JP2015524051A - ＣＤ９、Ａｋｔおよびテトラスパニンシグナル伝達ネットワークの分子の阻害剤に基づく抗腫瘍療法に対する応答の予測マーカーとしてのＴｒｏｐ−２の使用 - Google Patents

ＣＤ９、Ａｋｔおよびテトラスパニンシグナル伝達ネットワークの分子の阻害剤に基づく抗腫瘍療法に対する応答の予測マーカーとしてのＴｒｏｐ−２の使用 Download PDF

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JP2015524051A
JP2015524051A JP2015512199A JP2015512199A JP2015524051A JP 2015524051 A JP2015524051 A JP 2015524051A JP 2015512199 A JP2015512199 A JP 2015512199A JP 2015512199 A JP2015512199 A JP 2015512199A JP 2015524051 A JP2015524051 A JP 2015524051A
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trop
cells
akt
expressing
signaling network
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Japanese (ja)
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サヴェリオ・アルベルティ
エマヌエラ・グエッラ
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オンコックス・バイオテク・エッセ・エッレ・エッレ
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57575—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A—HUMAN NECESSITIES
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
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    • G01N2800/00—Detection or diagnosis of diseases
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  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Wood Science & Technology (AREA)
  • Mycology (AREA)
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JP2015512199A 2012-05-16 2013-05-16 ＣＤ９、Ａｋｔおよびテトラスパニンシグナル伝達ネットワークの分子の阻害剤に基づく抗腫瘍療法に対する応答の予測マーカーとしてのＴｒｏｐ−２の使用 Pending JP2015524051A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITCH2012A000008 2012-05-16
IT000008A ITCH20120008A1 (it) 2012-05-16 2012-05-16 Uso di trop-2 come marcatore predittivo di risposta a terapia anti-tumorale basata su inibitori di cd9, akt e vie di segnale collegate
PCT/IT2013/000139 WO2013171777A2 (en) 2012-05-16 2013-05-16 Use of trop-2 as predictive marker of response to anti-tumor therapy based on inhibitors of cd9, akt and molecules of the tetraspanin signalling network

Publications (1)

Publication Number Publication Date
JP2015524051A true JP2015524051A (ja) 2015-08-20

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JP2015512199A Pending JP2015524051A (ja) 2012-05-16 2013-05-16 ＣＤ９、Ａｋｔおよびテトラスパニンシグナル伝達ネットワークの分子の阻害剤に基づく抗腫瘍療法に対する応答の予測マーカーとしてのＴｒｏｐ−２の使用

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Country Link
US (1) US20210311061A1 (enExample)
EP (1) EP2850433B1 (enExample)
JP (1) JP2015524051A (enExample)
CN (1) CN104395754A (enExample)
AU (1) AU2013261018A1 (enExample)
CA (1) CA2873017A1 (enExample)
IN (1) IN2014DN10081A (enExample)
IT (1) ITCH20120008A1 (enExample)
WO (1) WO2013171777A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106467914A (zh) * 2015-08-18 2017-03-01 华东理工大学 靶向人TSPAN8基因的siRNA及其应用
ITUB20155701A1 (it) 2015-11-19 2017-05-19 Saverio Alberti Uso di Trop-2 circolante sierico come nuovo biomarcatore tumorale
KR101806294B1 (ko) * 2016-03-22 2017-12-07 주식회사 대웅제약 고형암 환자의 항암제 치료 반응성 예측용 마커
US12523663B2 (en) * 2019-06-04 2026-01-13 Inserm (Institut National De La Santé Et De La Rescherche Médicale) Use of CD9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis
EP4493933A1 (en) * 2022-03-16 2025-01-22 AstraZeneca UK Limited A scoring method for an anti-trop2 antibody-drug conjugate therapy
WO2025232712A1 (en) * 2024-05-06 2025-11-13 The Chinese University Of Hong Kong Cd9 inhibitors, pharmaceutical composition, and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090221444A1 (en) * 2005-10-31 2009-09-03 Anqewandlen Forschung E.V. Method for Identifying, Marking and Treating Epithelial Lung Tumour Cells and Means for Carrying Out Said Method
JP2010527232A (ja) * 2007-04-13 2010-08-12 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド 上皮増殖因子受容体キナーゼ阻害剤に対する抗癌反応を予測する生物学的マーカー
WO2010089782A1 (en) * 2009-02-05 2010-08-12 Saverio Alberti Anti-trop-2 monoclonal antibodies and uses thereof in the treatment and diagnosis of tumors
JP2010528056A (ja) * 2007-05-30 2010-08-19 エフ．ホフマン−ラ ロシュ アーゲー がん細胞の細胞殺作用を媒介するヒト化抗ｔｒｏｐ−２抗体とキメラ抗ｔｒｏｐ−２抗体

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Publication number Priority date Publication date Assignee Title
WO2011057222A1 (en) * 2009-11-06 2011-05-12 Infinity Pharmaceuticals, Inc. Oral formulations of a hedgehog pathway inhibitor
WO2011085276A2 (en) * 2010-01-09 2011-07-14 The Translational Genomics Research Institute Methods and kits to predict prognostic and therapeutic outcome in small cell lung cancer
KR20130058672A (ko) * 2010-04-16 2013-06-04 제넨테크, 인크. ＰＩ3Ｋ/ＡＫＴ 키나제 경로 억제제 효능에 대한 예측 바이오마커로서의 ＦＯＸＯ３ａ
EA201500220A1 (ru) * 2010-05-17 2015-10-30 Ливтех, Инк. Антитело против trop-2 человека, обладающее противоопухолевой активностью in vivo

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090221444A1 (en) * 2005-10-31 2009-09-03 Anqewandlen Forschung E.V. Method for Identifying, Marking and Treating Epithelial Lung Tumour Cells and Means for Carrying Out Said Method
JP2010527232A (ja) * 2007-04-13 2010-08-12 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド 上皮増殖因子受容体キナーゼ阻害剤に対する抗癌反応を予測する生物学的マーカー
JP2010528056A (ja) * 2007-05-30 2010-08-19 エフ．ホフマン−ラ ロシュ アーゲー がん細胞の細胞殺作用を媒介するヒト化抗ｔｒｏｐ−２抗体とキメラ抗ｔｒｏｐ−２抗体
WO2010089782A1 (en) * 2009-02-05 2010-08-12 Saverio Alberti Anti-trop-2 monoclonal antibodies and uses thereof in the treatment and diagnosis of tumors

Also Published As

Publication number Publication date
IN2014DN10081A (enExample) 2015-08-21
WO2013171777A3 (en) 2014-03-20
CN104395754A (zh) 2015-03-04
EP2850433B1 (en) 2018-08-15
CA2873017A1 (en) 2013-11-21
AU2013261018A1 (en) 2014-12-04
US20210311061A1 (en) 2021-10-07
ITCH20120008A1 (it) 2013-11-17
EP2850433A2 (en) 2015-03-25
WO2013171777A2 (en) 2013-11-21

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