JP2015521607A5 - - Google Patents
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- Publication number
- JP2015521607A5 JP2015521607A5 JP2015517621A JP2015517621A JP2015521607A5 JP 2015521607 A5 JP2015521607 A5 JP 2015521607A5 JP 2015517621 A JP2015517621 A JP 2015517621A JP 2015517621 A JP2015517621 A JP 2015517621A JP 2015521607 A5 JP2015521607 A5 JP 2015521607A5
- Authority
- JP
- Japan
- Prior art keywords
- preparation
- antibody
- administered
- treatment
- morphine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 claims 35
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 26
- 229960005181 morphine Drugs 0.000 claims 13
- 238000001802 infusion Methods 0.000 claims 8
- 238000001990 intravenous administration Methods 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 206010029260 Neuroblastoma Diseases 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- 208000007660 Residual Neoplasm Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 229960004497 dinutuximab Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000003352 fibrogenic effect Effects 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2012/061618 WO2013189516A1 (en) | 2012-06-18 | 2012-06-18 | Method for treating a gd2 positive cancer |
| EPPCT/EP2012/061618 | 2012-06-18 | ||
| PCT/EP2012/064970 WO2013189554A1 (en) | 2012-06-18 | 2012-07-31 | Method for treating a gd2 positive cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015521607A JP2015521607A (ja) | 2015-07-30 |
| JP2015521607A5 true JP2015521607A5 (cg-RX-API-DMAC7.html) | 2015-09-17 |
| JP6283665B2 JP6283665B2 (ja) | 2018-02-21 |
Family
ID=46317406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517621A Active JP6283665B2 (ja) | 2012-06-18 | 2012-07-31 | Ｇｄ２陽性癌を治療するための方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US10294305B2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6283665B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101927118B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN104487088A (cg-RX-API-DMAC7.html) |
| AP (1) | AP2014008129A0 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012383254B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112014031806A8 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2876529C (cg-RX-API-DMAC7.html) |
| EA (1) | EA038188B1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1203375A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL235696A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX377157B (cg-RX-API-DMAC7.html) |
| SG (2) | SG11201408487WA (cg-RX-API-DMAC7.html) |
| WO (2) | WO2013189516A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201407961B (cg-RX-API-DMAC7.html) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4218811A1 (en) | 2012-06-18 | 2023-08-02 | Apeiron Biologics AG | Method for treating a gd2 positive cancer |
| WO2013189516A1 (en) | 2012-06-18 | 2013-12-27 | Apeiron Biologics Ag | Method for treating a gd2 positive cancer |
| LT3071220T (lt) | 2013-11-21 | 2020-02-25 | Apeiron Biologics Ag | Preparatai, skirti gydyti gd2 gerybinį vėžį |
| US9840566B2 (en) | 2013-11-21 | 2017-12-12 | Apeiron Biologics Ag | Preparations and methods for treating a GD2 positive cancer |
| PT3154583T (pt) * | 2014-06-04 | 2021-03-24 | Biontech Res And Development Inc | Anticorpos monoclonais humanos para o gangliósido gd2 |
| US10329323B2 (en) | 2014-07-25 | 2019-06-25 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Method for purifying antibodies using PBS |
| WO2017055385A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Anti-cd3xgd2 bispecific t cell activating antigen binding molecules |
| AU2018234810B2 (en) | 2017-03-15 | 2023-05-11 | Pandion Operations, Inc. | Targeted immunotolerance |
| US10676516B2 (en) | 2017-05-24 | 2020-06-09 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| BR112020005742A2 (pt) * | 2017-09-21 | 2020-10-13 | Umc Utrecht Holding B.V. | anticorpo anti-gd2 para o tratamento de neuroblastoma |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| CN108948211B (zh) * | 2018-07-24 | 2021-08-20 | 北京美康基免生物科技有限公司 | 一种基于靶向gd2的嵌合抗原受体及其应用 |
| WO2020165402A1 (en) | 2019-02-14 | 2020-08-20 | Westfälische Wilhelms-Universität Münster | Gd2-upregulation by ezh2 inhibition in cancer therapy |
| CN114096240A (zh) | 2019-05-17 | 2022-02-25 | 癌症预防制药股份有限公司 | 用于治疗家族性腺瘤性息肉病的方法 |
| WO2020236875A1 (en) | 2019-05-20 | 2020-11-26 | Pandion Therapeutics, Inc. | Madcam targeted immunotolerance |
| BR112022001649A2 (pt) * | 2019-08-01 | 2022-03-22 | Univ Mie | Molécula de ligação ao gd2 |
| US20220411535A1 (en) * | 2019-11-26 | 2022-12-29 | University Of Utah Research Foundation | Compositions and methods for upregulating hla class i on tumor cells |
| US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
| JP2023532753A (ja) | 2020-07-06 | 2023-07-31 | イーユーエスエー ファーマ （ユーケー） リミテッド | Ｇｄ２陽性がんを治療するための方法 |
| JP2024524527A (ja) * | 2021-07-05 | 2024-07-05 | トリオン リサーチ ゲーエムベーハー | がん治療において神経疼痛の消失または軽減をもたらす腫瘍関連抗原に結合する多重特異性抗体 |
| EP4116330A1 (en) * | 2021-07-05 | 2023-01-11 | Trion Research GmbH | Multispecific antibodies with monovalent binding to tumor-associated antigens causing no or reduced nerve pain in the treatment of cancer |
| EP4194471A1 (en) * | 2021-12-10 | 2023-06-14 | Y-Mabs Therapeutics, Inc. | Anti-gd2 administration regimen |
| GB202307103D0 (en) | 2023-05-12 | 2023-06-28 | Prinses Maxima Centrum Voor Kinderoncologie B V | Method for detecting a GD2 positive cancer |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4863713A (en) | 1986-06-23 | 1989-09-05 | The Board Of Trustees Of Leland Stanford Jr. Univ. | Method and system for administering therapeutic and diagnostic agents |
| KR20030074693A (ko) * | 2000-12-28 | 2003-09-19 | 알투스 바이올로직스 인코포레이티드 | 전항체 및 이의 단편의 결정과 이의 제조 및 사용 방법 |
| US7455833B2 (en) | 2002-07-15 | 2008-11-25 | Board Of Regents, The University Of Texas System | Methods and compositions for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
| RU2366664C2 (ru) * | 2002-12-17 | 2009-09-10 | Мерк Патент Гмбх | Гуманизированное антитело (н14.18) на основании антитела 14.18 мыши, связывающееся с gd2, и его слияние с il-2 |
| DE602005016773D1 (de) | 2004-01-22 | 2009-11-05 | Merck Patent Gmbh | Antikrebs-antikörper mit reduzierter komplementfixierung |
| KR101030612B1 (ko) | 2005-10-21 | 2011-04-20 | 에프. 호프만-라 로슈 아게 | 폴리펩타이드의 재조합 발현 방법 |
| EP1916257A1 (en) | 2006-10-27 | 2008-04-30 | Charite-Universitätsmedizin Berlin | GD2 peptide mimotopes for anticancer vaccination |
| KR20110025859A (ko) | 2008-06-30 | 2011-03-11 | 모르포테크, 인크. | 항-ｇｄ２ 항체 및 이와 관련된 방법 및 용도 |
| AU2011268110B2 (en) * | 2010-06-19 | 2016-05-19 | Memorial Sloan-Kettering Cancer Center | Anti-GD2 antibodies |
| US8435972B2 (en) * | 2010-09-02 | 2013-05-07 | Emory University | Method for the treatment of central nervous system cancers and compositions related thereto |
| WO2013060867A2 (en) | 2011-10-27 | 2013-05-02 | Genmab A/S | Production of heterodimeric proteins |
| EP4218811A1 (en) | 2012-06-18 | 2023-08-02 | Apeiron Biologics AG | Method for treating a gd2 positive cancer |
| WO2013189516A1 (en) * | 2012-06-18 | 2013-12-27 | Apeiron Biologics Ag | Method for treating a gd2 positive cancer |
| US9840566B2 (en) * | 2013-11-21 | 2017-12-12 | Apeiron Biologics Ag | Preparations and methods for treating a GD2 positive cancer |
| LT3071220T (lt) | 2013-11-21 | 2020-02-25 | Apeiron Biologics Ag | Preparatai, skirti gydyti gd2 gerybinį vėžį |
-
2012
- 2012-06-18 WO PCT/EP2012/061618 patent/WO2013189516A1/en not_active Ceased
- 2012-07-31 AU AU2012383254A patent/AU2012383254B2/en active Active
- 2012-07-31 WO PCT/EP2012/064970 patent/WO2013189554A1/en not_active Ceased
- 2012-07-31 AP AP2014008129A patent/AP2014008129A0/xx unknown
- 2012-07-31 BR BR112014031806A patent/BR112014031806A8/pt not_active Application Discontinuation
- 2012-07-31 SG SG11201408487WA patent/SG11201408487WA/en unknown
- 2012-07-31 MX MX2014013858A patent/MX377157B/es active IP Right Grant
- 2012-07-31 EA EA201500019A patent/EA038188B1/ru unknown
- 2012-07-31 HK HK15103941.7A patent/HK1203375A1/xx unknown
- 2012-07-31 SG SG10201610532QA patent/SG10201610532QA/en unknown
- 2012-07-31 JP JP2015517621A patent/JP6283665B2/ja active Active
- 2012-07-31 CA CA2876529A patent/CA2876529C/en active Active
- 2012-07-31 KR KR1020147033790A patent/KR101927118B1/ko active Active
- 2012-07-31 CN CN201280074061.1A patent/CN104487088A/zh active Pending
-
2014
- 2014-02-18 US US14/182,776 patent/US10294305B2/en active Active
- 2014-10-31 ZA ZA2014/07961A patent/ZA201407961B/en unknown
- 2014-11-13 IL IL235696A patent/IL235696A0/en unknown
-
2017
- 2017-09-11 US US15/700,538 patent/US11447565B2/en active Active
-
2019
- 2019-04-04 US US16/375,022 patent/US20200055953A1/en not_active Abandoned
-
2022
- 2022-09-19 US US17/933,295 patent/US20230340148A1/en active Pending
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