JP2015519564A - 子癇前症評価を提供するための方法および組成物 - Google Patents

子癇前症評価を提供するための方法および組成物 Download PDF

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JP2015519564A
JP2015519564A JP2015511614A JP2015511614A JP2015519564A JP 2015519564 A JP2015519564 A JP 2015519564A JP 2015511614 A JP2015511614 A JP 2015511614A JP 2015511614 A JP2015511614 A JP 2015511614A JP 2015519564 A JP2015519564 A JP 2015519564A
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eclampsia
panel
marker
markers
sample
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JP2015519564A5 (enExample
Inventor
ジェイ． ビュート，アトゥール
ジェイ． ビュート，アトゥール
シュエフォン リン，ブルース
シュエフォン リン，ブルース
リュー ミラー，リンダ
リュー ミラー，リンダ
エー． モーガン，アレクサンダー
エー． モーガン，アレクサンダー
チェン，ゴンシン
ジー，ジュン
ヤン，ティン
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
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  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
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  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
JP2015511614A 2012-05-08 2013-05-07 子癇前症評価を提供するための方法および組成物 Pending JP2015519564A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261644254P 2012-05-08 2012-05-08
US61/644,254 2012-05-08
US201261731640P 2012-11-30 2012-11-30
US61/731,640 2012-11-30
PCT/US2013/039918 WO2013169751A1 (en) 2012-05-08 2013-05-07 Methods and compositions for providing a preeclampsia assessment

Publications (2)

Publication Number Publication Date
JP2015519564A true JP2015519564A (ja) 2015-07-09
JP2015519564A5 JP2015519564A5 (enExample) 2016-06-23

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JP2015511614A Pending JP2015519564A (ja) 2012-05-08 2013-05-07 子癇前症評価を提供するための方法および組成物

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US (1) US20150099655A1 (enExample)
EP (1) EP2847354A4 (enExample)
JP (1) JP2015519564A (enExample)
CN (1) CN104487593A (enExample)
GB (1) GB2515983A (enExample)
HK (2) HK1206071A1 (enExample)
WO (1) WO2013169751A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019508693A (ja) * 2016-02-29 2019-03-28 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 子癇前症におけるマーカーとしてのｉｇｆｂｐ−７

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014160237A2 (en) * 2013-03-14 2014-10-02 The Board Of Trustees Of The Leland Stanford Junior University Methods of prognosing preeclampsia
WO2016019176A1 (en) * 2014-07-30 2016-02-04 Matthew Cooper Methods and compositions for diagnosing, prognosing, and confirming preeclampsia
CN107367618B (zh) * 2014-10-10 2020-02-14 韦恩州立大学 与胎儿绒毛外滋养层细胞测定有关的方法和组合物
EP3259600B1 (en) * 2015-02-18 2024-07-24 MirZyme Therapeutics Limited Diagnostic assay and treatment for preeclampsia
CA2977458A1 (en) * 2015-03-16 2016-09-22 A1M Pharma Ab Biomarkers for preeclampsia
WO2017075027A1 (en) * 2015-10-26 2017-05-04 Brigham Young University Serum lipid biomarkers of preeclampsia
EP3458861A4 (en) * 2016-05-17 2019-12-11 LDX Prognostics Limited Co. METHOD AND COMPOSITIONS FOR ASSESSING PRECLAMPSY
KR20240100488A (ko) 2016-06-07 2024-07-01 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 세균성 감염 및 바이러스성 감염의 진단 방법
GB201702792D0 (en) 2017-02-21 2017-04-05 Queens Univ Of Belfast A new biomarker for preeclampsia
US20200264188A1 (en) 2017-09-13 2020-08-20 Progenity, Inc. Preeclampsia biomarkers and related systems and methods
RU2691114C1 (ru) * 2018-03-20 2019-06-11 федеральное государственное бюджетное образовательное учреждение высшего образования "Ростовский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ прогнозирования развития преэклампсии в поздние сроки беременности
WO2020117184A1 (en) * 2018-12-02 2020-06-11 Binhai Industrial Technology Research Institute Of Zhejiang University Methods and compositions for providing a preeclampsia assessment by proteomics
CN110305954B (zh) * 2019-07-19 2022-10-04 广州市达瑞生物技术股份有限公司 一种早期准确检测先兆子痫的预测模型
EP4070113A4 (en) 2019-12-04 2023-12-20 Biora Therapeutics, Inc. ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS
KR102302742B1 (ko) * 2019-12-31 2021-09-15 의료법인 성광의료재단 임신중독증 진단용 바이오마커 조성물 및 이의 용도
US12426782B2 (en) 2020-11-06 2025-09-30 The Board Of Trustees Of The Leland Stanford Junior University Systems and temporal alignment methods for evaluation of gestational age and time to delivery
CN112946283B (zh) * 2021-01-29 2022-11-29 暨南大学 定量a2m的产品在制备子痫前期诊断工具中的应用
WO2022186821A1 (en) * 2021-03-02 2022-09-09 Mprobe Inc., Methods and compositions for providing a preeclampsia assessment using leptin and ceramide
CN113223714B (zh) * 2021-05-11 2022-07-05 吉林大学 一种用于预测子痫前期风险的基因组合、子痫前期风险预测模型及其构建方法
CN115308423B (zh) * 2022-10-10 2023-02-10 天津云检医疗器械有限公司 用于先兆子痫风险预测、评估或诊断的生物标志物、试剂盒及方法
EP4636095A1 (en) * 2022-12-16 2025-10-22 BGI Genomics Co., Limited Preeclampsia biomarker and use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008524635A (ja) * 2004-12-21 2008-07-10 イェール ユニバーシティ 子癇前症の診断
JP2008524993A (ja) * 2005-03-18 2008-07-17 ザ チャイニーズ ユニバーシティー オブ ホンコン 出生前診断およびモニタリングのためのマーカー
US20090068683A1 (en) * 2007-06-11 2009-03-12 Mayo Foundation For Medical Education And Research Markers for preeclampsia
JP2009543066A (ja) * 2006-06-30 2009-12-03 アボット・ラボラトリーズ 子癇前症の診断のための方法および装置
US20100035284A1 (en) * 2005-10-27 2010-02-11 Yale Univeristy Urinary Proteomic Biomarker Patterns in Preeclampsia

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080233583A1 (en) * 2007-02-20 2008-09-25 Regents Of The University Of California Biomarkers for preeclampsia
WO2009108073A1 (en) * 2008-02-28 2009-09-03 Auckland Uniservices Limited Biomarkers for prediction of preeclampsia and/or cardiovascular disease
CA2795776A1 (en) * 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
JP2013524251A (ja) * 2010-04-13 2013-06-17 プロノタ エヌ．ヴェ． 妊娠高血圧疾患のバイオマーカー
CN103415769B (zh) * 2010-12-06 2017-04-12 迈卡蒂斯股份有限公司 用于妊娠性高血压疾病的生物标志物和参数
EP2766726A1 (en) * 2011-10-14 2014-08-20 Aarhus Universitet Diagnostic and prognostic use of prombp-complexes
WO2014160237A2 (en) * 2013-03-14 2014-10-02 The Board Of Trustees Of The Leland Stanford Junior University Methods of prognosing preeclampsia

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008524635A (ja) * 2004-12-21 2008-07-10 イェール ユニバーシティ 子癇前症の診断
JP2008524993A (ja) * 2005-03-18 2008-07-17 ザ チャイニーズ ユニバーシティー オブ ホンコン 出生前診断およびモニタリングのためのマーカー
US20100035284A1 (en) * 2005-10-27 2010-02-11 Yale Univeristy Urinary Proteomic Biomarker Patterns in Preeclampsia
JP2009543066A (ja) * 2006-06-30 2009-12-03 アボット・ラボラトリーズ 子癇前症の診断のための方法および装置
US20090068683A1 (en) * 2007-06-11 2009-03-12 Mayo Foundation For Medical Education And Research Markers for preeclampsia

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019508693A (ja) * 2016-02-29 2019-03-28 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 子癇前症におけるマーカーとしてのｉｇｆｂｐ−７
JP7080176B2 (ja) 2016-02-29 2022-06-03 エフ．ホフマン－ラ ロシュ アーゲー 子癇前症におけるマーカーとしてのｉｇｆｂｐ－７

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HK1206790A1 (en) 2016-01-15
CN104487593A (zh) 2015-04-01
HK1206071A1 (en) 2015-12-31
EP2847354A1 (en) 2015-03-18
GB201420279D0 (en) 2014-12-31
GB2515983A (en) 2015-01-07
WO2013169751A1 (en) 2013-11-14
US20150099655A1 (en) 2015-04-09
EP2847354A4 (en) 2015-12-30

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