JP2015518002A5 - - Google Patents

Info

Publication number

JP2015518002A5

JP2015518002A5 JP2015507308A JP2015507308A JP2015518002A5 JP 2015518002 A5 JP2015518002 A5 JP 2015518002A5 JP 2015507308 A JP2015507308 A JP 2015507308A JP 2015507308 A JP2015507308 A JP 2015507308A JP 2015518002 A5 JP2015518002 A5 JP 2015518002A5

Authority

JP

Japan

Prior art keywords

dietary fiber

administration

metformin

subject

sitagliptin

Prior art date

2013-04-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 claims description 95
• 235000013325 dietary fiber Nutrition 0.000 claims description 78
• 239000008194 pharmaceutical composition Substances 0.000 claims description 51
• XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims description 47
• 229960003105 metformin Drugs 0.000 claims description 47
• MFFMDFFZMYYVKS-SECBINFHSA-N sitagliptin Chemical compound C([C@H](CC(=O)N1CC=2N(C(=NN=2)C(F)(F)F)CC1)N)C1=CC(F)=C(F)C=C1F MFFMDFFZMYYVKS-SECBINFHSA-N 0.000 claims description 44
• 229960004034 sitagliptin Drugs 0.000 claims description 44
• 208000030159 metabolic disease Diseases 0.000 claims description 30
• 208000016097 disease of metabolism Diseases 0.000 claims description 15
• LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims description 12
• 229920002581 Glucomannan Polymers 0.000 claims description 12
• 229940046240 glucomannan Drugs 0.000 claims description 12
• 230000002265 prevention Effects 0.000 claims description 12
• 235000010493 xanthan gum Nutrition 0.000 claims description 12
• 229920001285 xanthan gum Polymers 0.000 claims description 12
• 229940082509 xanthan gum Drugs 0.000 claims description 12
• 239000000230 xanthan gum Substances 0.000 claims description 12
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 11
• 229940072056 alginate Drugs 0.000 claims description 11
• 235000010443 alginic acid Nutrition 0.000 claims description 11
• 229920000615 alginic acid Polymers 0.000 claims description 11
• 229940035748 metformin and sitagliptin Drugs 0.000 claims description 10
• 208000024891 symptom Diseases 0.000 claims description 7
• 239000008280 blood Substances 0.000 claims description 6
• 210000004369 blood Anatomy 0.000 claims description 6
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 6
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 6
• 208000001145 Metabolic Syndrome Diseases 0.000 claims description 5
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims description 5
• 238000011260 co-administration Methods 0.000 claims description 4
• 210000004153 islets of langerhan Anatomy 0.000 claims description 4
• 150000002632 lipids Chemical class 0.000 claims description 4
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
• 206010067125 Liver injury Diseases 0.000 claims description 3
• 230000005779 cell damage Effects 0.000 claims description 3
• 208000037887 cell injury Diseases 0.000 claims description 3
• 230000006378 damage Effects 0.000 claims description 3
• 230000006870 function Effects 0.000 claims description 3
• 239000008103 glucose Substances 0.000 claims description 3
• 231100000234 hepatic damage Toxicity 0.000 claims description 3
• 230000003907 kidney function Effects 0.000 claims description 3
• 230000008818 liver damage Effects 0.000 claims description 3
• 230000003908 liver function Effects 0.000 claims description 3
• 239000007903 gelatin capsule Substances 0.000 claims description 2
• 210000003734 kidney Anatomy 0.000 claims description 2
• 239000000843 powder Substances 0.000 claims description 2
• 238000000034 method Methods 0.000 description 29
• 235000013305 food Nutrition 0.000 description 1