JP2015516173A5 - - Google Patents
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- Publication number
- JP2015516173A5 JP2015516173A5 JP2015512786A JP2015512786A JP2015516173A5 JP 2015516173 A5 JP2015516173 A5 JP 2015516173A5 JP 2015512786 A JP2015512786 A JP 2015512786A JP 2015512786 A JP2015512786 A JP 2015512786A JP 2015516173 A5 JP2015516173 A5 JP 2015516173A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- buten
- synthase
- isoprene
- microbial organism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims 36
- HNVRRHSXBLFLIG-UHFFFAOYSA-N 3-hydroxy-3-methylbut-1-ene Chemical compound CC(C)(O)C=C HNVRRHSXBLFLIG-UHFFFAOYSA-N 0.000 claims 30
- 230000000813 microbial effect Effects 0.000 claims 18
- BZAZNULYLRVMSW-UHFFFAOYSA-N 2-Methyl-2-buten-3-ol Natural products CC(C)=C(C)O BZAZNULYLRVMSW-UHFFFAOYSA-N 0.000 claims 17
- ASUAYTHWZCLXAN-UHFFFAOYSA-N prenol Chemical compound CC(C)=CCO ASUAYTHWZCLXAN-UHFFFAOYSA-N 0.000 claims 10
- CBIDRCWHNCKSTO-UHFFFAOYSA-N prenyl diphosphate Chemical compound CC(C)=CCO[P@](O)(=O)OP(O)(O)=O CBIDRCWHNCKSTO-UHFFFAOYSA-N 0.000 claims 10
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims 9
- 108090000790 Enzymes Proteins 0.000 claims 8
- 102000004190 Enzymes Human genes 0.000 claims 8
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical group CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 claims 6
- NSPPRYXGGYQMPY-UHFFFAOYSA-N 3-Methylbuten-2-ol-1 Natural products CC(C)C(O)=C NSPPRYXGGYQMPY-UHFFFAOYSA-N 0.000 claims 5
- 108090000769 Isomerases Proteins 0.000 claims 5
- 102000004195 Isomerases Human genes 0.000 claims 5
- 238000006243 chemical reaction Methods 0.000 claims 5
- 230000037361 pathway Effects 0.000 claims 5
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 claims 3
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 claims 3
- 235000004347 Perilla Nutrition 0.000 claims 3
- 244000124853 Perilla frutescens Species 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 claims 3
- 229930007744 linalool Natural products 0.000 claims 3
- 238000003786 synthesis reaction Methods 0.000 claims 3
- 108010087432 terpene synthase Proteins 0.000 claims 3
- MAKBWIUHFAVVJP-HAXARLPTSA-N (2R,3S)-pentane-1,2,3,4-tetrol phosphoric acid Chemical compound OP(O)(O)=O.CC(O)[C@H](O)[C@H](O)CO MAKBWIUHFAVVJP-HAXARLPTSA-N 0.000 claims 2
- KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical compound OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 claims 2
- BKOOMYPCSUNDGP-UHFFFAOYSA-N 2-methylbut-2-ene Chemical compound CC=C(C)C BKOOMYPCSUNDGP-UHFFFAOYSA-N 0.000 claims 2
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims 2
- 244000063299 Bacillus subtilis Species 0.000 claims 2
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 235000010676 Ocimum basilicum Nutrition 0.000 claims 2
- 240000007926 Ocimum gratissimum Species 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 claims 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 claims 1
- 108010068049 1-deoxy-D-xylulose 5-phosphate reductoisomerase Proteins 0.000 claims 1
- WCASXYBKJHWFMY-NSCUHMNNSA-N 2-Buten-1-ol Chemical compound C\C=C\CO WCASXYBKJHWFMY-NSCUHMNNSA-N 0.000 claims 1
- 101710184086 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Proteins 0.000 claims 1
- 108030005203 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthases Proteins 0.000 claims 1
- 101710201168 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Proteins 0.000 claims 1
- 101710195531 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic Proteins 0.000 claims 1
- NVGOATMUHKIQQG-UHFFFAOYSA-N 2-Methyl-3-buten-1-ol Chemical compound OCC(C)C=C NVGOATMUHKIQQG-UHFFFAOYSA-N 0.000 claims 1
- 101710166309 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase Proteins 0.000 claims 1
- 101710139854 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin) Proteins 0.000 claims 1
- 101710088071 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic Proteins 0.000 claims 1
- 101710086072 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) Proteins 0.000 claims 1
- 241000219068 Actinidia Species 0.000 claims 1
- 241000219195 Arabidopsis thaliana Species 0.000 claims 1
- 101100108256 Bacillus subtilis (strain 168) nudF gene Proteins 0.000 claims 1
- 101100463951 Bacillus subtilis (strain 168) phoE gene Proteins 0.000 claims 1
- 235000005979 Citrus limon Nutrition 0.000 claims 1
- 244000131522 Citrus pyriformis Species 0.000 claims 1
- 101100281639 Escherichia coli (strain K12) frlR gene Proteins 0.000 claims 1
- 101100449334 Escherichia coli (strain K12) gpmB gene Proteins 0.000 claims 1
- 244000173610 Mentha aquatica Species 0.000 claims 1
- 235000012629 Mentha aquatica Nutrition 0.000 claims 1
- 101000894711 Origanum vulgare Bicyclo-germacrene synthase Proteins 0.000 claims 1
- 241000209094 Oryza Species 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- 244000000231 Sesamum indicum Species 0.000 claims 1
- 235000003434 Sesamum indicum Nutrition 0.000 claims 1
- 240000008042 Zea mays Species 0.000 claims 1
- 101000720152 Zea mays Acyclic sesquiterpene synthase Proteins 0.000 claims 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 1
- 230000001588 bifunctional effect Effects 0.000 claims 1
- 235000005822 corn Nutrition 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 108010060155 deoxyxylulose-5-phosphate synthase Proteins 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229940043259 farnesol Drugs 0.000 claims 1
- 229930002886 farnesol Natural products 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- -1 methyl pentaerythritol phosphate Chemical compound 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 claims 1
- 229940075420 xanthine Drugs 0.000 claims 1
- 101150093431 yhfR gene Proteins 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261688514P | 2012-05-16 | 2012-05-16 | |
| US61/688,514 | 2012-05-16 | ||
| US201361776485P | 2013-03-11 | 2013-03-11 | |
| US61/776,485 | 2013-03-11 | ||
| PCT/US2013/041108 WO2013173437A1 (en) | 2012-05-16 | 2013-05-15 | Microorganisms and processes for the production of isoprene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015516173A JP2015516173A (ja) | 2015-06-11 |
| JP2015516173A5 true JP2015516173A5 (https=) | 2016-06-30 |
Family
ID=49581617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015512786A Pending JP2015516173A (ja) | 2012-05-16 | 2013-05-15 | イソプレン生産用微生物およびプロセス |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8741612B2 (https=) |
| EP (1) | EP2850196A4 (https=) |
| JP (1) | JP2015516173A (https=) |
| KR (1) | KR20150014941A (https=) |
| BR (1) | BR112014028287A2 (https=) |
| SG (1) | SG11201406923WA (https=) |
| WO (1) | WO2013173437A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9422578B2 (en) | 2011-06-17 | 2016-08-23 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
| CN107254492A (zh) | 2011-06-17 | 2017-10-17 | 英威达技术有限责任公司 | 产生1,3‑丁二烯的方法 |
| BR112014028287A2 (pt) * | 2012-05-16 | 2017-06-27 | Glycos Biotechnologies Inc | micro-organismos e processos para a produção de isopreno |
| US8703455B2 (en) | 2012-08-29 | 2014-04-22 | Scientist of Fourtune, S.A. | Production of volatile dienes by enzymatic dehydration of light alkenols |
| WO2014085612A1 (en) | 2012-11-28 | 2014-06-05 | INVISTA North America S.á r.l. | Methods for biosynthesis of isobutene |
| JP2016511630A (ja) | 2012-12-21 | 2016-04-21 | ダニスコ・ユーエス・インク | 代案の下流メバロン酸経路を使用するイソプレン、イソプレノイド、およびイソプレノイド前駆体の生成 |
| ES2735331T3 (es) | 2013-04-10 | 2019-12-18 | Goodyear Tire & Rubber | Fosfocetolasas para mejorar la producción de metabolitos derivados de acetil-coenzima A, isopreno, precursores de isoprenoides e isoprenoides |
| US10294496B2 (en) | 2013-07-19 | 2019-05-21 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
| BR112016002626A2 (pt) | 2013-08-05 | 2017-09-12 | Invista Tech Sarl | método para sintetizar isobuteno e hospedeiro recombinante |
| WO2015021045A2 (en) | 2013-08-05 | 2015-02-12 | INVISTA North America S.á r.l. | Methods for biosynthesis of isoprene |
| WO2015073947A1 (en) * | 2013-11-18 | 2015-05-21 | Glycos Biotechnologies, Inc. | Compositions for 2-methyl-3-buten-2-ol dehydration and methods of producing isoprene using same |
| EP3155111A1 (en) | 2014-06-16 | 2017-04-19 | Invista Technologies S.à r.l. | Process for producing glutarate and glutaric acid methyl ester |
| CN107365758B (zh) * | 2016-05-12 | 2021-03-05 | 山东常青藤生物科技有限公司 | 五碳平台化合物合成基因及其应用 |
| WO2018206262A1 (en) | 2017-05-10 | 2018-11-15 | Global Bioenergies | Improved methods for producing isobutene from 3-methylcrotonic acid |
| US11162115B2 (en) | 2017-06-30 | 2021-11-02 | Inv Nylon Chemicals Americas, Llc | Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons |
| US11634733B2 (en) | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
| US11505809B2 (en) | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849970A (en) | 1995-06-23 | 1998-12-15 | The Regents Of The University Of Colorado | Materials and methods for the bacterial production of isoprene |
| EP1231273A1 (en) | 2001-02-12 | 2002-08-14 | Plant Research International B.V. | Terpene synthase/cyclase and olefin synthase and uses thereof |
| US7223909B2 (en) * | 2002-03-21 | 2007-05-29 | Ball Horticultural | 4-ketocarotenoids in flower petals |
| WO2005033287A2 (en) * | 2003-09-29 | 2005-04-14 | The Regents Of The University Of California | Methods for identifying a biosynthetic pathway gene product |
| SG172646A1 (en) * | 2006-05-26 | 2011-07-28 | Amyris Biotechnologies Inc | Production of isoprenoids |
| WO2009006429A1 (en) * | 2007-06-29 | 2009-01-08 | Regents Of The University Of California | Host cells and methods for producing 3-methyl-2-buten-1-ol, 3-methyl-3-buten-1-ol, and 3-methyl-butan-1-ol |
| JP2010539902A (ja) * | 2007-09-20 | 2010-12-24 | アミリス バイオテクノロジーズ，インコーポレイティド | イソプレノイドの生産 |
| AU2008334945C1 (en) * | 2007-12-13 | 2013-09-05 | Danisco Us Inc. | Compositions and methods for producing isoprene |
| MX2010011068A (es) * | 2008-04-08 | 2010-11-04 | Amyris Biotechnologies Inc | Expresion de secuencias heterologas. |
| MX318543B (es) | 2008-07-02 | 2014-03-18 | Danisco Us Inc | Composiciones y metodos para producir isopreno libre de hidrocarburos de c5 bajo condicion de desacoplamiento y/o intervalos de operacion seguros. |
| US7655739B1 (en) | 2009-06-26 | 2010-02-02 | Amyris Biotechnologies, Inc. | Adhesive compositions comprising a polyfarnesene |
| CA2737195A1 (en) | 2008-09-15 | 2010-03-18 | The Goodyear Tire & Rubber Company | Conversion of prenyl derivatives to isoprene |
| WO2010135674A2 (en) * | 2009-05-22 | 2010-11-25 | Board Of Trustees Of Michigan State University | Methyl butenol synthase |
| EP2336340A1 (en) | 2009-12-21 | 2011-06-22 | Philippe Marliere | Method for producing an alkene comprising the step of converting an alcohol by an enzymatic dehydration step |
| EP2336341A1 (en) | 2009-12-21 | 2011-06-22 | Philippe Marliere | Method for producing an alkene comprising the step of converting an alcohol by an enzymatic dehydration step |
| EP2857518A3 (en) * | 2009-12-23 | 2015-04-22 | Danisco US Inc. | Compositions and methods of PGL for the increased production of isoprene |
| EP2444415A1 (en) * | 2010-10-20 | 2012-04-25 | Genoplante-Valor | 1-Deoxy-D-xylulose 5-phosphate synthase alleles responsible for enhanced terpene biosynthesis |
| BR112014028287A2 (pt) * | 2012-05-16 | 2017-06-27 | Glycos Biotechnologies Inc | micro-organismos e processos para a produção de isopreno |
-
2013
- 2013-05-15 BR BR112014028287A patent/BR112014028287A2/pt not_active IP Right Cessation
- 2013-05-15 US US13/894,732 patent/US8741612B2/en not_active Expired - Fee Related
- 2013-05-15 EP EP13790445.4A patent/EP2850196A4/en not_active Withdrawn
- 2013-05-15 KR KR1020147033320A patent/KR20150014941A/ko not_active Withdrawn
- 2013-05-15 SG SG11201406923WA patent/SG11201406923WA/en unknown
- 2013-05-15 US US13/894,744 patent/US8741613B2/en not_active Expired - Fee Related
- 2013-05-15 JP JP2015512786A patent/JP2015516173A/ja active Pending
- 2013-05-15 WO PCT/US2013/041108 patent/WO2013173437A1/en not_active Ceased
-
2014
- 2014-06-02 US US14/293,362 patent/US20140349362A1/en not_active Abandoned
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