JP2015524397A5 - - Google Patents
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- JP2015524397A5 JP2015524397A5 JP2015521912A JP2015521912A JP2015524397A5 JP 2015524397 A5 JP2015524397 A5 JP 2015524397A5 JP 2015521912 A JP2015521912 A JP 2015521912A JP 2015521912 A JP2015521912 A JP 2015521912A JP 2015524397 A5 JP2015524397 A5 JP 2015524397A5
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- Japan
- Prior art keywords
- genes
- irf7
- tumor
- stat1
- pharmaceutical composition
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 claims 30
- 238000000034 method Methods 0.000 claims 17
- 101001032342 Homo sapiens Interferon regulatory factor 7 Proteins 0.000 claims 13
- 102100038070 Interferon regulatory factor 7 Human genes 0.000 claims 13
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 108010044012 STAT1 Transcription Factor Proteins 0.000 claims 9
- 102100029904 Signal transducer and activator of transcription 1-alpha/beta Human genes 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 238000012216 screening Methods 0.000 claims 7
- 101000840293 Homo sapiens Interferon-induced protein 44 Proteins 0.000 claims 5
- 101001034846 Homo sapiens Interferon-induced transmembrane protein 3 Proteins 0.000 claims 5
- 101001003135 Homo sapiens Interleukin-13 receptor subunit alpha-1 Proteins 0.000 claims 5
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims 5
- 102100029607 Interferon-induced protein 44 Human genes 0.000 claims 5
- 102100040035 Interferon-induced transmembrane protein 3 Human genes 0.000 claims 5
- 102100020791 Interleukin-13 receptor subunit alpha-1 Human genes 0.000 claims 5
- 102100024324 Toll-like receptor 3 Human genes 0.000 claims 5
- -1 CD86 Proteins 0.000 claims 4
- 102100039061 Cytokine receptor common subunit beta Human genes 0.000 claims 4
- 101001033280 Homo sapiens Cytokine receptor common subunit beta Proteins 0.000 claims 4
- 101001032341 Homo sapiens Interferon regulatory factor 9 Proteins 0.000 claims 4
- 102100038251 Interferon regulatory factor 9 Human genes 0.000 claims 4
- 206010061289 metastatic neoplasm Diseases 0.000 claims 4
- 102100040685 14-3-3 protein zeta/delta Human genes 0.000 claims 3
- 108010043471 Core Binding Factor Alpha 2 Subunit Proteins 0.000 claims 3
- 101800001649 Heparin-binding EGF-like growth factor Proteins 0.000 claims 3
- 101000964898 Homo sapiens 14-3-3 protein zeta/delta Proteins 0.000 claims 3
- 102100033762 Proheparin-binding EGF-like growth factor Human genes 0.000 claims 3
- 102100025373 Runt-related transcription factor 1 Human genes 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 102100033391 ATP-dependent RNA helicase DDX3X Human genes 0.000 claims 2
- 101000693933 Arabidopsis thaliana Fructose-bisphosphate aldolase 8, cytosolic Proteins 0.000 claims 2
- 102100032912 CD44 antigen Human genes 0.000 claims 2
- 102100024436 Caldesmon Human genes 0.000 claims 2
- 102100035654 Cathepsin S Human genes 0.000 claims 2
- 102100023768 Constitutive coactivator of PPAR-gamma-like protein 1 Human genes 0.000 claims 2
- 108010079362 Core Binding Factor Alpha 3 Subunit Proteins 0.000 claims 2
- 102100028572 Disabled homolog 2 Human genes 0.000 claims 2
- 102100025190 Histone-binding protein RBBP4 Human genes 0.000 claims 2
- 101000870662 Homo sapiens ATP-dependent RNA helicase DDX3X Proteins 0.000 claims 2
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 2
- 101000910297 Homo sapiens Caldesmon Proteins 0.000 claims 2
- 101000947086 Homo sapiens Cathepsin S Proteins 0.000 claims 2
- 101001048826 Homo sapiens Constitutive coactivator of PPAR-gamma-like protein 1 Proteins 0.000 claims 2
- 101000915391 Homo sapiens Disabled homolog 2 Proteins 0.000 claims 2
- 101001099586 Homo sapiens Pyridoxal kinase Proteins 0.000 claims 2
- 101000999079 Homo sapiens Radiation-inducible immediate-early gene IEX-1 Proteins 0.000 claims 2
- 101000591201 Homo sapiens Receptor-type tyrosine-protein phosphatase kappa Proteins 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 102100038517 Pyridoxal kinase Human genes 0.000 claims 2
- 102100036900 Radiation-inducible immediate-early gene IEX-1 Human genes 0.000 claims 2
- 102100034089 Receptor-type tyrosine-protein phosphatase kappa Human genes 0.000 claims 2
- 108010071034 Retinoblastoma-Binding Protein 4 Proteins 0.000 claims 2
- 102100025369 Runt-related transcription factor 3 Human genes 0.000 claims 2
- 102000005039 SLC6A6 Human genes 0.000 claims 2
- 108060007765 SLC6A6 Proteins 0.000 claims 2
- 210000000481 breast Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
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- 239000012634 fragment Substances 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 230000001394 metastastic effect Effects 0.000 claims 2
- 208000037819 metastatic cancer Diseases 0.000 claims 2
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 2
- 230000000683 nonmetastatic effect Effects 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 102000007863 pattern recognition receptors Human genes 0.000 claims 2
- 108010089193 pattern recognition receptors Proteins 0.000 claims 2
- 210000002307 prostate Anatomy 0.000 claims 2
- 210000000664 rectum Anatomy 0.000 claims 2
- 210000003491 skin Anatomy 0.000 claims 2
- 210000002784 stomach Anatomy 0.000 claims 2
- 210000001685 thyroid gland Anatomy 0.000 claims 2
- FBFJOZZTIXSPPR-UHFFFAOYSA-N 1-(4-aminobutyl)-2-(ethoxymethyl)imidazo[4,5-c]quinolin-4-amine Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CCCCN)C3=C(N)N=C21 FBFJOZZTIXSPPR-UHFFFAOYSA-N 0.000 claims 1
- YMZPQKXPKZZSFV-CPWYAANMSA-N 2-[3-[(1r)-1-[(2s)-1-[(2s)-2-[(1r)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H]([C@H]2C=CCCC2)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 YMZPQKXPKZZSFV-CPWYAANMSA-N 0.000 claims 1
- 102100037086 Bone marrow stromal antigen 2 Human genes 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102100036170 C-X-C motif chemokine 9 Human genes 0.000 claims 1
- 102100031634 Cold shock domain-containing protein E1 Human genes 0.000 claims 1
- 101800000026 Dentin sialoprotein Proteins 0.000 claims 1
- 102100038199 Desmoplakin Human genes 0.000 claims 1
- 206010061968 Gastric neoplasm Diseases 0.000 claims 1
- 102100029076 Histamine N-methyltransferase Human genes 0.000 claims 1
- 102100035081 Homeobox protein TGIF1 Human genes 0.000 claims 1
- 101000752037 Homo sapiens Arginase-1 Proteins 0.000 claims 1
- 101000740785 Homo sapiens Bone marrow stromal antigen 2 Proteins 0.000 claims 1
- 101000947172 Homo sapiens C-X-C motif chemokine 9 Proteins 0.000 claims 1
- 101000940535 Homo sapiens Cold shock domain-containing protein E1 Proteins 0.000 claims 1
- 101000988655 Homo sapiens Histamine N-methyltransferase Proteins 0.000 claims 1
- 101000596925 Homo sapiens Homeobox protein TGIF1 Proteins 0.000 claims 1
- 101001082060 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 3 Proteins 0.000 claims 1
- 101001063370 Homo sapiens Legumain Proteins 0.000 claims 1
- 101000780208 Homo sapiens Long-chain-fatty-acid-CoA ligase 4 Proteins 0.000 claims 1
- 101000578266 Homo sapiens Magnesium transporter NIPA2 Proteins 0.000 claims 1
- 101000933173 Homo sapiens Pro-cathepsin H Proteins 0.000 claims 1
- 101000864662 Homo sapiens Probable ATP-dependent RNA helicase DHX58 Proteins 0.000 claims 1
- 101000741544 Homo sapiens Properdin Proteins 0.000 claims 1
- 101000659879 Homo sapiens Thrombospondin-1 Proteins 0.000 claims 1
- 101000800287 Homo sapiens Tubulointerstitial nephritis antigen-like Proteins 0.000 claims 1
- 101000644847 Homo sapiens Ubl carboxyl-terminal hydrolase 18 Proteins 0.000 claims 1
- 101000850434 Homo sapiens V-type proton ATPase subunit B, brain isoform Proteins 0.000 claims 1
- 102100027302 Interferon-induced protein with tetratricopeptide repeats 3 Human genes 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 102100030985 Legumain Human genes 0.000 claims 1
- 102100034319 Long-chain-fatty-acid-CoA ligase 4 Human genes 0.000 claims 1
- 102100028111 Magnesium transporter NIPA2 Human genes 0.000 claims 1
- 206010029098 Neoplasm skin Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 102100025974 Pro-cathepsin H Human genes 0.000 claims 1
- 102100030090 Probable ATP-dependent RNA helicase DHX58 Human genes 0.000 claims 1
- 102100038567 Properdin Human genes 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 229940124613 TLR 7/8 agonist Drugs 0.000 claims 1
- 102100036034 Thrombospondin-1 Human genes 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 102000002689 Toll-like receptor Human genes 0.000 claims 1
- 108020000411 Toll-like receptor Proteins 0.000 claims 1
- 102100033469 Tubulointerstitial nephritis antigen-like Human genes 0.000 claims 1
- 102100020726 Ubl carboxyl-terminal hydrolase 18 Human genes 0.000 claims 1
- 102100033476 V-type proton ATPase subunit B, brain isoform Human genes 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims 1
- 229960002751 imiquimod Drugs 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000037841 lung tumor Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 208000023958 prostate neoplasm Diseases 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 208000013076 thyroid tumor Diseases 0.000 claims 1
- 208000025421 tumor of uterus Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2012903104 | 2012-07-20 | ||
| AU2012903104A AU2012903104A0 (en) | 2012-07-20 | Method of diagnosis and treatment | |
| PCT/AU2013/000801 WO2014012147A1 (en) | 2012-07-20 | 2013-07-19 | Method of diagnosis and treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015524397A JP2015524397A (ja) | 2015-08-24 |
| JP2015524397A5 true JP2015524397A5 (enExample) | 2016-07-21 |
Family
ID=49948115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015521912A Pending JP2015524397A (ja) | 2012-07-20 | 2013-07-19 | 診断及び処置の方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10441636B2 (enExample) |
| EP (1) | EP2874647B1 (enExample) |
| JP (1) | JP2015524397A (enExample) |
| CN (1) | CN104703620A (enExample) |
| AU (3) | AU2013293049A1 (enExample) |
| CA (1) | CA2879427A1 (enExample) |
| WO (1) | WO2014012147A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8834423B2 (en) | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
| TW201427681A (zh) * | 2013-01-07 | 2014-07-16 | Superlab Far East Ltd | 用空間構象改變的重組干擾素治療腫瘤的方法 |
| CN103966334B (zh) * | 2014-05-20 | 2015-09-23 | 李群 | Csf2rb基因在前列腺癌骨转移中的应用 |
| CA2967017C (en) * | 2014-11-06 | 2020-03-24 | Carnegie Mellon University | Microneedle arrays for cancer therapy applications |
| US10441768B2 (en) | 2015-03-18 | 2019-10-15 | University of Pittsburgh—of the Commonwealth System of Higher Education | Bioactive components conjugated to substrates of microneedle arrays |
| CN107849614A (zh) | 2015-05-22 | 2018-03-27 | 拉筹伯大学 | 诊断乳腺癌的方法 |
| CN106319038B (zh) * | 2015-07-02 | 2020-03-24 | 上海伯豪医学检验所有限公司 | 用于胃癌早期筛查的基因标志物及其应用 |
| US20180268937A1 (en) * | 2015-09-24 | 2018-09-20 | Caris Science, Inc. | Method, apparatus, and computer program product for analyzing biological data |
| WO2017066768A1 (en) | 2015-10-16 | 2017-04-20 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices |
| CN106701904B (zh) * | 2015-11-17 | 2020-06-12 | 上海市东方医院 | Acsl4基因和表达产物在胃癌诊断与治疗中的应用 |
| US11230735B2 (en) | 2015-12-24 | 2022-01-25 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Systems and methods for characterizing sepsis |
| US11744889B2 (en) | 2016-01-05 | 2023-09-05 | University of Pittsburgh—of the Commonwealth System of Higher Education | Skin microenvironment targeted delivery for promoting immune and other responses |
| CN108721603B (zh) * | 2017-04-14 | 2020-11-13 | 中国医学科学院基础医学研究所 | 干扰素α-1a在制备用于治疗癌症的药物中的用途 |
| JP2022532215A (ja) | 2019-05-16 | 2022-07-13 | ユニバーシティ オブ ピッツバーグ － オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 皮膚および非皮膚薬物送達のためのアンダーカット特徴を有するマイクロニードルアレイ |
| KR102854745B1 (ko) * | 2020-04-23 | 2025-09-04 | 진크래프트 주식회사 | R-point 조절 단백질 복합체를 유효성분으로 포함하는 폐암 치료용 약학적 조성물, 상기 복합체의 형성 여부를 이용한 폐암 치료제 스크리닝 방법 및 폐암 진단 방법 |
| CN111863126B (zh) * | 2020-05-28 | 2024-03-26 | 上海市生物医药技术研究院 | 构建结直肠肿瘤状态评估模型的方法及应用 |
| WO2022089426A1 (zh) * | 2020-10-27 | 2022-05-05 | 细胞图谱有限公司 | 外周血样本分析方法和试剂盒 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4868105A (en) | 1985-12-11 | 1989-09-19 | Chiron Corporation | Solution phase nucleic acid sandwich assay |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5470967A (en) | 1990-04-10 | 1995-11-28 | The Dupont Merck Pharmaceutical Company | Oligonucleotide analogs with sulfamate linkages |
| GB9022788D0 (en) | 1990-10-19 | 1990-12-05 | Cortecs Ltd | Pharmaceutical formulations |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5419966A (en) | 1991-06-10 | 1995-05-30 | Microprobe Corporation | Solid support for synthesis of 3'-tailed oligonucleotides |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US6015880A (en) | 1994-03-16 | 2000-01-18 | California Institute Of Technology | Method and substrate for performing multiple sequential reactions on a matrix |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
| US5753187A (en) | 1996-06-14 | 1998-05-19 | Stovall Life Science, Inc. | Combinatorial chemistry cassette |
| GB9920906D0 (en) | 1999-09-03 | 1999-11-10 | Glaxo Group Ltd | Increased production of interferon-a |
| US7955800B2 (en) * | 2002-06-25 | 2011-06-07 | Advpharma Inc. | Metastasis-associated gene profiling for identification of tumor tissue, subtyping, and prediction of prognosis of patients |
| US20080014579A1 (en) | 2003-02-11 | 2008-01-17 | Affymetrix, Inc. | Gene expression profiling in colon cancers |
| WO2007110231A2 (en) | 2006-03-28 | 2007-10-04 | Nautilus Biotech, S.A. | MODIFIED INTERFERON-β (IFN-β) POLYPEPTIDES |
-
2013
- 2013-07-19 WO PCT/AU2013/000801 patent/WO2014012147A1/en not_active Ceased
- 2013-07-19 CN CN201380049135.0A patent/CN104703620A/zh active Pending
- 2013-07-19 JP JP2015521912A patent/JP2015524397A/ja active Pending
- 2013-07-19 US US14/415,832 patent/US10441636B2/en active Active
- 2013-07-19 AU AU2013293049A patent/AU2013293049A1/en not_active Abandoned
- 2013-07-19 CA CA2879427A patent/CA2879427A1/en not_active Abandoned
- 2013-07-19 EP EP13819559.9A patent/EP2874647B1/en not_active Revoked
-
2018
- 2018-05-24 AU AU2018203670A patent/AU2018203670A1/en not_active Abandoned
-
2020
- 2020-01-14 AU AU2020200253A patent/AU2020200253A1/en not_active Abandoned
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