JP2015525349A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015525349A5 JP2015525349A5 JP2015516637A JP2015516637A JP2015525349A5 JP 2015525349 A5 JP2015525349 A5 JP 2015525349A5 JP 2015516637 A JP2015516637 A JP 2015516637A JP 2015516637 A JP2015516637 A JP 2015516637A JP 2015525349 A5 JP2015525349 A5 JP 2015525349A5
- Authority
- JP
- Japan
- Prior art keywords
- stained cells
- stained
- cells
- tumor
- density
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 18
- 238000000034 method Methods 0.000 claims 16
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 5
- 102100030385 Granzyme B Human genes 0.000 claims 5
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 5
- 101001009603 Homo sapiens Granzyme B Proteins 0.000 claims 5
- 210000002865 immune cell Anatomy 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 3
- 238000012744 immunostaining Methods 0.000 claims 2
- 230000008595 infiltration Effects 0.000 claims 2
- 238000001764 infiltration Methods 0.000 claims 2
- 230000002093 peripheral effect Effects 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 230000008520 organization Effects 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
- 238000010186 staining Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IBPCT/IB2012/001446 | 2012-06-14 | ||
| IB2012001446 | 2012-06-14 | ||
| PCT/EP2013/062405 WO2013186374A1 (en) | 2012-06-14 | 2013-06-14 | Method for quantifying immune cells in tumoral tissues and its applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015525349A JP2015525349A (ja) | 2015-09-03 |
| JP2015525349A5 true JP2015525349A5 (cg-RX-API-DMAC10.html) | 2016-07-14 |
| JP6449765B2 JP6449765B2 (ja) | 2019-01-09 |
Family
ID=46881097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516637A Active JP6449765B2 (ja) | 2012-06-14 | 2013-06-14 | 腫瘍組織における免疫細胞を定量するための方法及びその応用 |
Country Status (13)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6605506B2 (ja) | 2014-02-24 | 2019-11-13 | ヴェンタナ メディカル システムズ， インク． | ＣＤ３、ＣＤ８、ＣＤ２０及びＦｏｘＰ３の同時検出によりがんに対する免疫応答をスコア化するための方法、キット、及びシステム |
| JP6802153B2 (ja) * | 2014-09-03 | 2020-12-16 | ヴェンタナ メディカル システムズ， インク． | 免疫スコアを計算するためのシステム及び方法 |
| WO2016073760A1 (en) * | 2014-11-05 | 2016-05-12 | The Regents Of The University Of California | Methods for stratifying non-responders to therapies that block pd1/pdl1 axis |
| US10034901B2 (en) | 2015-01-22 | 2018-07-31 | University Of Massachusetts | Cancer immunotherapy |
| CN113671186A (zh) * | 2015-10-23 | 2021-11-19 | 诺华股份有限公司 | 对包含肿瘤组织的样品评分的方法 |
| JP7281903B2 (ja) * | 2016-05-09 | 2023-05-26 | アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） | 固形腫瘍を有する患者をクラス分けするための方法 |
| EP3459046B1 (en) * | 2016-05-18 | 2021-06-16 | F. Hoffmann-La Roche AG | Tumor proximity measure |
| WO2018027223A1 (en) * | 2016-08-05 | 2018-02-08 | Duke University | Camkk2 inhibitor compositions and methods of using the same |
| EP3532984B1 (en) * | 2016-10-27 | 2024-05-08 | Koninklijke Philips N.V. | Apparatus for determining cellular composition information in one or more tissue samples |
| WO2018081817A2 (en) | 2016-10-31 | 2018-05-03 | University Of Massachusetts | Targeting microrna-101-3p in cancer therapy |
| CN106846310A (zh) * | 2017-01-19 | 2017-06-13 | 宁波江丰生物信息技术有限公司 | 一种基于免疫组化技术的病理辅助分析方法 |
| WO2019020556A1 (en) * | 2017-07-24 | 2019-01-31 | Ventana Medical Systems, Inc. | METHODS AND SYSTEMS FOR ASSESSING INFILTRAT OF IMMUNE CELLS IN TUMOR SAMPLES |
| CA3089562A1 (en) | 2018-01-30 | 2019-08-08 | University Of Massachusetts | Methods of treating a wound using epigenetic regulation |
| WO2019149817A1 (en) | 2018-01-31 | 2019-08-08 | Ventana Medical Systems, Inc. | Methods and systems for evaluation of immune cell infiltrate in stage iii colorectal cancer |
| WO2020161125A1 (en) * | 2019-02-05 | 2020-08-13 | Ventana Medical Systems, Inc. | Methods and systems for evaluation of immune cell infiltrate in stage iv colorectal cancer |
| CN114072676B (zh) | 2019-06-03 | 2024-07-12 | 法国国家卫生及研究医学协会 | 调节治疗方案的方法 |
| WO2021092071A1 (en) | 2019-11-07 | 2021-05-14 | Oncxerna Therapeutics, Inc. | Classification of tumor microenvironments |
| CN111551546B (zh) * | 2020-06-01 | 2023-01-03 | 南京瑟斯检测科技有限公司 | 一种基于光学微腔结构超材料的免疫组化便捷检测方法 |
| EP4172621A1 (en) | 2020-06-30 | 2023-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies |
| JP7741831B2 (ja) * | 2020-06-30 | 2025-09-18 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 術前補助療法及び根治手術後の固形がんを患っている患者の再発及び／又は死亡のリスクを予測するための方法 |
| TWI838687B (zh) * | 2021-01-30 | 2024-04-11 | 奇美醫療財團法人奇美醫院 | 評估腫瘤標本免疫狀態的方法 |
| CN113092202A (zh) * | 2021-03-25 | 2021-07-09 | 上海福君基因生物科技有限公司 | 一种胃癌预后预测装置 |
| CN113515077A (zh) * | 2021-04-23 | 2021-10-19 | 重庆德方信息技术有限公司 | 人体细胞染色过程监控系统及方法 |
| WO2023018085A1 (ko) * | 2021-08-10 | 2023-02-16 | 주식회사 루닛 | 병리 슬라이드 이미지와 관련된 정보를 출력하는 방법 및 장치 |
| CN114494155B (zh) * | 2021-12-31 | 2026-07-28 | 广东省人民医院 | 非小细胞肺癌ihc染色图像肿瘤区域免疫分级方法、系统及存储介质 |
| US20250035635A1 (en) | 2022-03-17 | 2025-01-30 | Institut National De La Sante Et De La Recherche Medicale | Methods for predicting response to an immunotherapeutic treatment in a patient with a cancer |
| TW202440636A (zh) | 2023-03-21 | 2024-10-16 | 美商傳記５５有限公司 | Ｃｄ１９／ｃｄ３８多特異性抗體 |
| US12700249B2 (en) * | 2023-07-06 | 2026-08-04 | Pictor Labs, Inc. | Systems and methods for training machine learning on noisy and inaccurate immunostains |
| CN116646088B (zh) * | 2023-07-27 | 2023-12-01 | 广东省人民医院 | 一种预测方法、装置、设备及介质 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997020198A2 (en) * | 1995-11-30 | 1997-06-05 | Chromavision Medical Systems, Inc. | Method and apparatus for automated image analysis of biological specimens |
| EP1777523A1 (en) * | 2005-10-19 | 2007-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method |
| JP4933563B2 (ja) * | 2005-12-19 | 2012-05-16 | ヴェンタナ メディカル システムズ， インコーポレイテッド | 解剖病理学における自動リーンメソッド |
| CN102165489B (zh) * | 2008-09-16 | 2015-11-25 | 赫斯托克斯公司 | 生物标志物表达的可再现量化 |
| FR2964744B1 (fr) * | 2010-09-10 | 2015-04-03 | Univ Versailles St Quentin En Yvelines | Test pronostic de l'evolution d'une tumeur solide par analyse d'images |
-
2013
- 2013-06-14 ES ES13731071T patent/ES2902879T3/es active Active
- 2013-06-14 JP JP2015516637A patent/JP6449765B2/ja active Active
- 2013-06-14 SG SG11201408107RA patent/SG11201408107RA/en unknown
- 2013-06-14 US US14/407,698 patent/US10317408B2/en active Active
- 2013-06-14 AU AU2013276470A patent/AU2013276470B2/en not_active Ceased
- 2013-06-14 EP EP13731071.0A patent/EP2861986B1/en active Active
- 2013-06-14 CA CA2873278A patent/CA2873278C/en active Active
- 2013-06-14 BR BR112014031143A patent/BR112014031143B8/pt not_active IP Right Cessation
- 2013-06-14 CN CN201380030888.7A patent/CN104541167B/zh active Active
- 2013-06-14 DE DE13731071.0T patent/DE13731071T1/de active Pending
- 2013-06-14 KR KR1020157000987A patent/KR102179848B1/ko active Active
- 2013-06-14 WO PCT/EP2013/062405 patent/WO2013186374A1/en not_active Ceased
-
2014
- 2014-11-17 IL IL235738A patent/IL235738B/en active IP Right Grant
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE13731071T1 (de) | Verfahren zur Quantifizierung von Immunzellen in Tumorgewebe und dessen Anwendungen | |
| Kidman et al. | Characteristics of TCR repertoire associated with successful immune checkpoint therapy responses | |
| KR102770415B1 (ko) | 항-pd-1/pd-l1에 의해 치료되는 암 환자의 종양-림프구 침윤 및 결과를 모니터링하기 위한 라디오믹스 기반 영상 툴 | |
| Kotoula et al. | Tumors with high-density tumor infiltrating lymphocytes constitute a favorable entity in breast cancer: a pooled analysis of four prospective adjuvant trials | |
| Pedersen et al. | High intratumoral macrophage content is an adverse prognostic feature in anaplastic large cell lymphoma | |
| MX2017001472A (es) | Metodo y sistema para obtener informacion geoquimica de pirolisis mediante espectroscopia de descomposicion inducida por laser. | |
| WO2019012147A1 (en) | RADIOMY-BASED IMAGING TOOL FOR MONITORING INFILTRATION AND TUMOR LYMPHOCYTE AND RESULTS IN CANCER PATIENTS TREATED WITH ANTI-PD-1 / PD-L1 AGENTS | |
| JP2020522697A5 (cg-RX-API-DMAC10.html) | ||
| Kozlowski et al. | An entirely automated method to score DSS-induced colitis in mice by digital image analysis of pathology slides | |
| US20210223251A1 (en) | Immune response profiling of tumor-derived exosomes for cancer diagnosis | |
| EA201891085A1 (ru) | Получение геномных профилей отдельных клеток для циркулирующих клеток опухолей (ctc) при метастазирующем заболевании для характеризации гетерогенности заболевания | |
| JP2018511029A5 (cg-RX-API-DMAC10.html) | ||
| Di Gangi et al. | Analytical metabolomics-based approaches to pancreatic cancer | |
| Jasar et al. | Clinicopathological and histomorphological association in K-ras mutated colorectal cancer | |
| CN103217367B (zh) | 基于三维随机球仿真的雪粒径谱分布特征参数优化方法 | |
| Kivelä | Composition and prognostic significance of T helper lymphocytes in lung cancer | |
| Kimura et al. | 18 F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Predicts the Function of Tumor Immune Microenvironment in Early Triple-Negative Breast Cancer | |
| Porsch et al. | An automated CT scanner system for quality control | |
| JP2025537743A (ja) | がん免疫療法の有効性を予測するための新規バイオマーカー | |
| JP6763611B2 (ja) | アスベスト曝露歴または中皮腫の検査方法 | |
| SONG | Plasma concentration of 5-fluorouracil predicts the efficacy and safety of capecitabine plus cisplatin as first-line chemotherapy in patients with advanced gastric cancer: a single-center clinical trial | |
| Formenti | SP-0604: Challenges combining radiotherapy with immunotherapy | |
| SH | Quantitive assessment of bone marrow trephan biopsy | |
| Turnbull et al. | Accurate and robust prediction of clinical response to aromatase inhibitors by two weeks of neoadjuvant breast cancer treatment | |
| Arrieta et al. | 5PSQ-058 Comparative effectiveness of regorafenib versus trifluridine/tipiracil in metastatic colorectal cancer |