JP2006512097A5 - - Google Patents

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Publication number
JP2006512097A5
JP2006512097A5 JP2005510053A JP2005510053A JP2006512097A5 JP 2006512097 A5 JP2006512097 A5 JP 2006512097A5 JP 2005510053 A JP2005510053 A JP 2005510053A JP 2005510053 A JP2005510053 A JP 2005510053A JP 2006512097 A5 JP2006512097 A5 JP 2006512097A5
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JP
Japan
Prior art keywords
composition
nucleic acid
ctla
acid sequence
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2005510053A
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English (en)
Japanese (ja)
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JP2006512097A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2003/041053 external-priority patent/WO2004058801A2/en
Publication of JP2006512097A publication Critical patent/JP2006512097A/ja
Publication of JP2006512097A5 publication Critical patent/JP2006512097A5/ja
Withdrawn legal-status Critical Current

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JP2005510053A 2002-12-23 2003-12-22 癌免疫療法におけるp53を発現する改変・ワクシニア・アンカラ Withdrawn JP2006512097A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43626802P 2002-12-23 2002-12-23
US46660703P 2003-04-30 2003-04-30
PCT/US2003/041053 WO2004058801A2 (en) 2002-12-23 2003-12-22 Modified vaccinia ankara expressing p53 in cancer immunotherapy

Publications (2)

Publication Number Publication Date
JP2006512097A JP2006512097A (ja) 2006-04-13
JP2006512097A5 true JP2006512097A5 (https=) 2007-02-15

Family

ID=32685446

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2005510053A Withdrawn JP2006512097A (ja) 2002-12-23 2003-12-22 癌免疫療法におけるp53を発現する改変・ワクシニア・アンカラ

Country Status (6)

Country Link
US (2) US7256037B2 (https=)
EP (1) EP1575611A4 (https=)
JP (1) JP2006512097A (https=)
AU (1) AU2003297499A1 (https=)
CA (1) CA2511625A1 (https=)
WO (1) WO2004058801A2 (https=)

Families Citing this family (33)

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US10100316B2 (en) * 2002-11-21 2018-10-16 Archemix Llc Aptamers comprising CPG motifs
WO2004081021A2 (en) * 2003-03-12 2004-09-23 Duke University Oligonucleotide mimetics
US7674456B2 (en) * 2004-06-14 2010-03-09 Charles Wiseman Breast cancer cell lines and uses thereof
AU2006218115B2 (en) 2005-02-23 2012-08-02 Bavarian Nordic A/S Use of a modified poxvirus for the rapid induction of immunity against a poxvirus or other infectious agents
JP2009500412A (ja) * 2005-07-07 2009-01-08 コーリー ファーマシューティカル グループ,インコーポレイテッド 癌の処置のための、抗ctla−4抗体とcpgモチーフ含有合成オリゴデオキシヌクレオチドとの組み合わせ治療
CN1919873B (zh) * 2005-08-25 2012-05-30 北京沙东生物技术有限公司 包含人HSP70 ATPase结构域与哺乳动物p53蛋白的融合蛋白及其应用
JP6092497B2 (ja) * 2006-03-30 2017-03-08 ユニバーシティー オブ カリフォルニア 抗ctla−4抗体の限局性分泌のための方法および組成物
BRPI0811228A2 (pt) * 2007-05-24 2014-10-21 Glaxonsmithkline Biolog S A Composição liofilizada, e, métodos para produzir uma composição liofilizada e para produzir uma composição imunológica.
US7998488B2 (en) * 2008-11-14 2011-08-16 Baxter International Inc. Vaccine formulations and uses thereof
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
WO2015085147A1 (en) 2013-12-05 2015-06-11 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
EP3082853A2 (en) * 2013-12-20 2016-10-26 The Broad Institute, Inc. Combination therapy with neoantigen vaccine
US10993997B2 (en) 2014-12-19 2021-05-04 The Broad Institute, Inc. Methods for profiling the t cell repertoire
US10975442B2 (en) 2014-12-19 2021-04-13 Massachusetts Institute Of Technology Molecular biomarkers for cancer immunotherapy
ES3011733T3 (en) 2015-02-13 2025-04-08 Transgene Immunotherapeutic vaccine and antibody combination therapy
EP4122492A1 (en) 2015-02-25 2023-01-25 Memorial Sloan Kettering Cancer Center Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors
KR20180006916A (ko) * 2015-04-17 2018-01-19 메모리얼 슬로안-케터링 캔서 센터 고형 종양에 대한 면역치료제로서 mva 또는 mva델타e3l의 용도
TW202523682A (zh) 2015-05-20 2025-06-16 美商博德研究所有限公司 共有之gata3相關之腫瘤特異性新抗原
US20190038713A1 (en) * 2015-11-07 2019-02-07 Multivir Inc. Compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer
JP7025339B2 (ja) 2016-02-25 2022-02-24 メモリアル スローン ケタリング キャンサー センター 癌免疫療法のための、チミジンキナーゼの欠失を伴い、ヒトflt3lまたはgm-csfの発現を伴うかまたは伴わない、複製可能な弱毒化ワクシニアウイルス
CN109152827B (zh) * 2016-02-25 2023-07-21 纪念斯隆凯特琳癌症中心 重组mva或表达人flt3l的mvaδe3l及其作为抗固体肿瘤的免疫治疗剂的用途
WO2018107011A1 (en) * 2016-12-08 2018-06-14 City Of Hope P53-targeting vaccines and pd-1 pathway inhibitors and methods of use thereof
WO2018111902A1 (en) 2016-12-12 2018-06-21 Multivir Inc. Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases
WO2018112470A1 (en) * 2016-12-16 2018-06-21 The Brigham And Women's Hospital, Inc. Co-delivery of nucleic acids for simultaneous suppression and expression of target genes
WO2018140391A1 (en) 2017-01-24 2018-08-02 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
EP3621646A4 (en) 2017-05-12 2021-06-02 Memorial Sloan Kettering Cancer Center VACCINIA VIRUS MUTANTS FOR CANCER IMMUNOTHERAPY
WO2019090343A1 (en) * 2017-11-06 2019-05-09 Memorial Sloan Kettering Cancer Center Heat-inactivated vaccinia virus as a vaccine immune adjuvant
EP3768698B1 (en) 2018-03-19 2025-02-12 MultiVir Inc. Methods and compositions comprising tumor suppressor gene therapy and cd122/cd132 agonists for the treatment of cancer
BR112021004692A2 (pt) 2018-09-15 2021-06-08 Memorial Sloan Kettering Cancer Center poxvírus recombinantes para imunoterapia de câncer
US12274784B2 (en) 2018-10-12 2025-04-15 Synergene Therapeutics, Inc. Methods for reducing side effects of immunotherapy
WO2021113644A1 (en) 2019-12-05 2021-06-10 Multivir Inc. Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer
US11938124B2 (en) * 2020-06-24 2024-03-26 Pmv Pharmaceuticals, Inc. Combination therapy for treatment of cancer
CN115537399B (zh) * 2022-09-22 2025-02-11 沈阳药科大学 修饰化外泌体及其制法和外泌体联合pd-1抗体的原位喷雾水凝胶和应用

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
CA1341245C (en) * 1988-01-12 2001-06-05 F. Hoffmann-La Roche Ag Recombinant vaccinia virus mva
US6410010B1 (en) * 1992-10-13 2002-06-25 Board Of Regents, The University Of Texas System Recombinant P53 adenovirus compositions
US6045802A (en) * 1994-10-03 2000-04-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Enhanced immune response to an antigen by a composition of a recombinant virus expressing the antigen with a recombinant virus expressing an immunostimulatory molecule
DE602004015418D1 (de) * 2003-02-18 2008-09-11 Helmholtz Zentrum Muenchen Rekombinantes mva und verfahren zur erzeugung davon

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