JP2015527366A5 - - Google Patents
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- Publication number
- JP2015527366A5 JP2015527366A5 JP2015528591A JP2015528591A JP2015527366A5 JP 2015527366 A5 JP2015527366 A5 JP 2015527366A5 JP 2015528591 A JP2015528591 A JP 2015528591A JP 2015528591 A JP2015528591 A JP 2015528591A JP 2015527366 A5 JP2015527366 A5 JP 2015527366A5
- Authority
- JP
- Japan
- Prior art keywords
- stradobody
- domain
- domains
- igg2 hinge
- carboxy terminus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261691057P | 2012-08-20 | 2012-08-20 | |
| US61/691,057 | 2012-08-20 | ||
| US201361785144P | 2013-03-14 | 2013-03-14 | |
| US61/785,144 | 2013-03-14 | ||
| PCT/US2013/055800 WO2014031646A2 (en) | 2012-08-20 | 2013-08-20 | Molecules with antigen binding and polyvalent fc gamma receptor binding activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015527366A JP2015527366A (ja) | 2015-09-17 |
| JP2015527366A5 true JP2015527366A5 (https=) | 2016-09-23 |
Family
ID=50150476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015528591A Pending JP2015527366A (ja) | 2012-08-20 | 2013-08-20 | 抗原結合および多価ｆｃガンマ受容体結合活性を有する分子 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9683044B2 (https=) |
| EP (1) | EP2885320A4 (https=) |
| JP (1) | JP2015527366A (https=) |
| KR (1) | KR20150058236A (https=) |
| CN (1) | CN104718223A (https=) |
| AU (1) | AU2013305885B2 (https=) |
| BR (1) | BR112015003459A2 (https=) |
| CA (1) | CA2882296A1 (https=) |
| HK (1) | HK1210792A1 (https=) |
| IL (1) | IL237307A0 (https=) |
| MX (1) | MX2015002269A (https=) |
| RU (1) | RU2015109591A (https=) |
| WO (1) | WO2014031646A2 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2185589T3 (pl) | 2007-06-01 | 2016-09-30 | Środki wiążące receptor regionu stałego Fc immunoglobuliny | |
| TWI542597B (zh) | 2010-07-28 | 2016-07-21 | 吉林尼克公司 | 產生依序多聚體化免疫球蛋白ｆｃ組合物之天然人類蛋白質片段之融合蛋白 |
| US9683044B2 (en) * | 2012-08-20 | 2017-06-20 | Gliknik Inc. | Molecules with antigen binding and polyvalent FC gamma receptor binding activity |
| MX2016010951A (es) | 2014-03-05 | 2016-11-29 | Ucb Biopharma Sprl | Proteinas de fc multimericas. |
| EP4299595A3 (en) | 2014-05-02 | 2024-03-13 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc constructs |
| WO2016073917A1 (en) * | 2014-11-06 | 2016-05-12 | Gliknik Inc. | Molecules with bimodal activity depleting target at low dose and increasing immunosuppression at higher dose |
| JP2018510864A (ja) * | 2015-03-10 | 2018-04-19 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | トランスグルタミナーゼによって結合可能な抗体およびそれによって製造される結合体 |
| KR20250053203A (ko) | 2015-07-24 | 2025-04-21 | 글리크닉 인코포레이티드 | 향상된 상보체 결합을 갖는 규칙적으로 다형체화된 면역글로불린 fc 조성물을 생성하기 위한 인간 단백질 단편의 융합 단백질 |
| EP3328362A4 (en) * | 2015-07-29 | 2019-03-06 | Nanotics, LLC | MODULAR COMPOSITIONS FOR THE DISPOSAL OF SOLUBLE BIOMOLECULES AND RELATED METHODS |
| CN106554968A (zh) * | 2015-09-29 | 2017-04-05 | 中国农业科学院上海兽医研究所 | 日本血吸虫重组蛋白及其制备方法和应用 |
| EP3423572B1 (en) * | 2016-03-02 | 2023-11-29 | Momenta Pharmaceuticals, Inc. | Methods related to engineered fc constructs |
| CN105647946B (zh) * | 2016-03-18 | 2019-09-20 | 江苏普瑞康生物医药科技有限公司 | 一种基于FcγRⅢa的嵌合基因及其用途 |
| AU2017245143B2 (en) | 2016-03-30 | 2024-01-11 | Ab Biosciences, Inc. | Recombinant intravenous immunoglobulin (rIVIG) compositions and methods for their production and use |
| DK3484514T3 (da) * | 2016-05-23 | 2024-01-29 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc constructs |
| AU2017279538A1 (en) | 2016-06-07 | 2019-01-03 | Gliknik Inc. | Cysteine-optimized stradomers |
| US20190276549A1 (en) | 2016-11-01 | 2019-09-12 | Genmab B.V. | Polypeptide variants and uses thereof |
| MX2019006573A (es) | 2016-12-09 | 2019-11-18 | Gliknik Inc | Optimizacion de fabricacion de gl-2045 un stradomer multimerizante. |
| CN110022898B (zh) | 2016-12-09 | 2023-07-04 | 格利克尼克股份有限公司 | 用多价Fc化合物治疗炎性疾病的方法 |
| JP7146771B2 (ja) * | 2017-01-06 | 2022-10-04 | モメンタ ファーマシューティカルズ インコーポレイテッド | 操作されたＦｃコンストラクトに関する組成物及び方法 |
| EP3580233A1 (en) | 2017-02-10 | 2019-12-18 | Genmab B.V. | Polypeptide variants and uses thereof |
| CN111315405A (zh) * | 2017-11-09 | 2020-06-19 | 免疫医疗有限责任公司 | 双特异性融合多肽及其使用方法 |
| MA51666A (fr) | 2018-01-24 | 2020-12-02 | Genmab Bv | Variants polypeptidiques et leurs utilisations |
| MX2020011552A (es) | 2018-05-03 | 2020-11-24 | Genmab Bv | Combinaciones de variantes de anticuerpos y usos de las mismas. |
| CN110540590B (zh) * | 2018-05-29 | 2023-08-18 | 康诺亚生物医药科技（成都）有限公司 | 一种自免疫抑制物的开发和应用 |
| WO2019243636A1 (en) | 2018-06-22 | 2019-12-26 | Genmab Holding B.V. | Anti-cd37 antibodies and anti-cd20 antibodies, compositions and methods of use thereof |
| CA3106212A1 (en) * | 2018-07-11 | 2020-01-16 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc-antigen binding domain constructs |
| CN113382749A (zh) * | 2018-07-11 | 2021-09-10 | 动量制药公司 | 与工程化Fc-抗原结合结构域构建体有关的组合物和方法 |
| US20200017600A1 (en) | 2018-07-13 | 2020-01-16 | Genmab A/S | Variants of cd38 antibody and uses thereof |
| US20240254252A1 (en) | 2018-07-13 | 2024-08-01 | Genmab A/S | Trogocytosis-mediated therapy using cd38 antibodies |
| US20220315661A1 (en) | 2019-05-09 | 2022-10-06 | Genmab B.V. | Dosage regimens for a combination of anti-dr5 antibodies for use in treating cancer |
| JP2023500701A (ja) | 2019-11-06 | 2023-01-10 | ジェンマブ ビー．ブイ． | 抗体変種の組み合わせおよびその使用 |
| US20230272105A1 (en) | 2020-01-16 | 2023-08-31 | Genmab A/S | Formulations of cd38 antibodies and uses thereof |
| TW202216777A (zh) | 2020-07-10 | 2022-05-01 | 美商生質分子控股有限責任公司 | 四面體抗體 |
| JP2023534726A (ja) | 2020-07-23 | 2023-08-10 | ジェンマブ ビー．ブイ． | 多発性骨髄腫の治療に使用するための抗ｄｒ５抗体と免疫調節イミド薬との併用 |
| JP2023547329A (ja) | 2020-10-02 | 2023-11-10 | ジェンマブ エー／エス | Ｒｏｒ２へと結合することができる抗体ならびにｒｏｒ２およびｃｄ３に結合する二重特異性抗体 |
| IL311141A (en) | 2021-09-06 | 2024-04-01 | Genmab As | Antibodies capable of binding to CD27, their variants and uses thereof |
| WO2023083381A1 (zh) | 2021-11-15 | 2023-05-19 | 成都百利多特生物药业有限责任公司 | 双特异性抗体-喜树碱类药物偶联物及其医药用途 |
| US20250084169A1 (en) | 2022-01-12 | 2025-03-13 | Biomolecular Holdings Llc | Nk/monocyte engagers |
| WO2023218051A1 (en) | 2022-05-12 | 2023-11-16 | Genmab A/S | Binding agents capable of binding to cd27 in combination therapy |
| EP4522657A1 (en) | 2022-05-12 | 2025-03-19 | Genmab A/S | Binding agents capable of binding to cd27 in combination therapy |
| TW202432177A (zh) | 2022-10-31 | 2024-08-16 | 丹麥商珍美寶股份有限公司 | Ｃｄ３８抗體及其用途 |
| EP4700047A1 (en) * | 2023-04-21 | 2026-02-25 | Centenaire Biosciences, Inc. | Antigen-binding protein containing two fc domains and use thereof |
| TW202509071A (zh) | 2023-05-12 | 2025-03-01 | 丹麥商珍美寶股份有限公司 | 能夠與ｏｘ４０結合之抗體、其變異體及其用途 |
| TW202540189A (zh) | 2023-11-30 | 2025-10-16 | 德商生物新技術公司 | 在組合療法中能夠結合ｏｘ４０之抗體 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6004781A (en) | 1988-01-22 | 1999-12-21 | The General Hospital Corporation | Nucleic acid encoding Ig-CD4 fusion proteins |
| GB8824869D0 (en) | 1988-10-24 | 1988-11-30 | Stevenson G T | Synthetic antibody |
| US5681566A (en) | 1988-10-24 | 1997-10-28 | 3I Research Exploitation Limited | Antibody conjugates with two or more covalently linked FC regions |
| EP0680337A4 (en) | 1993-01-12 | 1997-07-30 | Anthony George Gristina | METHODS AND COMPOSITIONS FOR DIRECT APPLICATION WITH HIGH CONCENTRATION OF ANTIBODIES, PRODUCING PASSIVE IMMUNITY. |
| US5877396A (en) | 1993-04-23 | 1999-03-02 | Sloan Kettering Institute For Cancer Research | Mice mutant for functional Fc receptors and method of treating autoimmune diseases |
| US6750334B1 (en) | 1996-02-02 | 2004-06-15 | Repligen Corporation | CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor |
| EP1082137A4 (en) | 1998-05-06 | 2004-05-19 | Univ Temple | REVERSE OF PERCENTAL RESPONSE BY INTERRUPTING THE MACROPHAGE RECEPTOR FcSg (g) RI |
| EP1105427A2 (en) | 1998-08-17 | 2001-06-13 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| IL150571A0 (en) | 2000-01-03 | 2003-02-12 | Tr Associates L L C | Novel chimeric proteins and methods for using the same |
| EP1349569B1 (en) | 2001-01-12 | 2007-04-18 | Becton Dickinson and Company | Intrinsically fluorescent, self-multimerizing mhc fusion proteins and complexes thereof |
| AU2002250293B2 (en) | 2001-03-09 | 2007-10-11 | Arnason, Barry G. Mr | Polymeric immunoglobulin fusion proteins that target low-affinity FCGammaReceptors |
| WO2002092784A2 (en) | 2001-05-15 | 2002-11-21 | Emory University | POLYNUCLEOTIDES AND POLYPEPTIDES RELATING TO THE MODULATION OF SIRP α-CD47 |
| AU2003217912A1 (en) | 2002-03-01 | 2003-09-16 | Xencor | Antibody optimization |
| WO2006061650A2 (en) | 2004-12-10 | 2006-06-15 | Trigen Gmbh | Methods, products and uses involving platelets and/or the vasculature |
| WO2003105898A1 (en) | 2002-06-14 | 2003-12-24 | Centocor, Inc. | Modified "s" antibodies |
| PT1606318E (pt) | 2003-03-26 | 2009-11-10 | Deutsches Krebsforsch | Proteínas de fusão de fc melhoradas |
| JP2007501021A (ja) | 2003-05-30 | 2007-01-25 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 遺伝子操作された定常領域を含む、抗体および融合タンパク質 |
| WO2005005604A2 (en) | 2003-06-30 | 2005-01-20 | Centocor, Inc. | Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses |
| ES2383300T3 (es) | 2003-11-13 | 2012-06-20 | Hanmi Holdings Co., Ltd | Fragmento Fc de IgG para un vehículo de fármacos y procedimiento para su preparación |
| EP1697520A2 (en) * | 2003-12-22 | 2006-09-06 | Xencor, Inc. | Fc polypeptides with novel fc ligand binding sites |
| WO2005089503A2 (en) | 2004-03-19 | 2005-09-29 | Progenics Pharmaceuticals, Inc. | Cd4-igg2 formulations |
| WO2006008739A2 (en) | 2004-07-19 | 2006-01-26 | Elutex Ltd. | Modified conductive surfaces having active substances attached thereto |
| WO2006113889A2 (en) | 2005-04-19 | 2006-10-26 | University Of Maryland | Compositions and methods for modulating interleukin-10 |
| DK2439273T3 (da) | 2005-05-09 | 2019-06-03 | Ono Pharmaceutical Co | Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| US7666622B2 (en) | 2005-10-19 | 2010-02-23 | Regeneron Pharmaceuticals, Inc. | Monomeric self-associating fusion polypeptides and therapeutic uses thereof |
| EP1991578A2 (en) | 2006-02-17 | 2008-11-19 | Rappaport Family Institute For Research in the Medical Sciences | Molecules and methods of using same for treating ccr5/ccr5 ligands associated diseases |
| US20090304715A1 (en) * | 2006-03-03 | 2009-12-10 | Tokyo University Of Science | Modified antibodies with enhanced biological activities |
| AT503889B1 (de) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
| GB0614780D0 (en) | 2006-07-25 | 2006-09-06 | Ucb Sa | Biological products |
| EP2144930A1 (en) | 2007-04-18 | 2010-01-20 | ZymoGenetics, Inc. | Single chain fc, methods of making and methods of treatment |
| HUE031655T2 (hu) | 2007-05-11 | 2017-07-28 | Alexion Pharma Inc | Csontot targetáló alkálikus foszfatáz, készletek és eljárások alkalmazásukra |
| EP2158318A2 (en) | 2007-05-14 | 2010-03-03 | Biogen Idec MA, Inc. | Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto |
| EP2176298B1 (en) | 2007-05-30 | 2017-11-15 | Xencor, Inc. | Methods and compositions for inhibiting cd32b expressing cells |
| PL2185589T3 (pl) * | 2007-06-01 | 2016-09-30 | Środki wiążące receptor regionu stałego Fc immunoglobuliny | |
| CN101868246A (zh) * | 2007-09-21 | 2010-10-20 | 加利福尼亚大学董事会 | 被导靶的干扰素显示强的细胞凋亡和抗肿瘤活性 |
| WO2010065578A2 (en) | 2008-12-04 | 2010-06-10 | Leukosight Inc. | POLYPEPTIDES COMPRISING Fc FRAGMENTS OF IMMUNOGLOBULIN G (IgG) AND METHODS OF USING THE SAME |
| WO2011060242A2 (en) | 2009-11-13 | 2011-05-19 | Talecris Biotherapeutics, Inc. | Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto |
| AU2011272941B2 (en) | 2010-06-30 | 2014-05-29 | Compugen Ltd. | C10RF32 for the treatment of multiple sclerosis, rheumatoid arthritis and other autoimmune disorders |
| TWI542597B (zh) | 2010-07-28 | 2016-07-21 | 吉林尼克公司 | 產生依序多聚體化免疫球蛋白ｆｃ組合物之天然人類蛋白質片段之融合蛋白 |
| WO2013112986A1 (en) | 2012-01-27 | 2013-08-01 | Gliknik Inc. | Fusion proteins comprising igg2 hinge domains |
| US9683044B2 (en) * | 2012-08-20 | 2017-06-20 | Gliknik Inc. | Molecules with antigen binding and polyvalent FC gamma receptor binding activity |
-
2013
- 2013-08-20 US US13/971,584 patent/US9683044B2/en active Active
- 2013-08-20 EP EP13830394.6A patent/EP2885320A4/en not_active Withdrawn
- 2013-08-20 RU RU2015109591A patent/RU2015109591A/ru not_active Application Discontinuation
- 2013-08-20 KR KR1020157006960A patent/KR20150058236A/ko not_active Withdrawn
- 2013-08-20 CN CN201380053362.0A patent/CN104718223A/zh active Pending
- 2013-08-20 MX MX2015002269A patent/MX2015002269A/es unknown
- 2013-08-20 HK HK15111563.7A patent/HK1210792A1/xx unknown
- 2013-08-20 JP JP2015528591A patent/JP2015527366A/ja active Pending
- 2013-08-20 WO PCT/US2013/055800 patent/WO2014031646A2/en not_active Ceased
- 2013-08-20 BR BR112015003459A patent/BR112015003459A2/pt not_active IP Right Cessation
- 2013-08-20 CA CA2882296A patent/CA2882296A1/en not_active Abandoned
- 2013-08-20 AU AU2013305885A patent/AU2013305885B2/en not_active Ceased
-
2015
- 2015-02-19 IL IL237307A patent/IL237307A0/en unknown
-
2017
- 2017-05-16 US US15/596,178 patent/US20180094061A1/en not_active Abandoned
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