JP2015519061A5 - - Google Patents
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- Publication number
- JP2015519061A5 JP2015519061A5 JP2015514155A JP2015514155A JP2015519061A5 JP 2015519061 A5 JP2015519061 A5 JP 2015519061A5 JP 2015514155 A JP2015514155 A JP 2015514155A JP 2015514155 A JP2015514155 A JP 2015514155A JP 2015519061 A5 JP2015519061 A5 JP 2015519061A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- recombinant nucleic
- plasmid
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020004707 nucleic acids Proteins 0.000 claims description 32
- 102000039446 nucleic acids Human genes 0.000 claims description 32
- 150000007523 nucleic acids Chemical class 0.000 claims description 32
- 239000013612 plasmid Substances 0.000 claims description 18
- 108091026890 Coding region Proteins 0.000 claims description 12
- 241000588724 Escherichia coli Species 0.000 claims description 12
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 10
- 241000607479 Yersinia pestis Species 0.000 claims description 9
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims description 8
- 108020001507 fusion proteins Proteins 0.000 claims description 8
- 102000037865 fusion proteins Human genes 0.000 claims description 8
- 230000002163 immunogen Effects 0.000 claims description 8
- 230000028327 secretion Effects 0.000 claims description 8
- 241000894006 Bacteria Species 0.000 claims description 6
- 230000028993 immune response Effects 0.000 claims description 6
- 239000003550 marker Substances 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 206010035148 Plague Diseases 0.000 claims description 5
- 101150018266 degP gene Proteins 0.000 claims description 4
- 101150007310 htrA gene Proteins 0.000 claims description 4
- 239000002773 nucleotide Substances 0.000 claims description 4
- 125000003729 nucleotide group Chemical group 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 230000003115 biocidal effect Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000001681 protective effect Effects 0.000 claims description 2
- 230000010076 replication Effects 0.000 claims description 2
- 230000003248 secreting effect Effects 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261650676P | 2012-05-23 | 2012-05-23 | |
| US61/650,676 | 2012-05-23 | ||
| PCT/US2013/042240 WO2013177291A1 (en) | 2012-05-23 | 2013-05-22 | Salmonella typhi ty21a expressing yersinia pestis f1-v fusion protein and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015519061A JP2015519061A (ja) | 2015-07-09 |
| JP2015519061A5 true JP2015519061A5 (https=) | 2016-06-09 |
| JP6216371B2 JP6216371B2 (ja) | 2017-10-18 |
Family
ID=48539444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514155A Expired - Fee Related JP6216371B2 (ja) | 2012-05-23 | 2013-05-22 | ＹｅｒｓｉｎｉａｐｅｓｔｉｓＦ１−Ｖ融合タンパク質を発現するＳａｌｍｏｎｅｌｌａＴｙｐｈｉＴｙ２１ａおよびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9409956B2 (https=) |
| EP (1) | EP2852405B1 (https=) |
| JP (1) | JP6216371B2 (https=) |
| CN (1) | CN104470537B (https=) |
| IL (1) | IL235615A0 (https=) |
| IN (1) | IN2014DN09618A (https=) |
| WO (1) | WO2013177291A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10806778B2 (en) * | 2019-01-30 | 2020-10-20 | Prokarium Limited | Modified strain of Salmonella enterica Typhi |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3856935A (en) | 1971-04-29 | 1974-12-24 | Schweiz Serum & Impfinst | Oral typhoid vaccine and method of preparing the same |
| GB9326425D0 (en) | 1993-12-24 | 1994-02-23 | Secr Defence | Vaccine compositions |
| US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| ATE509102T1 (de) | 1994-07-15 | 2011-05-15 | Univ Iowa Res Found | Immunomodulatorische oligonukleotide |
| CA2215203C (en) * | 1995-03-13 | 2008-12-09 | The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland | Vaccines for plague |
| WO1998037919A1 (en) | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| AU7690898A (en) | 1997-05-20 | 1998-12-11 | Ottawa Civic Hospital Loeb Research Institute | Vectors and methods for immunization or therapeutic protocols |
| ATE356630T1 (de) | 1998-04-03 | 2007-04-15 | Univ Iowa Res Found | Verfahren und produkte zur stimulierung des immunsystems mittels immunotherapeutischer oligonukleotide und zytokine |
| PT1108034E (pt) * | 1998-09-04 | 2008-11-14 | Emergent Product Dev Uk Ltd | Mutantes de spi2 de salmonela atenuados como transportadores de antigénios |
| GB9921275D0 (en) * | 1999-09-10 | 1999-11-10 | Secr Defence | Recombinant microorganisms |
| EP1670505B1 (en) * | 2003-09-18 | 2012-11-14 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Dna promoters and anthrax vaccines |
| WO2005056769A2 (en) * | 2003-12-09 | 2005-06-23 | Avant Immunotherapeutics, Inc. | Orally-administered live bacterial vaccines for plague |
| US20080124355A1 (en) * | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
| EP1921149A1 (en) * | 2006-11-13 | 2008-05-14 | AEterna Zentaris GmbH | Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof |
-
2013
- 2013-05-22 WO PCT/US2013/042240 patent/WO2013177291A1/en not_active Ceased
- 2013-05-22 JP JP2015514155A patent/JP6216371B2/ja not_active Expired - Fee Related
- 2013-05-22 US US14/402,457 patent/US9409956B2/en active Active
- 2013-05-22 EP EP13726394.3A patent/EP2852405B1/en not_active Not-in-force
- 2013-05-22 IN IN9618DEN2014 patent/IN2014DN09618A/en unknown
- 2013-05-22 CN CN201380038155.8A patent/CN104470537B/zh not_active Expired - Fee Related
-
2014
- 2014-11-10 IL IL235615A patent/IL235615A0/en unknown
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