JP2015525071A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015525071A5 JP2015525071A5 JP2015516160A JP2015516160A JP2015525071A5 JP 2015525071 A5 JP2015525071 A5 JP 2015525071A5 JP 2015516160 A JP2015516160 A JP 2015516160A JP 2015516160 A JP2015516160 A JP 2015516160A JP 2015525071 A5 JP2015525071 A5 JP 2015525071A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- human immunoglobulin
- chain variable
- heavy chain
- genetically engineered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims description 44
- 102000038129 antigens Human genes 0.000 claims description 44
- 108091007172 antigens Proteins 0.000 claims description 44
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 39
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 39
- 229920001850 Nucleic acid sequence Polymers 0.000 claims description 26
- 150000007523 nucleic acids Chemical group 0.000 claims description 24
- 210000004602 germ cell Anatomy 0.000 claims description 22
- 210000004027 cells Anatomy 0.000 claims description 21
- 101710009640 IGKV1D-8 Proteins 0.000 claims description 20
- 101710024481 IGKV2-29 Proteins 0.000 claims description 20
- 101710009635 IGKV2D-26 Proteins 0.000 claims description 20
- 102100005978 IGKV3-20 Human genes 0.000 claims description 20
- 101710024987 IGKV3-20 Proteins 0.000 claims description 20
- 101710009651 IGKV3D-15 Proteins 0.000 claims description 20
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 13
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 13
- 102000025417 antigen binding proteins Human genes 0.000 claims description 12
- 108091000829 antigen binding proteins Proteins 0.000 claims description 12
- 230000003053 immunization Effects 0.000 claims description 4
- 230000004048 modification Effects 0.000 claims description 4
- 238000006011 modification reaction Methods 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004965 antibodies Human genes 0.000 claims 3
- 108090001123 antibodies Proteins 0.000 claims 3
- 210000003719 B-Lymphocytes Anatomy 0.000 claims 2
- 102100008989 IGHV1-2 Human genes 0.000 claims 2
- 101710003461 IGHV1-2 Proteins 0.000 claims 2
- 241000700159 Rattus Species 0.000 claims 2
- 238000002649 immunization Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/488,628 US20130045492A1 (en) | 2010-02-08 | 2012-06-05 | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US13/488,628 | 2012-06-05 | ||
| PCT/US2013/044257 WO2013184761A1 (en) | 2012-06-05 | 2013-06-05 | Methods for making fully human bispecific antibodies using a common light chain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015525071A JP2015525071A (ja) | 2015-09-03 |
| JP2015525071A5 true JP2015525071A5 (ko) | 2016-07-21 |
Family
ID=48652344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516160A Pending JP2015525071A (ja) | 2012-06-05 | 2013-06-05 | 共通の軽鎖を用いて完全ヒト型二重特異性抗体を作製するための方法 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2854523A1 (ko) |
| JP (1) | JP2015525071A (ko) |
| KR (1) | KR20150023535A (ko) |
| CN (1) | CN104582476B (ko) |
| AU (1) | AU2013271737A1 (ko) |
| CA (1) | CA2874846A1 (ko) |
| HK (1) | HK1208994A1 (ko) |
| IL (1) | IL235781A0 (ko) |
| MX (1) | MX2014014891A (ko) |
| RU (1) | RU2014153674A (ko) |
| SG (2) | SG11201407644UA (ko) |
| WO (1) | WO2013184761A1 (ko) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| RS55315B2 (sr) | 2010-02-08 | 2020-08-31 | Regeneron Pharma | Miš sa zajedničkim lakim lancem |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| RU2644684C2 (ru) | 2012-03-16 | 2018-02-13 | Регенерон Фармасьютикалз, Инк. | Антитела со встроенным в легкие цепи гистидином и генетически модифицированные отличные от человека животные для их получения |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| MX2014011047A (es) | 2012-03-16 | 2015-04-08 | Regeneron Pharma | Ratones que producen proteinas de union a un antigeno con caracteristicas de union dependientes del ph. |
| BR112014022855A2 (pt) | 2012-03-16 | 2017-07-18 | Regeneron Pharma | animal não humano geneticamente modificado, mamífero geneticamente modificado, e, método para fabricar um animal não humano |
| EA035344B1 (ru) | 2012-04-20 | 2020-05-29 | Мерюс Н.В. | Способ получения двух антител из одной клетки-хозяина |
| TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
| RU2015143108A (ru) * | 2013-03-13 | 2017-04-20 | Регенерон Фарматютикалз, Инк. | Мышь с общей легкой цепью |
| TWI754319B (zh) | 2014-03-19 | 2022-02-01 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| EP3699198A1 (en) | 2014-11-17 | 2020-08-26 | Regeneron Pharmaceuticals, Inc. | Methods for tumor treatment using cd3xcd20 bispecific antibody |
| EP3023437A1 (en) * | 2014-11-20 | 2016-05-25 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| SI3221357T1 (sl) * | 2014-11-20 | 2020-09-30 | F. Hoffmann-La Roche Ag | Pogoste lahke verige in načini uporabe |
| CA2981312C (en) | 2015-03-30 | 2023-09-26 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to fc gamma receptors |
| PL3294775T3 (pl) | 2015-05-12 | 2021-12-13 | Regeneron Pharmaceuticals, Inc. | Oznaczanie czystości białka multimerycznego |
| EP3353212B1 (en) * | 2015-09-23 | 2021-11-03 | Regeneron Pharmaceuticals, Inc. | Optimized anti-cd3 bispecific antibodies and uses thereof |
| CA3011359A1 (en) | 2016-01-13 | 2017-07-20 | Regeneron Pharmaceuticals, Inc. | Rodents having an engineered heavy chain diversity region |
| SG11202012084WA (en) | 2018-06-14 | 2021-01-28 | Regeneron Pharma | Non-human animals capable of dh-dh rearrangement in the immunoglobulin heavy chain coding sequences |
| JP2021535142A (ja) | 2018-08-31 | 2021-12-16 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Ｃｄ３／ｃ２０二重特異性抗体のサイトカイン放出症候群を軽減する投与戦略 |
| EP3883967A4 (en) * | 2018-11-16 | 2023-04-19 | Virtuoso Binco, Inc. | ANTI-CD38 AND ANTI-ICAM1 ANTIBODIES AND THEIR USES |
| AU2020226865A1 (en) | 2019-02-22 | 2021-07-29 | Regeneron Pharmaceuticals, Inc. | Rodents having genetically modified sodium channels and methods of use thereof |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| TW202229328A (zh) | 2020-09-11 | 2022-08-01 | 美商再生元醫藥公司 | 抗原特異性抗體之鑑定及產生 |
| KR20230147048A (ko) | 2020-12-16 | 2023-10-20 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 Fc 알파 수용체를 발현하는 마우스 |
| US20240317849A1 (en) | 2020-12-23 | 2024-09-26 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| CA3197426A1 (en) | 2020-12-23 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same |
| CN118496357A (zh) * | 2023-02-15 | 2024-08-16 | 康源博创生物科技(北京)有限公司 | 一种多肽以及包含其作为轻链的抗体 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU643189B2 (en) * | 1988-09-06 | 1993-11-11 | Xoma Corporation | Production of chimeric mouse-human antibodies with specificity to human tumor antigens |
| US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| CA2161351C (en) * | 1993-04-26 | 2010-12-21 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| CA2491864C (en) * | 2001-07-12 | 2012-09-11 | Jefferson Foote | Super humanized antibodies |
| ES2350248T3 (es) * | 2001-10-01 | 2011-01-20 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Procedimiento de producción de bibliotecas de proteínas y de selección de proteínas a partir de las mismas. |
| WO2003061363A2 (en) * | 2002-01-17 | 2003-07-31 | Albert Einstein College Of Medicine Of Yeshiva University | Mutations caused by activation-induced cytidine deaminase |
| CN101824090B (zh) * | 2002-06-14 | 2013-01-02 | 免疫医疗公司 | 人源化单克隆抗体hPAM4 |
| CN101962408A (zh) * | 2002-07-12 | 2011-02-02 | 杰斐逊·富特 | 超人源化抗体 |
| PT2147594E (pt) * | 2008-06-27 | 2014-02-17 | Merus B V | Mamíferos não humanos que produzem anticorpos |
| RS55315B2 (sr) * | 2010-02-08 | 2020-08-31 | Regeneron Pharma | Miš sa zajedničkim lakim lancem |
| PT2739740T (pt) * | 2011-08-05 | 2020-01-09 | Regeneron Pharma | Cadeia leve universal humanizada de murganhos |
-
2013
- 2013-06-05 WO PCT/US2013/044257 patent/WO2013184761A1/en active Application Filing
- 2013-06-05 AU AU2013271737A patent/AU2013271737A1/en not_active Abandoned
- 2013-06-05 EP EP13729875.8A patent/EP2854523A1/en not_active Ceased
- 2013-06-05 SG SG11201407644UA patent/SG11201407644UA/en unknown
- 2013-06-05 MX MX2014014891A patent/MX2014014891A/es unknown
- 2013-06-05 CA CA2874846A patent/CA2874846A1/en not_active Abandoned
- 2013-06-05 SG SG10201609535TA patent/SG10201609535TA/en unknown
- 2013-06-05 JP JP2015516160A patent/JP2015525071A/ja active Pending
- 2013-06-05 RU RU2014153674A patent/RU2014153674A/ru not_active Application Discontinuation
- 2013-06-05 KR KR20147036869A patent/KR20150023535A/ko not_active Application Discontinuation
- 2013-06-05 CN CN201380030014.1A patent/CN104582476B/zh active Active
-
2014
- 2014-11-18 IL IL235781A patent/IL235781A0/en unknown
-
2015
- 2015-10-06 HK HK15109745.2A patent/HK1208994A1/xx unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015525071A5 (ko) | ||
| JP2023011882A5 (ko) | ||
| RU2014153674A (ru) | Способ получения полностью человеческих биспецифических антител с применением общей легкой цепи | |
| JP2019076108A5 (ko) | ||
| JP7233504B2 (ja) | 共通の軽鎖のマウス | |
| JP2015502177A5 (ko) | ||
| JP2014110814A5 (ko) | ||
| HRP20190706T1 (hr) | Miševi koji izražavaju ograničeni repertoar lakog lanca imunoglobulina | |
| JP2015509380A5 (ko) | ||
| JP2016512034A5 (ko) | ||
| JP2014524243A5 (ko) | ||
| JP2019076109A5 (ko) | ||
| JP2015505477A5 (ko) | ||
| RU2019121863A (ru) | Антитела со встроенным в легкие цепи гистидином и генетически модифицированные отличные от человека животные для их получения | |
| JP2015510767A5 (ko) | ||
| JP2015519076A5 (ko) | ||
| JP2021137030A5 (ko) | ||
| RU2014127339A (ru) | Мыши с гуманизированной легкой цепью | |
| JP6393613B2 (ja) | 共通の軽鎖を有する抗体を発現する非ヒト動物 | |
| JP2020530760A5 (ko) | ||
| JP2013535213A5 (ko) | ||
| JP2017509355A5 (ko) | ||
| JP2015519055A5 (ko) | ||
| JP2008512987A5 (ko) | ||
| CA2445253A1 (en) | Single chain camelid vhh antibodies, method for their production in a mammal, and their uses |