JP2015523330A5 - - Google Patents
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- Publication number
- JP2015523330A5 JP2015523330A5 JP2015511734A JP2015511734A JP2015523330A5 JP 2015523330 A5 JP2015523330 A5 JP 2015523330A5 JP 2015511734 A JP2015511734 A JP 2015511734A JP 2015511734 A JP2015511734 A JP 2015511734A JP 2015523330 A5 JP2015523330 A5 JP 2015523330A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- composition according
- pharmaceutical composition
- bacterial biofilm
- ulcer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims description 76
- 230000001580 bacterial effect Effects 0.000 claims description 25
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- 108010038346 Seaprose S Proteins 0.000 claims description 13
- 239000004599 antimicrobial Substances 0.000 claims description 12
- 241000191967 Staphylococcus aureus Species 0.000 claims description 10
- 206010052428 Wound Diseases 0.000 claims description 10
- 208000027418 Wounds and injury Diseases 0.000 claims description 10
- 241000191940 Staphylococcus Species 0.000 claims description 9
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 241000894006 Bacteria Species 0.000 claims description 6
- 206010040943 Skin Ulcer Diseases 0.000 claims description 6
- 230000001338 necrotic effect Effects 0.000 claims description 6
- 210000001519 tissue Anatomy 0.000 claims description 6
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims description 5
- 239000003242 anti bacterial agent Substances 0.000 claims description 5
- 239000003429 antifungal agent Substances 0.000 claims description 5
- 229940121375 antifungal agent Drugs 0.000 claims description 5
- 230000003115 biocidal effect Effects 0.000 claims description 5
- 239000012459 cleaning agent Substances 0.000 claims description 5
- 239000006071 cream Substances 0.000 claims description 5
- 229960003085 meticillin Drugs 0.000 claims description 5
- 239000002674 ointment Substances 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- 230000002335 preservative effect Effects 0.000 claims description 5
- 206010011985 Decubitus ulcer Diseases 0.000 claims description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 4
- 208000005230 Leg Ulcer Diseases 0.000 claims description 4
- 239000004264 Petrolatum Substances 0.000 claims description 4
- 208000004210 Pressure Ulcer Diseases 0.000 claims description 4
- 230000000843 anti-fungal effect Effects 0.000 claims description 4
- 230000001684 chronic effect Effects 0.000 claims description 4
- 239000008387 emulsifying waxe Substances 0.000 claims description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 4
- 239000007943 implant Substances 0.000 claims description 4
- 229940066842 petrolatum Drugs 0.000 claims description 4
- 235000019271 petrolatum Nutrition 0.000 claims description 4
- 229920000058 polyacrylate Polymers 0.000 claims description 4
- 239000000243 solution Substances 0.000 claims description 3
- 230000000699 topical effect Effects 0.000 claims description 3
- 208000008960 Diabetic foot Diseases 0.000 claims description 2
- 208000025865 Ulcer Diseases 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 claims description 2
- 230000001079 digestive effect Effects 0.000 claims description 2
- 210000000959 ear middle Anatomy 0.000 claims description 2
- 210000004392 genitalia Anatomy 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 210000000214 mouth Anatomy 0.000 claims description 2
- 210000002307 prostate Anatomy 0.000 claims description 2
- 230000000241 respiratory effect Effects 0.000 claims description 2
- 231100000075 skin burn Toxicity 0.000 claims description 2
- 231100000019 skin ulcer Toxicity 0.000 claims description 2
- 231100000397 ulcer Toxicity 0.000 claims description 2
- 230000002485 urinary effect Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 238000000034 method Methods 0.000 description 31
- 239000000499 gel Substances 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261645815P | 2012-05-11 | 2012-05-11 | |
| US61/645,815 | 2012-05-11 | ||
| US201361820915P | 2013-05-08 | 2013-05-08 | |
| US61/820,915 | 2013-05-08 | ||
| PCT/US2013/040514 WO2013170128A1 (en) | 2012-05-11 | 2013-05-10 | Use of seaprose to remove bacterial biofilm |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018003062A Division JP2018083830A (ja) | 2012-05-11 | 2018-01-12 | 細菌性バイオフィルムを除去するためのセアプローゼの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015523330A JP2015523330A (ja) | 2015-08-13 |
| JP2015523330A5 true JP2015523330A5 (cg-RX-API-DMAC7.html) | 2016-06-30 |
Family
ID=48468851
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511734A Withdrawn JP2015523330A (ja) | 2012-05-11 | 2013-05-10 | 細菌性バイオフィルムを除去するためのセアプローゼの使用 |
| JP2018003062A Pending JP2018083830A (ja) | 2012-05-11 | 2018-01-12 | 細菌性バイオフィルムを除去するためのセアプローゼの使用 |
| JP2019050562A Active JP7118022B2 (ja) | 2012-05-11 | 2019-03-19 | 細菌性バイオフィルムを除去するためのセアプローゼの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018003062A Pending JP2018083830A (ja) | 2012-05-11 | 2018-01-12 | 細菌性バイオフィルムを除去するためのセアプローゼの使用 |
| JP2019050562A Active JP7118022B2 (ja) | 2012-05-11 | 2019-03-19 | 細菌性バイオフィルムを除去するためのセアプローゼの使用 |
Country Status (16)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0811530B1 (pt) | 2007-05-14 | 2019-01-02 | Research Foundation Of State Univ Of New York | composição compreendendo indutor(es) de resposta fisiológica à dispersão ácido decanóico, superfície, solução, método ex vivo de tratamento ou inibição da formação de um biofilme sobre uma superfície |
| KR20150013280A (ko) | 2012-05-11 | 2015-02-04 | 스미스 앤드 네퓨, 인크. | 박테리아 균막을 제거하기 위한 세아프로제의 용도 |
| WO2014078581A1 (en) * | 2012-11-14 | 2014-05-22 | Smith & Nephew, Inc. | Stable thermolysin hydrogel |
| MX2015013244A (es) | 2013-03-15 | 2016-04-15 | Smith & Nephew Inc | Pelicula soluble formadora de gel para suministrar agentes activos. |
| EP2857025A1 (en) * | 2013-10-02 | 2015-04-08 | Special Water Patents B.V. | Wound treatment composition |
| EP3120866A1 (en) | 2015-07-24 | 2017-01-25 | Zymetech ehf. | Use of marine serine proteases for removal, prevention and inhibition of formation and growth of biofilms |
| AU2017304271B2 (en) * | 2016-07-27 | 2024-07-18 | Smith & Nephew, Inc. | Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces |
| WO2018071506A1 (en) * | 2016-10-11 | 2018-04-19 | Sharklet Technologies, Inc | Composition for biofilm disruption, methods of manufacture thereof and articles comprising the same |
| US11413300B2 (en) | 2017-01-30 | 2022-08-16 | Smith & Nephew, Inc. | Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces |
| JP6955784B2 (ja) * | 2017-07-04 | 2021-10-27 | フルケム リミテッドＦｌｕｃｈｅｍ Ｌｔｄ | 水溶解性が向上されたヨード剤及び塩化ナトリウムを含む固体組成物及びその水溶液を含む目、口腔用、鼻腔用又は吸入用抗ウイルス及び抗菌組成物 |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| EP4189051B1 (en) * | 2020-07-27 | 2024-02-28 | Unilever IP Holdings B.V. | Use of an enzyme and surfactant for inhibiting microorganisms |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4197291A (en) | 1974-01-08 | 1980-04-08 | Gerold K. V. Klein | Hydrolytic enzyme material |
| JPS5692217A (en) | 1979-12-26 | 1981-07-25 | Kowa Co | Easily absorbable enzyme preparation |
| IT1264322B (it) | 1992-07-30 | 1996-09-23 | Lanfranco Callegaro | Esteri di gellano autoreticolato, procedimento di preparazione e loro applicazioni farmaceutiche e biomedico-sanitarie |
| CA2106609A1 (en) | 1992-09-28 | 1994-03-29 | Irene Yeatman Aldridge | Proteases to inhibit and remove biofilm |
| US5902600A (en) | 1992-12-21 | 1999-05-11 | Healthpoint, Ltd. | Hydrogel polymer wound dressing |
| US6395529B1 (en) | 1998-11-10 | 2002-05-28 | Novozymes Biotech, Inc. | Polypeptides having lactonohydrolase activity and nucleic acids encoding same |
| US6548556B2 (en) | 2000-12-27 | 2003-04-15 | Healthpoint, Ltd. | Stable enzymatic wound debrider |
| US6399092B1 (en) | 2000-12-27 | 2002-06-04 | Healthpoint, Ltd. | Anhydrous, hydrophilic absorbent wound dressing (tube) with antimicrobials or other pharmaceutically active agents |
| US20030026794A1 (en) * | 2001-07-31 | 2003-02-06 | Howard Fein | Selective enzyme treatment of skin conditions |
| US6479060B1 (en) | 2001-09-04 | 2002-11-12 | Healthpoint, Ltd. | Elegant hydrogenated castor oil ointments |
| US20030198631A1 (en) | 2002-04-18 | 2003-10-23 | Healthpoint, Ltd. | Thermolysin enzymatic wound debrider |
| AU2003287105A1 (en) | 2002-10-10 | 2004-05-04 | Verenium Corporation | Proteases, nucleic acids encoding them and methods for making and using them |
| US20050079594A1 (en) | 2002-10-31 | 2005-04-14 | Karine Marion | Method of removing a biofilm |
| AU2003284385B2 (en) | 2002-12-20 | 2009-08-27 | Rutgers, The State University Of New Jersey | Compositions and methods for enzymatic detachment of bacterial and fungal biofilms |
| US8821862B2 (en) | 2002-12-20 | 2014-09-02 | Kane Biotech Inc. | Soluble β-N-acetylglucosaminidase based antibiofilm compositions and uses thereof |
| US20100221237A1 (en) | 2003-03-26 | 2010-09-02 | Biosynexus Incorporated | Enzyme disruption of bacterial biofilms |
| US7785584B2 (en) | 2003-08-13 | 2010-08-31 | Healthpoint, Ltd. | Ointment wound spray |
| AU2004285558A1 (en) * | 2003-10-29 | 2005-05-12 | Altus Pharmaceuticals Inc. | Non-pancreatic proteases for controlling plasma cholecystokinin (CCK) concentration and for treating pain |
| GB0326194D0 (en) | 2003-11-10 | 2003-12-17 | Univ Kent Canterbury | Proteins involved in signal transduction |
| WO2005115357A2 (en) | 2004-05-14 | 2005-12-08 | Hans-Dietrich Polaschegg | Taurolidine formulations and delivery |
| EP1666075A1 (en) | 2004-10-04 | 2006-06-07 | Switch Biotech Aktiengesellschaft | Wound dressing compositions, especially for delivery of protease inhibitors |
| IL165334A0 (en) | 2004-11-22 | 2006-01-15 | Mediwound Ltd | Debriding composition from bromelain and methods of producing same |
| WO2007047205A2 (en) * | 2005-10-11 | 2007-04-26 | Amano Enzyme Usa Co., Ltd. | Enzyme inhibitors of pai-1 |
| WO2008021987A2 (en) | 2006-08-10 | 2008-02-21 | Jon Barron | Proteolytic enzyme formulations |
| AT504159A1 (de) | 2006-08-16 | 2008-03-15 | Marlyn Nutraceuticals Inc | Verwendung von proteasen |
| WO2008118377A2 (en) | 2007-03-23 | 2008-10-02 | Danisco Us, Inc., Genencor Division | Enhanced amylase production by n-terminal addition to mature amylase protein |
| JP2008290966A (ja) | 2007-05-24 | 2008-12-04 | Michiharu Sasaki | 養毛剤 |
| ES2625866T3 (es) | 2007-11-27 | 2017-07-20 | Algipharma As | Uso de oligómeros de alginatos para combatir las biopelículas |
| AT506095A1 (de) * | 2007-12-03 | 2009-06-15 | Volopharm Gmbh | Verwendung von proteasen |
| US8309081B2 (en) | 2008-11-18 | 2012-11-13 | Scarguard Labs, Llc. | Composition and method for treatment of bruising |
| JP2010126710A (ja) | 2008-12-01 | 2010-06-10 | Kao Corp | バイオフィルム除去剤組成物 |
| WO2010079209A2 (en) * | 2009-01-08 | 2010-07-15 | Golub Alexandr A | Compositions for treating wounds and skin conditions |
| GB0905451D0 (en) | 2009-03-31 | 2009-05-13 | Novabiotics Ltd | Biofilms |
| EP3037102A1 (en) * | 2009-11-23 | 2016-06-29 | Stephen F. Olmstead | Compositions and methods comprising serratia peptidase for inhibition and treatment of biofilms related to certain conditions |
| RU2585373C2 (ru) | 2009-12-08 | 2016-05-27 | Смит & Невью Ортопедикс АГ | Ферментная композиция и способ обработки ран |
| MX2013013219A (es) | 2011-05-12 | 2014-07-28 | Smith & Nephew Orthopaedics Ag | Composiciones para el desbridamiento de heridas que contienen seaprosa y metodos para tratar heridas usando esas composiciones. |
| WO2013096337A1 (en) | 2011-12-20 | 2013-06-27 | Kci Licensing, Inc. | Composition for enzymatic debridement |
| KR20150013280A (ko) | 2012-05-11 | 2015-02-04 | 스미스 앤드 네퓨, 인크. | 박테리아 균막을 제거하기 위한 세아프로제의 용도 |
| WO2014078581A1 (en) | 2012-11-14 | 2014-05-22 | Smith & Nephew, Inc. | Stable thermolysin hydrogel |
| MX2015013244A (es) | 2013-03-15 | 2016-04-15 | Smith & Nephew Inc | Pelicula soluble formadora de gel para suministrar agentes activos. |
| CA2907175C (en) * | 2013-03-15 | 2022-11-08 | M. Alphabet 3, L.L.C. | Methods and compositions for enhancing oxygen levels in tissues |
| AU2016311235B2 (en) | 2015-08-24 | 2021-02-11 | Smith & Nephew, Inc. | Synergistic antibacterial activity of medium polarity oils in combination with antibacterial agents on bacterial biofilms |
-
2013
- 2013-05-10 KR KR20147034713A patent/KR20150013280A/ko not_active Withdrawn
- 2013-05-10 CA CA 2872530 patent/CA2872530A1/en not_active Abandoned
- 2013-05-10 JP JP2015511734A patent/JP2015523330A/ja not_active Withdrawn
- 2013-05-10 EP EP13724135.2A patent/EP2849777B1/en not_active Not-in-force
- 2013-05-10 NZ NZ701623A patent/NZ701623A/en not_active IP Right Cessation
- 2013-05-10 IN IN9412DEN2014 patent/IN2014DN09412A/en unknown
- 2013-05-10 BR BR112014027995A patent/BR112014027995A2/pt not_active IP Right Cessation
- 2013-05-10 WO PCT/US2013/040514 patent/WO2013170128A1/en not_active Ceased
- 2013-05-10 CN CN201380036705.2A patent/CN104602700A/zh active Pending
- 2013-05-10 AU AU2013259360A patent/AU2013259360B2/en not_active Ceased
- 2013-05-10 MX MX2014013745A patent/MX2014013745A/es unknown
- 2013-05-10 US US14/399,124 patent/US11096992B2/en active Active
- 2013-05-10 RU RU2014145270A patent/RU2014145270A/ru not_active Application Discontinuation
-
2014
- 2014-11-10 IL IL235617A patent/IL235617A0/en unknown
- 2014-11-11 CL CL2014003059A patent/CL2014003059A1/es unknown
- 2014-11-11 CO CO14248773A patent/CO7250444A2/es unknown
-
2018
- 2018-01-12 JP JP2018003062A patent/JP2018083830A/ja active Pending
-
2019
- 2019-03-19 JP JP2019050562A patent/JP7118022B2/ja active Active
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