JP2015519057A - Ｐｔｅｎ発現を調節するための組成物及び方法 - Google Patents

Ｐｔｅｎ発現を調節するための組成物及び方法 Download PDF

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JP2015519057A
JP2015519057A JP2015512846A JP2015512846A JP2015519057A JP 2015519057 A JP2015519057 A JP 2015519057A JP 2015512846 A JP2015512846 A JP 2015512846A JP 2015512846 A JP2015512846 A JP 2015512846A JP 2015519057 A JP2015519057 A JP 2015519057A
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nucleotide
oligonucleotide
stranded oligonucleotide
nucleotides
sequence
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JP2015519057A5 (enExample
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アーサー エム． クリーグ，
アーサー エム． クリーグ，
ロメシュ スブラマニアン，
ロメシュ スブラマニアン，
ジェイムズ マクスウィゲン，
ジェイムズ マクスウィゲン，
ジェニー ティー． リー，
ジェニー ティー． リー，
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ラナ セラピューティクス インコーポレイテッド
ラナ セラピューティクス インコーポレイテッド
ザ ジェネラル ホスピタル コーポレイション
ザ ジェネラル ホスピタル コーポレイション
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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JP2015512846A 2012-05-16 2013-05-16 Ｐｔｅｎ発現を調節するための組成物及び方法 Pending JP2015519057A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261648041P 2012-05-16 2012-05-16
US61/648,041 2012-05-16
US201361785885P 2013-03-14 2013-03-14
US61/785,885 2013-03-14
PCT/US2013/041389 WO2013173605A1 (en) 2012-05-16 2013-05-16 Compositions and methods for modulating pten expression

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JP2015519057A true JP2015519057A (ja) 2015-07-09
JP2015519057A5 JP2015519057A5 (enExample) 2016-06-30

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US (1) US20150159161A1 (enExample)
EP (1) EP2850187A4 (enExample)
JP (1) JP2015519057A (enExample)
CN (1) CN104583400A (enExample)
AU (1) AU2013262706A1 (enExample)
BR (1) BR112014028646A2 (enExample)
CA (1) CA2873776A1 (enExample)
EA (1) EA201492118A1 (enExample)
WO (1) WO2013173605A1 (enExample)

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US12319913B2 (en) 2018-10-31 2025-06-03 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer

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CN104540946A (zh) 2012-05-16 2015-04-22 Rana医疗有限公司 用于调节utrn表达的组合物和方法
US10174315B2 (en) 2012-05-16 2019-01-08 The General Hospital Corporation Compositions and methods for modulating hemoglobin gene family expression
EA201492120A1 (ru) 2012-05-16 2015-10-30 Рана Терапьютикс, Инк. Композиции и способы для модулирования экспрессии atp2a2
JP2015523854A (ja) 2012-05-16 2015-08-20 ラナ セラピューティクス インコーポレイテッド Ｓｍｎ遺伝子ファミリー発現を調節するための組成物及び方法
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PT2970974T (pt) 2013-03-14 2017-11-29 Alnylam Pharmaceuticals Inc Composições de irna de componente do complemento c5 e métodos para a sua utilização
WO2016040589A1 (en) * 2014-09-12 2016-03-17 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting complement component c5 and methods of use thereof
WO2016070060A1 (en) 2014-10-30 2016-05-06 The General Hospital Corporation Methods for modulating atrx-dependent gene repression
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US10900036B2 (en) 2015-03-17 2021-01-26 The General Hospital Corporation RNA interactome of polycomb repressive complex 1 (PRC1)
CN105063196B (zh) * 2015-08-03 2018-08-28 中国人民解放军第二军医大学 蛋白酶体抑制剂与细胞自噬激活剂联合在胆管癌治疗中的应用
EP3368089B1 (en) 2015-10-26 2025-11-05 Translate Bio Ma, Inc. Nanoparticle formulations for delivery of nucleic acid complexes
EP3405583B1 (en) 2016-01-20 2024-04-03 Dana-Farber Cancer Institute, Inc. Compositions and methods for screening and identifying clinically aggressive prostate cancer
EP3541939A4 (en) * 2016-11-17 2020-06-24 Ramot at Tel-Aviv University Ltd. HUMAN KAI1 METASTASE SUPPRESSOR MODULATORS METHOD AND USES THEREOF
US20180193270A1 (en) 2016-11-29 2018-07-12 PureTech Health LLC Exosomes for delivery of therapeutic agents
CN109022462B (zh) * 2017-06-08 2021-12-21 中山大学附属第一医院 一种PTEN基因的上游开放阅读框31aa-uORF核苷酸及其编码的多肽的应用
WO2019048645A1 (en) 2017-09-08 2019-03-14 Mina Therapeutics Limited STABILIZED COMPOSITIONS OF SMALL ACTIVATOR RNA (PARNA) FROM CEBPA AND METHODS OF USE
WO2019048632A1 (en) 2017-09-08 2019-03-14 Mina Therapeutics Limited STABILIZED COMPOSITIONS OF SMALL ACTIVATORY RNA (PARNA) OF HNF4A AND METHODS OF USE
CN114585633A (zh) 2019-08-19 2022-06-03 米纳治疗有限公司 寡核苷酸缀合物组合物和使用方法
EP4229202A4 (en) * 2020-10-13 2025-10-01 Brigham & Womens Hospital Inc COMPOSITIONS AND METHODS TARGETING CIRC2082 FOR THE TREATMENT OF CANCER
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JP2010507579A (ja) * 2006-10-18 2010-03-11 アイシス ファーマシューティカルズ， インコーポレーテッド アンチセンス化合物
WO2010065787A2 (en) * 2008-12-04 2010-06-10 Curna, Inc. Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11584932B2 (en) 2016-11-01 2023-02-21 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
US12371693B2 (en) 2016-11-01 2025-07-29 The Research Foundation For The State University Of New York 5-halouracil-modified micrornas and their use in the treatment of cancer
US12319913B2 (en) 2018-10-31 2025-06-03 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer

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US20150159161A1 (en) 2015-06-11
EP2850187A1 (en) 2015-03-25
EP2850187A4 (en) 2016-01-20
CA2873776A1 (en) 2013-11-21
WO2013173605A8 (en) 2014-11-27
CN104583400A (zh) 2015-04-29
BR112014028646A2 (pt) 2017-08-15
AU2013262706A1 (en) 2015-01-22
WO2013173605A1 (en) 2013-11-21
EA201492118A1 (ru) 2015-04-30

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