JP2015524055A5 - - Google Patents
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- Publication number
- JP2015524055A5 JP2015524055A5 JP2015513339A JP2015513339A JP2015524055A5 JP 2015524055 A5 JP2015524055 A5 JP 2015524055A5 JP 2015513339 A JP2015513339 A JP 2015513339A JP 2015513339 A JP2015513339 A JP 2015513339A JP 2015524055 A5 JP2015524055 A5 JP 2015524055A5
- Authority
- JP
- Japan
- Prior art keywords
- mmp2
- cancer
- levels
- treatment
- angiogenic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000000424 Matrix Metalloproteinase 2 Human genes 0.000 claims 14
- 108010016165 Matrix Metalloproteinase 2 Proteins 0.000 claims 14
- 238000000034 method Methods 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 238000011122 anti-angiogenic therapy Methods 0.000 claims 6
- 239000012472 biological sample Substances 0.000 claims 4
- 230000001772 anti-angiogenic effect Effects 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 3
- 230000004083 survival effect Effects 0.000 claims 3
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 239000013060 biological fluid Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 108091008605 VEGF receptors Proteins 0.000 claims 1
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims 1
- 206010071989 Vascular endothelial growth factor overexpression Diseases 0.000 claims 1
- 230000003527 anti-angiogenesis Effects 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 238000003499 nucleic acid array Methods 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 239000000092 prognostic biomarker Substances 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 229940124617 receptor tyrosine kinase inhibitor Drugs 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305565.9 | 2012-05-23 | ||
| EP12305565.9A EP2667193A1 (en) | 2012-05-23 | 2012-05-23 | MMP2 as a predictive biomarker of response to antiangiogenic therapy and survival after therapy in cancer patients |
| PCT/IB2013/054275 WO2013175429A1 (en) | 2012-05-23 | 2013-05-23 | Mmp2 as a predictive biomarker of response to antiangiogenic therapy and survival after therapy in cancer patients |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015524055A JP2015524055A (ja) | 2015-08-20 |
| JP2015524055A5 true JP2015524055A5 (enExample) | 2016-06-16 |
Family
ID=48782563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015513339A Withdrawn JP2015524055A (ja) | 2012-05-23 | 2013-05-23 | ガン患者における抗血管新生療法に対する応答及び該療法後の生存についての予知バイオマーカーとしてのｍｍｐ２ |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20150148248A1 (enExample) |
| EP (2) | EP2667193A1 (enExample) |
| JP (1) | JP2015524055A (enExample) |
| WO (1) | WO2013175429A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013031019A2 (pt) | 2011-06-02 | 2017-03-21 | Almac Diagnostics Ltd | teste diagnóstico molecular para câncer |
| US11091809B2 (en) | 2012-12-03 | 2021-08-17 | Almac Diagnostic Services Limited | Molecular diagnostic test for cancer |
| GB201409476D0 (en) * | 2014-05-28 | 2014-07-09 | Almac Diagnostics Ltd | Molecular subtype for use in prognosis |
| CN108496084B (zh) * | 2016-01-25 | 2021-11-05 | 赛诺菲 | 通过测量血浆生物标记的水平预测疑似患有癌症的患者使用阿柏西普的治疗的结果的方法 |
| CN107604074B (zh) * | 2017-10-27 | 2020-06-30 | 中南大学湘雅医院 | 胶质瘤预后标志物circ15:101235082|101235577及应用 |
| CN107937532B (zh) * | 2017-12-28 | 2020-06-30 | 中南大学湘雅医院 | 胶质瘤诊断标志物hsa_circ_0021827及应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| BR112013031019A2 (pt) * | 2011-06-02 | 2017-03-21 | Almac Diagnostics Ltd | teste diagnóstico molecular para câncer |
-
2012
- 2012-05-23 EP EP12305565.9A patent/EP2667193A1/en not_active Ceased
-
2013
- 2013-05-23 US US14/402,913 patent/US20150148248A1/en not_active Abandoned
- 2013-05-23 JP JP2015513339A patent/JP2015524055A/ja not_active Withdrawn
- 2013-05-23 EP EP13735437.9A patent/EP2852842A1/en not_active Withdrawn
- 2013-05-23 WO PCT/IB2013/054275 patent/WO2013175429A1/en not_active Ceased
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