 claims description 22
- 210000003593 megakaryocyte Anatomy 0.000 claims description 14
- KDDXOGDIPZSCTM-UHFFFAOYSA-N 2-[1H-indol-3-yl(oxo)methyl]-4-thiazolecarboxylic acid methyl ester Chemical compound COC(=O)C1=CSC(C(=O)C=2C3=CC=CC=C3NC=2)=N1 KDDXOGDIPZSCTM-UHFFFAOYSA-N 0.000 claims description 6
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 5
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 2
- 101001078143 Homo sapiens Integrin alpha-IIb Proteins 0.000 claims description 2
- 102100025306 Integrin alpha-IIb Human genes 0.000 claims description 2
- 239000000203 mixture Substances 0.000 description 23
- 210000004027 cell Anatomy 0.000 description 17
- 239000002609 medium Substances 0.000 description 15
- 150000001875 compounds Chemical class 0.000 description 12
- 241000124008 Mammalia Species 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 208000007502 anemia Diseases 0.000 description 7
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 description 6
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 6
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 6
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 6
- 238000012216 screening Methods 0.000 description 6
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 description 4
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 description 4
- 206010043554 thrombocytopenia Diseases 0.000 description 4
- 210000003311 CFU-EM Anatomy 0.000 description 3
- 102100023072 Neurolysin, mitochondrial Human genes 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- UZOVYGYOLBIAJR-UHFFFAOYSA-N 4-isocyanato-4'-methyldiphenylmethane Chemical compound C1=CC(C)=CC=C1CC1=CC=C(N=C=O)C=C1 UZOVYGYOLBIAJR-UHFFFAOYSA-N 0.000 description 2
- 101000693922 Bos taurus Albumin Proteins 0.000 description 2
- 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 description 2
- 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 description 2
- 239000012580 N-2 Supplement Substances 0.000 description 2
- 239000012979 RPMI medium Substances 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- -1 hSCF Proteins 0.000 description 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 description 1
- 101100239628 Danio rerio myca gene Proteins 0.000 description 1
- 108010074604 Epoetin Alfa Proteins 0.000 description 1
- 206010016803 Fluid overload Diseases 0.000 description 1
- 101001139134 Homo sapiens Krueppel-like factor 4 Proteins 0.000 description 1
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 description 1
- 101000687905 Homo sapiens Transcription factor SOX-2 Proteins 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 102100020677 Krueppel-like factor 4 Human genes 0.000 description 1
- 102100035423 POU domain, class 5, transcription factor 1 Human genes 0.000 description 1
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 description 1
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 description 1
- 208000002903 Thalassemia Diseases 0.000 description 1
- 102100024270 Transcription factor SOX-2 Human genes 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940089118 epogen Drugs 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 208000007056 sickle cell anemia Diseases 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261683246P | 2012-08-15 | 2012-08-15 | |
| US61/683,246 | 2012-08-15 | ||
| US13/828,357 | 2013-03-14 | ||
| US13/828,357 US9074186B2 (en) | 2012-08-15 | 2013-03-14 | Production of red blood cells and platelets from stem cells |
| PCT/US2013/055160 WO2014028749A2 (en) | 2012-08-15 | 2013-08-15 | Production of red blood cells and platelets from stem cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015528284A JP2015528284A (ja) | 2015-09-28 |
| JP2015528284A5 true JP2015528284A5 (enExample) | 2016-09-29 |
| JP6506689B2 JP6506689B2 (ja) | 2019-04-24 |
Family
ID=50100189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015527637A Active JP6506689B2 (ja) | 2012-08-15 | 2013-08-15 | 幹細胞からの赤血球および血小板の生成 |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US9074186B2 (enExample) |
| EP (2) | EP2909313B1 (enExample) |
| JP (1) | JP6506689B2 (enExample) |
| CN (1) | CN104919041B (enExample) |
| AU (1) | AU2013302512B2 (enExample) |
| BR (1) | BR112015003250B1 (enExample) |
| CA (1) | CA2882030C (enExample) |
| IN (1) | IN2015DN01402A (enExample) |
| WO (1) | WO2014028749A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201210857D0 (en) | 2012-06-19 | 2012-08-01 | Cambridge Entpr Ltd | Transcription factor mediated programming towards megakaryocytes |
| US9074186B2 (en) | 2012-08-15 | 2015-07-07 | Boston Medical Center Corporation | Production of red blood cells and platelets from stem cells |
| EP3973967A1 (en) | 2012-12-21 | 2022-03-30 | Astellas Institute for Regenerative Medicine | Methods for production of platelets from pluripotent stem cells and compositions thereof |
| WO2014138485A1 (en) * | 2013-03-08 | 2014-09-12 | Irm Llc | Ex vivo production of platelets from hematopoietic stem cells and the product thereof |
| JP6551963B2 (ja) * | 2014-05-14 | 2019-07-31 | 国立大学法人京都大学 | 巨核球前駆細胞の製造方法 |
| JP6814507B2 (ja) * | 2015-06-16 | 2021-01-20 | 国立大学法人京都大学 | 高機能性血小板の製造方法 |
| FR3039166B1 (fr) * | 2015-07-23 | 2018-10-26 | Institut National De La Sante Et De La Recherche Medicale | Progeniteurs de megacaryocytes cd34+cd41dim et leurs utilisations pour produire des plaquettes et/ou des mk portant des proplaquettes |
| EP3362075B1 (en) * | 2015-10-15 | 2023-06-07 | Celularity Inc. | Natural killer cells and ilc3 cells and uses thereof |
| AU2017306700A1 (en) | 2016-08-04 | 2019-03-07 | Icahn School Of Medicine At Mount Sinai | Production of megakaryoctye compositions and therapies for treatment of thrombocytopenia |
| WO2018085775A1 (en) * | 2016-11-04 | 2018-05-11 | Ohio State Innovation Foundation | Methods and compositions for treating multiple myeloma and increasing antibody dependent cell cytotoxicity by targeting the aryl hydrocarbon receptor |
| MX2020007071A (es) | 2018-01-05 | 2020-11-11 | Platelet Biogenesis Inc | Composiciones y metodos para producir megacariocitos. |
| WO2020006539A1 (en) | 2018-06-29 | 2020-01-02 | Platelet Biogenesis, Inc. | Compositions for drug delivery and methods of use thereof |
| CA3178252A1 (en) | 2020-05-11 | 2021-11-18 | Erytech Pharma | Red cell extracellular vesicles (rcevs) containing cargoes and methods of use and production thereof |
| CN113046310B (zh) * | 2020-12-30 | 2023-08-18 | 中国人民解放军军事科学院军事医学研究院 | 摇动培养促进造血干细胞诱导分化为巨核系细胞的培养基及方法 |
| CN118382694A (zh) * | 2021-12-08 | 2024-07-23 | 特雷尔赫德生物系统股份有限公司 | 产生人红系祖细胞的方法和组合物 |
| WO2024018018A1 (fr) * | 2022-07-21 | 2024-01-25 | Etablissement Francais Du Sang | Utilisation d'un composé vitisine pour la production de cellules hématopoïétiques |
| WO2024108461A1 (zh) * | 2022-11-24 | 2024-05-30 | 苏州血霁生物科技有限公司 | 一种分化血小板的方法、培养基及其应用 |
| WO2024205363A1 (ko) * | 2023-03-29 | 2024-10-03 | 주식회사 듀셀바이오테라퓨틱스 | 적혈구 및 혈소판의 제조 방법 |
| WO2025037108A2 (en) | 2023-08-15 | 2025-02-20 | Board Of Trustees Of The Leland Stanford Junior University | Modified thrombopoietin |
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| KR20190142424A (ko) | 2009-12-04 | 2019-12-26 | 스템 셀 앤드 리제너러티브 메디신 인터내셔날, 인크. | 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성 |
| EP2547764B1 (en) * | 2010-03-18 | 2019-01-23 | Kyoto University | Method for inducing differentiation of pluripotent stem cells into mesodermal cells |
| BR112013002079B1 (pt) | 2010-07-27 | 2021-09-14 | Trustees Of Boston University | Modificadores do receptor de aril hidrocarboneto (ahr) como novos terapêuticos contra o câncer |
| WO2012061146A1 (en) | 2010-10-25 | 2012-05-10 | The Children's Hospital Of Philadelphia | Compositions and methods for the generation of platelets and methods of use thereof |
| US9074186B2 (en) | 2012-08-15 | 2015-07-07 | Boston Medical Center Corporation | Production of red blood cells and platelets from stem cells |
-
2013
- 2013-03-14 US US13/828,357 patent/US9074186B2/en active Active
- 2013-08-15 BR BR112015003250-8A patent/BR112015003250B1/pt not_active IP Right Cessation
- 2013-08-15 US US14/421,191 patent/US9896660B2/en active Active
- 2013-08-15 CA CA2882030A patent/CA2882030C/en active Active
- 2013-08-15 CN CN201380053972.0A patent/CN104919041B/zh active Active
- 2013-08-15 JP JP2015527637A patent/JP6506689B2/ja active Active
- 2013-08-15 EP EP13829847.6A patent/EP2909313B1/en active Active
- 2013-08-15 IN IN1402DEN2015 patent/IN2015DN01402A/en unknown
- 2013-08-15 AU AU2013302512A patent/AU2013302512B2/en active Active
- 2013-08-15 WO PCT/US2013/055160 patent/WO2014028749A2/en not_active Ceased
- 2013-08-15 EP EP20198278.2A patent/EP3789483A1/en active Pending
-
2015
- 2015-06-02 US US14/729,008 patent/US10544393B2/en active Active
- 2015-06-02 US US14/729,004 patent/US9919009B2/en active Active
-
2018
- 2018-02-17 US US15/898,526 patent/US11124769B2/en active Active
-
2021
- 2021-08-20 US US17/407,349 patent/US12173320B2/en active Active
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