GB2515983A - Methods and compositions for providing a preeclampsia assessment - Google Patents

Methods and compositions for providing a preeclampsia assessment Download PDF

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Publication number
GB2515983A
GB2515983A GB1420279.0A GB201420279A GB2515983A GB 2515983 A GB2515983 A GB 2515983A GB 201420279 A GB201420279 A GB 201420279A GB 2515983 A GB2515983 A GB 2515983A
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United Kingdom
Prior art keywords
preeclampsia
methods
compositions
providing
find use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB1420279.0A
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English (en)
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GB201420279D0 (en
Inventor
Atul J Butte
Bruce Xuefeng Ling
Linda Liu Miller
Alexander A Morgan
Gongxing Chen
Jun Ji
Ting Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
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Leland Stanford Junior University
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Publication of GB201420279D0 publication Critical patent/GB201420279D0/en
Publication of GB2515983A publication Critical patent/GB2515983A/en
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
GB1420279.0A 2012-05-08 2013-05-07 Methods and compositions for providing a preeclampsia assessment Withdrawn GB2515983A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261644254P 2012-05-08 2012-05-08
US201261731640P 2012-11-30 2012-11-30
PCT/US2013/039918 WO2013169751A1 (en) 2012-05-08 2013-05-07 Methods and compositions for providing a preeclampsia assessment

Publications (2)

Publication Number Publication Date
GB201420279D0 GB201420279D0 (en) 2014-12-31
GB2515983A true GB2515983A (en) 2015-01-07

Family

ID=49551212

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1420279.0A Withdrawn GB2515983A (en) 2012-05-08 2013-05-07 Methods and compositions for providing a preeclampsia assessment

Country Status (7)

Country Link
US (1) US20150099655A1 (enExample)
EP (1) EP2847354A4 (enExample)
JP (1) JP2015519564A (enExample)
CN (1) CN104487593A (enExample)
GB (1) GB2515983A (enExample)
HK (2) HK1206071A1 (enExample)
WO (1) WO2013169751A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160018413A1 (en) * 2013-03-14 2016-01-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of Prognosing Preeclampsia
CN107155350A (zh) * 2014-07-30 2017-09-12 马修·库珀 用于诊断、预后和确认先兆子痫的方法与组合物
US10330680B2 (en) * 2014-10-10 2019-06-25 Wayne State University Methods of assaying RNA from fetal extravillous trophoblast cells isolated from a maternal endocervical sample
US10357469B2 (en) * 2015-02-18 2019-07-23 Aston University Diagnostic assay and treatment for preeclampsia
TW201702383A (zh) * 2015-03-16 2017-01-16 Ａ１Ｍ藥品公司 用於子癇前症之生物標記
WO2017075027A1 (en) * 2015-10-26 2017-05-04 Brigham Young University Serum lipid biomarkers of preeclampsia
BR112018015532A2 (pt) * 2016-02-29 2018-12-26 Hoffmann La Roche métodos para o diagnóstico de pré-eclâmpsia, para avaliar a gravidade da pré-eclâmpsia, e para o monitoramento pré-eclâmpsia, usos de biomarcador, kit adaptado para a realização do método e dispositivo adaptado para diagnosticar se uma paciente sofre de pré-eclâmpsia
CN109196362A (zh) * 2016-05-17 2019-01-11 苏州爱尔迪思生物科技有限公司 用于提供子痫前期评估的方法和组合物
AU2017278254A1 (en) * 2016-06-07 2018-11-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for diagnosis of bacterial and viral infections
GB201702792D0 (en) 2017-02-21 2017-04-05 Queens Univ Of Belfast A new biomarker for preeclampsia
KR20200109293A (ko) 2017-09-13 2020-09-22 프로제너티, 인크. 자간전증 바이오마커 및 관련된 시스템 및 방법
RU2691114C1 (ru) * 2018-03-20 2019-06-11 федеральное государственное бюджетное образовательное учреждение высшего образования "Ростовский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ прогнозирования развития преэклампсии в поздние сроки беременности
WO2020117184A1 (en) * 2018-12-02 2020-06-11 Binhai Industrial Technology Research Institute Of Zhejiang University Methods and compositions for providing a preeclampsia assessment by proteomics
CN110305954B (zh) * 2019-07-19 2022-10-04 广州市达瑞生物技术股份有限公司 一种早期准确检测先兆子痫的预测模型
EP4070113A4 (en) 2019-12-04 2023-12-20 Biora Therapeutics, Inc. ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS
KR102302742B1 (ko) * 2019-12-31 2021-09-15 의료법인 성광의료재단 임신중독증 진단용 바이오마커 조성물 및 이의 용도
US12426782B2 (en) 2020-11-06 2025-09-30 The Board Of Trustees Of The Leland Stanford Junior University Systems and temporal alignment methods for evaluation of gestational age and time to delivery
CN112946283B (zh) * 2021-01-29 2022-11-29 暨南大学 定量a2m的产品在制备子痫前期诊断工具中的应用
WO2022186821A1 (en) * 2021-03-02 2022-09-09 Mprobe Inc., Methods and compositions for providing a preeclampsia assessment using leptin and ceramide
CN113223714B (zh) * 2021-05-11 2022-07-05 吉林大学 一种用于预测子痫前期风险的基因组合、子痫前期风险预测模型及其构建方法
CN117867094A (zh) * 2022-10-10 2024-04-12 天津云检医疗器械有限公司 用于先兆子痫风险预测、评估或诊断的生物标志物、试剂盒及方法
WO2024124587A1 (zh) * 2022-12-16 2024-06-20 深圳华大基因股份有限公司 子痫前期生物标志物及其用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080233583A1 (en) * 2007-02-20 2008-09-25 Regents Of The University Of California Biomarkers for preeclampsia
US20100267034A1 (en) * 2005-03-18 2010-10-21 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
WO2011127219A1 (en) * 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
US20120142559A1 (en) * 2010-12-06 2012-06-07 Pronota N.V. Biomarkers and parameters for hypertensive disorders of pregnancy

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE519109T1 (de) * 2004-12-21 2011-08-15 Univ Yale Präeklampsie-diagnose
WO2007051069A2 (en) * 2005-10-27 2007-05-03 Yale University Urinary proteomic biomarker patterns in preeclampsia
US20080071151A1 (en) * 2006-06-30 2008-03-20 Sogin David C Method and Apparatus for Diagnosing Pre-eclampsia
US20090068683A1 (en) * 2007-06-11 2009-03-12 Mayo Foundation For Medical Education And Research Markers for preeclampsia
WO2009108073A1 (en) * 2008-02-28 2009-09-03 Auckland Uniservices Limited Biomarkers for prediction of preeclampsia and/or cardiovascular disease
US20130045889A1 (en) * 2010-04-13 2013-02-21 Pronota N.V. Biomarkers for hypertensive disorders of pregnancy
CA2886489A1 (en) * 2011-10-14 2013-04-18 Aarhus Universitet Diagnostic and prognostic use of prombp-complexes
US20160018413A1 (en) * 2013-03-14 2016-01-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of Prognosing Preeclampsia

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100267034A1 (en) * 2005-03-18 2010-10-21 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
US20080233583A1 (en) * 2007-02-20 2008-09-25 Regents Of The University Of California Biomarkers for preeclampsia
WO2011127219A1 (en) * 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
US20120142559A1 (en) * 2010-12-06 2012-06-07 Pronota N.V. Biomarkers and parameters for hypertensive disorders of pregnancy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCHUTZER ET AL.: 'Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome' PLOS ONE vol. 6, no. 2, 23 February 2011, pages 1 - 8 *

Also Published As

Publication number Publication date
JP2015519564A (ja) 2015-07-09
EP2847354A1 (en) 2015-03-18
CN104487593A (zh) 2015-04-01
EP2847354A4 (en) 2015-12-30
HK1206071A1 (en) 2015-12-31
WO2013169751A1 (en) 2013-11-14
US20150099655A1 (en) 2015-04-09
GB201420279D0 (en) 2014-12-31
HK1206790A1 (en) 2016-01-15

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