JP2015519043A5 - - Google Patents
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- Publication number
- JP2015519043A5 JP2015519043A5 JP2015505056A JP2015505056A JP2015519043A5 JP 2015519043 A5 JP2015519043 A5 JP 2015519043A5 JP 2015505056 A JP2015505056 A JP 2015505056A JP 2015505056 A JP2015505056 A JP 2015505056A JP 2015519043 A5 JP2015519043 A5 JP 2015519043A5
- Authority
- JP
- Japan
- Prior art keywords
- breast cancer
- cancer cells
- histological grade
- biomarkers
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010006187 Breast cancer Diseases 0.000 claims 42
- 208000026310 Breast neoplasm Diseases 0.000 claims 42
- 239000000090 biomarker Substances 0.000 claims 25
- 238000000034 method Methods 0.000 claims 20
- 239000013068 control sample Substances 0.000 claims 11
- 206010027476 Metastases Diseases 0.000 claims 7
- 239000000523 sample Substances 0.000 claims 7
- 230000004083 survival effect Effects 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 102100035923 4-aminobutyrate aminotransferase, mitochondrial Human genes 0.000 claims 2
- 101001000686 Homo sapiens 4-aminobutyrate aminotransferase, mitochondrial Proteins 0.000 claims 2
- -1 RAPEF1 Proteins 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- WWJZWCUNLNYYAU-UHFFFAOYSA-N temephos Chemical compound C1=CC(OP(=S)(OC)OC)=CC=C1SC1=CC=C(OP(=S)(OC)OC)C=C1 WWJZWCUNLNYYAU-UHFFFAOYSA-N 0.000 claims 2
- 102100036659 26S proteasome non-ATPase regulatory subunit 9 Human genes 0.000 claims 1
- 102100022721 40S ribosomal protein S25 Human genes 0.000 claims 1
- 102100032500 40S ribosomal protein S27-like Human genes 0.000 claims 1
- 102100023779 40S ribosomal protein S5 Human genes 0.000 claims 1
- 102100040883 60S acidic ribosomal protein P0-like Human genes 0.000 claims 1
- 102100035623 ATP-citrate synthase Human genes 0.000 claims 1
- 102100040958 Aconitate hydratase, mitochondrial Human genes 0.000 claims 1
- 102100024394 Adipocyte enhancer-binding protein 1 Human genes 0.000 claims 1
- 102100025672 Angiopoietin-related protein 2 Human genes 0.000 claims 1
- 102100022444 CMRF35-like molecule 9 Human genes 0.000 claims 1
- 102100024539 Chymase Human genes 0.000 claims 1
- 102100039606 DNA replication licensing factor MCM3 Human genes 0.000 claims 1
- 102100033711 DNA replication licensing factor MCM7 Human genes 0.000 claims 1
- 102100040515 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Human genes 0.000 claims 1
- 102100024425 Dihydropyrimidinase-related protein 3 Human genes 0.000 claims 1
- 102100032058 EARP and GARP complex-interacting protein 1 Human genes 0.000 claims 1
- 101150017533 ERP44 gene Proteins 0.000 claims 1
- 102100031853 Endoplasmic reticulum resident protein 44 Human genes 0.000 claims 1
- 102100034237 Endosome/lysosome-associated apoptosis and autophagy regulator 1 Human genes 0.000 claims 1
- 102100036763 Extended synaptotagmin-1 Human genes 0.000 claims 1
- 101001136710 Homo sapiens 26S proteasome non-ATPase regulatory subunit 9 Proteins 0.000 claims 1
- 101000678929 Homo sapiens 40S ribosomal protein S25 Proteins 0.000 claims 1
- 101000731896 Homo sapiens 40S ribosomal protein S27-like Proteins 0.000 claims 1
- 101000622644 Homo sapiens 40S ribosomal protein S5 Proteins 0.000 claims 1
- 101000673446 Homo sapiens 60S acidic ribosomal protein P0-like Proteins 0.000 claims 1
- 101000782969 Homo sapiens ATP-citrate synthase Proteins 0.000 claims 1
- 101000965314 Homo sapiens Aconitate hydratase, mitochondrial Proteins 0.000 claims 1
- 101000833122 Homo sapiens Adipocyte enhancer-binding protein 1 Proteins 0.000 claims 1
- 101000693081 Homo sapiens Angiopoietin-related protein 2 Proteins 0.000 claims 1
- 101000901716 Homo sapiens CMRF35-like molecule 9 Proteins 0.000 claims 1
- 101000909983 Homo sapiens Chymase Proteins 0.000 claims 1
- 101000722264 Homo sapiens DENN domain-containing protein 2B Proteins 0.000 claims 1
- 101000963174 Homo sapiens DNA replication licensing factor MCM3 Proteins 0.000 claims 1
- 101001018431 Homo sapiens DNA replication licensing factor MCM7 Proteins 0.000 claims 1
- 101000966982 Homo sapiens Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Proteins 0.000 claims 1
- 101001053501 Homo sapiens Dihydropyrimidinase-related protein 3 Proteins 0.000 claims 1
- 101000921326 Homo sapiens EARP and GARP complex-interacting protein 1 Proteins 0.000 claims 1
- 101000925880 Homo sapiens Endosome/lysosome-associated apoptosis and autophagy regulator 1 Proteins 0.000 claims 1
- 101000851525 Homo sapiens Extended synaptotagmin-1 Proteins 0.000 claims 1
- 101000625192 Homo sapiens Glutamine-tRNA ligase Proteins 0.000 claims 1
- 101000971769 Homo sapiens Keratocan Proteins 0.000 claims 1
- 101000578867 Homo sapiens Mis18-binding protein 1 Proteins 0.000 claims 1
- 101000601581 Homo sapiens NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial Proteins 0.000 claims 1
- 101000603068 Homo sapiens Nucleolar protein 56 Proteins 0.000 claims 1
- 101000741894 Homo sapiens POTE ankyrin domain family member F Proteins 0.000 claims 1
- 101001064779 Homo sapiens Plexin domain-containing protein 2 Proteins 0.000 claims 1
- 101000595182 Homo sapiens Podocan Proteins 0.000 claims 1
- 101000611663 Homo sapiens Prolargin Proteins 0.000 claims 1
- 101000630284 Homo sapiens Proline-tRNA ligase Proteins 0.000 claims 1
- 101000739214 Homo sapiens Protein SGT1 homolog Proteins 0.000 claims 1
- 101001130458 Homo sapiens Ras-related protein Ral-B Proteins 0.000 claims 1
- 101000849747 Homo sapiens Regulation of nuclear pre-mRNA domain-containing protein 1A Proteins 0.000 claims 1
- 101000849744 Homo sapiens Regulation of nuclear pre-mRNA domain-containing protein 1B Proteins 0.000 claims 1
- 101001119115 Homo sapiens Ribosomal RNA-processing protein 8 Proteins 0.000 claims 1
- 101000709114 Homo sapiens SAFB-like transcription modulator Proteins 0.000 claims 1
- 101000674278 Homo sapiens Serine-tRNA ligase, cytoplasmic Proteins 0.000 claims 1
- 101000674040 Homo sapiens Serine-tRNA ligase, mitochondrial Proteins 0.000 claims 1
- 101001092910 Homo sapiens Serum amyloid P-component Proteins 0.000 claims 1
- 101000642262 Homo sapiens Spondin-1 Proteins 0.000 claims 1
- 101000738413 Homo sapiens T-cell surface glycoprotein CD3 gamma chain Proteins 0.000 claims 1
- 101000653567 Homo sapiens T-complex protein 1 subunit delta Proteins 0.000 claims 1
- 101000659863 Homo sapiens Translin Proteins 0.000 claims 1
- 101000761741 Homo sapiens Ubiquitin-conjugating enzyme E2 Q1 Proteins 0.000 claims 1
- 101000940063 Homo sapiens Ubiquitin-conjugating enzyme E2 variant 2 Proteins 0.000 claims 1
- 101001030255 Homo sapiens Unconventional myosin-XVIIIa Proteins 0.000 claims 1
- 101000806424 Homo sapiens V-type proton ATPase subunit G 1 Proteins 0.000 claims 1
- 101000599042 Homo sapiens Zinc finger protein Aiolos Proteins 0.000 claims 1
- 108091007984 KARS Proteins 0.000 claims 1
- 102100021497 Keratocan Human genes 0.000 claims 1
- 102100035529 Lysine-tRNA ligase Human genes 0.000 claims 1
- 102100025354 Macrophage mannose receptor 1 Human genes 0.000 claims 1
- 108010031099 Mannose Receptor Proteins 0.000 claims 1
- 102100028344 Mis18-binding protein 1 Human genes 0.000 claims 1
- 102100021769 Mitochondrial 2-oxoglutarate/malate carrier protein Human genes 0.000 claims 1
- 102100037519 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial Human genes 0.000 claims 1
- 102100037052 Nucleolar protein 56 Human genes 0.000 claims 1
- 102100038760 POTE ankyrin domain family member F Human genes 0.000 claims 1
- 102100031889 Plexin domain-containing protein 2 Human genes 0.000 claims 1
- 102100036036 Podocan Human genes 0.000 claims 1
- 102100040659 Prolargin Human genes 0.000 claims 1
- 102100026126 Proline-tRNA ligase Human genes 0.000 claims 1
- 102100037337 Protein SGT1 homolog Human genes 0.000 claims 1
- 102100031425 Ras-related protein Ral-B Human genes 0.000 claims 1
- 102100033797 Regulation of nuclear pre-mRNA domain-containing protein 1A Human genes 0.000 claims 1
- 102100033796 Regulation of nuclear pre-mRNA domain-containing protein 1B Human genes 0.000 claims 1
- 102100026762 Ribosomal RNA-processing protein 8 Human genes 0.000 claims 1
- 102100032664 SAFB-like transcription modulator Human genes 0.000 claims 1
- 108091006417 SLC25A11 Proteins 0.000 claims 1
- 101100181439 Schizosaccharomyces pombe (strain 972 / ATCC 24843) lcf1 gene Proteins 0.000 claims 1
- 102100040597 Serine-tRNA ligase, mitochondrial Human genes 0.000 claims 1
- 102100036202 Serum amyloid P-component Human genes 0.000 claims 1
- 102100036428 Spondin-1 Human genes 0.000 claims 1
- 102100037911 T-cell surface glycoprotein CD3 gamma chain Human genes 0.000 claims 1
- 102100029958 T-complex protein 1 subunit delta Human genes 0.000 claims 1
- 102100036032 Translin Human genes 0.000 claims 1
- 102100024121 U1 small nuclear ribonucleoprotein 70 kDa Human genes 0.000 claims 1
- 102100024846 Ubiquitin-conjugating enzyme E2 Q1 Human genes 0.000 claims 1
- 102100031122 Ubiquitin-conjugating enzyme E2 variant 2 Human genes 0.000 claims 1
- 102100038932 Unconventional myosin-XVIIIa Human genes 0.000 claims 1
- 102100037433 V-type proton ATPase subunit G 1 Human genes 0.000 claims 1
- 102100037798 Zinc finger protein Aiolos Human genes 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 101150083938 snrnp70 gene Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1206323.6A GB201206323D0 (en) | 2012-04-10 | 2012-04-10 | Methods and arrays for use in the same |
| PCT/IB2013/052858 WO2013153524A1 (en) | 2012-04-10 | 2013-04-10 | Methods for determining a breast cancer-associated disease state and arrays for use in the methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018187868A Division JP2019032334A (ja) | 2018-10-03 | 2018-10-03 | 乳癌関連の疾患状態を決定する方法およびこの方法における使用のためのアレイ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015519043A JP2015519043A (ja) | 2015-07-09 |
| JP2015519043A5 true JP2015519043A5 (enExample) | 2016-06-02 |
| JP6470681B2 JP6470681B2 (ja) | 2019-02-13 |
Family
ID=46177101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505056A Expired - Fee Related JP6470681B2 (ja) | 2012-04-10 | 2013-04-10 | 乳癌関連の疾患状態を決定する方法およびこの方法における使用のためのアレイ |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20150057177A1 (enExample) |
| EP (1) | EP2836838A4 (enExample) |
| JP (1) | JP6470681B2 (enExample) |
| KR (1) | KR20140143457A (enExample) |
| CN (2) | CN107782901A (enExample) |
| AU (1) | AU2013248138B2 (enExample) |
| CA (1) | CA2869696A1 (enExample) |
| GB (1) | GB201206323D0 (enExample) |
| MX (1) | MX2014012192A (enExample) |
| WO (1) | WO2013153524A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201410226D0 (en) * | 2014-06-09 | 2014-07-23 | Immunovia Ab | Methods and arrays for use in the same |
| CN106596494B (zh) * | 2016-12-29 | 2019-05-10 | 青岛科技大学 | 一种基于荧光传感阵列的快速筛查早中晚期乳腺癌技术 |
| GB201701572D0 (en) * | 2017-01-31 | 2017-03-15 | Immunovia Ab | Methods, arrays and uses thereof |
| CN111458512A (zh) * | 2019-01-21 | 2020-07-28 | 中国科学院分子细胞科学卓越创新中心 | 一种动脉粥样硬化生物标志物及其用途 |
| JP7352937B2 (ja) * | 2019-07-19 | 2023-09-29 | 公立大学法人福島県立医科大学 | 乳癌のサブタイプを鑑別又は分類するための鑑別マーカー遺伝子セット、方法およびキット |
| CA3206126A1 (en) * | 2021-01-15 | 2022-07-21 | Universite De Fribourg | Biomarkers for breast cancer detection |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR19990077146A (ko) * | 1996-01-11 | 1999-10-25 | 길리스 스티브 | 유방암의 치료 및 진단용 조성물 및 방법 |
| US20030138793A1 (en) * | 2001-06-10 | 2003-07-24 | Irm Llc, A Delaware Limited Liability Company | Molecular signatures of commonly fatal carcinomas |
| WO2004106495A2 (en) * | 2003-05-29 | 2004-12-09 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
| KR20060031809A (ko) * | 2003-06-09 | 2006-04-13 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 암 치료 및 진단용 조성물 및 방법 |
| JP2005270093A (ja) * | 2004-02-24 | 2005-10-06 | Nippon Medical School | 乳癌の術後予後予測に関与する遺伝子 |
| US20080026950A1 (en) * | 2004-02-24 | 2008-01-31 | Mitsubishi Rayon Co., Ltd. | Gene Relating to Estimation of Postoperative Prognosis for Breast Cancer |
| WO2006105642A1 (en) * | 2005-04-05 | 2006-10-12 | British Columbia Cancer Agency | Biomarkers for the detection of lung cancer and uses thereof |
| US20070099209A1 (en) * | 2005-06-13 | 2007-05-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| SG142186A1 (en) * | 2006-10-20 | 2008-05-28 | Agency Science Tech & Res | Breast tumour grading |
| JP5196465B2 (ja) * | 2007-04-24 | 2013-05-15 | 公益財団法人東京都農林水産振興財団 | Ｍｍｐ遺伝子発現促進剤、および、コラーゲン分解促進剤 |
| NZ562237A (en) * | 2007-10-05 | 2011-02-25 | Pacific Edge Biotechnology Ltd | Proliferation signature and prognosis for gastrointestinal cancer |
| GB0723179D0 (en) * | 2007-11-27 | 2008-01-02 | Immunovia Ab | Diagnostic methods and arrays for use in the same |
| US8519116B2 (en) * | 2008-04-29 | 2013-08-27 | Siemens Healthcare Diagnostics Inc. | Method for predicting a clinical response of a patient suffering from or at risk of developing cancer towards a given mode of treatment |
| JP2010151800A (ja) * | 2008-11-06 | 2010-07-08 | Kumamoto Univ | 生活習慣病及び／又は癌の診断剤 |
| WO2010076322A1 (en) * | 2008-12-30 | 2010-07-08 | Siemens Healthcare Diagnostics Inc. | Prediction of response to taxane/anthracycline-containing chemotherapy in breast cancer |
| WO2010088386A1 (en) * | 2009-01-28 | 2010-08-05 | University Of Notre Dame Du Lac | Accelerated progression relapse test |
| WO2011063274A2 (en) * | 2009-11-23 | 2011-05-26 | Genomic Health, Inc. | Methods to predict clinical outcome of cancer |
| WO2011065533A1 (ja) * | 2009-11-30 | 2011-06-03 | 国立大学法人大阪大学 | 乳癌術前化学療法に対する感受性の判定方法 |
-
2012
- 2012-04-10 GB GBGB1206323.6A patent/GB201206323D0/en not_active Ceased
-
2013
- 2013-04-10 AU AU2013248138A patent/AU2013248138B2/en not_active Ceased
- 2013-04-10 US US14/391,144 patent/US20150057177A1/en not_active Abandoned
- 2013-04-10 CA CA2869696A patent/CA2869696A1/en not_active Abandoned
- 2013-04-10 WO PCT/IB2013/052858 patent/WO2013153524A1/en not_active Ceased
- 2013-04-10 CN CN201710403116.3A patent/CN107782901A/zh active Pending
- 2013-04-10 EP EP13775332.3A patent/EP2836838A4/en not_active Withdrawn
- 2013-04-10 MX MX2014012192A patent/MX2014012192A/es unknown
- 2013-04-10 KR KR1020147031565A patent/KR20140143457A/ko not_active Abandoned
- 2013-04-10 CN CN201380029458.3A patent/CN104508486B/zh not_active Expired - Fee Related
- 2013-04-10 JP JP2015505056A patent/JP6470681B2/ja not_active Expired - Fee Related
-
2017
- 2017-12-27 US US15/855,156 patent/US20180284120A1/en not_active Abandoned
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