JP2015523349A5 - - Google Patents
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- Publication number
- JP2015523349A5 JP2015523349A5 JP2015516430A JP2015516430A JP2015523349A5 JP 2015523349 A5 JP2015523349 A5 JP 2015523349A5 JP 2015516430 A JP2015516430 A JP 2015516430A JP 2015516430 A JP2015516430 A JP 2015516430A JP 2015523349 A5 JP2015523349 A5 JP 2015523349A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- arabinofuranosyl
- unsubstituted
- cancer
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000328 arabinofuranosyl group Chemical group C1([C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 16
- 150000004032 porphyrins Chemical class 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 15
- -1 cyano, hydroxyl Chemical group 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
- 208000032612 Glial tumor Diseases 0.000 claims 3
- 206010018338 Glioma Diseases 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 208000034578 Multiple myelomas Diseases 0.000 claims 3
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 claims 3
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 3
- 208000025188 carcinoma of pharynx Diseases 0.000 claims 3
- 201000010881 cervical cancer Diseases 0.000 claims 3
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 3
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 3
- 206010017758 gastric cancer Diseases 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- 201000007270 liver cancer Diseases 0.000 claims 3
- 208000014018 liver neoplasm Diseases 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 201000011216 nasopharynx carcinoma Diseases 0.000 claims 3
- 208000018026 neoplasm of middle ear Diseases 0.000 claims 3
- 201000008968 osteosarcoma Diseases 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 201000011549 stomach cancer Diseases 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 150000001263 acyl chlorides Chemical class 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000003238 esophagus Anatomy 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 150000003573 thiols Chemical class 0.000 claims 2
- 125000006334 2,4-difluoro benzoyl group Chemical group [H]C1=C([H])C(C(*)=O)=C(F)C([H])=C1F 0.000 claims 1
- 125000001999 4-Methoxybenzoyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(*)=O 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 125000005251 aryl acyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 230000032050 esterification Effects 0.000 claims 1
- 238000005886 esterification reaction Methods 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2012/076840 | 2012-06-13 | ||
| CN2012076840 | 2012-06-13 | ||
| PCT/CN2013/077165 WO2013185613A1 (zh) | 2012-06-13 | 2013-06-13 | 重楼皂苷i的酰化衍生物、及其制备方法和应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015523349A JP2015523349A (ja) | 2015-08-13 |
| JP2015523349A5 true JP2015523349A5 (cg-RX-API-DMAC7.html) | 2016-07-07 |
Family
ID=49757536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516430A Pending JP2015523349A (ja) | 2012-06-13 | 2013-06-13 | ポリフィリンｉのアシル化誘導体、その調製方法及び使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9353146B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2862869B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2015523349A (cg-RX-API-DMAC7.html) |
| CN (1) | CN104334571B (cg-RX-API-DMAC7.html) |
| DK (1) | DK2862869T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013185613A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104098646B (zh) * | 2014-07-17 | 2017-01-11 | 云南省药物研究所 | 纤细薯蓣皂苷衍生物及其抗肿瘤活性应用 |
| CN107619427B (zh) * | 2017-11-03 | 2020-09-15 | 广西南宁成远科技有限公司 | 一种从重楼中提取纯化重楼皂苷ⅰ的方法 |
| CN112402438B (zh) * | 2020-12-05 | 2022-01-11 | 中南大学 | 重楼皂苷ⅶ在制备msn蛋白抑制剂中的应用 |
| CN113694046B (zh) * | 2021-08-27 | 2023-04-07 | 广东药科大学 | 一种重楼皂苷纳米脂质体粉雾剂的制备方法及其应用 |
| CN115429759B (zh) * | 2022-08-24 | 2023-07-21 | 中国人民解放军空军军医大学 | 以重楼皂苷活性提取物为膜材的脂质体的制备方法及应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1153779C (zh) * | 2001-05-11 | 2004-06-16 | 中国科学院上海有机化学研究所 | 薯蓣皂甙的酰基化衍生物、制备方法及用途 |
| CN101143148B (zh) | 2007-10-16 | 2010-12-08 | 浙江大学 | 重楼皂甙ⅰ及其衍生物的应用 |
-
2013
- 2013-06-13 US US14/407,622 patent/US9353146B2/en not_active Expired - Fee Related
- 2013-06-13 CN CN201380024577.XA patent/CN104334571B/zh not_active Expired - Fee Related
- 2013-06-13 EP EP13805106.5A patent/EP2862869B1/en not_active Not-in-force
- 2013-06-13 DK DK13805106.5T patent/DK2862869T3/en active
- 2013-06-13 WO PCT/CN2013/077165 patent/WO2013185613A1/zh not_active Ceased
- 2013-06-13 JP JP2015516430A patent/JP2015523349A/ja active Pending