JP2015521483A5 - - Google Patents
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- JP2015521483A5 JP2015521483A5 JP2015518637A JP2015518637A JP2015521483A5 JP 2015521483 A5 JP2015521483 A5 JP 2015521483A5 JP 2015518637 A JP2015518637 A JP 2015518637A JP 2015518637 A JP2015518637 A JP 2015518637A JP 2015521483 A5 JP2015521483 A5 JP 2015521483A5
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- 239000000090 biomarker Substances 0.000 claims description 82
- 239000000523 sample Substances 0.000 claims description 62
- 230000014509 gene expression Effects 0.000 claims description 61
- 238000000034 method Methods 0.000 claims description 41
- 210000002752 melanocyte Anatomy 0.000 claims description 20
- 101001109700 Homo sapiens Nuclear receptor subfamily 4 group A member 1 Proteins 0.000 claims description 19
- 102100022679 Nuclear receptor subfamily 4 group A member 1 Human genes 0.000 claims description 19
- 101150043341 Socs3 gene Proteins 0.000 claims description 18
- 102000058015 Suppressor of Cytokine Signaling 3 Human genes 0.000 claims description 18
- 108700027337 Suppressor of Cytokine Signaling 3 Proteins 0.000 claims description 18
- 102100026349 Beta-1,4-galactosyltransferase 1 Human genes 0.000 claims description 17
- 101000766145 Homo sapiens Beta-1,4-galactosyltransferase 1 Proteins 0.000 claims description 17
- 108010043471 Core Binding Factor Alpha 2 Subunit Proteins 0.000 claims description 15
- 101001134647 Homo sapiens PDZ and LIM domain protein 7 Proteins 0.000 claims description 15
- 102100033337 PDZ and LIM domain protein 7 Human genes 0.000 claims description 15
- 102100025373 Runt-related transcription factor 1 Human genes 0.000 claims description 15
- 102000036673 PRAME Human genes 0.000 claims description 14
- 108060006580 PRAME Proteins 0.000 claims description 14
- 101000641077 Homo sapiens Diamine acetyltransferase 1 Proteins 0.000 claims description 13
- 101001005718 Homo sapiens Melanoma-associated antigen 2 Proteins 0.000 claims description 13
- 101001098824 Homo sapiens Protein disulfide-isomerase A4 Proteins 0.000 claims description 13
- 101000713305 Homo sapiens Sodium-coupled neutral amino acid transporter 1 Proteins 0.000 claims description 13
- 102100025081 Melanoma-associated antigen 2 Human genes 0.000 claims description 13
- 102100037089 Protein disulfide-isomerase A4 Human genes 0.000 claims description 13
- 102100030100 Sulfate anion transporter 1 Human genes 0.000 claims description 13
- 238000001514 detection method Methods 0.000 claims description 12
- 230000003211 malignant effect Effects 0.000 claims description 12
- 102000039446 nucleic acids Human genes 0.000 claims description 12
- 108020004707 nucleic acids Proteins 0.000 claims description 12
- 150000007523 nucleic acids Chemical class 0.000 claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims description 11
- -1 MET Proteins 0.000 claims description 8
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 claims description 6
- 101000759188 Homo sapiens Zinc finger FYVE domain-containing protein 16 Proteins 0.000 claims description 6
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims description 6
- 108010002687 Survivin Proteins 0.000 claims description 6
- 102100023385 Zinc finger FYVE domain-containing protein 16 Human genes 0.000 claims description 6
- 230000001588 bifunctional effect Effects 0.000 claims description 6
- 238000010801 machine learning Methods 0.000 claims description 6
- 239000002853 nucleic acid probe Substances 0.000 claims description 6
- 102100040074 DNA-directed RNA polymerase II subunit RPB11-b2 Human genes 0.000 claims description 5
- 101001104175 Homo sapiens DNA-directed RNA polymerase II subunit RPB11-b2 Proteins 0.000 claims description 5
- 208000007256 Nevus Diseases 0.000 claims description 5
- 101710163270 Nuclease Proteins 0.000 claims description 5
- 201000001441 melanoma Diseases 0.000 claims description 5
- 102100027308 Apoptosis regulator BAX Human genes 0.000 claims description 4
- 108050006685 Apoptosis regulator BAX Proteins 0.000 claims description 4
- 108090000654 Bone morphogenetic protein 1 Proteins 0.000 claims description 4
- 101001057156 Homo sapiens Melanoma-associated antigen C2 Proteins 0.000 claims description 4
- 101000798109 Homo sapiens Melanotransferrin Proteins 0.000 claims description 4
- 101000582254 Homo sapiens Nuclear receptor corepressor 2 Proteins 0.000 claims description 4
- 102100027252 Melanoma-associated antigen C2 Human genes 0.000 claims description 4
- 102100032239 Melanotransferrin Human genes 0.000 claims description 4
- 102100030569 Nuclear receptor corepressor 2 Human genes 0.000 claims description 4
- 230000000295 complement effect Effects 0.000 claims description 4
- 102100022794 Bestrophin-1 Human genes 0.000 claims description 3
- 101000903449 Homo sapiens Bestrophin-1 Proteins 0.000 claims description 3
- 206010027145 Melanocytic naevus Diseases 0.000 claims description 3
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
- 239000012139 lysis buffer Substances 0.000 claims description 3
- 102000004152 Bone morphogenetic protein 1 Human genes 0.000 claims description 2
- 102100028728 Bone morphogenetic protein 1 Human genes 0.000 claims description 2
- 108091006146 Channels Proteins 0.000 claims description 2
- 101001046870 Homo sapiens Hypoxia-inducible factor 1-alpha Proteins 0.000 claims description 2
- 101000583474 Homo sapiens Phosphatidylinositol-binding clathrin assembly protein Proteins 0.000 claims description 2
- 101001130437 Homo sapiens Ras-related protein Rap-2b Proteins 0.000 claims description 2
- 101001051714 Homo sapiens Ribosomal protein S6 kinase beta-2 Proteins 0.000 claims description 2
- 101000685323 Homo sapiens Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Proteins 0.000 claims description 2
- 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 102100031014 Phosphatidylinositol-binding clathrin assembly protein Human genes 0.000 claims description 2
- 102100031421 Ras-related protein Rap-2b Human genes 0.000 claims description 2
- 102100024917 Ribosomal protein S6 kinase beta-2 Human genes 0.000 claims description 2
- 102100023155 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Human genes 0.000 claims description 2
- 230000003321 amplification Effects 0.000 claims description 2
- 239000011324 bead Substances 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 238000009396 hybridization Methods 0.000 claims description 2
- 238000007477 logistic regression Methods 0.000 claims description 2
- 230000036210 malignancy Effects 0.000 claims description 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 2
- 102100028164 Bestrophin-3 Human genes 0.000 claims 1
- 101000697366 Homo sapiens Bestrophin-3 Proteins 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 238000003491 array Methods 0.000 description 2
- 102100028170 Bestrophin-2 Human genes 0.000 description 1
- 101000697368 Homo sapiens Bestrophin-2 Proteins 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261663428P | 2012-06-22 | 2012-06-22 | |
| US61/663,428 | 2012-06-22 | ||
| PCT/US2013/047354 WO2013192616A1 (en) | 2012-06-22 | 2013-06-24 | Molecular malignancy in melanocytic lesions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015521483A JP2015521483A (ja) | 2015-07-30 |
| JP2015521483A5 true JP2015521483A5 (https=) | 2016-07-21 |
| JP6366580B2 JP6366580B2 (ja) | 2018-08-01 |
Family
ID=49769469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015518637A Expired - Fee Related JP6366580B2 (ja) | 2012-06-22 | 2013-06-24 | メラニン細胞性病変における分子悪性度 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9758829B2 (https=) |
| EP (1) | EP2864500B1 (https=) |
| JP (1) | JP6366580B2 (https=) |
| CN (1) | CN104603291B (https=) |
| AU (1) | AU2013277971B2 (https=) |
| CA (1) | CA2875710C (https=) |
| WO (1) | WO2013192616A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014149629A1 (en) * | 2013-03-15 | 2014-09-25 | Htg Molecular Diagnostics, Inc. | Subtyping lung cancers |
| US11021752B2 (en) * | 2013-03-15 | 2021-06-01 | Myriad Genetics, Inc. | Genes and gene signatures for diagnosis and treatment of melanoma |
| WO2014182330A1 (en) | 2013-05-06 | 2014-11-13 | Hitachi Chemical Company Ltd | Devices and methods for capturing target molecules |
| JP6496899B2 (ja) * | 2014-07-01 | 2019-04-10 | 公立大学法人福島県立医科大学 | 浸潤性髄膜腫判別用試薬、及びその判別方法 |
| EP3164508B1 (en) * | 2014-07-02 | 2023-06-07 | Myriad myPath, LLC | Genes and gene signatures for diagnosis and treatment of melanoma |
| EP3218521B1 (en) * | 2014-11-12 | 2019-12-25 | Hitachi Chemical Co., Ltd. | Method for diagnosing organ injury |
| WO2016152352A1 (ja) * | 2015-03-20 | 2016-09-29 | 国立大学法人名古屋大学 | メラノーマ特異的バイオマーカー及びその利用 |
| GB2544834A (en) * | 2015-06-09 | 2017-05-31 | Waters Technologies Corp | Profile diagnositcs in personalized dermatology, dermatopathology and cosmetics |
| GB2565238A (en) * | 2015-06-09 | 2019-02-06 | Waters Technologies Corp | Molecular diagnostics in personalized dermatology, dermatopathology and cosmetics |
| CN107636678B (zh) * | 2015-06-29 | 2021-12-14 | 北京市商汤科技开发有限公司 | 用于预测图像样本的属性的方法和设备 |
| DE112016003948T5 (de) | 2015-08-31 | 2018-05-09 | City Of Sapporo | Molekulare verfahren zum beurteilen einer urothelialen erkrankung |
| JP7354099B2 (ja) * | 2017-10-03 | 2023-10-02 | ジェネシーク ピーティーワイ リミテッド | マイクロｒｎａ遺伝子発現を使用して黒色腫を診断し、病期分類し、モニタリングする方法 |
| US20210012214A1 (en) * | 2018-03-29 | 2021-01-14 | Nec Corporation | Learning apparatus, learning method, and computer-readable recording medium |
| CN108537005B (zh) * | 2018-04-03 | 2019-04-02 | 福州大学 | 一种基于BPSO-KNN模型的关键lncRNA预测方法 |
| JP7526100B2 (ja) | 2018-05-31 | 2024-07-31 | バークレー ライツ，インコーポレイテッド | マイクロ流体デバイスによる微小物体の自動検出及び特徴付け |
| US11017896B2 (en) * | 2018-06-28 | 2021-05-25 | Case Western Reserve University | Radiomic features of prostate bi-parametric magnetic resonance imaging (BPMRI) associate with decipher score |
| FR3085825B1 (fr) | 2018-09-14 | 2021-07-16 | Fermentalg | Huile de microorganismes riche en acide docosahexaenoique |
| FR3085962B1 (fr) | 2018-09-14 | 2021-06-18 | Fermentalg | Procede d'extracton d'une huile riche en pufa |
| TW202018727A (zh) | 2018-11-09 | 2020-05-16 | 財團法人工業技術研究院 | 整體式學習預測方法與系統 |
| CN112513891B (zh) * | 2019-01-02 | 2025-12-05 | 松下电器（美国）知识产权公司 | 信息处理装置、信息处理方法及记录介质 |
| CN114693646B (zh) * | 2022-03-31 | 2023-04-11 | 中山大学中山眼科中心 | 一种基于深度学习的角膜内皮细胞活性因子的分析方法 |
| JP7806660B2 (ja) * | 2022-11-11 | 2026-01-27 | コニカミノルタ株式会社 | 検出方法 |
| WO2024108191A1 (en) * | 2022-11-18 | 2024-05-23 | University Of Virginia Patent Foundation | Machine learning approach to predicting lymph node metastases |
| CN117625632A (zh) * | 2024-01-22 | 2024-03-01 | 中国医学科学院北京协和医院 | 肌萎缩侧索硬化症的SQSTM1的p.L382CfsTer13突变致病基因及其应用 |
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| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| WO1985001051A1 (en) | 1983-09-02 | 1985-03-14 | Molecular Biosystems, Inc. | Oligonucleotide polymeric support system |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| US5219727A (en) | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
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| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
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| NZ516848A (en) | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
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| BRPI0512587A (pt) | 2004-06-25 | 2007-09-18 | Veridex Llc | processo e reagentes para detecção de melanoma |
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| US20080268451A1 (en) | 2007-03-30 | 2008-10-30 | Bruce Seligmann | Measurement of an insoluble analyte in a sample |
| WO2009062199A1 (en) | 2007-11-09 | 2009-05-14 | Fox Chase Cancer Center | EGFR/NEDD9/TGF-β LNTERACTOME AND METHODS OF USE THEREOF FOR THE IDENTIFICATION OF AGENTS HAVING EFFICACY IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS |
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| CN102089444A (zh) | 2008-05-14 | 2011-06-08 | 德玛泰克国际公司 | 利用核酸分析方法来诊断黑素瘤和太阳能雀斑 |
| US20120041274A1 (en) | 2010-01-07 | 2012-02-16 | Myriad Genetics, Incorporated | Cancer biomarkers |
| EP3812469A1 (en) | 2010-07-07 | 2021-04-28 | Myriad Genetics, Inc. | Gene signatures for cancer prognosis |
| WO2012031008A2 (en) * | 2010-08-31 | 2012-03-08 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| EP2619332A4 (en) | 2010-09-22 | 2014-04-16 | Dave S B Hoon | DIRECT BLOOD ASSAY TO DETECT MICROARN CIRCULATING IN PATIENTS WITH CANCER |
| ES2597032T3 (es) | 2011-05-04 | 2017-01-13 | HTG Molecular Diagnostics, Inc | Mejoras en un ensayo cuantitativo de protección contra la nucleasa (qNPA) y secuenciación (qNPS) |
| AU2012316129B2 (en) | 2011-09-28 | 2017-10-05 | Htg Molecular Diagnostics, Inc. | Methods of co-detecting mRNA and small non-coding RNA |
-
2013
- 2013-06-24 US US14/405,739 patent/US9758829B2/en active Active
- 2013-06-24 JP JP2015518637A patent/JP6366580B2/ja not_active Expired - Fee Related
- 2013-06-24 EP EP13806645.1A patent/EP2864500B1/en active Active
- 2013-06-24 WO PCT/US2013/047354 patent/WO2013192616A1/en not_active Ceased
- 2013-06-24 AU AU2013277971A patent/AU2013277971B2/en active Active
- 2013-06-24 CN CN201380045664.3A patent/CN104603291B/zh active Active
- 2013-06-24 CA CA2875710A patent/CA2875710C/en active Active
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