JP2015527396A5 - - Google Patents
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- Publication number
- JP2015527396A5 JP2015527396A5 JP2015531217A JP2015531217A JP2015527396A5 JP 2015527396 A5 JP2015527396 A5 JP 2015527396A5 JP 2015531217 A JP2015531217 A JP 2015531217A JP 2015531217 A JP2015531217 A JP 2015531217A JP 2015527396 A5 JP2015527396 A5 JP 2015527396A5
- Authority
- JP
- Japan
- Prior art keywords
- deuterium
- hydrogen
- ring atoms
- heterocyclyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 26
- 229910052805 deuterium Inorganic materials 0.000 claims 26
- 229910052739 hydrogen Inorganic materials 0.000 claims 23
- 239000001257 hydrogen Substances 0.000 claims 23
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000006413 ring segment Chemical group 0.000 claims 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000000623 heterocyclic group Chemical group 0.000 claims 11
- 201000010099 disease Diseases 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000001072 heteroaryl group Chemical group 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 8
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 3
- -1 C 2-6 Al Kenyl Chemical group 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 claims 2
- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 claims 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 201000010105 allergic rhinitis Diseases 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 208000010247 contact dermatitis Diseases 0.000 claims 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 239000006186 oral dosage form Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 208000016557 Acute basophilic leukemia Diseases 0.000 claims 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 claims 1
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 claims 1
- 206010003557 Asthma exercise induced Diseases 0.000 claims 1
- 102000004499 CCR3 Receptors Human genes 0.000 claims 1
- 108010017316 CCR3 Receptors Proteins 0.000 claims 1
- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 claims 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 206010065563 Eosinophilic bronchitis Diseases 0.000 claims 1
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims 1
- 208000004657 Exercise-Induced Asthma Diseases 0.000 claims 1
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
- 206010016946 Food allergy Diseases 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010039094 Rhinitis perennial Diseases 0.000 claims 1
- 208000036284 Rhinitis seasonal Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010052568 Urticaria chronic Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 201000009961 allergic asthma Diseases 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 210000003651 basophil Anatomy 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000024376 chronic urticaria Diseases 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000001564 eosinophilic gastroenteritis Diseases 0.000 claims 1
- 208000024695 exercise-induced bronchoconstriction Diseases 0.000 claims 1
- 230000002349 favourable effect Effects 0.000 claims 1
- 235000020932 food allergy Nutrition 0.000 claims 1
- 210000003630 histaminocyte Anatomy 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 239000006207 intravenous dosage form Substances 0.000 claims 1
- 230000000155 isotopic effect Effects 0.000 claims 1
- 206010024378 leukocytosis Diseases 0.000 claims 1
- 208000008585 mastocytosis Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000000414 obstructive effect Effects 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000006201 parenteral dosage form Substances 0.000 claims 1
- 208000022719 perennial allergic rhinitis Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000001185 psoriatic effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000017022 seasonal allergic rhinitis Diseases 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261698390P | 2012-09-07 | 2012-09-07 | |
| US61/698,390 | 2012-09-07 | ||
| PCT/US2013/058386 WO2014039748A1 (en) | 2012-09-07 | 2013-09-06 | Isotopically enriched arylsulfonamide ccr3 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015527396A JP2015527396A (ja) | 2015-09-17 |
| JP2015527396A5 true JP2015527396A5 (https=) | 2016-10-27 |
Family
ID=49226545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531217A Pending JP2015527396A (ja) | 2012-09-07 | 2013-09-06 | 同位体濃縮されたアリールスルホンアミドｃｃｒ３アンタゴニスト |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9156799B2 (https=) |
| EP (1) | EP2892884A1 (https=) |
| JP (1) | JP2015527396A (https=) |
| KR (1) | KR20150053906A (https=) |
| CN (1) | CN104781240A (https=) |
| AR (1) | AR093763A1 (https=) |
| AU (1) | AU2013312420A1 (https=) |
| BR (1) | BR112015004959A2 (https=) |
| CA (1) | CA2881129A1 (https=) |
| HK (1) | HK1212351A1 (https=) |
| IL (1) | IL237519A0 (https=) |
| RU (1) | RU2015112605A (https=) |
| TW (1) | TW201414721A (https=) |
| WO (1) | WO2014039748A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104781240A (zh) * | 2012-09-07 | 2015-07-15 | 埃克希金医药品有限公司 | 同位素富集的芳基磺酰胺ccr3拮抗剂 |
| CN108623501B (zh) * | 2017-03-21 | 2022-04-19 | 润佳（苏州）医药科技有限公司 | 同位素富集的3-氨基-1-丙磺酸衍生物及其用途 |
| CN116059192B (zh) | 2019-11-13 | 2024-10-29 | 润佳（苏州）医药科技有限公司 | 同位素富集的3-氨基-1-丙磺酸及其衍生物的用途 |
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| CN103298786B (zh) | 2010-10-11 | 2016-01-20 | 埃克希金医药品有限公司 | 芳基磺酰胺盐ccr3拮抗剂 |
| CN104781240A (zh) * | 2012-09-07 | 2015-07-15 | 埃克希金医药品有限公司 | 同位素富集的芳基磺酰胺ccr3拮抗剂 |
-
2013
- 2013-09-06 CN CN201380057685.7A patent/CN104781240A/zh active Pending
- 2013-09-06 RU RU2015112605A patent/RU2015112605A/ru unknown
- 2013-09-06 WO PCT/US2013/058386 patent/WO2014039748A1/en not_active Ceased
- 2013-09-06 TW TW102132284A patent/TW201414721A/zh unknown
- 2013-09-06 US US14/020,597 patent/US9156799B2/en not_active Expired - Fee Related
- 2013-09-06 KR KR1020157005751A patent/KR20150053906A/ko not_active Withdrawn
- 2013-09-06 JP JP2015531217A patent/JP2015527396A/ja active Pending
- 2013-09-06 BR BR112015004959A patent/BR112015004959A2/pt not_active IP Right Cessation
- 2013-09-06 EP EP13765874.6A patent/EP2892884A1/en not_active Withdrawn
- 2013-09-06 HK HK16100426.6A patent/HK1212351A1/xx unknown
- 2013-09-06 AU AU2013312420A patent/AU2013312420A1/en not_active Abandoned
- 2013-09-06 CA CA2881129A patent/CA2881129A1/en not_active Abandoned
- 2013-09-06 AR ARP130103196A patent/AR093763A1/es unknown
-
2015
- 2015-03-02 IL IL237519A patent/IL237519A0/en unknown
- 2015-07-13 US US14/798,356 patent/US9637460B2/en not_active Expired - Fee Related