JP2015524055A - ガン患者における抗血管新生療法に対する応答及び該療法後の生存についての予知バイオマーカーとしてのmmp2 - Google Patents

ガン患者における抗血管新生療法に対する応答及び該療法後の生存についての予知バイオマーカーとしてのmmp2 Download PDF

Info

Publication number
JP2015524055A
JP2015524055A JP2015513339A JP2015513339A JP2015524055A JP 2015524055 A JP2015524055 A JP 2015524055A JP 2015513339 A JP2015513339 A JP 2015513339A JP 2015513339 A JP2015513339 A JP 2015513339A JP 2015524055 A JP2015524055 A JP 2015524055A
Authority
JP
Japan
Prior art keywords
mmp2
cancer
patients
levels
response
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2015513339A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015524055A5 (enExample
Inventor
シノ,オリヴィエ
タブレ,エメリン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aix Marseille Universite
Assistance Publique Hopitaux de Marseille APHM
Original Assignee
Aix Marseille Universite
Assistance Publique Hopitaux de Marseille APHM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aix Marseille Universite, Assistance Publique Hopitaux de Marseille APHM filed Critical Aix Marseille Universite
Publication of JP2015524055A publication Critical patent/JP2015524055A/ja
Publication of JP2015524055A5 publication Critical patent/JP2015524055A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486Metalloendopeptidases (3.4.24)
    • G01N2333/96491Metalloendopeptidases (3.4.24) with definite EC number
    • G01N2333/96494Matrix metalloproteases, e. g. 3.4.24.7
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/70Mechanisms involved in disease identification
    • G01N2800/7014(Neo)vascularisation - Angiogenesis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2015513339A 2012-05-23 2013-05-23 ガン患者における抗血管新生療法に対する応答及び該療法後の生存についての予知バイオマーカーとしてのmmp2 Withdrawn JP2015524055A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12305565.9 2012-05-23
EP12305565.9A EP2667193A1 (en) 2012-05-23 2012-05-23 MMP2 as a predictive biomarker of response to antiangiogenic therapy and survival after therapy in cancer patients
PCT/IB2013/054275 WO2013175429A1 (en) 2012-05-23 2013-05-23 Mmp2 as a predictive biomarker of response to antiangiogenic therapy and survival after therapy in cancer patients

Publications (2)

Publication Number Publication Date
JP2015524055A true JP2015524055A (ja) 2015-08-20
JP2015524055A5 JP2015524055A5 (enExample) 2016-06-16

Family

ID=48782563

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015513339A Withdrawn JP2015524055A (ja) 2012-05-23 2013-05-23 ガン患者における抗血管新生療法に対する応答及び該療法後の生存についての予知バイオマーカーとしてのmmp2

Country Status (4)

Country Link
US (1) US20150148248A1 (enExample)
EP (2) EP2667193A1 (enExample)
JP (1) JP2015524055A (enExample)
WO (1) WO2013175429A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021167827A (ja) * 2016-01-25 2021-10-21 サノフイSanofi 血漿バイオマーカーのレベルを測定することによる、がんに罹患していることが疑われる患者のアフリベルセプトによる治療の転帰を予測するための方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013031019A2 (pt) 2011-06-02 2017-03-21 Almac Diagnostics Ltd teste diagnóstico molecular para câncer
US11091809B2 (en) 2012-12-03 2021-08-17 Almac Diagnostic Services Limited Molecular diagnostic test for cancer
GB201409476D0 (en) * 2014-05-28 2014-07-09 Almac Diagnostics Ltd Molecular subtype for use in prognosis
CN107604074B (zh) * 2017-10-27 2020-06-30 中南大学湘雅医院 胶质瘤预后标志物circ15:101235082|101235577及应用
CN107937532B (zh) * 2017-12-28 2020-06-30 中南大学湘雅医院 胶质瘤诊断标志物hsa_circ_0021827及应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
BR112013031019A2 (pt) * 2011-06-02 2017-03-21 Almac Diagnostics Ltd teste diagnóstico molecular para câncer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021167827A (ja) * 2016-01-25 2021-10-21 サノフイSanofi 血漿バイオマーカーのレベルを測定することによる、がんに罹患していることが疑われる患者のアフリベルセプトによる治療の転帰を予測するための方法
JP7170096B2 (ja) 2016-01-25 2022-11-11 サノフイ 血漿バイオマーカーのレベルを測定することによる、がんに罹患していることが疑われる患者のアフリベルセプトによる治療の転帰を予測するための方法

Also Published As

Publication number Publication date
EP2667193A1 (en) 2013-11-27
EP2852842A1 (en) 2015-04-01
US20150148248A1 (en) 2015-05-28
WO2013175429A1 (en) 2013-11-28

Similar Documents

Publication Publication Date Title
Martins et al. Proinflammatory and anti‐inflammatory cytokines mediated by NF‐κB factor as prognostic markers in mammary tumors
Tabouret et al. Association of matrix metalloproteinase 2 plasma level with response and survival in patients treated with bevacizumab for recurrent high-grade glioma
WO2011026962A1 (en) Biomarker for colorectal cancer
JP2015524055A (ja) ガン患者における抗血管新生療法に対する応答及び該療法後の生存についての予知バイオマーカーとしてのmmp2
WO2013116735A1 (en) Methods for predicting tumor response to targeted therapies
Radhakrishnan et al. Inhibition of rapamycin-induced AKT activation elicits differential antitumor response in head and neck cancers
Hou et al. Osteopontin is a useful predictor of bone metastasis and survival in patients with locally advanced nasopharyngeal carcinoma
Zhao et al. Cortactin is a sensitive biomarker relative to the poor prognosis of human hepatocellular carcinoma
Farina et al. Relationship between magnetic resonance imaging characteristics and plasmatic levels of MMP2 and MMP9 in patients with recurrent high-grade gliomas treated by Bevacizumab and Irinotecan
US12298307B2 (en) PD-ECGF as biomarker of cancer
JP7564097B2 (ja) ソラフェニブ化合物を含む療法のためのバイオマーカー
JP7122016B2 (ja) グリオーマの予後、遠隔部再発リスク及び浸潤を判定する方法及びキット並びにグリオーマを処置するための医薬組成物
JP6836230B2 (ja) がん又は炎症性疾患患者の予後を予測する方法
Kim et al. Elevation of PRKCDBP, a novel transcriptional target of TNF-α, and its downregulation by infliximab in patients with ulcerative colitis
US11415584B2 (en) Biomarkers, test method, and test kit for predicting therapeutic effect of anti-VEGFR-2 antibody drug
US12504431B2 (en) Biomarkers for a therapy comprising a sorafenib compound
WO2009098656A2 (en) Method for predicting or diagnosing outcome of intracranial tumors in a subject
Gharib et al. Prognostic significance of dipeptidyl peptidase-7 (DPP7) in HPV16-negative head and neck squamous cell carcinoma treated with induction chemoradiotherapy
KR20250033118A (ko) 신장암에서 면역 관문 억제제의 치료 반응성 예측 마커 및 이를 이용한 치료 반응성 예측 방법
Ianza VALIDATION OF PREDICTIVE AND PROGNOSTIC BIOMARKERS AS A GUIDE FOR A PERSONALIZED APPROACH IN SOLID TUMOURS
WO2025121385A1 (ja) T細胞関連疾患の病態、予後及び治療効果の予測技術
WO2023022200A1 (ja) 免疫チェックポイント阻害剤に対する応答性の予測用バイオマーカー
CN103620412A (zh) 作为对表皮生长因子受体治疗剂治疗的响应的预测物的cxcr1
WO2020257461A1 (en) A method for predicting risk of recurrence for early-stage colon cancer by measuring focal adhesion kinase
HK1262691A1 (en) Chromogranin a as a marker for bladder cancer

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160419

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160419

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20160620