JP2015516173A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015516173A5 JP2015516173A5 JP2015512786A JP2015512786A JP2015516173A5 JP 2015516173 A5 JP2015516173 A5 JP 2015516173A5 JP 2015512786 A JP2015512786 A JP 2015512786A JP 2015512786 A JP2015512786 A JP 2015512786A JP 2015516173 A5 JP2015516173 A5 JP 2015516173A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- buten
- synthase
- isoprene
- microbial organism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims 36
- HNVRRHSXBLFLIG-UHFFFAOYSA-N 3-hydroxy-3-methylbut-1-ene Chemical compound CC(C)(O)C=C HNVRRHSXBLFLIG-UHFFFAOYSA-N 0.000 claims 30
- 230000000813 microbial effect Effects 0.000 claims 18
- BZAZNULYLRVMSW-UHFFFAOYSA-N 2-Methyl-2-buten-3-ol Natural products CC(C)=C(C)O BZAZNULYLRVMSW-UHFFFAOYSA-N 0.000 claims 17
- ASUAYTHWZCLXAN-UHFFFAOYSA-N prenol Chemical compound CC(C)=CCO ASUAYTHWZCLXAN-UHFFFAOYSA-N 0.000 claims 10
- CBIDRCWHNCKSTO-UHFFFAOYSA-N prenyl diphosphate Chemical compound CC(C)=CCO[P@](O)(=O)OP(O)(O)=O CBIDRCWHNCKSTO-UHFFFAOYSA-N 0.000 claims 10
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims 9
- 108090000790 Enzymes Proteins 0.000 claims 8
- 102000004190 Enzymes Human genes 0.000 claims 8
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical group CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 claims 6
- NSPPRYXGGYQMPY-UHFFFAOYSA-N 3-Methylbuten-2-ol-1 Natural products CC(C)C(O)=C NSPPRYXGGYQMPY-UHFFFAOYSA-N 0.000 claims 5
- 108090000769 Isomerases Proteins 0.000 claims 5
- 102000004195 Isomerases Human genes 0.000 claims 5
- 238000006243 chemical reaction Methods 0.000 claims 5
- 230000037361 pathway Effects 0.000 claims 5
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 claims 3
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 claims 3
- 235000004347 Perilla Nutrition 0.000 claims 3
- 244000124853 Perilla frutescens Species 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 claims 3
- 229930007744 linalool Natural products 0.000 claims 3
- 238000003786 synthesis reaction Methods 0.000 claims 3
- 108010087432 terpene synthase Proteins 0.000 claims 3
- MAKBWIUHFAVVJP-HAXARLPTSA-N (2R,3S)-pentane-1,2,3,4-tetrol phosphoric acid Chemical compound OP(O)(O)=O.CC(O)[C@H](O)[C@H](O)CO MAKBWIUHFAVVJP-HAXARLPTSA-N 0.000 claims 2
- KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical compound OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 claims 2
- BKOOMYPCSUNDGP-UHFFFAOYSA-N 2-methylbut-2-ene Chemical compound CC=C(C)C BKOOMYPCSUNDGP-UHFFFAOYSA-N 0.000 claims 2
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims 2
- 244000063299 Bacillus subtilis Species 0.000 claims 2
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 235000010676 Ocimum basilicum Nutrition 0.000 claims 2
- 240000007926 Ocimum gratissimum Species 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 claims 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 claims 1
- 108010068049 1-deoxy-D-xylulose 5-phosphate reductoisomerase Proteins 0.000 claims 1
- WCASXYBKJHWFMY-NSCUHMNNSA-N 2-Buten-1-ol Chemical compound C\C=C\CO WCASXYBKJHWFMY-NSCUHMNNSA-N 0.000 claims 1
- 101710184086 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Proteins 0.000 claims 1
- 108030005203 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthases Proteins 0.000 claims 1
- 101710201168 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Proteins 0.000 claims 1
- 101710195531 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic Proteins 0.000 claims 1
- NVGOATMUHKIQQG-UHFFFAOYSA-N 2-Methyl-3-buten-1-ol Chemical compound OCC(C)C=C NVGOATMUHKIQQG-UHFFFAOYSA-N 0.000 claims 1
- 101710166309 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase Proteins 0.000 claims 1
- 101710139854 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin) Proteins 0.000 claims 1
- 101710088071 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic Proteins 0.000 claims 1
- 101710086072 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) Proteins 0.000 claims 1
- 241000219068 Actinidia Species 0.000 claims 1
- 241000219195 Arabidopsis thaliana Species 0.000 claims 1
- 101100108256 Bacillus subtilis (strain 168) nudF gene Proteins 0.000 claims 1
- 101100463951 Bacillus subtilis (strain 168) phoE gene Proteins 0.000 claims 1
- 235000005979 Citrus limon Nutrition 0.000 claims 1
- 244000131522 Citrus pyriformis Species 0.000 claims 1
- 101100281639 Escherichia coli (strain K12) frlR gene Proteins 0.000 claims 1
- 101100449334 Escherichia coli (strain K12) gpmB gene Proteins 0.000 claims 1
- 244000173610 Mentha aquatica Species 0.000 claims 1
- 235000012629 Mentha aquatica Nutrition 0.000 claims 1
- 101000894711 Origanum vulgare Bicyclo-germacrene synthase Proteins 0.000 claims 1
- 241000209094 Oryza Species 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- 244000000231 Sesamum indicum Species 0.000 claims 1
- 235000003434 Sesamum indicum Nutrition 0.000 claims 1
- 240000008042 Zea mays Species 0.000 claims 1
- 101000720152 Zea mays Acyclic sesquiterpene synthase Proteins 0.000 claims 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 1
- 230000001588 bifunctional effect Effects 0.000 claims 1
- 235000005822 corn Nutrition 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 108010060155 deoxyxylulose-5-phosphate synthase Proteins 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229940043259 farnesol Drugs 0.000 claims 1
- 229930002886 farnesol Natural products 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- -1 methyl pentaerythritol phosphate Chemical compound 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 claims 1
- 229940075420 xanthine Drugs 0.000 claims 1
- 101150093431 yhfR gene Proteins 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261688514P | 2012-05-16 | 2012-05-16 | |
| US61/688,514 | 2012-05-16 | ||
| US201361776485P | 2013-03-11 | 2013-03-11 | |
| US61/776,485 | 2013-03-11 | ||
| PCT/US2013/041108 WO2013173437A1 (en) | 2012-05-16 | 2013-05-15 | Microorganisms and processes for the production of isoprene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015516173A JP2015516173A (ja) | 2015-06-11 |
| JP2015516173A5 true JP2015516173A5 (https=) | 2016-06-30 |
Family
ID=49581617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015512786A Pending JP2015516173A (ja) | 2012-05-16 | 2013-05-15 | イソプレン生産用微生物およびプロセス |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8741613B2 (https=) |
| EP (1) | EP2850196A4 (https=) |
| JP (1) | JP2015516173A (https=) |
| KR (1) | KR20150014941A (https=) |
| BR (1) | BR112014028287A2 (https=) |
| SG (1) | SG11201406923WA (https=) |
| WO (1) | WO2013173437A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9422578B2 (en) | 2011-06-17 | 2016-08-23 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
| US9663801B2 (en) | 2011-06-17 | 2017-05-30 | Invista North America S.A.R.L. | Methods of producing four carbon molecules |
| US8741613B2 (en) * | 2012-05-16 | 2014-06-03 | Glycos Biotechnologies, Inc. | Microorganisms and processes for the production of isoprene |
| US8703455B2 (en) | 2012-08-29 | 2014-04-22 | Scientist of Fourtune, S.A. | Production of volatile dienes by enzymatic dehydration of light alkenols |
| CN104903455A (zh) | 2012-11-28 | 2015-09-09 | 英威达技术有限责任公司 | 用于异丁烯生物合成的方法 |
| US20160002672A1 (en) | 2012-12-21 | 2016-01-07 | Danisco Us Inc. | Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway |
| SG11201508186XA (en) | 2013-04-10 | 2015-11-27 | Danisco Us Inc | Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids |
| US10294496B2 (en) | 2013-07-19 | 2019-05-21 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
| US10533193B2 (en) | 2013-08-05 | 2020-01-14 | Invista North America S.A.R.L. | Methods for biosynthesis of isobutene |
| US9862973B2 (en) | 2013-08-05 | 2018-01-09 | Invista North America S.A.R.L. | Methods for biosynthesis of isoprene |
| WO2015073947A1 (en) * | 2013-11-18 | 2015-05-21 | Glycos Biotechnologies, Inc. | Compositions for 2-methyl-3-buten-2-ol dehydration and methods of producing isoprene using same |
| US20170152531A1 (en) | 2014-06-16 | 2017-06-01 | North America S.A.R.L. | Process for producing glutarate and glutaric acid methyl ester |
| CN107365758B (zh) * | 2016-05-12 | 2021-03-05 | 山东常青藤生物科技有限公司 | 五碳平台化合物合成基因及其应用 |
| EP3622080B1 (en) | 2017-05-10 | 2024-03-27 | Global Bioenergies | Improved methods for producing isobutene from 3-methylcrotonic acid |
| US11634733B2 (en) | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
| US11162115B2 (en) | 2017-06-30 | 2021-11-02 | Inv Nylon Chemicals Americas, Llc | Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons |
| US11505809B2 (en) | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849970A (en) | 1995-06-23 | 1998-12-15 | The Regents Of The University Of Colorado | Materials and methods for the bacterial production of isoprene |
| EP1231273A1 (en) | 2001-02-12 | 2002-08-14 | Plant Research International B.V. | Terpene synthase/cyclase and olefin synthase and uses thereof |
| US7223909B2 (en) * | 2002-03-21 | 2007-05-29 | Ball Horticultural | 4-ketocarotenoids in flower petals |
| US7927794B2 (en) * | 2003-09-29 | 2011-04-19 | The Regents Of The University Of California | Methods for identifying a biosynthetic pathway gene product |
| WO2007140339A2 (en) * | 2006-05-26 | 2007-12-06 | Amyris Biotechnologies, Inc. | Production of isoprenoids |
| WO2009006429A1 (en) | 2007-06-29 | 2009-01-08 | Regents Of The University Of California | Host cells and methods for producing 3-methyl-2-buten-1-ol, 3-methyl-3-buten-1-ol, and 3-methyl-butan-1-ol |
| AU2008305655B2 (en) | 2007-09-20 | 2013-10-31 | Amyris, Inc. | Production of isoprenoids |
| CN105368764B (zh) * | 2007-12-13 | 2019-03-12 | 丹尼斯科美国公司 | 用于生产异戊二烯的组合物和方法 |
| US20090253174A1 (en) * | 2008-04-08 | 2009-10-08 | Zach Serber | Expression of Heterologous Sequences |
| MX318543B (es) | 2008-07-02 | 2014-03-18 | Danisco Us Inc | Composiciones y metodos para producir isopreno libre de hidrocarburos de c5 bajo condicion de desacoplamiento y/o intervalos de operacion seguros. |
| US7655739B1 (en) | 2009-06-26 | 2010-02-02 | Amyris Biotechnologies, Inc. | Adhesive compositions comprising a polyfarnesene |
| EP2340312A2 (en) | 2008-09-15 | 2011-07-06 | Danisco US Inc. | Conversion of prenyl derivatives to isoprene |
| WO2010135674A2 (en) * | 2009-05-22 | 2010-11-25 | Board Of Trustees Of Michigan State University | Methyl butenol synthase |
| EP2336340A1 (en) | 2009-12-21 | 2011-06-22 | Philippe Marliere | Method for producing an alkene comprising the step of converting an alcohol by an enzymatic dehydration step |
| EP2336341A1 (en) | 2009-12-21 | 2011-06-22 | Philippe Marliere | Method for producing an alkene comprising the step of converting an alcohol by an enzymatic dehydration step |
| SG196782A1 (en) * | 2009-12-23 | 2014-02-13 | Danisco Us Inc | Compositions and methods for the increased production of isoprene and other products with 6 - phosphogluconolactonase (pgl) |
| EP2444415A1 (en) * | 2010-10-20 | 2012-04-25 | Genoplante-Valor | 1-Deoxy-D-xylulose 5-phosphate synthase alleles responsible for enhanced terpene biosynthesis |
| US8741613B2 (en) * | 2012-05-16 | 2014-06-03 | Glycos Biotechnologies, Inc. | Microorganisms and processes for the production of isoprene |
-
2013
- 2013-05-15 US US13/894,744 patent/US8741613B2/en not_active Expired - Fee Related
- 2013-05-15 JP JP2015512786A patent/JP2015516173A/ja active Pending
- 2013-05-15 US US13/894,732 patent/US8741612B2/en not_active Expired - Fee Related
- 2013-05-15 WO PCT/US2013/041108 patent/WO2013173437A1/en not_active Ceased
- 2013-05-15 KR KR1020147033320A patent/KR20150014941A/ko not_active Withdrawn
- 2013-05-15 BR BR112014028287A patent/BR112014028287A2/pt not_active IP Right Cessation
- 2013-05-15 EP EP13790445.4A patent/EP2850196A4/en not_active Withdrawn
- 2013-05-15 SG SG11201406923WA patent/SG11201406923WA/en unknown
-
2014
- 2014-06-02 US US14/293,362 patent/US20140349362A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015516173A5 (https=) | ||
| CA2880962C (en) | Increased production of terpenes and terpenoids | |
| JP6983512B2 (ja) | テルペン又はテルペノイドを産生する方法 | |
| JP5706444B2 (ja) | ６−ホスホグルコノラクトナーゼ（ｐｇｌ）によりイソプレン及び他の産物の生産を増加させるためのｐｇｌに関する組成物及び方法 | |
| US11130972B2 (en) | Method for producing fragrant alcohols | |
| Kim et al. | CRISPR interference-guided balancing of a biosynthetic mevalonate pathway increases terpenoid production | |
| JP6231011B2 (ja) | ３−ヒドロキシアルク−４−エノエートおよび／または３−ホスホノキシアルク−４−エノエートの酵素変換による１，３−ジエンの産生 | |
| JP2008500063A5 (https=) | ||
| WO2010019696A3 (en) | Method for production of isoprenoids | |
| CN104846020A (zh) | 生产香紫苏醇的方法 | |
| JP2016512047A5 (https=) | ||
| US11584941B2 (en) | Terpene synthase producing patchoulol and elemol, and preferably also pogostol | |
| CN105255921B (zh) | 异源合成广霍香醇的方法和微生物 | |
| Tong et al. | Cloning and functional characterization of an isopentenyl diphosphate isomerase gene from Tripterygium wilfordii | |
| Liu et al. | Combinational biosynthesis of isoprene by engineering the MEP pathway in Escherichia coli | |
| US20200308612A1 (en) | Vetiver | |
| CN112391371B (zh) | 一种烟草单萜合成酶TPS2b及其编码基因和应用 | |
| US20210002678A1 (en) | Enzymes, cells and methods for production of 3-(4-farnesyloxyphenyl)propionic acid and derivatives thereof | |
| CN112391327A (zh) | 一种用于联产香叶醇和橙花醇的工程菌及其构建方法与应用 | |
| Baadhe et al. | New trends in microbial production of natural complex bioactive isoprenoids | |
| KR100809582B1 (ko) | 알콜 유사체의 인산화 효소를 암호화하는 유전자 및 이를이용한 아이소프레노이드의 제조방법 | |
| IN2012DE00302A (https=) |